Clinical Trials Sponsored by Roche s.r.o.

Total 3329 results

Hoffmann-La Roche

Completed

Study To Evaluate the Efficacy and Safety Of Bevacizumab, and Associated Biomarkers, In Combination With Paclitaxel Compared With Paclitaxel Plus Placebo as First-line Treatment Of Patients With Her2-Negative Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Korea, Republic of, United Kingdom, Italy, Russian Federation, Argentina, Belgium, Brazil, Panama, Germany, Japan, Ukraine, Chile, South Africa, Bulgaria, Romania
Hoffmann-La Roche

Completed

A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer (ASCENT)

Colorectal Neoplasms

Australia
Hoffmann-La Roche

Completed

A Study to Assess the Efficacy of Rituximab (MabThera) in First Line Treatment of Chronic Lymphocytic Leukemia (CLL)

Leukemia, Lymphocytic, Chronic, B-Cell

Spain
Hoffmann-La Roche

Completed

A Study of Pegasys (Peginterferon Alfa 2a) Alone or in Combination With Tenofovir in Patients With Chronic Hepatitis D.

Hepatitis D, Chronic

Turkey
Hoffmann-La Roche

Completed

Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment (CONIFER)

Rheumatoid Arthritis

Germany
Hoffmann-La Roche

Completed

A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent (ACT-MOVE)

Rheumatoid Arthritis

United Kingdom
Hoffmann-La Roche

Completed

Study of the Pharmacokinetics and Safety of Trastuzumab Emtansine in Chinese Participants With Locally Advanced Inoperable or Metastatic HER2+ Breast Cancer

Breast Neoplasms

China
Hoffmann-La Roche

Completed

Disease Characteristics, Treatment Patterns and Clinical Outcomes in Patients With Newly Diagnosed Unresectable Stage IIIB/IV Non-Small Cell Lung Cancer (NSCLC) in China

Non-Small Cell Lung Cancer, Lung Cancer, Cancer

China
Hoffmann-La Roche

Completed

A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy (TOSCA)

Rheumatoid Arthritis

France
Hoffmann-La Roche

Completed

A Study of Erlotinib in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations

Non-Squamous Non-Small Cell Lung Cancer

Portugal
Hoffmann-La Roche

Terminated

A Study of the Efficacy and Safety of Tocilizumab for Confirmed Rheumatoid Arthritis (RA) Participants in Clinical Practice

Rheumatoid Arthritis

Saudi Arabia
Hoffmann-La Roche

Completed

A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection

Influenza

United States, Spain, Belgium, Canada, Colombia, Germany, Israel, Poland, Brazil, Chile, Finland, Greece, Italy, Mexico, South Africa
Hoffmann-La Roche

Completed

A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Neoplasms

Belgium, France, Spain
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) in Healthy Japanese Participants

Healthy Volunteers

United States
Hoffmann-La Roche

Completed

A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants

Healthy

Netherlands
Hoffmann-La Roche

Completed

A Study on Spermatogenesis in Male Renal Transplant Recipients Receiving Valganciclovir (Valcyte®) Versus Untreated Matched Controls

Cytomegalovirus Infections

United States, Mexico
Hoffmann-La Roche

Completed

A Study of Lebrikizumab in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United States, Belgium, Germany, Peru, Mexico, Poland, France, Italy, United Kingdom, Australia, Canada, Spain, Japan
Hoffmann-La Roche

Completed

A Study to Evaluate Efficacy and Safety of Epoetin Beta (NeoRecormon®) in Anemic Participants With Breast Cancer Undergoing Chemotherapy

Anemia

Italy
Hoffmann-La Roche

Completed

An Observational Study of Continued Bevacizumab Plus Chemotherapy Until First Progression in Participants With Metastatic Colorectal Cancer (CRC) (AVACONT)

Colorectal Cancer

Hungary
Hoffmann-La Roche

Completed

A Study of Alectinib (CH5424802/RO5424802) in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer

United States, Canada
Hoffmann-La Roche

Completed

A Study of a Combination of Trastuzumab and Capecitabine With or Without Pertuzumab in Patients With HER2-positive Metastatic Breast Cancer (PHEREXA)

Breast Cancer

Spain, United Kingdom, Belgium, Austria, Brazil, France, Germany, Hungary, Italy, Thailand, Korea, Republic of, Hong Kong, Romania, Canada, Argentina, Czechia, Peru, Estonia, Mexico, Poland, Russian Federation, Croatia, Netherlands
Hoffmann-La Roche

Completed

A Study of RO6870868 in Healthy Volunteers

Healthy Volunteer

Netherlands
Hoffmann-La Roche

Completed

A Comparative Study to Observe the Effect of Concomitant Use of Corticosteroid Treatment in Rheumatoid Arthritis (RA) Participants Who Are Treated With a Tumor Necrosis Factor (TNF) Inhibitor or Tocilizumab (TCZ) as Their Second Biological Treatment.

Rheumatoid Arthritis

Sweden
Hoffmann-La Roche

Completed

A Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) for the Treatment of Chronic Renal Anemia in Participants With Diabetic Nephropathy

Anemia

India
Hoffmann-La Roche

Completed

An Observational Study of Herceptin (Trastuzumab) in Patients With HER2-positive Advanced Gastric Cancer

Gastric Cancer

Germany
Hoffmann-La Roche

Completed

Safety and Tolerability Study of Pirfenidone in Combination With Nintedanib in Participants With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United States, Canada, Denmark, France, Germany, Italy, Netherlands, Spain
Hoffmann-La Roche

Completed

A Dose-Finding Study of Pertuzumab (Perjeta) in Combination With Trastuzumab (Herceptin) in Healthy Male Participants and Women With Early Breast Cancer (EBC)

Early Breast Cancer

New Zealand
Hoffmann-La Roche

Completed

A Study of Emactuzumab and RO7009789 Administered in Combination in Participants With Advanced Solid Tumors

Neoplasms

Belgium, France, United States
Hoffmann-La Roche

Completed

A Study of the Safety and Pharmacokinetics of RO6839921, An MDM2 Antagonist, in Patients With Advanced Cancers, Including Acute Myeloid Leukemia.

Neoplasms, Myelogenous Leukemia, Acute

United States, Canada
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Patients With Metastatic Colorectal Cancer (ACORN)

Colorectal Cancer

United Kingdom
Hoffmann-La Roche

Completed

Retrospective Data Collection: Post Study Treatment Anticancer Therapy From IMELDA MO22223

Breast Cancer

France, Italy, Spain, Turkey, Brazil, India
Hoffmann-La Roche

Completed

A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

Rheumatoid Arthritis

Denmark, Finland, Norway, Sweden
Hoffmann-La Roche

Completed

A Study of Herceptin (Trastuzumab)and Biomarkers in Patients With HER2-Positive Metastatic Breast Cancer

Breast Cancer

United Kingdom, Spain, Australia, Sweden
Hoffmann-La Roche

Completed

A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs

Rheumatoid Arthritis

Portugal
Hoffmann-La Roche

Completed

A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs.

Rheumatoid Arthritis

Russian Federation
Hoffmann-La Roche

Completed

PHOENIX Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) and COPEGUS (Ribavirin) Administered After Liver Transplantation for Hepatitis C.

Hepatitis C, Chronic

United States
Hoffmann-La Roche

Completed

A Non-Interventional Study of Treatment Pattern and Clinical Outcomes in Chinese Participants With Gastric Cancer (EVIDENCE)

Gastric Cancer

China
Hoffmann-La Roche

Completed

A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy

Post-Operative Nausea and Vomiting

United States
Hoffmann-La Roche

Terminated

A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status

Lymphocytic Leukemia, Chronic

Russian Federation
Hoffmann-La Roche

Completed

A Study of Mircera in Anemic Patients With Multiple Myeloma

Anemia

Poland, Czechia
Hoffmann-La Roche

Completed

A Phase IV Study to Evaluate the Effect of Subcutaneous (SC) Tocilizumab Administered to Participants With Rheumatoid Arthritis (RA) Assessed Using Disease Activity Score (DAS28)

Rheumatoid Arthritis

Slovakia
Hoffmann-La Roche

Completed

Observational Study of Vismodegib (Erivedge) in Patients Treated in Argentina

Basal Cell Carcinoma
Hoffmann-La Roche

Completed

A Study Examining Maintenance Bevacizumab (Avastin®) Monotherapy in Participants With Advanced Lung Adenocarcinoma

Lung Adenocarcinoma

Hungary
Hoffmann-La Roche

Completed

A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)

Carcinoma, Hepatocellular

United States
Hoffmann-La Roche

Completed

A Study of Participant Preference With Subcutaneous Versus Intravenous MabThera/Rituxan in Participants With CD20+ Diffuse Large B-Cell Lymphoma or CD20+ Follicular Non-Hodgkin's Lymphoma Grades 1, 2 or 3a

Diffuse Large B-Cell Lymphoma, Non-Hodgkin's Lymphoma

Hong Kong, Germany, Philippines, Taiwan, Turkey, Canada, Australia, Austria, New Zealand, Thailand, Hungary, Italy, Korea, Republic of, Romania, Netherlands, Brazil, Indonesia, Croatia, Egypt, Portugal, Sweden, Colombia, Argentina, De... and more
Hoffmann-La Roche

Completed

A Study to Compare Subcutaneous (SC) Versus Intravenous (IV) Administration of Herceptin (Trastuzumab) in Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Early Breast Cancer

Breast Cancer

Canada, Germany, Korea, Republic of, Panama, Spain, Turkey, Brazil, Colombia, France, Hungary, Russian Federation, Taiwan, Thailand, Czechia, Italy, Estonia, Peru, South Africa, Sweden, Poland, Israel, Hong Kong, Mexico, Guatemala, Arge... and more
Hoffmann-La Roche

Completed

A Two Part Study of RO6870810. Dose-Escalation Study in Participants With Advanced Solid Tumors and Expansion Study in Participants With Selected Malignancies

Solid Tumors, Advanced Solid Tumors

United States
Hoffmann-La Roche

Completed

A Study of Mircera in Anemic Patients With Chronic Kidney Disease Not Yet on Dialysis.

Anemia

United States, Canada, United Kingdom, Mexico, Poland
Hoffmann-La Roche

Completed

A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTX

Rheumatoid Arthritis

United States
Hoffmann-La Roche

Completed

A Study of Subcutaneously Administered Tocilizumab in Participants With Systemic Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis

United States, Canada, United Kingdom, Brazil, Argentina, Germany, Italy, Russian Federation, Spain, Mexico, Australia, France

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