Search clinical trials for: safe dose

Total 61656 results

Hospital Universitario Dr. Jose E. Gonzalez

Recruiting

Effectiveness and Safety of Therapy Based on Attenuated ATO Plus Low-Dose ATRA in Patients With APL

Promyelocytic Leukemia

Mexico
Huashan Hospital

Recruiting

A Real-world Study to Evaluate the Safety and Immunogenicity of a Third-dose Booster After Two Doses of an Inactivated COVID-19 Vaccine

COVID-19 | Vaccine Reaction

China
Zhongnan Hospital

Recruiting

The Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (SYS6006) as Heterologous Booster in Participants Aged 18 Years and Older Vaccinated With Inactivated SARS-CoV-2 Vaccine

SARS-CoV-2 | Safety | Immunotoxicity

China
GlaxoSmithKline
Bill and Melinda Gates Foundation; Wellcome Trust; Biomedical Advanced Research... and other collaborators

Recruiting

A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever

Salmonella Infections

Belgium, Malawi
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Italy, Germany, Saudi Arabia
Godavari Biorefineries Limited

Not yet recruiting

Assessment of Safety, Tolerability and PK Profile of MSP008-22 in Patients With Advanced Solid Tumours

Advanced Solid Tumor

India
Kira Pharmacenticals (US), LLC.

Not yet recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of KP104

Paroxysmal Nocturnal Hemoglobinuria

China
D'Or Institute for Research and Education
Bill and Melinda Gates Foundation; University of Oxford

Not yet recruiting

An Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various Regimens

COVID-19

Brazil
Pacira Pharmaceuticals, Inc

Recruiting

Phase 1, Dose Escalation Study to Evaluate of Safety, Pharmacokinetics and Pharmacodynamics of Liposomal Bupivacaine 13.3 Administered Via a Single Intrathecal Injection to Healthy Volunteers

Healthy

United States
Esfam Biotech Pty Ltd

Not yet recruiting

A Dose Escalation Phase 1 Study Evaluating the Safety and Pharmacokinetics of an Inhaled COVID-19 Inhibitor Delcetravir in Healthy Subjects

COVID-19
AstraZeneca
Parexel

Recruiting

AZD7798 Safety, Tolerability, and Pharmacokinetics After a Single Ascending and Repeat Dose Administrations to Healthy Subjects, and Patients With Crohn's Disease

Healthy Subjects | Crohns Disease

United Kingdom
Sinovac Biotech (Colombia) S.A.S.
Sinovac Life Sciences Co., Ltd.

Not yet recruiting

Immunogenicity and Safety Study of One Booster Dose of Trivalent COVID-19 Vaccine (Vero Cell), Inactivated

COVID-19

Colombia
Drugs for Neglected Diseases

Recruiting

Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients (OXA005)

Trypanosomiasis, African | Sleeping Sickness | Trypanosoma Brucei Gambiense; Infection

Congo, The Democratic Republic of the
LG Chem

Recruiting

Study to Evaluate Eupolio(IPV)'s Safety, Long-term Protective Effect and Boosting Effect of One Booster Dose in the Three Primary Vaccination Plus Boosting Schedule, and Protective Effect in the Schedule With Bivalent OPV in Infants

Vaccine Reaction | Poliomyelitis

Philippines
Idorsia Pharmaceuticals Ltd.

Recruiting

Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder

Insomnia

Spain, United States, Belgium, Germany, Bulgaria
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Not yet recruiting

The Efficacy and Safety of Different Doses of SY-009 in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes

China
Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of TSL-1502 Capsules in Breast Cancer Patients With Germline BRCA Mutations

Breast Cancer Metastatic

China
Legend Labz, Inc.

Recruiting

Effect of Different Ingestion Doses of Celastrol on Human Sperm Motility

Safety Issues

United States
Boryung Pharmaceutical Co., Ltd

Recruiting

An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ

Hypertension,Essential

Korea, Republic of
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction (OPTIMA-6)

ST Elevation Myocardial Infarction

China
Lumosa Therapeutics Co., Ltd.

Not yet recruiting

A Study to Evaluate the Safety and Efficacy of Multiple Doses of LT3001 Drug Product in AIS Subjects (BRIGHT)

Acute Ischemic Stroke
Fundació Sant Joan de Déu

Recruiting

A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS) (SPIOMET4HEALTH)

Polycystic Ovary Syndrome (PCOS)

Norway, Italy, Denmark, Spain, Austria, Turkey
CytomX Therapeutics

Recruiting

A Trial to Find Safe and Active Doses for an Investigational Drug, CX-904, for Patients With Advanced Solid Tumors

Solid Tumors

United States
Cutia Therapeutics（Wuxi）Co.,Ltd

Recruiting

A Phase I Clinical Trial Evaluating the Safety, Tolerability, and Pharmacokinetics of CU-40101 Liniment in Single and Multiple Doses in Adult Male Androgenic Alopecia Subjects

AGA

China
Washington University School of Medicine
Wugen, Inc.

Recruiting

Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of Anti-CD7 Allogeneic CAR T-Cells (WU-CART-007) in Patients With CD7+ Hematologic Malignancies

Acute Myeloid Leukemia | Sezary Syndrome | Anaplastic Large Cell Lymphoma | Angioimmunoblastic T-cell Lymphoma | Adult T Cell Leukemia | Adult T Cell Lymphoma | Hepatosplenic T-cell Lymphoma | Peripheral T Cell Lymphoma | Extranodal NK/T-cell Lymphoma | Enteropathy-Associated T-Cell Lymphoma | T-Cell Non-Hodgkin... and other conditions

United States
Milton S. Hershey Medical Center

Recruiting

AGN-CognI.Q Acute Dose Safety and Pharmacokinetics Dose-Response in Prostate Cancer Patients

Prostate Cancer

United States
Zhejiang Provincial Center for Disease Control...

Recruiting

Sequential Immunization With Recombinant Adenovirus Type-5-vectored COVID-19 Vaccine in Health Adults Based on 3 Doses Inactivated COVID-19 Vaccine

Immunogenicity and Safety of a Recombinant Adenovirus Type-5-vectored COVID-19 Vaccine Using for Sequential Immunization

China
Newsoara Biopharma Co., Ltd.

Recruiting

Safety, Tolerance and Pharmacokinetics of THR-1442 in Chinese Healthy Subjects

T2DM (Type 2 Diabetes Mellitus)

China
West China Hospital

Recruiting

To Explore the Safety and Efficacy of Intravenous Infusion of Different Doses of Lidocaine in Patients

Liver Cancer

China
Lava Therapeutics
Merck Sharp & Dohme LLC

Recruiting

Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer (mCRPC) Resistant Prostate Cancer

Metastatic Castration Resistant Prostate Cancer

United States, Spain, Netherlands
Advenchen Pharmaceuticals, LLC.

Recruiting

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

Small Cell Lung Cancer

United States
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.

CML, Chronic Phase

China
Genoscience Pharma

Not yet recruiting

Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GNS561 After One Single Dose (50 and 200mg) in Healthy Volunteers

Primary Liver Cancer

France
Beyond Air Inc.

Recruiting

A Study to Assess the Safety and Efficacy of Nitric Oxide Injection Into Unresectable Solid Primary or Metastatic Tumors

Cancer

Israel
Hospital Universitario Dr. Jose E. Gonzalez

Recruiting

Efficacy and Safety of Low-dose Ibrutinib and Itraconazole in Chronic Graft Versus Host Disease

Chronic Graft-versus-host-disease

Mexico
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

A Phase I Single- and Multiple- Ascending Dose and Food Effect Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-7535 in Healthy Subjects

Healthy Subjects
Sinocelltech Ltd.

Not yet recruiting

A Study to Evaluate the Immunogenicity and Safety of a Recombinant Protein COVID-19 Vaccine as a Booster Dose in Population Aged 12-17 Years

COVID-19 | SARS-CoV-2 Infection
Fifth Affiliated Hospital, Sun Yat-Sen University
Dongguan People's Hospital

Recruiting

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC

Head and Neck Squamous Cell Carcinoma | Neoadjuvant Treatment

China
Rutgers, The State University of New Jersey

Recruiting

Study to Evaluate the Safety of Colchicine

Radiation Therapy

United States
First Affiliated Hospital, Sun Yat-Sen University

Recruiting

Efficacy and Safety of Low-dose Rituximab in the Treatment of Refractory Myasthenia Gravis

Refractory Myasthenia Gravis | Rituximab

China
Beijing Suncadia Pharmaceuticals Co., Ltd

Not yet recruiting

Single Ascending Dose and Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-1816 in Healthy Subjects

Diabetes
Zhuhai Yufan Biotechnologies Co., Ltd

Recruiting

A Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Efficacy of PRJ1-3024 in Subjects With Advanced Solid Tumors

Advanced Solid Tumor | Advanced Solid Malignancies

China
People's Hospital of Quzhou

Recruiting

Efficacy and Safety of Conventional and Low-dose Platinum Gemcitabine Combined With Cindilimab With Delayed Administration in First-line Treatment of Advanced Squamous Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

China
Belgian Inflammatory Bowel Disease Research and...
Janssen Cilag N.V./S.A.

Recruiting

An Open-Label Extension and Long-term Efficacy and Safety Monitoring Study of Patients With Crohn's Disease Previously Included in the Loss of RESponse to Ustekinumab Treated by Dose Escalation Study (REScUE-OLE)

Crohn Disease

Belgium
Celon Pharma SA
National Center for Research and Development, Poland

Recruiting

Efficacy, Safety and Pharmacokinetic Study of CPL500036 in Patients With Levodopa Induced Dyskinesia

Parkinson Disease | Dyskinesia, Medication-Induced

Poland, Ukraine
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

Locally Advanced or Metastatic Breast Cancer

France, Belgium, United States, Korea, Republic of, Taiwan, Brazil, China, Italy, Argentina, Jordan, Mexico, Germany, Portugal, Spain, Thailand, United Kingdom, Kenya, Turkey, Hungary, Colombia, India, Oman, Saudi Arabia, Poland, Uganda, United... and more
Federal University of Espirito Santo
Centro de Pesquisas René Rachou; Secretaria de Estado da Saúde do Espírito...

Not yet recruiting

Effectiveness, Immunogenicity and Safety of the Second Booster Dose of the Vaccine Against COVID-19 in the Elderly (Plus_Booster)

COVID-19 | Vaccine Adverse Reaction | Vaccine-Preventable Diseases

Brazil
Kiora Pharmaceuticals, Inc.

Recruiting

A Phase I/II Dose-escalating Study of the Safety, Tolerability and Efficacy of KIO-301 Administered Intravitreally to Patients With Retinitis Pigmentosa and Choroideremia (ABACUS) (ABACUS)

Retinitis Pigmentosa | Choroideremia

Australia
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
Vir Biotechnology, Inc.
GlaxoSmithKline

Recruiting

Relative Bioavailability, Safety, and Tolerability of Single-dose Sotrovimab Injection in Adults (COSMIC) (COSMIC)

Covid19

United States

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