Search clinical trials for: Locally Advanced Gastroesophageal Junction Adenocarcinoma

Total 33223 results

Yonsei University

Not yet recruiting

An Open Label, Single-arm, Multicenter Phase Ib/II Study to Evaluate the Safety and Efficacy of T-Dxd in Combination With Ramucirumab as a 2nd Line in Patients With HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

Gastric Cancer | Gastroesophageal Junction (GEJ) Cancer
Servier Affaires Médicales

Recruiting

An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma (ProvIDHe)

Cholangiocarcinoma

France, Netherlands, Spain, Belgium, Sweden, Italy, Australia, Austria, Germany, United Kingdom
Iksuda Therapeutics Ltd.

Recruiting

IKS014 in Advanced Solid Tumors That Express HER2

Breast Cancer | Gastric Cancer | Gastroesophageal-junction Cancer

Australia
Genentech, Inc.
Chugai Pharmaceutical Co.

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination With a Checkpoint Inhibitor With or Without Standard-of-Care Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

Gastric Cancer | Metastatic Solid Tumor | Non-small Cell Lung Cancer | Pancreatic Ductal Adenocarcinoma

Korea, Republic of, Spain, Japan, New Zealand, Australia, United States, Italy, Brazil
RemeGen Co., Ltd.

Recruiting

A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors

Melanoma | Renal Cell Carcinoma | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Urothelial Carcinoma | Colorectal Carcinoma

Australia, China
AIPING ZHOU

Recruiting

Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction

Esophagus Squamous Cell Carcinoma

China
Sir Run Run Shaw Hospital

Recruiting

Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Ultra Low Rectal Adenocarcinoma (RECMULRA-TNT)

Rectal Cancer

China
Amal Therapeutics
Boehringer Ingelheim

Recruiting

A Study to Evaluate ATP150/ATP152, VSV-GP154 and Ezabenlimab in Patients With KRAS G12D/G12V Mutated PDAC (KISIMA-02)

Pancreatic Ductal Adenocarcinoma

United States, Switzerland
National Cancer Institute (NCI)

Recruiting

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

Gastric Adenocarcinoma | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage I Gastric Cancer AJCC v8 | Clinical Stage II Gastric Cancer AJCC v8 | Clinical Stage IVA Gastric... and other conditions

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Neoadjuvant Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

Pancreas Adenocarcinoma | Locally Advanced Pancreatic Adenocarcinoma | Borderline Resectable Pancreatic Adenocarcinoma

United States
Peking University Cancer Hospital & Institute

Recruiting

Clinical Study of Pabolizumab for Neoadjuvant Immunotherapy of Locally Advanced Microsatellite-unstable Gastric Adenocarcinoma

Gastric Cancer | Gastric Adenocarcinoma

China
Zhejiang University

Recruiting

Study of Comparing of With and Without Sequential Therapy of S-1

Chemotherapy Effect | Locally Advanced Gastric Adenocarcinoma

China
Hoffmann-La Roche

Recruiting

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Renal Cell Carcinoma

Korea, Republic of, United States, China, Spain, Germany, France, United Kingdom, Poland, Australia
Mayo Clinic

Recruiting

Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis

Gastric Adenocarcinoma | Clinical Stage IV Gastric Cancer AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Metastatic Gastric Carcinoma | Metastatic Malignant Neoplasm in the Peritoneum

United States
Institut de cancérologie Strasbourg Europe

Recruiting

Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma (TEPIREC)

Rectal Cancer

France
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Astellas Pharma Inc; Seagen...

Recruiting

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Cancer of Variant Histology

Stage III Bladder Cancer AJCC v8 | Stage IV Bladder Cancer AJCC v8 | Bladder Adenocarcinoma | Bladder Squamous Cell Carcinoma | Metastatic Bladder Carcinoma | Urachal Adenocarcinoma | Locally Advanced Bladder Carcinoma | Malignant Renal Pelvis Neoplasm | Malignant Ureter Neoplasm | Malignant Urethral Neoplasm and other conditions

United States
Mayo Clinic

Recruiting

Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study

Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma | Metastatic Malignant Neoplasm in the Peritoneum

United States
Sir Run Run Shaw Hospital

Recruiting

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Rectal Cancer

China
Replimune Inc.
Roche Pharma AG

Not yet recruiting

RP3 in Combination With 1L or 2L Therapy in Patients With Locally Advanced Unresectable or Metastatic HCC

Recurrent Hepatocellular Carcinoma | Metastatic Hepatocellular Carcinoma | Locally Advanced Hepatocellular Carcinoma

United States, United Kingdom, France, Germany, Greece
University of California, Irvine
Natera, Inc.

Not yet recruiting

Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial)

Gastroesophageal Adenocarcinoma

United States
Suzhou Transcenta Therapeutics Co., Ltd.

Recruiting

A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors

Colorectal Adenocarcinoma | Locally Advanced Solid Tumor | Metastatic Tumor

United States
University of Arizona

Recruiting

Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ Cancer

Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Recruiting

A Study of Docetaxel for Injection (Albumin-bound) in Patients With Gastric Cancer

Gastric Adenocarcinoma | Adenocarcinoma of Gastroesophageal Junction

China
Debiopharm International SA

Recruiting

A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

Pancreatic Ductal Adenocarcinoma (PDAC) | Colorectal Cancer (CRC) | Clear Cell Renal Cell Cancer (ccRCC)

France, Australia
Michael Chuong
NovoCure Ltd.

Recruiting

Stereotactic Body Radiation and Tumor Treating Fields for Locally Advanced Pancreas Cancer

Pancreas Cancer | Locally Advanced Pancreatic Adenocarcinoma | Locally Advanced

United States
CHA University

Recruiting

Clinical Feasibility of Nab-paclitaxel Plus Gemcitabine-cisplatin Chemotherapy in Locally Advanced Cholangiocarcinoma

Locally Advanced Cholangiocarcinoma

Korea, Republic of
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Rectal Cancer | Rectal Adenocarcinoma | Adenocarcinoma of the Rectum | Locally Advanced Rectal Adenocarcinoma | HER2 Positive Rectal Adenocarcinoma

United States
Centre Leon Berard

Recruiting

GastrOesophageal Tumor, Immune Microenvionnment (GOTIM) (GOTIM)

GastroEsophageal Cancer

France
Tianjin Medical University Cancer Institute and...

Recruiting

Tislelizumab Combined With Lenvatinib and GEMOX Versus Tislelizumab Combined With GEMOX in Conversion Therapy of ICC and GBC.

Potentially Resectable Locally Advanced Intrahepatic Cholangiocarcinoma and Gallbladder Cancer

China
Catharina Ziekenhuis Eindhoven

Recruiting

Therapeutic Oncolytic Monitoring as a Tool for Effective Exposure to 5-FU in Patients With Locally Advanced, Resectable Gastric or Gastro-oesophageal Junction Cancer Treated With Perioperative FLOT (THOMAS FU FLOT)

TDM of 5-FU | Pharmacokinetic Observational Study

Netherlands
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation (JANUS)

Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Locally Advanced Rectal Carcinoma

United States, Puerto Rico
TriSalus Life Sciences, Inc.

Recruiting

Pressure Enabled Intrapancreatic Delivery of SD-101 With Checkpoint Blockade for Locally Advanced Pancreatic Adenocarcinoma

Locally Advanced Pancreatic Adenocarcinoma

United States
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Envafolimab, Lenvatinib Combined With TACE in the Treatment of Unresectable Locally Advanced Hepatocellular Carcinoma

Objective Response Rate (ORR)
Institut Claudius Regaud
Institute of Cancer Research, United Kingdom; Hellenic Cooperative Oncology... and other collaborators

Recruiting

PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer (PAROLA)

Adenocarcinoma | Cervical Carcinoma | Adenosquamous Carcinoma

France, Italy, Spain
Baylor College of Medicine

Recruiting

A Study of Total Neoadjuvant Chemotherapy With FLOT VS Standard Perioperative FLOT in Patients With Gastric or GEJ Cancer (TOGAR)

Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

United States
VA Office of Research and Development
VA Palo Alto Health Care System; VA Puget Sound Health Care System; Michael E... and other collaborators

Not yet recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Gastroesophageal Junction Carcinoma

United States
Renmin Hospital of Wuhan University

Recruiting

Short-course Radiotherapy Combined With Neoadjuvant Chemotherapy and PD-1 Inhibitor in the Treatment of Locally Advanced Gastric Adenocarcinoma

Disorder in Complete Remission in Response to Treatment

China
Sun Yat-sen University

Recruiting

TACE Combined With Lenvatinib and MWA in the Treatment of Locally Advanced Large Hepatocellular Carcinoma

Liver Tumor

China
University Hospital, Grenoble
NETRIS Pharma

Recruiting

Study Investigating the Association of NP137 With mFOLFIRINOX in Locally Advanced Pancreatic Ductal Adenocarcinoma (LAP-NET1)

Pancreatic Ductal Adenocarcinoma

France
Academisch Medisch Centrum - Universiteit van Amsterdam...
M.D. Anderson Cancer Center; University of Colorado, Denver; Radboud University... and other collaborators

Recruiting

PREOPANC-4 Implementation Program for Locally Advanced Pancreatic Cancer (PREOPANC-4)

Pancreatic Cancer | Chemotherapy Effect | Locally Advanced Pancreatic Adenocarcinoma | Pancreatic Adenocarcinoma Non-resectable

Netherlands
Xijing Hospital

Recruiting

Tislelizumab Combined With XELOX as Neoadjuvant Therapy for G/GEJ Adenocarcinoma

Locally Advanced Gastric Adenocarcinoma

China
Xijing Hospital

Recruiting

Biomarker Analysis of Tislelizumab Combined With Chemotherapy for Perioperative Treatment of G/GEJ Adenocarcinoma

PD-1 | Locally Advanced Gastric Adenocarcinoma

China
AIM ImmunoTech Inc.
Amarex Clinical Research

Recruiting

Ampligen Compared to No Treatment Following FOLFIRINOX in Subjects With Locally Advanced Pancreatic Adenocarcinoma

Pancreatic Cancer

United States
The First Affiliated Hospital with Nanjing Medical...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

XELOX Combined With Anlotinib and Penpulimab vs XELOX as Adjuvant Therapy in ctDNA Positive Gastric and Esophagogastric Junction Adenocarcinoma (EXPLORING)

Digestive System Diseases | Gastrointestinal Diseases | Carcinoma | Gastrointestinal Neoplasms | Stomach Cancer | Gastric Cancer | Gastroesophageal-junction Cancer

China
Brown University
AstraZeneca

Recruiting

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Esophageal Cancer | Esophageal Adenocarcinoma | HER-2 Protein Overexpression | Gastroesophageal-junction Cancer

United States
University Hospital, Clermont-Ferrand

Not yet recruiting

PAncreas Borderline and Locally Advanced Snapshot Study (PALASS)

Pancreatic Cancer

France
OncoSil Medical Limited

Recruiting

FOLFIRINOX Versus OncoSil™ in Addition to FOLFIRINOX in Patients With Locally Advanced Pancreatic Adenocarcinoma (TRIPP-FFX)

Locally Advanced Pancreatic Cancer

Spain, Belgium, United Kingdom, Italy, Australia
Second Affiliated Hospital, School of Medicine,...
TCRx Therapeutics Co.Ltd

Not yet recruiting

TCRx_T Cells for Advanced or Recurrent Gastric/Gastroesophageal Junction Cancer After Failure of First Chemotherapy

Gastric Cancer | Gastroesophageal-junction Cancer
Tvardi Therapeutics, Incorporated

Recruiting

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

Hepatocellular Carcinoma

United States
Shanghai JMT-Bio Inc.

Recruiting

KN026 in Combination With Chemotherapy in HER2 Positive Gastric Cancer Subjects Who Have Failed First-line Therapy

Stomach Cancer

China

Search clinical trials for: Locally Advanced Gastroesophageal Junction Adenocarcinoma

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