Search clinical trials for: Multiple dose

Total 31492 results

Boehringer Ingelheim

Completed

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effects of Multiple Rising Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate Therapy

Healthy | Arthritis, Rheumatoid

Germany, Netherlands, New Zealand, Poland, Spain, Czechia
Bugworks Research Inc.
Avance Clinical Pty Ltd.

Terminated

The Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of BWC0977 in Healthy Adult Volunteers

Bacterial Infections | Infectious Diseases

Australia
Emergent BioSolutions

Completed

Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults

Opioid Overdose

United States
Emergent BioSolutions
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Safety and Pharmacokinetics of UV-4B Solution Administered Orally as Multiple Ascending Doses to Healthy Subjects

Viral Infection

United States
University of Maryland, Baltimore

Active, not recruiting

Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

United States
Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)

Multiple Sclerosis

United States, Brazil, Poland, United Kingdom, Turkey, Bulgaria, Belgium, Canada, Denmark, France, Germany, Greece, Hungary, Italy, Peru, Portugal, Russian Federation, Spain, Switzerland, Ukraine, Mexico, Argentina
Aligos Therapeutics

Terminated

A Study of ALG-125755 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single Doses in Healthy Volunteers, and Single and Multiple Doses in CHB Subjects

Chronic Hepatitis B

New Zealand, Bulgaria, Moldova, Republic of, Romania
Boehringer Ingelheim

Terminated

Multiple Rising Does Study (Subcutaneous Doses) of BI 655064 in Male and Female Patients With Chronic Primary Immune Thrombocytopenic Purpura (ITP).

Purpura, Thrombocytopenic, Idiopathic

United States
University Hospital, Lille

Active, not recruiting

Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy (IFM2017_03)

Multiple Myeloma

France
J2H Biotech

Completed

Phase 1 Study to Investigate Safety, Tolerability, PK/PK of J2H-1702 in Healthy Males

Non-alcoholic Steatohepatitis

Korea, Republic of
GlaxoSmithKline

Completed

A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (PD) of GSK3888130B in Healthy Participants

Multiple Sclerosis

United Kingdom
Boehringer Ingelheim

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of BI 409306

Healthy

Germany
Boehringer Ingelheim

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Doses

Healthy

Germany
Spero Therapeutics

Completed

A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Healthy Volunteer

United States
Albireo

Completed

An Open Label, Single-dose, Single Period ADME Study of A4250 in Healthy Subjects

Primary Biliary Cirrhosis | Alagille Syndrome | Progressive Familial Intrahepatic Cholestasis | Orphan Cholestatic Liver Diseases

United Kingdom
Tianjin Hemay Pharmaceutical Co., Ltd

Completed

Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects (Hemay005)

Psoriasis

China
Longbio Pharma

Active, not recruiting

A Study of Single and Multiple Doses of LP-003 in Healthy Adult Participants

Chronic Spontaneous Urticaria

China
Astellas Pharma Global Development, Inc.
Kyowa Kirin Co., Ltd.

Completed

A Multiple Dose Escalation Study of ASKP1240 in Subjects With Moderate to Severe Plaque Psoriasis

Psoriasis

Canada, Australia, New Zealand
Longbio Pharma

Active, not recruiting

A Study of Single and Multiple Dose Administration of LP-001 in Healthy Subjects

Myelodysplastic Syndrome (MDS)

China
Johnson & Johnson Consumer Inc. (J&JCI)

Withdrawn

A Multiple-Dose Safety Study of Fixed Combination of Acetaminophen/Naproxen Sodium in Adolescents With Orthodontic Pain

Orthodontic Pain

United States
Ganzhou Hemay Pharmaceutical Co., Ltd
Hemay Pharmaceutical PTY. LTD.

Completed

A Study to Evaluate the Effects of Single and Multiple Doses of Hemay005 Tablets in Health Caucasian Adult Volunteers

Healthy

Australia
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer

Head and Neck Cancer
Design Therapeutics, Inc.

Completed

Study to Evaluate Multiple Ascending Dose and Multi-Dose of DT-216 in Adult Patients With Friedreich Ataxia

Friedreich Ataxia

United States
Actelion

Completed

A Study of Single and Multiple Doses of Different Formulations of a Prostacyclin Receptor Agonist

Pulmonary Arterial Hypertension

United States
Neurocrine Biosciences
Takeda

Completed

A Study to Evaluate Multiple Oral Doses of Luvadaxistat in Adults With Schizophrenia

Schizophrenia

United States
Waterstone Pharmaceutical (Wuhan) Co., LTD.

Completed

The Safety and Tolerability of WS016 in Healthy Chinese Volunteers

Hyperkalemia

China
KBP Biosciences
Covance

Completed

A Multiple Ascending Dose Study to Investigate Safety of KBP-7072 in Healthy Subjects

Healthy

United States
KBP Biosciences

Completed

A Multiple Ascending Dose Study of KBP-7072 in Healthy Subjects

Healthy

United States
Merck KGaA, Darmstadt, Germany

Completed

Phase I/Ib Multiple Ascending Dose Study in China

Metastatic Solid Tumors

China
Endevica Bio

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Doses in Health Subjects

Cachexia

United States
Mayo Clinic

Active, not recruiting

Immunomodulatory Drugs (Lenalidomide With or Without Pomalidomide) in Combination With a Corticosteroid Drug (Dexamethasone) for the Treatment of Multiple Myeloma

Plasma Cell Myeloma | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Smoldering Plasma Cell Myeloma

United States
Emory University
National Cancer Institute (NCI); Sanofi; National Institutes of Health (NIH)

Completed

Influenza Vaccination for Flu Prevention in Patients With Plasma Cell Disorders

Plasma Cell Neoplasm

United States
Guangzhou Zhiyi Biotechnology Co., Ltd.

Completed

A Sequential Single and Multiple Ascending Dose (SAD/MAD) Study of SK10 Powders in Healthy Adult Subjects

Chemotherapy-induced Diarrhea

United States
Celgene

Active, not recruiting

ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Low-dose Dex in Relapsed-and-Refractory Multiple Myeloma

Multiple Myeloma

United States
ImmuneMed, Inc.

Completed

Safety, Tolerability, Pharmacokinetics of hzVSf-v13 in Healthy Adults (Intravenous and Subcutaneous Administration)

Healthy Volunteers

Australia
Gasherbrum Bio, Inc

Active, not recruiting

A Study of Multiple-ascending Doses of GSBR-1290 in Healthy Overweight/Obese Participants

Healthy Volunteers

United States
Memorial Sloan Kettering Cancer Center
Amgen

Completed

Using Romiplostim to Treat Low Platelet Counts Following Chemotherapy and Autologous Hematopoietic Cell Transplantation in People With Blood Cancer

Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin Lymphoma | HDT-AHCT

United States
Contineum Therapeutics

Completed

Study Evaluating Safety and Tolerability of Escalating Single and Multiple Doses of PIPE-791 and Food Effect in Healthy Volunteers

Multiple Sclerosis

United States
Anaveon AG

Terminated

A Study of ANV419 Alone or in Combination With Approved Treatments in Patients With Multiple Myeloma (OMNIA-2)

Hematologic Diseases | Multiple Myeloma | Refractory Multiple Myeloma | Adult Disease | Relapsed Cancer

Spain, Germany, France, Denmark, Switzerland
Cerevel Therapeutics, LLC

Completed

Multiple-dose Trial to Determine the Clinical Bioequivalence Between Tavapadon Tablets in Participants With Parkinson's Disease

Parkinson Disease

United States
Hoffmann-La Roche

Completed

A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531

Hepatitis B, Chronic

Thailand, Taiwan, United Kingdom, Hong Kong, Netherlands, New Zealand, Bulgaria, Italy
Pfizer

Completed

Multiple Escalating Oral Doses Study of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus

Diabetes Mellitus Type 2

United States
Alexion Pharmaceuticals, Inc.

Completed

A Study of Single and Multiple Doses of ALXN1210 in Healthy, Adult Japanese Participants

Healthy

United Kingdom
Reata, a wholly owned subsidiary of Biogen

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of RTA 901 in Healthy Adults

Healthy

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers

Healthy Volunteers

United States
Ironwood Pharmaceuticals, Inc.

Completed

A Study of Multiple-ascending Doses of IW-3300 in Healthy Subjects

Healthy Volunteers

United States
Aelis Farma
European Commission

Completed

AEF0217 First-in-Human Phase I Study in 3 Parts (Single and Multiple Ascending Doses, and Food Effect) in Healthy Subjects. (AEF0217-101)

Safety, Tolerability, Pharmacokinetics of AEF0217

Spain
Pfizer

Completed

Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants

Healthy

Japan
Shionogi

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants

Sepsis | Gram-negative Bacterial Infections | Bloodstream Infections (BSI) | Complicated Intra-abdominal Infection (cIAI) | Hospital Acquired Pneumonia (HAP) | Ventilator-acquired Pneumonia | Complicated Urinary Tract Infection (cUTI)

Spain, Belgium, Latvia, Russian Federation, Estonia, Georgia, Hungary, Thailand, Ukraine
Federal Teaching Hospital Abakaliki

Completed

Efficacy of Single Dose Rectal Diclofenac With Oral Diclofenac for the Relief of Perineal Pain Within 24 Hours After Episiotomy

Pain Relief After Episiotomy

Nigeria

3

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