Search clinical trials for: Impaired Hepatic Function

Total 27787 results

Albert Einstein Healthcare Network

Completed

Monitoring of Symptoms and Cognitive Function Using Telehealth

End Stage Liver Disease

United States
Novo Nordisk A/S

Completed

Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Various Degrees of Impaired Renal Function Compared to Subjects With Normal Renal Function

Growth Hormone Disorder | Growth Hormone Deficiency in Children | Adult Growth Hormone Deficiency

Germany
Geisinger Clinic

Completed

Comparison of 19g FNA and 19g FNB Needles for EUS-LB

Abnormal Liver Function

United States
Gilead Sciences

Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

HCV Infection

United States, Germany, New Zealand
University of North Carolina, Chapel Hill
National Institute of General Medical Sciences (NIGMS)

Completed

ADPKD Alterations in Hepatic Transporter Function

Renal Disease | Autosomal Dominant Polycystic Kidney Disease | ADPKD

United States
Universidad Santo Tomas
Universidad Pública de Navarra; Universidad del Rosario; Universidad de Santiago... and other collaborators

Withdrawn

Exercise, Gut Microbiota in Sedentary Adults With Overweight

Metabolic Disturbance

Colombia
Bezmialem Vakif University

Completed

"Core Stabilization Exercises in Hearing Impaired Children"

Postural Control | Hearing Disorders in Children | Respiratory Muscle Strength | Respiratory Functions | Core Stabilization

Turkey
Royal Devon and Exeter NHS Foundation Trust
University of Exeter

Completed

Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men (Rejuvenate)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
Pharbil Waltrop GmbH

Completed

Bioavailability Study With Oral Single Dose Administration of Ethinylestradiol and Dienogest

Focus: Bioequivalence

Germany
CTI BioPharma
SGS S.A.

Completed

Determine Pacritinib Pharmacokinetics in Impaired Hepatic Patients and Healthy Subjects

Myelofibrosis

Moldova, Republic of, Germany
ObsEva SA

Completed

Safety and Pharmacokinetics of Linzagolix in Female Subjects With Normal and Impaired Renal Function

Renal Impairment | Healthy Participants

United States
Kartal Kosuyolu Yuksek Ihtisas Education and Research...

Completed

The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries

Surgery | Hepatic Impairment | Cardiac Disease | Hyperbilirubinemia
Astellas Pharma Europe B.V.
FibroGen

Completed

A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function

Impaired Renal Function | Normal Renal Function

Germany, United Kingdom
IlDong Pharmaceutical Co Ltd

Unknown

Pharmacokinetics of Besifovir in Adults With Normal and Impaired Renal Function

Renal Impairment
Progenity, Inc.

Unknown

Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women

Hypertension | Renal Insufficiency | Thrombocytopenia | Headache | Pre-Eclampsia | Pulmonary Edema | Visual Impairment | Impaired Liver Function | Proteinuria in Pregnancy

United States
Shanghai Zhongshan Hospital

Unknown

The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy

Liver Failure | Acute Kidney Injury | Ascites Hepatic | Terlipressin Adverse Reaction

China
The University of Texas Health Science Center at...
Janssen Scientific Affairs, LLC

Completed

Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients

Type 2 Diabetes Mellitus

United States
Mallinckrodt

Terminated

Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function

Renal Impairment

United States
Eli Lilly and Company
CoLucid Pharmaceuticals

Completed

Study of Oral Lasmiditan in Participants With Normal and Impaired Renal Function

Migraine

Canada
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function

Renal Impairment

United States
Augusta University
Yale University; University of Alabama at Birmingham; Tufts University

Unknown

Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)

Obesity | Insulin Resistance | Insulin Sensitivity | Prediabetes | Beta-Cell Dysfunction

United States
Celgene

Completed

Pharmacokinetics and Safety Study of Azacitidine in Cancer Patients With and Without Impaired Renal Function (RENAL)

Multiple Myeloma | Non-Hodgkin's Lymphoma | AML | Solid Tumors | MDS | Hodgkin's Disease

United States
Celgene

Completed

Study to Evaluate Pharmacokinetics of Pomalidomide in Hepatically Impaired Males

Clinical Pharmacology, Healthy Volunteer Study

United States
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Study of Dapagliflozin on Mitochondrial Dysfunction and Impaired Insulin Signaling/Action (DAPA MITO)

Insulin Sensitivity | Multiple Mitochondrial Dysfunctions Syndrome

United States
Gilead Sciences

Completed

Pharmacokinetics of Lanraplenib in Adults With Impaired Renal Function

Inflammatory Disease

United States, New Zealand, Germany
Guerbet

Completed

Pharmacokinetics, Dialysability and Safety of P03277 in Healthy Volunteers and in Patients With Impaired Renal Function

Renal Insufficiency | Healthy Volunteers

Moldova, Republic of, Romania
Imperial College London
Pfizer

Completed

Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or Boosted Darunavir With Maraviroc and Kivexa (CogUK)

HIV | Impaired Cognition

United Kingdom
Gilead Sciences

Completed

Pharmacokinetics of Bictegravir in Adults With Normal and Impaired Renal Function

HIV

United States, New Zealand
Dr Anders Ullén

Completed

A Trial With Vinflunine in Patients With Metastatic Bladder Cancer and Impaired Renal Function (VINGEM)

Bladder Cancer | Urothelial Carcinoma | Urethra Cancer | Ureter Cancer | Renal Pelvis Cancer

Denmark, Sweden
University of Edinburgh
Perspectum; Hampshire Hospitals NHS Foundation Trust

Completed

HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies (Hepatica)

Surgery | Colorectal Cancer Metastatic | Liver Cancer | Liver Regeneration

United Kingdom
University of Exeter
Royal Devon and Exeter NHS Foundation Trust

Terminated

Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance (Rejuvenate2)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

France, United Kingdom, Czechia, Korea, Republic of, Netherlands
Genfit
University of Miami; Syneos Health

Completed

Elafibranor Pharmacokinetic Parameters in Hepatic Impaired Patients

Pharmacokinetics | Hepatic Impairment | Liver Disease

United States
Institut Claudius Regaud

Completed

A Study Evaluating Chemotherapy With Fractionated Cisplatin/Gemcitabine Versus Carboplatin/Gemcitabine in the Treatment of Advanced or Metastatic Urothelial Cancer With Impaired Renal Function. (VEFORA)

Metastatic Urothelial Cancer | Advanced Urothelial Cancer

France
Barcelona Institute for Global Health
Recercaixa; Centre de Recerca per a l'Educació Científica i Matemàtica (CRECIM) and other collaborators

Completed

Effect of Air Pollution on the Cognitive Function of Adolescents (ATENC!Ó)

Risk Behavior | Attention Impaired | Risk-Taking | Social Preferences | Decision Making | Attention

Spain
Gilead Sciences

Completed

Pharmacokinetics of Entospletinib in Adults With Normal and Impaired Liver Function

Oncology

United States, New Zealand, Germany
Universidade Metodista de Piracicaba

Completed

Effects of Respiratory Muscle Training in Obese Women

Hypertension | Diabetes | Inadequate or Impaired Respiratory Function

Brazil
Zagazig University

Unknown

Coenzyme Q10 and Meclofenoxate in Hepatic Encephalopathy (EH)

Hepatic Encephalopathy | Coenzyme Q10 | Intellectual Functioning Disability

Egypt
King's College London
Naturex-Dbs

Completed

Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women (CONCARD)

Healthy Men and Women

United Kingdom
Swiss Tropical & Public Health Institute
Institute for Interdisciplinary Research on the Human-Pet Relationship

Completed

Effects of Animal-assisted Therapy on Brain-injured Patients

Impaired Social Functioning

Switzerland
Novo Nordisk A/S

Completed

Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Mild and Moderate Degrees of Hepatic Impairment Compared to Subjects With Normal Hepatic Function.

Growth Hormone Disorder | Growth Hormone Deficiency in Children | Adult Growth Hormone Deficiency

Slovakia
Aragon Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Pharmacokinetics of JNJ-56021927 in Participants With Mild or Moderate Hepatic Impairment Compared With Participants With Normal Hepatic Function

Hepatic Impairment

United States
Seagen Inc.

Completed

A Safety Study of Tucatinib in Healthy and Hepatically-Impaired Subjects

Hepatic Impairment

United States
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)

Renal Impairment

United States
University of Nottingham

Completed

The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery (POETold)

Quality of Life | Delirium | Prostatic Neoplasms | Surgery | Colorectal Carcinoma | Bladder Carcinoma | Colon Carcinoma | Impaired Cognition | Abdominal Hysterectomy (& Wertheim) | Renal Carcinoma

United Kingdom
Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Renal Function and Subjects With Normal Renal Function

Patients With Impaired Renal Function

Japan
Merck Sharp & Dohme LLC

Terminated

Evaluation of Renal Function, Efficacy, and Safety When Switching From Tenofovir/Emtricitabine Plus a Protease Inhibitor/Ritonavir, to a Combination of Raltegravir (MK-0518) Plus Nevirapine Plus Lamivudine in HIV-1 Participants With Suppressed Viremia and Impaired Renal Function (MK-0518-284) (RANIA)

HIV Infections
LEO Pharma

Completed

Innohep® in Elderly Patients With Impaired Renal Function Treated for Acute Deep Vein Thrombosis

Deep Vein Thrombosis

Bulgaria, Croatia, Czechia, France, Germany, Poland, Romania, Serbia, Spain
University of Manitoba

Completed

Effects of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism

Impaired Glucose Tolerance

Canada
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

United States, Spain, Belgium, France, Korea, Republic of, United Kingdom

Search clinical trials for: Impaired Hepatic Function

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