Search clinical trials for: Dose reduction

Total 25034 results

Wave Life Sciences Ltd.

Not yet recruiting

A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD (RestorAATion-2)

Alpha-1 Antitrypsin Deficiency
Bayer

Recruiting

A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Chronic Kidney Disease | Hepatic Impairment

United States
Pivot Health Technologies Inc.

Not yet recruiting

Study of a Smartphone-Based Alcohol Reduction Program

Alcohol Use, Unspecified

United States
Traws Pharma, Inc.

Recruiting

Evaluation Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of 83-0060 in Healthy Volunteers

Healthy Volunteers Only

Australia
Beni-Suef University

Not yet recruiting

Effect of Intra-articular Injection of Tenoxicam or Meloxicam in TMJ Anterior Disc Displacement With Reduction

Temporomandibular Joint Disc Displacement, With Reduction
Semmelweis University

Recruiting

The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate (NEOKOFF22)

Premature Birth | Respiratory Failure | Apnea of Prematurity

Hungary
Eilean Therapeutics

Recruiting

Study of Single and Multiple Ascending Doses of ZE46-0134 in Healthy Volunteers

AML

Australia
University Hospital, Ghent
Belgium Health Care Knowledge Centre

Not yet recruiting

Proactive TDM Versus Standard Use of Biologics in Psoriasis (HELIOS)

Psoriasis Vulgaris

Belgium
GE Healthcare
PPD; Fortrea

Not yet recruiting

A Phase 1, Dose-Escalation, Positron Emission Tomography Study to Assess the Safety, Pharmacokinetics, Dosimetry and Biodistribution of GEH200521 (18F) Injection Co-Administered With GEH200520 Injection in Healthy Volunteers

Healthy Volunteers

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Not yet recruiting

Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy (EROS3)

Locally Advanced Cervical Carcinoma
University of California, San Francisco
National Institute on Aging (NIA)

Recruiting

Enhancing Attention and Wellbeing Using Digital Therapeutics

Aging | Cognitive Decline | MCI

United States
University Of Perugia

Not yet recruiting

D-chiro-inositol and AUB

Abnormal Uterine Bleeding
Baptist Health South Florida
Ion Beam Applications SA

Not yet recruiting

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial (POPCORN)

Glioma | Recurrent Glioma | Glioma, Malignant

United States
Oneness Biotech Co., Ltd.

Not yet recruiting

Evaluate Efficacy, Pharmacokinetics, and Safety of Repeat Subcutaneous Doses of FB825 in Adults With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis
Debiopharm International SA

Recruiting

A Dose Finding Study of Debio 4228 in Participants With Locally Advanced/Metastatic Prostate Cancer

Prostate Cancer

United States
Beijing Hospital of Traditional Chinese Medicine

Not yet recruiting

A Multicentre Randomized Controlled Clinical Study on the Chitosan Nanocrystalline Qinteng Huoxue Runji Ointment Therapy for Psoriasis With Blood Stasis Syndrome.

Plaque Psoriasis
University of Maryland, Baltimore

Not yet recruiting

Assessment of Fall Risks and Subject-specific Training for Fall Reduction

Fall Risk
Pfizer

Not yet recruiting

A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants

Healthy Participants | Biological Availability
University of Chile
Agencia Nacional de Investigación y Desarrollo

Not yet recruiting

Optimal Therapeutic Dose of tDCS for Functional Upper Limb Recovery in People With Stroke

Stroke | Neurologic Deficits
Hansoh BioMedical R&D Company

Not yet recruiting

A Study to Find the Best Dose of HS-10384 to Treat Vasomotor Symptoms in Postmenopausal Women

Vasomotor Symptoms

China
Médecins du Monde
University of Bristol; PATH; UNITAID; Burnet Institute; Population Services International and other collaborators

Not yet recruiting

Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries

Hepatitis | Hiv | Drug Use
Changhai Hospital
Shanghai Chest Hospital; Shanghai Changzheng Hospital; First Affiliated Hospital... and other collaborators

Recruiting

High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib

Non-Small Cell Lung Cancer

China
Boehringer Ingelheim

Not yet recruiting

A Study in Healthy People to Compare How 2 Different High Dose Formulations of BI 1015550 Are Taken up in the Body

Healthy
Pfizer

Not yet recruiting

Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Transthyretin Amyloid Cardiomyopathy

Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

United States
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1 Dose Escalation Study of Intravenous VX-993 in Healthy Adults

Pain

United States
Cairo University

Recruiting

CAD/CAM Angle Fracture Reduction/Plate Guide and Customized 3D Grid Plate Versus Champy's Technique

Mandibular Fractures

Egypt
Ferring Pharmaceuticals

Not yet recruiting

A Phase 4, Multi-center, Open Label Trial to Evaluate Efficacy of Retreatment With Nadofaragene Firadenovec in Subjects With CIS ± High-grade Ta/T1 and no Complete Response to First Nadofaragene Firadenovec Dose (ABLE-42)

Bladder Cancer | CIS | Ta/T1
University of Wisconsin, Madison

Not yet recruiting

Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

Xerostomia | Graft-versus-host-disease | Sjogren's Disease

United States
Dong-A ST Co., Ltd.

Not yet recruiting

A Study to Evaluate Safety, Tolerability, and PK of DA-7503 in Healthy Adult and Elderly Participants

Healthy

Korea, Republic of
St. Jude Children's Research Hospital
AbbVie

Not yet recruiting

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

T-cell Lymphoma | T-cell Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States
National Taipei University of Nursing and Health...

Not yet recruiting

MBI in Generation Z Nursing Students During Clinical Practicum (MBI)

Depression | Anxiety | Mental Health | Resilience
Norroy Bioscience Co., LTD

Recruiting

Pharmacokinetics, Biodistribution, Radiation Dose and Safety Study of 68Ga-NYM005 in Patients

Clear Cell Renal Cell Carcinoma Metastatic

China
Radboud University Medical Center

Recruiting

Mindfulness-Based Stress Reduction (MBSR) for People High on the Personality Trait Sensory Processing Sensitivity: A Mixed Methods Study (MindSens)

Sensory Processing Sensitivity

Netherlands
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Phase II Study of Moderate-dose Hypofractionated RT Combined With Pembrolizumab for HCC With Diffuse Tumor Thrombosis

Hepatocellular Carcinoma | Radiotherapy | Pembrolizumab | Tumor Thrombosis

China
Chengdu Zenitar Biomedical Technology Co., Ltd

Recruiting

A Randomized, Double-blind,Dose-escalating, Single-dose, Oral Phase I Clinical Study of Flunotinib Healthy People

Healthy Person

China
Norroy Bioscience Co., LTD

Recruiting

Pharmacokinetics, Biodistribution, Radiation Dose and Safety Study of 68Ga-NYM032 in Patients

Prostate Cancer

China
Hospital Universiti Sains Malaysia

Not yet recruiting

Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block

End Stage Renal Failure
Novo Nordisk A/S

Not yet recruiting

A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Obesity

United Kingdom, Germany, Canada, United States, France
Universitair Ziekenhuis Brussel

Recruiting

Pharmacokinetics of Inhaled Levosimendan (Symbiov)

Left Ventricular Dysfunction

Belgium
Aldeyra Therapeutics, Inc.

Recruiting

A Clinical Trial to Assess the Efficacy and Safety of Subjects With Dry Eye Disease

Dry Eye Disease

Canada
AbbVie

Recruiting

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (Switch-Up)

Atopic Dermatitis

United States
Assistance Publique Hopitaux De Marseille

Recruiting

Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway (BIOCEPTION)

Lung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 Years

France
Central Hospital, Nancy, France

Not yet recruiting

Strategy to Adapt Botulinum Toxin Doses in Dystonia

Dystonia
Tongji Hospital

Not yet recruiting

Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions

Hemodynamics Instability | Amobarbital Sodium
Mayo Clinic

Recruiting

Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma

Indolent B-Cell Non-Hodgkin Lymphoma | Recurrent Indolent Non-Hodgkin Lymphoma | Refractory Indolent Non-Hodgkin Lymphoma | Recurrent Indolent B-Cell Non-Hodgkin Lymphoma | Refractory Indolent B-Cell Non-Hodgkin Lymphoma

United States
Institute of Hematology & Blood Diseases Hospital...

Not yet recruiting

Efficacy and Safety of Low-dose Chemotherapy Plus Immuno-targeted Drugs in Newly Diagnosed Elderly/Unfit Ph- B-ALL

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Universiteit Antwerpen

Recruiting

Study of the Patient Radiation Dose During Five Endourological Procedures (PRDE)

Urolithiasis | Radiation Exposure

Belgium
Eli Lilly and Company

Recruiting

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity

United States, Australia, Italy, Hungary, Spain, Canada, Germany, Argentina, Belgium, Czechia, Greece, Israel, Austria, Brazil, Mexico, Netherlands, Romania, India, United Kingdom, Slovakia, Poland, Turkey, Puerto Rico, France, Denmark
University Health Network, Toronto

Not yet recruiting

Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation (TRADR)

Distal Radius Fractures

Canada
Indivior Inc.

Not yet recruiting

Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorder

Opioid Use Disorder

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