Search clinical trials for: Motor Neuron Disease

Total 383747 results

Neuromed IRCCS
IRCCS Multimedica

Recruiting

Biomarkers of Synaptic Damage in Multiple Sclerosis

Multiple Sclerosis | Parkinson Disease | Amyotrophic Lateral Sclerosis | Alzheimer Disease

Italy
Kaohsiung Medical University Chung-Ho Memorial...
The Chinese Foundation of Health; Taipei Institute of Pathology

Recruiting

Neonatal Spinal Muscular Atrophy (SMA) Screening (SMA)

Spinal Muscular Atrophy

Taiwan
AB Science

Recruiting

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

Amyotrophic Lateral Sclerosis

France, Spain, United States, Sweden, Denmark, Portugal, Italy, Israel, Germany, Norway, Poland, Russian Federation, Slovenia, Ukraine, Greece, Belgium, Serbia
Ottawa Hospital Research Institute

Recruiting

NeuroCognitive Communicator: Safety Study (NCC-1701)

Tetraplegia | Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Canada
Neuromed IRCCS

Recruiting

Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS)

Italy
Revalesio Corporation

Not yet recruiting

Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
Rigshospitalet, Denmark
Odense University Hospital; Zealand University Hospital; Aarhus University Hospital and other collaborators

Recruiting

Amyotrophic Lateral Sclerosis and the Innate Immune System

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Neurodegenerative Disease

Denmark
MD Stem Cells

Recruiting

Neurologic Stem Cell Treatment Study (NEST)

Stroke | Nervous System Diseases | Diabetic Neuropathies | Neurodegenerative Diseases | Cognitive Impairment | Amyotrophic Lateral Sclerosis | Dementia | Neurological Disorders | Alzheimer Disease | ALS | Traumatic Brain Injury | Cerebral Infarction | Lewy Body Disease | Cerebral Hemorrhage | Frontotemporal Dementia | Progressive... and other conditions

United States, United Arab Emirates
Nemours Children's Clinic

Recruiting

Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases

Charcot-Marie-Tooth Disease | Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Spinal Muscular Atrophy | Neuromuscular Disease | Spinal Muscular Atrophy With Respiratory Distress 1 | Peroneal Muscular Atrophy

United States
Q Therapeutics, Inc.

Not yet recruiting

Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis
Foundation Fighting Blindness

Recruiting

Inherited Retinal Degenerative Disease Registry (MRTR)

Retinitis Pigmentosa | Choroideremia | Usher Syndrome | Batten Disease | Leber Congenital Amaurosis | Goldmann-Favre Syndrome | Kearns-Sayre Syndrome | Retinal Disease | Bardet-Biedl Syndrome | Stargardt Disease | Cone Dystrophy | Retinoschisis | Achromatopsia | Gyrate Atrophy | Eye Diseases Hereditary | Bassen-Kornzweig... and other conditions

United States
University Hospital, Lille

Recruiting

Study of Predictive Factors of Progression of Motor Neurone Disease (PULSE)

Motor Neuron Disease | Amyotrophic Lateral Sclerosis

France
Richard A. Andersen, PhD
University of Southern California; Rancho Los Amigos National Rehabilitation... and other collaborators

Recruiting

Sensory Motor Transformations in Human Cortex

Quadriplegia

United States
National Institute of Neurological Disorders and...

Recruiting

Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers

Motor Neuron Disease | Neuromuscular Disease | Inherited Neuromuscular Conditions | Inherited Neuropathies

United States
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Centers for Disease Control and Prevention
US Department of Veterans Affairs; Centers for Medicare and Medicaid Services

Recruiting

The National Amyotrophic Lateral Sclerosis Registry

Amyotrophic Lateral Sclerosis

United States
Leigh R. Hochberg, MD, PhD.
National Institute of Neurological Disorders and Stroke (NINDS); US Department... and other collaborators

Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia (BrainGate2)

Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Spinal Cord Injuries | Tetraplegia | Brain Stem Infarctions | Locked in Syndrome

United States
University of Miami
ALS Association

Recruiting

The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study (Pre-fALS)

Amyotrophic Lateral Sclerosis

United States
University of Miami
ALS Association; ALS Recovery Fund

Recruiting

Clinical Research in ALS Study (CRiALS)

Amyotrophic Lateral Sclerosis

United States
National Institute of Neurological Disorders and...

Recruiting

Study of Inherited Neurological Disorders

Motor Neuron Disease | Muscular Dystrophy | Peripheral Nervous System Disease | Muscular Disease

United States, Mali
Biogen

Completed

Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy (DEVOTE)

Muscular Atrophy, Spinal

China, United States, Netherlands, Spain, Korea, Republic of, Taiwan, Australia, Canada, Chile, Saudi Arabia, Poland, Israel, Brazil, Russian Federation, Hungary, Japan, United Kingdom, Italy, Germany, Estonia, Greece, Mexico, Colombia and more
Brainstorm-Cell Therapeutics

Completed

Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS (NurOwn)

Amyotrophic Lateral Sclerosis (ALS)

United States
MaaT Pharma

Active, not recruiting

Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis (IASO)

Amyotrophic Lateral Sclerosis | ALS

France
Scholar Rock, Inc.

Active, not recruiting

Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab-ONYX (ONYX)

Neuromuscular Diseases | Neuromuscular Manifestations | Atrophy | Muscular Atrophy | Spinal Muscular Atrophy | Muscular Atrophy, Spinal | Spinal Muscular Atrophy Type 3 | SMA | Anti-myostatin | Spinal Muscular Atrophy Type II

United States, Spain, Belgium, Germany, Netherlands, Poland, Italy, France, United Kingdom
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (OFELIA) (OFELIA)

Muscular Atrophy, Spinal

Brazil, Argentina
Cytokinetics

Terminated

A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) (COURAGE OLE)

Amyotrophic Lateral Sclerosis

Canada, United States, Australia, Spain, Belgium, Ireland, Italy, Netherlands, Sweden
Centre Hospitalier Universitaire de Liege
Queen Fabiola Children's University Hospital; Erasme University Hospital; Centre... and other collaborators

Active, not recruiting

Holter of Movement in Patients With SMA Undergoing Treatment.

Spinal Muscular Atrophy

Belgium
Cytokinetics

Terminated

A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) (COURAGE-ALS)

Amyotrophic Lateral Sclerosis

United States, Germany, Spain, Australia, United Kingdom, Canada, France, Belgium, Denmark, Ireland, Italy, Netherlands, Poland, Portugal, Sweden, Switzerland
Zydus Lifesciences Limited

Active, not recruiting

Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZYIL1 in Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

India
Calico Life Sciences LLC
AbbVie

Active, not recruiting

A Phase 1 Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis | ALS

United States, Canada
AnnJi Pharmaceutical Co., Ltd.

Active, not recruiting

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of AJ201 In Patients

Spinal and Bulbar Muscular Atrophy | Kennedy's Disease

United States
Clene Nanomedicine

Available

Intermediate Expanded Access Protocol (EAP) CNMAu8.EAP02

Amyotrophic Lateral Sclerosis

United States
Clene Nanomedicine
National Institute of Neurological Disorders and Stroke (NINDS)

Available

Intermediate Expanded Access Protocol CNMAu8.EAP04

Amyotrophic Lateral Sclerosis | ALS | PALS
Clene Nanomedicine
Massachusetts General Hospital

Available

Intermediate Expanded Access Protocol for ALS

Amyotrophic Lateral Sclerosis

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Active, not recruiting

TRIAL READY (Clinical Trial Readiness)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
Amylyx Pharmaceuticals Inc.
ALS Association; ALS Finding a Cure; Northeast ALS Consortium; Neurological Clinical... and other collaborators

Completed

AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) (CENTAUR)

Central Nervous System Diseases | Nervous System Diseases | Neuromuscular Diseases | Neurodegenerative Diseases | Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Spinal Cord Diseases | TDP-43 Proteinopathies

United States
PTC Therapeutics

Active, not recruiting

Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS (CARDINALS)

Amyotrophic Lateral Sclerosis

United States, Belgium, Spain, Australia, Germany, Italy, Czechia, France, Netherlands, Japan, Poland, Argentina, Sweden
Biogen

Active, not recruiting

A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy (NURTURE)

Spinal Muscular Atrophy

United States, Taiwan, Israel, Australia, Qatar, United Kingdom, Turkey, Italy, Germany, Argentina, Canada
Clene Nanomedicine

Active, not recruiting

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

Amyotrophic Lateral Sclerosis

Australia
Halic University

Completed

The Effect of a Mindfulness-Based Stress Reduction Program in Patients With Multiple Sclerosis

Multiple Sclerosis | Mindfulness | Upper Motor Neuron Lesion

Turkey
Duke University

Completed

Reducing Disparities in the Quality of Advance Care Planning for Older Adults (EQUALACP)

End Stage Liver Disease | Diabetes Complications | Chronic Obstructive Pulmonary Disease | Parkinson Disease | Amyotrophic Lateral Sclerosis | End Stage Renal Disease | Metastatic Cancer | Interstitial Lung Disease | Congestive Heart Failure

United States
Merit E. Cudkowicz, MD
Massachusetts General Hospital

Active, not recruiting

HEALEY ALS Platform Trial - Master Protocol

Amyotrophic Lateral Sclerosis

United States
Scholar Rock, Inc.

Active, not recruiting

Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinersen or Risdiplam (SAPPHIRE)

Neuromuscular Diseases | Neuromuscular Manifestations | Atrophy | Muscular Atrophy | Spinal Muscular Atrophy | Muscular Atrophy, Spinal | Spinal Muscular Atrophy Type 3 | SMA | Spinal Muscular Atrophy Type 2 | Anti-myostatin

United States, Germany, Belgium, Spain, United Kingdom, Netherlands, France, Italy, Poland
Columbia University
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Clinical Trial of High Dose CoQ10 in ALS

Amyotrophic Lateral Sclerosis | Lou Gehrig's Disease

United States
University of Florida
ALS Association

Active, not recruiting

Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

Frontotemporal Dementia | C9orf72 Amyotrophic Lateral Sclerosis (ALS)

United States
University of Maryland, Baltimore

Active, not recruiting

Neural Mechanisms of Motor Recovery With Technology Assisted Training

Stroke Sequelae | Hemiparesis

United States
Dartmouth-Hitchcock Medical Center
The Cleveland Clinic

Completed

Environmental Exposure and Neurological Diseases Questionnaire (Cleveland Ohio)

Amyotrophic Lateral Sclerosis

United States
n-Lorem Foundation
Mayo Clinic

Active, not recruiting

Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS

Amyotrophic Lateral Sclerosis

United States
The Hong Kong Polytechnic University

Completed

A BHI to Increase Hope Level and Stress Level of Parents With a CMC

Endocrine System Diseases | Muscular Atrophy, Spinal | Child With Cancer | Child With Cerebral Palsy

China
Corcept Therapeutics

Active, not recruiting

Dazucorilant in Patients With Amyotrophic Lateral Sclerosis (DAZALS)

Amyotrophic Lateral Sclerosis

United States, Belgium, Canada, France, Germany, Ireland, Netherlands, Poland, Spain, United Kingdom

Search clinical trials for: Motor Neuron Disease

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