Clinical Trials Sponsored by Roswell Park Cancer Institute

Total 497 results

Medical University of South Carolina
Roswell Park Cancer Institute

Completed

Quit4hlth: Enhancing Tobacco and Cancer Control Through Framed Text Messages

Smoking
Roswell Park Cancer Institute
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream

Cannabis Dependence

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Analyzing a New Mechanism in Response to Tamoxifen Therapy in Breast Cancer Patients

Breast Cancer

United States
Roswell Park Cancer Institute
Johns Hopkins University; National Cancer Institute (NCI)

Terminated

Broccoli Sprout Extract in Treating Patients With Transitional Cell Bladder Cancer Undergoing Surgery

Recurrent Bladder Cancer | Transitional Cell Carcinoma of the Bladder | Stage 0 Bladder Cancer | Stage I Bladder Cancer | Stage II Bladder Cancer

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Comprehensive Cancer Network

Terminated

Axitinib in Treating Patients With Melanoma That is Metastatic or Cannot Be Removed by Surgery

Recurrent Melanoma | Stage IV Melanoma | Metastatic Intraocular Melanoma | Recurrent Intraocular Melanoma | Stage IV Intraocular Melanoma | Stage IIIA Melanoma | Stage IIIB Melanoma | Stage IIIC Melanoma | Extraocular Extension Melanoma | Stage IIIA Intraocular Melanoma | Stage IIIB Intraocular Melanoma | Stage...

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Cianna Medical, Inc.

Terminated

Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIC Breast Cancer | Lobular Breast Carcinoma In Situ | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative | Progesterone Receptor Positive | Ductal Breast Carcinoma In Situ | Mucinous Breast Carcinoma | Tubular Breast Carcinoma and other conditions

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Cleveland BioLabs, Inc.

Withdrawn

Entolimod in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Receiving Cisplatin and Radiation Therapy

Mucositis | Tongue Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma of the Oropharynx | Recurrent Squamous Cell Carcinoma of the Paranasal... and other conditions
Roswell Park Cancer Institute
United States Department of Defense

Recruiting

Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastroesophageal Junction Adenocarcinoma | Unresectable Gastroesophageal Junction Adenocarcinoma | Locally Advanced Gastroesophageal Junction... and other conditions

United States
Roswell Park Cancer Institute

Completed

Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia

Aplastic Anemia

United States
Roswell Park Cancer Institute
Susan G. Komen Breast Cancer Foundation

Recruiting

Photoacoustic Imaging of the Breast in Patients With Breast Cancer and Healthy Subjects

Breast Carcinoma | Healthy Subject

United States
Roswell Park Cancer Institute
National Institute on Drug Abuse (NIDA)

Not yet recruiting

PK/PD of Vaping THC-containing Liquids vs. Smoked Cannabis

Cigarette Smoking-Related Carcinoma
Virginia Polytechnic Institute and State University
Roswell Park Cancer Institute

Recruiting

The Impact of Innovative Tax Proposals on Purchase Patterns

Cigarette Smoking

United States
Roswell Park Cancer Institute
United States Department of Defense

Recruiting

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain

United States
Roswell Park Cancer Institute
National Institute of Nursing Research (NINR)

Recruiting

A Sugar-Sweetened Beverage Reduction Intervention for Native American Men

Coronary Artery Disease | Diabetes Mellitus | Cardiovascular Disorder | Obesity-Related Malignant Neoplasm

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Comprehensive Cancer Network

Completed

Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer

Gastric Adenocarcinoma | Recurrent Gastric Carcinoma | Esophageal Undifferentiated Carcinoma | Gastric Squamous Cell Carcinoma | Adenocarcinoma of the Gastroesophageal Junction | Stage IV Gastric Cancer | Stage IIIB Gastric Cancer | Stage IIIC Gastric Cancer | Stage IV Esophageal Adenocarcinoma | Stage... and other conditions

United States
Roswell Park Cancer Institute
National Center for Advancing Translational Sciences (NCATS)

Recruiting

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

Recurrent Colorectal Carcinoma | Locally Advanced Colorectal Carcinoma | Stage III Colorectal Cancer

United States
Roswell Park Cancer Institute
National Center for Advancing Translational Sciences (NCATS)

Completed

Chemokine Modulation Therapy and Standard Chemotherapy Before Surgery for the Treatment of Early Stage Triple Negative Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Prognostic Stage I Breast Cancer AJCC v8 | Prognostic... and other conditions

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Incyte Corporation; Celldex Therapeutics

Completed

DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, and IDO1 Inhibitor INCB024360 in Treating Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Remission

Fallopian Tube Carcinoma | Ovarian Carcinoma | Primary Peritoneal Carcinoma

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Merck Sharp & Dohme LLC

Completed

Cetuximab and Pembrolizumab in Treating Patients With Colorectal Cancer That is Metastatic or Cannot Be Removed by Surgery

Recurrent Colorectal Carcinoma | Stage IVA Colorectal Cancer | Stage IVB Colorectal Cancer

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Teva Pharmaceutical Industries, Ltd.

Terminated

Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic... and other conditions

United States
Ludwig Institute for Cancer Research
Roswell Park Cancer Institute; New York University Cancer Institute

Completed

Vaccine Therapy in Stage II, III, or IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer

United States
Roswell Park Cancer Institute
National Institutes of Health (NIH); Biolitec Pharma Ltd.

Withdrawn

Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent Oral Cavity or Oropharyngeal Cancer

Tongue Cancer | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma of the Oropharynx | Recurrent Verrucous Carcinoma of the Oral Cavity | Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage I Squamous Cell Carcinoma of the Oropharynx and other conditions
Roswell Park Cancer Institute
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Donor Umbilical Cord Blood Transplantation in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myelodysplastic-Myeloproliferative Diseases

United States
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI); Roswell Park Cancer Institute

Completed

Relapse-Prevention Booklets as an Adjunct to a Tobacco Telephone Helpline("Quitline")

Smoking Cessation

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Sanofi Pasteur, a Sanofi Company

Completed

Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer

Stage IV Ovarian Epithelial Cancer | Recurrent Ovarian Epithelial Cancer | Recurrent Primary Peritoneal Cavity Cancer | Stage IV Primary Peritoneal Cavity Cancer | Recurrent Fallopian Tube Cancer | Stage IIA Fallopian Tube Cancer | Stage IIB Fallopian Tube Cancer | Stage IIC Fallopian Tube Cancer | Stage... and other conditions

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Pinnacle Biologics Inc.; Simphotek Inc.

Recruiting

Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer

Small Cell Lung Carcinoma | Stage III Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8 | Non-Small Cell Lung Carcinoma | Locally Advanced Lung Carcinoma

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Boehringer Ingelheim; National Comprehensive...

Completed

Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer

Recurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Rectal Adenocarcinoma | Colon Adenocarcinoma | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Roswell Park Cancer Institute
National Institute on Drug Abuse (NIDA); National Cancer Institute (NCI)

Completed

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers (ENDS)

Current Smoker | Healthy Subject | Cigarette Smoker

United States
Pfizer
Roswell Park Cancer Institute; South Texas Accelerated Research Therapeutics...

Completed

A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

Advanced Malignant Solid Tumors

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Institutes of Health (NIH); University...

Recruiting

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems (CRoFT)

Electronic Cigarette Use

United States
Roswell Park Cancer Institute
AstraZeneca; National Center for Complementary and Integrative Health (NCCIH)

Completed

Flaxseed, Aromatase Inhibitors and Breast Tumor Characteristics (FABrC)

Breast Cancer

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Celldex Therapeutics

Recruiting

Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Endometrial Serous Adenocarcinoma | Ovarian Clear Cell Adenocarcinoma | Recurrent Platinum-Resistant Ovarian Carcinoma | Platinum-Sensitive Ovarian Carcinoma | Recurrent Fallopian... and other conditions

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Comprehensive Cancer Network; AVEO...

Completed

Tivozanib in Treating Patients With Liver Cancer That Is Metastatic or Cannot Be Removed by Surgery

Advanced Adult Hepatocellular Carcinoma | Non-Resectable Hepatocellular Carcinoma

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); University of Pittsburgh; AIM ImmunoTech Inc.

Suspended

Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines

Ovarian Cancer | Cancer of the Ovary | Ovary Cancer | Neoplasms, Ovarian | Ovary Neoplasms | Cancer of Ovary

United States
Tracon Pharmaceuticals Inc.
United States Department of Defense; Roswell Park Cancer Institute

Completed

Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer (TRC105)

Metastatic Breast Cancer

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Institute on Minority Health and...

Recruiting

Implementation of Evidence-Based Strategy (PC TEACH) for the Optimization of HPV Vaccination in Rural Primary Care

Human Papillomavirus Infection

United States
University of Rochester NCORP Research Base
National Cancer Institute (NCI); Roswell Park Cancer Institute

Recruiting

An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study (DiRECT)

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); Roswell Park Cancer Institute; American Lebanese...

Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Glioblastoma Multiforme | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | High-grade Astrocytoma NOS

United States, Canada
Roswell Park Cancer Institute
National Cancer Institute (NCI); Fred Hutchinson Cancer Center; University of... and other collaborators

Completed

Biomarkers in Post-Menopausal Women Receiving Flaxseed

No Evidence of Disease

United States
State University of New York at Buffalo
National Institute on Drug Abuse (NIDA); Roswell Park Cancer Institute

Recruiting

Vaping and Smoking Withdrawal Project (VASP)

Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

United States
State University of New York at Buffalo
National Institute of Nursing Research (NINR); Roswell Park Cancer Institute

Completed

Brief Behavioral Treatment for Insomnia in Cancer Survivors

Chronic Insomnia

United States
University of California, San Francisco
National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH); Roswell Park Cancer Institute

Completed

Clinical Pharmacology of Electronic Cigarettes

Nicotine Dependence

United States
Memorial Sloan Kettering Cancer Center
M.D. Anderson Cancer Center; National Cancer Institute (NCI); NYU Langone Health and other collaborators

Completed

Liposomal Doxorubicin Followed By Bexarotene in Treating Patients With Cutaneous T-Cell Lymphoma

Lymphoma

United States
HealthPartners Institute
International Diabetes Center at Park Nicollet; Park Nicollet Eating Disorder... and other collaborators

Completed

Support Group Surveys for Individuals Who Have Type 1 Diabetes and an Eating Disorder

Type 1 Diabetes | Eating Disorder

United States
HealthPartners Institute
International Diabetes Center at Park Nicollet; Park Nicollet Eating Disorder... and other collaborators

Completed

Develop and Validate a Self-Administered Instrument That Will Screen for Eating Disorder Symptoms in Persons Aged 12 and Older With Type 1 Diabetes.

Type 1 Diabetes | Eating Disorder

United States
HealthPartners Institute
International Diabetes Center at Park Nicollet; Park Nicollet Eating Disorder... and other collaborators

Completed

Characteristics of Persons With an Eating Disorder and Type 1 Diabetes

Type 1 Diabetes | Eating Disorder

United States
UConn Health
National Cancer Institute (NCI); University of Colorado, Denver; Roswell Park... and other collaborators

Completed

Electronic Cigarette Use During Pregnancy

Cigarette Smoking-Related Carcinoma

United States
HealthPartners Institute
International Diabetes Center at Park Nicollet; Park Nicollet Foundation

Completed

Barriers to the Implementation of Complete Insulin Order Sets

Hyperglycemia

United States
HealthPartners Institute
International Diabetes Center at Park Nicollet; Park Nicollet Foundation; Melrose...

Terminated

Type 1 Diabetes and Eating Disorder Diurnal Glucose Patterns (REACT5)

Eating Disorder | Type I Diabetes Mellitus Without Complication

United States
Aiwu Ruth He, MD
Merck Sharp & Dohme LLC; Georgetown University; The Cleveland Clinic; Hoosier Cancer... and other collaborators

Terminated

Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron

Advanced Cholangiocarcinoma

United States

Clinical Trials Sponsored by Roswell Park Cancer Institute

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