Search clinical trials for: Moderate to severe acute pain

Total 476476 results

Revive Therapeutics, Ltd.

Completed

Bucillamine for the Treatment of Acute Gout Flare in Subjects With Moderate to Severe Gout

Gout

United States
Mundipharma Pte Ltd.
Mundipharma Korea Ltd; Mundipharma (Hong Kong) Ltd; Mundipharma Distribution...

Completed

Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain

Osteoarthritis | Rheumatoid Arthritis | Lower Back Pain | Joint Pain | Muscle Pain

Hong Kong, Korea, Republic of, Philippines
Kompetenznetz Sepsis
Biosyn; Brahms AG

Completed

Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT)

Septic Shock | Severe Sepsis

Germany
Norwegian University of Science and Technology

Completed

Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury

Traumatic Brain Injury

Norway
University Hospital, Angers

Completed

Morphine Titration by Patient Self-controlled by a Mechanical Device Versus Administration by the Nurse for Patients With Severe Acute Pain in the Emergency Department (TACIDOU)

Acute Pain

France
Southeast University, China

Completed

Respiratory System Compliance Guided VT in Moderate to Severe ARDS Patients

Respiratory Failure | Acute Respiratory Distress Syndrome

China
Biogen
Elan Pharmaceuticals

Completed

A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease

Crohn's Disease

United States, Canada
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain

Low Back Pain | Low Back Pain, Recurrent

United States, Belgium, Canada, Netherlands
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpetic Neuralgia and Post-traumatic Neuralgia)

Pain | Mononeuropathies | Neuralgia | Neuralgia, Postherpetic

United States, Spain, Belgium, Netherlands
Shanghai Jiao Tong University School of Medicine

Unknown

Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population

Morbid Obesity

China
Neil Singla
Mallinckrodt

Terminated

A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain

Post Operative Pain

United States
Antonios Likourezos

Completed

Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department

Pain

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma

Lymphoma | Leukemia

United States
Institute of Liver and Biliary Sciences, India

Completed

Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF

Acute Liver Failure

India
Novartis Pharmaceuticals

Completed

Swiss studY for the Treatment of COPD Patients With the Free combiNation of indacatERol and GlYcopyrroniumbromide. (SYNERGY)

Chronic Obstructive Pulmonary Disease: COPD

Switzerland
Scripps Health
Depomed

Unknown

IM Ketorolac vs Cambia for the Acute Treatment of Severe Migraine

Migraine Headache

United States
Hospices Civils de Lyon

Completed

Prone Position Effects on Work of Breathing and Intrinsic PEEP in Children With Severe Acute Viral Bronchiolitis (BRONCHIO-DV)

Severe Bronchiolitis

France
Janssen Research & Development, LLC

Completed

A Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Cancer-related Pain

Pain, Radiating | Pain, Burning | Pain, Crushing | Pain, Migratory | Pain, Splitting

United States, France, Spain, Poland, Portugal
Mario Negri Institute for Pharmacological Research

Completed

RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. (CERP)

Cancer | Cancer Pain

Italy
Janssen Pharmaceutica

Withdrawn

A Safety and Effectiveness Study of Prolonged Release Tapentadol Hydrochloride Among Filipino Patients With Moderate to Severe Chronic Non-Cancer Pain

Moderate to Severe Chronic Non-cancer Pain
Purdue Pharma LP

Completed

Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
Rigshospitalet, Denmark
Glostrup University Hospital, Copenhagen

Completed

The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery

Postoperative Pain | Chlorzoxazone

Denmark
Purdue Pharma LP

Completed

Long-Term Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children Who Completed OTR3001

Pain

United States, Israel
Pain Therapeutics

Completed

Food Effect And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers

Healthy

United States
Pain Therapeutics

Completed

Pharmacokinetics And Relative Bioavailability Study Of Oxycodone in Healthy Volunteers

Healthy

United States
Francisco Campos-Rodriguez
Sociedad Española de Neumología y Cirugía Torácica; Fondo de Investigacion...

Completed

Effect of CPAP Treatment in Women With Moderate-to-severe OSA.

Obstructive Sleep Apnea

Spain
Kythera Biopharmaceuticals

Completed

Patient Experience Study of Deoxycholic Acid Injection

Moderate or Severe Submental Fullness

United States
International Centre for Diarrhoeal Disease Research...
Washington University School of Medicine; University of Virginia; International...

Completed

Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children (RUTF)

Severe Acute Malnutrition

Bangladesh
Urmia University of Medical Sciences

Completed

Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography

Stable Angina | Unstable Angina | Non ST Segment Elevation Myocardial Infarction | Post MI

Iran, Islamic Republic of
University of Helsinki
Finnish Cultural Foundation; University of Oulu; Finnish Work Environment Fund; Juho Vainio Foundation and other collaborators

Unknown

Managing Non-acute Low Back Symptoms in Occupational Health: Two Trials

Low Back Pain | Low Back Pain, Recurrent

Finland
Lake Erie Research Institute

Completed

RESTIFFIC™ Foot Wrap Reduces Moderate to Severe Restless Leg Syndrome (RESTIFFIC)

Restless Leg Syndrome

United States
Purdue Pharma LP

Completed

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
Wayne State University
Abbott

Terminated

Addition of Modulators of Homocysteine to Adalimumab Therapy in the Treatment of Moderate to Severe Plaque Psoriasis

Psoriasis
Purdue Pharma LP

Completed

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Low Back Pain

United States, Poland, Czech Republic, Italy
Olatec Therapeutics LLC

Completed

Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee

Osteoarthritis of the Knee

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Leukemia

United States, Australia, Canada
Wex Pharmaceuticals Inc.

Completed

Safety & Efficacy Study of Subcutaneous Tetrodotoxin for Moderate to Severe Inadequately Controlled Cancer-related Pain (TEC-006)

Pain | Cancer

Canada
Amneal Pharmaceuticals, LLC
Symbio, LLC

Completed

Safety and Efficacy of Phenazopyridine Hydrochloride Tablets, USP 200 mg as an Analgesic for Short-Term Treatment in Female Subjects Suffering From Moderate-to-Severe Pain and Burning Upon Urination Associated With Uncomplicated Urinary Tract Infections (uUTI)

Uncomplicated Urinary Tract Infections

United States
Bayer

Completed

SYMPROVE III: Health Services Research Study for Treatment of the Moderate and Severe Acute Exacerbations of Chronic Bronchitis (AECB) (SYMPROVE III)

Chronic Bronchitis

Germany
Hospital Sao Joao

Completed

Positive Pressure During Bronchoscopy

Acute Respiratory Failure With Hypoxia

Portugal
Purdue Pharma LP

Completed

Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Postherpetic Neuralgia (PHN)

Pain | Postherpetic Neuralgia

United States
Johnson & Johnson Pharmaceutical Research & Development...
Grünenthal GmbH

Completed

An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain

Pain | Osteoarthritis | Low Back Pain

United States, Australia, Canada, New Zealand
Janssen-Cilag International NV

Completed

Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee

Pain | Osteoarthritis, Knee | Osteoarthritis, Hip

United Kingdom, Romania, Slovakia, Czech Republic
University of California, San Francisco

Completed

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients (BufferDent)

Pain

United States
Gyeongsang National University Hospital

Unknown

Study of Opioid Rotation Versus Opioid Escalation in Patients With Moderate to Severe Cancer Pain

Pain | Cancer

Korea, Republic of
Johnson & Johnson Pharmaceutical Research & Development...
Grünenthal GmbH

Terminated

A Long-term Safety Study With Tapentadol ER and Oxycodone CR in Patients With Moderate to Severe Pain Due to Chronic, Painful Diabetic Peripheral Neuropathy (DPN)

Diabetic Neuropathy, Painful | Diabetic Polyneuropathy

United States
University of Milan

Completed

Helmet Continuous Positive Airway Pressure (CPAP) Versus Oxygen Venturi in Severe Acute Respiratory Failure in Pneumonia

Pneumonia | Respiratory Insufficiency

Italy
AbbVie (prior sponsor, Abbott)

Completed

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

Chronic Low Back Pain

United States
AbbVie (prior sponsor, Abbott)

Completed

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

Chronic Low Back Pain

United States
Mundipharma Research GmbH & Co KG

Completed

A Randomised Placebo Controlled Study of OXN PR for Severe Parkinson's Disease Associated Pain

Parkinson's Disease With Severe Pain

United Kingdom, Spain, Germany, Hungary, Czech Republic, Poland, Romania

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