- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02537938
Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose)
March 27, 2017 updated by: NeuroGenetic Pharmaceuticals Inc
A Randomized, Placebo-Controlled, Double-blind, Parallel-Group, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally-administered NGP 555 in Healthy Subjects
This study involves the use of an investigational drug called NGP 555.
In each group of healthy subjects, 2 people will receive placebo and 6 people will receive NGP 555.
Study Overview
Detailed Description
The purpose of this research study is to determine the safety, tolerability, and pharmacokinetics (PK) of multiple (14 days), oral doses of NGP 555 in healthy volunteers.
NGP 555 has been created for the treatment of Alzheimer's disease (AD). NGP 555 is being developed to prevent Abeta 42 amyloid formation, a protein that is likely a key factor in the development of AD.
Study Type
Interventional
Enrollment (Actual)
24
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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California
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Cypress, California, United States, 90630
- WCCT Global
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
38 years to 63 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Male and female volunteers aged 40-65 yrs and in good health as determined by medical history, physical examination, clinical laboratory studies, electrocardiograms (ECGs), vital signs, and investigator judgement
- Volunteer voluntarily agrees to participate in this study and signs an Institutional Review Board (IRB)-approved informed consent prior to performing any of the screening procedures
- Female volunteers who are post-menopausal or surgically sterile
- Female volunteers who are of child-bearing potential must agree to use a medically acceptable method of contraception
- Male healthy volunteers willing to use barrier contraception (i.e., condoms) even if their partners are post-menopausal, surgically sterile or are using acceptable contraceptive methods
- Body mass index (BMI) of ≥ 18.0 kg/m2 to ≤ 32.0 kg/m2
Exclusion Criteria:
- Personal history of seizure disorder, symptomatic seizures (not including a history of simple febrile seizures in childhood) or any past or present medical condition which, in the opinion of the investigator has the potential to reduce seizure threshold (e.g., history of head trauma or concussion, previous alcohol abuse, substance abuse)
- Any concurrent disease or condition that, in the opinion of the Investigator, would make the volunteer unsuitable for participation in the clinical study
- Volunteer has history of alcohol and/or illicit drug abuse within two years of entry
- Any psychiatric diagnosis or symptoms (e.g., hallucinations, major depression, anxiety or delusions)
- History of cerebrovascular events or non-vasovagal related loss of consciousness
- History of cardiac arrhythmias, ischemic heart disease, cerebrovascular disease.
- Hepatic impairment as defined by >1.3 times the upper limit of normal ranges of serum liver enzymes
- Renal impairment as defined by >1.3 abnormal ranges of serum creatinine
- Abnormal blood pressure
- Abnormal cardiovascular parameters
- Volunteers with abnormally low serum B12, folate or abnormal thyroid function tests
- Positive Screening test for Hepatitis B surface antigen (HBsAg), Hepatitis C antibody, or human immunodeficiency virus (HIV) antibody
- Positive urine test for alcohol or drugs
- Any suicidal behavior in the last 2 years
- Female volunteers that are breastfeeding or female volunteers with a positive urine pregnancy test
- Volunteers unwilling to avoid consumption of coffee and caffeine containing beverages
- Unable to abstain from smoking (or other nicotine use)
- Donation of blood (> 500 mL) or blood products within 2 months
- Volunteers who take prohibited medications
- Use of an investigational drug within 30 days prior to Screening (Visit 1)
- Unwilling to abstain from vigorous exercise
- Clinically significant deviation from normal in physical examination, vital signs or clinical laboratory tests
- Volunteer is unable to understand the protocol requirements, instructions and study-related restrictions, the nature, scope and possible consequences of the clinical study
- Volunteer is unlikely to comply with the protocol requirements, instructions and study-related restrictions (e.g., uncooperative attitude, inability to return for follow-up visit and improbability of completing the clinical study)
- Volunteer has medical conditions that are unstable or which, in the clinical opinion of the Investigator, may interfere with study procedures or volunteer safety. Volunteers with the following stable medical conditions, adequately controlled with stable doses of concomitant medications, need not be excluded if in the opinion of the Investigator, their conditions do not compromise volunteer safety or study procedures:
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: NGP 555
NGP 555 given once a day for 14 days as a capsule; 100 mg, 200 mg, or 400 mg
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No Intervention: Placebo
Placebo comparator given once a day for 14 days as a capsule.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of adverse events or safety outcomes
Time Frame: Baseline to 23 days
|
Number of Participants With Abnormal Laboratory Values and/or Adverse Events That Are Related to Treatment
|
Baseline to 23 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Apinya Vutikkilaird, DO, WCCT
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2016
Primary Completion (Actual)
December 1, 2016
Study Completion (Actual)
December 1, 2016
Study Registration Dates
First Submitted
August 26, 2015
First Submitted That Met QC Criteria
August 28, 2015
First Posted (Estimate)
September 2, 2015
Study Record Updates
Last Update Posted (Actual)
March 29, 2017
Last Update Submitted That Met QC Criteria
March 27, 2017
Last Verified
March 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NGP 555-002
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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