Search clinical trials for: Multiple Ascending Dose

Total 31472 results

Aelis Farma
National Institute on Drug Abuse (NIDA)

Completed

Multiple Ascending Dose to Study the Safety, Tolerability, PK and PD Effects of AEF0117

Healthy Volunteers

United States
Sanofi

Completed

Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients

Type 2 Diabetes Mellitus

Germany
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Japanese Men

Coronary Artery Disease

United States
Biota Pharmaceuticals, Inc.

Completed

Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Healthy Volunteers | Pharmacokinetics

United States
Eidos Therapeutics, a BridgeBio company
Celerion

Completed

Single and Multiple Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of AG10

Amyloid Cardiomyopathy, Transthyretin-Related

United States
Prothena Biosciences Limited

Completed

Multiple Ascending Dose Study of PRX003 in Subjects With Psoriasis

Psoriasis

United States
Enterome
Quotient Clinical

Completed

First-in-Human Single and Multiple Dose of EB8018

Healthy Volunteers

United Kingdom
ZZ Biotech, LLC

Completed

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of 3K3A-APC in Healthy Adult Volunteers

Healthy

Austria
AstraZeneca
Parexel

Terminated

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of AZD9898

Asthma

United Kingdom
Cinclus Pharma AG

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study

Healthy Volunteers

Sweden
Hanmi Pharmaceutical Company Limited

Unknown

Multiple Ascending Dose Study of HM12470 in Type 1 and Type 2 Diabetes Mellitus

Type2 Diabetes Mellitus | Type1 Diabetes Mellitus

United States
AstraZeneca
Parexel; Covance; The Doctors Laboratory; Industrias Farmacéuticas Almirall S.A.

Completed

Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Male Japanese Subjects

Chronic Obstructive Pulmonary Disease - COPD

United Kingdom
Bristol-Myers Squibb

Terminated

Single Ascending Dose and Multiple Ascending Dose Study in Healthy Participants and Proof of Mechanism Study in Patients With Ulcerative Colitis

Healthy Volunteers | Ulcerative Colitis

Australia, Georgia, Moldova, Republic of
Oscotec Inc.
PPD

Completed

Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers

Arthritis, Rheumatoid

United States
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.

Rheumatoid Arthritis

Germany, United Kingdom
Genmedica Therapeutics S.L.
Simbec Research

Terminated

Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics

Healthy | Type 2 Diabetes Mellitus

United Kingdom
Galapagos NV
MorphoSys AG

Completed

First in Human of Single and Multiple Doses of MOR106

Healthy | Dermatitis, Atopic

Belgium, Hungary, Moldova, Republic of, Romania
Bristol-Myers Squibb

Completed

Phase 1, Multiple Ascending Dose Study of Anti-HER2 FCAB FS102 in HER2 Positive Solid Tumors (Anti HER2 Fcab)

Solid Tumors That Overexpress HER2 (HER2 Positive)

United States, Canada
ContraVir Pharmaceuticals, Inc.

Completed

Phase 2, Multiple Ascending Dose Proof of Concept Study

Infectious Disease

Thailand
Hoffmann-La Roche

Completed

Placebo-Controlled, Single and Multiple Ascending Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986089 in Healthy Adult Subjects

Healthy Adults

United States
Pfizer

Completed

Multiple Ascending Dose and DDI Study

Healthy Volunteers

Belgium
Trius Therapeutics LLC

Completed

Single and Multiple Ascending Dose Pharmacokinetic Study of TR701 in Healthy Adults (SAD/MAD)

Healthy Subjects

United States
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates

Completed

A Study of EDP 305 in Healthy Subjects and Subjects With Presumptive NAFLD

Presumptive NAFLD

United States
Biosplice Therapeutics, Inc.

Completed

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SM04755 Following Topical Administration to Healthy Subjects

Tendinopathy

United States
GlaxoSmithKline

Completed

Assessment of Repeat Ascending Doses of GSK2018682 in Healthy Volunteers (P1A114347)

Multiple Sclerosis, Relapsing-Remitting

Australia
Cidara Therapeutics Inc.

Completed

An Ascending Multiple Dose Study of CD101 IV in Healthy Subjects

Healthy

United States
Pfizer

Terminated

Topical Multiple Ascending Dose Study for PF-06423264

Normal Healthy

Belgium
eXIthera Pharmaceuticals
Syneos Health; CPR Pharma Services Pty Ltd, Australia; IDT CMAX Clinical Trials

Completed

Study to Evaluate Safety, PK and PD of Single and Multiple Ascending Doses of EP-7041 in Healthy Subjects

Arthroplasty, Replacement, Knee

Australia
F2G Biotech GmbH
SimbecRresearch Ltd.

Completed

Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects (ORALMAD)

Invasive Aspergillosis

United Kingdom
Theron Pharmaceuticals, Inc.

Completed

Multiple Ascending Dose Study of TRN-157 in Stable Mild and Moderate Asthmatics

Asthma

United States
Afferent Pharmaceuticals, Inc.

Completed

A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations

Healthy

United States
Bristol-Myers Squibb

Completed

Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986141 in Healthy Subjects

Thrombosis

United States
NeuroGenetic Pharmaceuticals Inc
WCCT Global

Completed

Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose)

Alzheimer's Disease

United States
MyoKardia, Inc.

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of MYK-461 in Healthy Volunteers

Healthy

Australia
ReveraGen BioPharma, Inc.

Completed

A Phase 1 Single Ascending Dose and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of VBP15 in Healthy Adult Subjects

Healthy

United States
ASLAN Pharmaceuticals

Completed

A Phase I Multiple Ascending Dose Study of ASLAN002 in Subjects With Advanced or Metastatic Solid Tumours

Malignant Solid Tumour
Merck KGaA, Darmstadt, Germany

Completed

Multiple Ascending Dose Trial of MSB0010841 (Anti-IL17A/F Nanobody) in Psoriasis Subjects

Psoriasis

Germany
Tetra Discovery Partners

Completed

A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects

Alzheimer's Disease

United States
Biogen

Completed

Safety Study of BIIB033 in Subjects With Multiple Sclerosis

Multiple Sclerosis | Relapsing-Remitting Multiple Sclerosis

United States
AstraZeneca

Completed

A Two-part Single and Multiple Dose Study to Assess the Safety , Pharmacokinetics and Effects of AZD3293 in Healthy Japanese Young and Elderly Volunteers

Healthy Japanese Young and Elderly Male and Non-fertile Female Volunteers

Japan
Hoffmann-La Roche

Terminated

A Multiple Ascending Dose Study of the mTOR Inhibitor (RAD001) in Combination With R1507 in Patients With Advanced Solid Tumors

Neoplasms

Italy, United States
Hoffmann-La Roche

Completed

A Multiple Ascending Dose Study of R1530 in Patients With Advanced Solid Tumors.

Neoplasms

United States
Hoffmann-La Roche

Completed

A Multiple Ascending Dose Study of R4733 in Patients With Advanced Solid Tumors.

Neoplasms

United States
Hoffmann-La Roche

Completed

A Multiple Ascending-Dose Study of RG7625 in Healthy Volunteers

Healthy Volunteer

Netherlands
Hoffmann-La Roche

Completed

A Multiple Ascending Dose Study of R1507 in Patients With Advanced Solid Tumors.

Neoplasms

United States
Hoffmann-La Roche

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Dose Basimglurant in Healthy Subjects and in Patients With Major Depressive Disorder (MDD)

Major Depressive Disorder, Healthy Volunteer

United States
Hoffmann-La Roche

Completed

A Study of RO6867461 Administered in Single- and Multiple-Ascending Doses in Patients With Wet Age-Related Macular Degeneration

Macular Degeneration

United States, United Kingdom
Hoffmann-La Roche

Completed

A Multiple Ascending Dose Study of RO4905417 in Healthy Volunteers and Patients With Peripheral Arterial Disease (PAD).

Peripheral Arterial Disease (PAD)

United States, Canada, Australia
Hoffmann-La Roche

Completed

A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease.

Alzheimer's Disease

Sweden, Israel, Denmark, Netherlands, United Kingdom
Hoffmann-La Roche

Completed

A Single Ascending And Multiple Ascending Dose Study of RO5271983 in Healthy Volunteers

Healthy Volunteer

New Zealand

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