Search clinical trials for: Synthetic lethality

Total 1325 results

Charles Drew University of Medicine and Science

Terminated

Efficacy of Mifepristone in Males With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus | Insulin Resistance

United States
Galmed Pharmaceuticals Ltd
Quotient Sciences

Completed

A First-in-Human Study of Single and Multiple Doses of Amilo-5MER in Healthy Subjects

Inflammatory Disease

United Kingdom
University of Chicago

Active, not recruiting

Study of Pembrolizumab and Mifepristone in Patients With Advanced HER2-negative Breast Cancer

Breast Cancer | Triple Negative Breast Neoplasms

United States
Groupe Hospitalier Paris Saint Joseph

Completed

Evaluation of the Modalities of Administration of Synthetic Oxytocin During Spontaneous Labor (LAMA)

Oxytocin

France
Washington University School of Medicine

Terminated

Medication Enhanced Rapid Therapy (MERiT)

Anxiety Disorders

United States
Rodrigo Cardenas
U.S. National Science Foundation

Completed

The Role of Oxytocin in the Perception of Faces

Healthy
University of Oklahoma

Completed

Immediate Postpartum Insertion of Contraceptive Intrauterine Devices

Contraception

United States
Queensland Centre for Gynaecological Cancer
The University of Queensland; Queensland University of Technology

Active, not recruiting

Improving the Treatment for Women With Early Stage Cancer of the Uterus (feMMe)

Complex Endometrial Hyperplasia With Atypia | Grade 1 Endometrial Endometrioid Adenocarcinoma

Australia, New Zealand
University of British Columbia
BC Children's Hospital Research Institute

Completed

Natural Folate vs. Synthetic Folic Acid in Pregnancy

Pregnancy

Canada
University of Colorado, Denver

Completed

Desogestrel-containing COCP Pharmacokinetic Validation Study

Contraception

United States
AbbVie

Completed

A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone (SELECT-NEXT)

Rheumatoid Arthritis

United States, Argentina, Australia, Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Ireland, Italy, Kazakhstan, Korea, Republic of, Latvia, Lithuan... and more
Universitair Ziekenhuis Brussel
Merck Sharp & Dohme LLC

Completed

Optimisation of Follicular Recruitment in IVM Cycles (Elonva_IVM)

Polycystic Ovary Syndrome | Infertility, Female

Belgium
Universidad Autonoma de Nuevo Leon

Withdrawn

Femoral Pediatric Fractures. Walking Spica Cast vs Synthetic Pants

Pediatric ALL | Femoral Shaft Fracture

Mexico
University of Chicago

Terminated

Postplacental Insertion of Levonorgestrel-releasing Intrauterine System (LNG-IUS) After Cesarean vs. Interval Insertion

Healthy

United States
University of Exeter
Quorn

Completed

Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response (BPM)

Muscle Protein Synthesis

United Kingdom
Tanta University

Completed

Progesterone Containing Contraceptive Methods on Endogenous Progesterone Level

Progesterone | Contraceptive Methods

Egypt
University of Chicago
University of Illinois at Chicago

Completed

Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial (MINT)

Contraception

United States
Jaime Leandro Foundation for Therapeutic Cancer...

Enrolling by invitation

Basket Trial of Neoantigen Synthetic Long Peptide Vaccines in Patients With Advanced Malignancy

Cancer | Solid Tumor

United States
C. R. Bard

Completed

Lutonix® Global AV Registry Investigating Lutonix Drug Coated Balloon for Treatment of Native and Synthetic AV Fistulae (AVR)

Arteriovenous Fistula

United Kingdom, Singapore, France, Italy, Germany, Switzerland, Greece, Austria, Poland, Portugal, Saudi Arabia, Taiwan, Turkey
Xiaojun Chen

Completed

MPA Versus Dydrogesterone for Management of Endometrial Hyperplasia Without Atypia

Endometrial Hyperplasia Without Atypia

China
CorNeat Vision Ltd.

Active, not recruiting

Pivotal Trial for a Synthetic Tissue Substitute for Concealment of Artificial Ocular Implants (EverPatch)

Glaucoma Eye | Tissue Breakdown

Canada, France, Georgia
AbbVie

Completed

A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs (SELECT-BEYOND)

Rheumatoid Arthritis

United States, Australia, Austria, Belgium, Canada, Czechia, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Korea, Republic of, Latvia, New Zealand, Poland, Portugal, Puerto Rico, Russian Federation, Slovakia, ... and more
University of Southern California
Society of Family Planning

Suspended

Ovulation Incidence in Oral Contraceptive Users

Contraception | Ovulation

United States
Zealand University Hospital

Completed

Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment

Infertility | Weight Loss | Overweight and Obesity | DNA Damage | Vaginal Flora Imbalance

Denmark
Zagazig University

Completed

LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia

Atypical Endometrial Hyperplasia

Egypt
Bayer

Completed

PROMES: A Clinical Study in Which Researchers Want to Learn More About the Safety Profile of MESIGYNA (Norethisterone Enantate 50 mg and Estradiol Valerate 5 mg) Used as a Medication to Prevent Pregnancy for Adult Women in Reproductive Age in the Peruvian Population at the Outpatient Clinic. (PROMES)

Contraceptive

Peru
University Hospital, Ghent
Nobel Biocare

Completed

Immediate Load of Dental Implants, Placed in Atrophic Upper and/or Lower Jaw of Partial or Complete Edentate Patients, According to Flapless Technique

Dental Implants

Belgium
Bayer
Karolinska Institutet, Stockholm, Sweden

Active, not recruiting

JAYDESS Drug Utilization Study in Sweden

Contraception

Sweden
Indiana University
Breast Cancer Research Foundation

Withdrawn

Breast Cancer BRCA1 Carriers: a Pilot Study

High-grade Serous Ovarian Cancer | BRCA1 Mutation | TNBC - Triple-Negative Breast Cancer

United States
Altimmune, Inc.

Completed

ALT-801 DDI Study in Healthy Volunteers

NASH - Nonalcoholic Steatohepatitis

Australia
Assiut University

Terminated

Levonorgestrel-releasing Intrauterine System and Tubal Ligation

Tubal Ligation

Egypt
Idorsia Pharmaceuticals Ltd.

Completed

To Study the Effect of Cenerimod on the Electrical Activity of the Heart, in Men and Women. To Study the Effect of Cenerimod on the Use of Oral Contraceptives in Women. To Study the Effect That Charcoal Has on the Elimination of Cenerimod From the Body, in Women and Men.

Healthy Subjects

France
Assistance Publique Hopitaux De Marseille

Completed

Cervical Preparation of Abortions Under Paracervical Block in the First Trimester: (BPCEN)

Surgical Abortion

France
University Hospital, Lille
National Research Agency, France

Active, not recruiting

Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS) (MRI-PCOS)

Polycystic Ovary Syndrome

France
Milton S. Hershey Medical Center

Terminated

Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis

Endometriosis

United States
University of Manchester
National Institute for Health Research, United Kingdom

Completed

A Phase I Trial of a Novel Synthetic Polymer Nerve Conduit 'Polynerve' in Participants With Sensory Digital Nerve Injury (UMANC)

Injury of Nerves at Wrist and Hand Level

United Kingdom
Rajavithi Hospital

Completed

Desogestrel for the Preoperative Treatment of Endometrioma Compared With Placebo

Endometrioma

Thailand
Saudi German Hospital - Madinah

Completed

Nonsurgical Management of Cesarean Scar Niche Related Abnormal Uterine Bleeding

Intermenstrual Bleeding

Saudi Arabia
Botanix Pharmaceuticals

Completed

Study of the Safety, Tolerability and Efficacy of BTX 1204 in Patients With Moderate Atopic Dermatitis

Atopic Dermatitis

United States, Australia, New Zealand
Medstar Health Research Institute

Completed

Efficacy Study of Vaginal Mesh for Prolapse (VAMP)

Pelvic Organ Prolapse | Cystocele | Uterine Prolapse | Rectocele | Vaginal Prolapse

United States
The Scripps Research Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Mifepristone Treatment of Alcohol Use Disorder

Alcohol Dependence | Alcoholism | Alcohol Use Disorders | Alcohol Abuse

United States
Michael Rosen

Completed

Biologic Mesh Versus Synthetic Mesh in Repair of Ventral Hernias

Ventral Hernia

United States
Medicines360

Completed

A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception

Contraception

United States
Eskisehir Osmangazi University

Completed

Antimicrobial Synthetic Bone Grafts

Bone Infection | Bone Graft Infection

Turkey
Imperial College London

Active, not recruiting

Modelling the Interaction Between Rationally-designed Synthetic Model Viral Protein Immunogens (EAVI2020_01)

HIV-1-infection

United Kingdom
Stanford University

Completed

Labor and Delivery Implant Insertion: A Randomized Controlled Trial (LADII)

Postpartum Contraception | Family Planning

United States
Pfizer

Completed

STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS

Healthy Adults

United States
Stanford University
Society for Urodynamics & Female Urology Foundation

Completed

Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder (FETOC)

Overactive Bladder | Urge Incontinence | Urinary Frequency/Urgency | Bladder, Overactive | Urgency Urinary

United States
University of Chicago
National Cancer Institute (NCI)

Completed

Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer

Recurrent Prostate Cancer | Hormone-resistant Prostate Cancer | Stage IV Prostate Cancer

United States
Cedars-Sinai Medical Center
Synthetic Biologics Inc.

Terminated

Efficacy and Safety of SYN-010 in IBS-C

Irritable Bowel Syndrome With Constipation

United States

Search clinical trials for: Synthetic lethality

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Spain

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations