Search clinical trials for: challenge study

Total 120397 results

McGill University Health Centre/Research Institute...

Unknown

Fluid Responsiveness in the Postoperative Patient: a Prospective Study

Actual Impaired Fluid Volume
AstraZeneca

Completed

The Study Will Evaluate the Efficacy of AZD5423 in Patients With Mild Asthma Challenged With an Inhaled Allergen (Allergen)

Asthma

Canada
Merck Sharp & Dohme LLC

Terminated

Two-Part Study to Evaluate the Dose Response of SCH 527123 on Sputum Neutrophilia Following Ozone Challenge in Healthy Subjects and Chronic Obstructive Pulmonary Disease (COPD) Patients (P05567 AM7)

Chronic Obstructive Pulmonary Disease
University of Oxford

Completed

A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates (VAC045)

Plasmodium Falciparum Malaria

United Kingdom
University of Oxford
University of Birmingham; Aeras

Completed

A Clinical Challenge Study of BCG in Healthy Volunteers

Tuberculosis

United Kingdom
AstraZeneca

Completed

Study to Assess Safety & Tolerability of AZD2281 in Combination With Bevacizumab in Patients With Advanced Solid Tumours

Neoplasm Metastasis

United Kingdom
Alios Biopharma Inc.

Completed

A Phase 2a Study to Evaluate ALS-008176 in the Virus Challenge Model

Respiratory Syncytial Virus Infections

United Kingdom
Sanwa Kagaku Kenkyusho Co., Ltd.

Completed

A Study to Evaluate Efficacy and Safety of Methacholine Chloride Challenge Test in Diagnosis of Adult Asthma

Asthma

Japan
Johns Hopkins Bloomberg School of Public Health
PATH Vaccine Solutions

Completed

Low-dose Challenge Model With Enterotoxigenic E Coli

Diarrhea

United States
European Society of Intensive Care Medicine

Completed

Fluid Challenges in Intensive Care (FENICE)

Focus: Fluid Challenge

Belgium
Stephen Bawden
Biotechnology and Biological Sciences Research Council; Unilever R&D

Completed

31P Magnetic Resonance Spectroscopy Fructose Study (31PMRS_FRU)

Healthy

United Kingdom
Alcon Research

Completed

Study of Olopatadine HCl Ophthalmic Solutions Compared to Vehicle Using the Conjunctival Allergen Challenge (CAC) Model of Acute Allergic Conjunctivitis in Japanese Subjects

Allergic Conjunctivitis
University Hospital, Caen

Completed

Observational Study of Oxygen Delivery During a Fractional Fluid Expansion (OR)

Hypovolemia | Cardiac Output, Low | Impaired Oxygen Delivery

France
Boehringer Ingelheim

Completed

Randomized, Placebo Controlled, Crossover Study in an Environmental Challenge Chamber to Assess Safety & Efficacy of Three Oral Doses of BI 671800 Versus Fluticasone Propionate and Montelukast in Sensitive Seasonal Allergic Rhinitis Patients Out of Season

Asthma | Rhinitis, Allergic, Seasonal

Germany
AstraZeneca

Completed

Study to Investigate the Effect of a Single Dose of AZD7624 on Inflammation Caused by an Endotoxin Challenge

LPS Challenge, Neutrophils

United Kingdom
Pfizer

Completed

A Study to Test a New Decongestant in Patients With Allergic Rhinitis Following a Nasal Allergen Challenge

Allergic Rhinitis

United States
Aerocrine AB

Completed

A Study to Explore the Utility of Fractional Exhaled Nitric Oxide (FeNO) Compared With Methacholine Challenge (MCC) Testing in the Assessment of Patients With Suspected But Undiagnosed Asthma

Asthma

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

Ketamine Challenge Study With JNJ-40411813

Confusion | Schizophrenia | Perceptual Disorders

Germany
BL&H Co., Ltd

Completed

A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population

Asthma
MedImmune LLC

Terminated

A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With Asthma

Asthma

United States, Canada
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Monocenter 6-period Study in Patients With Seasonal Allergic Rhinitis to Birch Pollen to Establish a Challenge Model With Natural Birch Pollen in an Environmental Challenge Chamber (ECC)

Seasonal Allergic Rhinitis
University of Nottingham

Completed

Pilot Study of the Effect of Fructans on Fermentation in the Colon & Transit (PERFECT)

Evidence of Adaptation to Dietary Exposure to Fructans

United Kingdom
University of Nottingham
University of Maryland; Imperial College London; University College, London; Wake... and other collaborators

Completed

Evaluating Modes of Influenza Transmission (EMIT)

Influenza, Human

United Kingdom
AstraZeneca

Completed

Study to Assess the Safety & Tolerability of a PARP Inhibitor in Combination With Gemcitabine in Pancreatic Cancer

Pancreatic Neoplasms

United States, United Kingdom
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Dust Mite Inhalation in Humans

Allergy | Mild Asthma

United States
Emory University
Johns Hopkins University

Completed

Infectivity of Norovirus in Groundwater-Human Challenge Study

Healthy

United States
Emory University
Virginia Polytechnic Institute and State University

Completed

Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study (Shellfish)

Healthy

United States
University of Oxford

Completed

A Phase I/IIa Sporozoite Challenge Study to Assess the Efficacy of Candidate Combination Malaria Vaccine Approaches Using the ChAd63 and MVA Vectors Encoding the Antigens ME-TRAP, CS and AMA1

Plasmodium Falciparum Malaria

United Kingdom
Otsuka Pharmaceutical Development & Commercialization...

Completed

Comparative Study of Aripiprazole and Olanzapine in the Treatment of Patients With Acute Schizophrenia

Schizophrenia
Otsuka Pharmaceutical Development & Commercialization...
Otsuka America Pharmaceutical

Completed

Study of Aripiprazole in Patients With Bipolar I Disorder

Bipolar Disorder

France, Portugal, Spain, Italy, Germany, South Africa, United Kingdom, United States, Russian Federation, Poland, Czech Republic, Hungary, Netherlands, Estonia, Australia, Bulgaria, Switzerland
Otsuka Pharmaceutical Development & Commercialization...
Otsuka America Pharmaceutical

Completed

A Study of Adjunctive Treatment of Aripiprazole in Schizophrenic Patients

Schizophrenia

Turkey, Austria, Germany, South Africa, Sweden, Finland, Czech Republic, Poland, France, Hungary, United Kingdom, Switzerland
Fraunhofer-Institute of Toxicology and Experimental...
Hannover Medical School

Completed

Ex Vivo Effect of Surfactant Protein D on Pulmonary Cells in Patients With Asthma and Pilot Study to Assess Local Inflammation Induced by Segmental Allergen Challenge by Magnetic Resonance Imaging

Mild Intermittent Asthma (Gina 1)

Germany
Otsuka Pharmaceutical Development & Commercialization...

Completed

Oral Aripiprazole Open-Label Rollover Study

Schizophrenia

Russian Federation, Argentina, Croatia, India, Serbia, Ukraine
ProtAffin Biotechnologie AG

Terminated

A Phase 1, First in Human Study to Investigate the Safety and Tolerability of PA401

Healthy Volunteers

United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Study of the Physiology of the Asthma of the Obese Subjects. Breathing Obesity Asthma Study (BOA) (BOA)

Obesity | Asthma

France
GlaxoSmithKline

Completed

A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.

Sinusitis | Seasonal Allergic Rhinitis

United Kingdom
Ono Pharma USA Inc
Ono Pharmaceutical Co. Ltd

Completed

A Placebo and Active Controlled Study of ONO-6950 Following Allergen Challenge in Patients With Asthma

Asthma

Canada
Maastricht University Medical Center
Maastricht University

Completed

A Fmri Study on the Effects of a Conjugate Vaccine and Placebo on CNS Activation and Behavior Following a Nicotine Challenge (EPU057)

Smoking | Nicotine Dependency

Netherlands
Mahidol University

Completed

Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Wheat Allergy

Thailand
GlaxoSmithKline

Completed

A Study To Investigate The Effect Of Inhaled Fluticasone Propionate On The Bronchial Responsiveness To Leukotriene D4 In Asthmatics Patients

Asthma | Mild Asthma
National Institute of Allergy and Infectious Diseases...

Completed

Safety Study of a Human Metapneumovirus Challenge Virus in Healthy Adults

Human Metapneumovirus

United States
University of Oxford

Completed

A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites

Malaria

United Kingdom
PepTcell Limited

Completed

Influenza Vaccine Challenge Study in Healthy Subjects

Influenza

United Kingdom
Theraclone Sciences, Inc.

Unknown

Influenza Virus Challenge Study to Test Monoclonal Antibody TCN-032 as a Treatment for Influenza

Influenza

United Kingdom
GlaxoSmithKline

Completed

A Randomised, Double Blind, Placebo Controlled, 4 Period, Incomplete Block, Crossover Study Assessing the Dose-response Curve of Fluticasone Propionate in an Antigen Challenge Chamber

Allergic Rhinitis | Rhinitis, Allergic, Perennial

Austria
Crucell Holland BV
The PATH Malaria Vaccine Initiative (MVI); Seattle Children's Research Institute...

Completed

A Study to Assess the Immunogenicity, Tolerability and Safety of a Malaria Vaccine and Also Its Protective Efficacy in a Malaria Challenge Model

Malaria

United States
University of Oxford

Completed

A BCG Challenge Model Study to Assess Anti-mycobacterial Immunity Induced by BCG and a Candidate TB Vaccine, MVA85A

Tuberculosis

United Kingdom
GlaxoSmithKline

Completed

A Phase II Study Evaluating Intranasal GSK256066 and Azelastine Hydrochloride in Subjects With Seasonal Allergic Rhinitis

Allergic Rhinitis | Rhinitis, Allergic, Seasonal

Austria
GlaxoSmithKline

Completed

This Study Will Examine the Effects of GSK256066 to Protect Mild Steroid-naive Asthmatics Against an Antigen Challenge

Asthma

New Zealand
GlaxoSmithKline

Completed

Study To Evaluate GSK256066 In Subjects With Mild Bronchial Asthma

Asthma | Mild Asthma

United Kingdom

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