Search clinical trials for: Synthetic Lethality

Total 1328 results

Pfizer

Completed

STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS

Healthy Adults

United States
Stanford University
Society for Urodynamics & Female Urology Foundation

Completed

Transvaginal Botulinum Toxin A Chemodenervation for Overactive Bladder (FETOC)

Overactive Bladder | Urge Incontinence | Urinary Frequency/Urgency | Bladder, Overactive | Urgency Urinary

United States
University of Chicago
National Cancer Institute (NCI)

Completed

Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer

Recurrent Prostate Cancer | Hormone-resistant Prostate Cancer | Stage IV Prostate Cancer

United States
Cedars-Sinai Medical Center
Synthetic Biologics Inc.

Terminated

Efficacy and Safety of SYN-010 in IBS-C

Irritable Bowel Syndrome With Constipation

United States
University of Utah

Completed

RAPID EC - Rct Assessing Pregnancy With Intrauterine Devices for EC

Contraception

United States
University Hospitals Cleveland Medical Center
Repligen Corporation

Withdrawn

Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor Conspicuity

Pancreas Cancer

United States
La Jolla Pharmaceutical Company
PRA Health Sciences

Completed

A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis

Hereditary Hemochromatosis

United States, Australia, France, United Kingdom
University of California, Davis
Society of Family Planning

Terminated

Cervical Preparation With Mifepristone Prior to Osmotic Dilators

Second Trimester Abortion

United States
Xenetic Biosciences, Inc.

Terminated

An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial Cancer

Endometrial Cancer

United States
Laboratorios Andromaco S.A.

Completed

Bioavailability of Levonorgestrel and Ethinyl Estradiol Tablets 15.0 mg/0.03 mg With Regards to Reference Product

Therapeutic Equivalency

India
Bristol-Myers Squibb

Completed

A Study Measuring the Effectiveness of BMS-986256 Combined With Oral Contraceptive in Healthy Female Participants

Healthy Participants

United States
University of Exeter
Quorn

Completed

Mycoprotein and Muscle Protein Synthetic Response (PIMP)

Anabolic Response to Mycoprotein and Micronutrient Ingeston

United Kingdom
Hugel
Sihuan Pharmaceutical Limited

Completed

Efficacy and Safety Assessment of Botulax® and BOTOX® for Improvement of Glabellar Lines.

Glabellar Lines

Korea, Republic of
HRA Pharma

Completed

Adherence With Continuous-dose Oral Contraceptive: Evaluation of Self-Selection and Use (ACCESS)

Contraception

United States
Hospital Provincial Magdalena V. de Martínez
National Agency for Scientific and Technological Promotion, Argentina; Instituto...

Completed

Mifepristone for Breast Cancer Patients With Higher Levels of Progesterone Receptor Isoform A Than Isoform B. (MIPRA)

Breast Cancer

Argentina
HRA Pharma

Completed

Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception

Contraception

United States, Ireland, United Kingdom
Bayer

Completed

Mirena Extension Trial (MET)

Contraception

United States
Diakonhjemmet Hospital
The Research Council of Norway; South-Eastern Norway Regional Health Authority

Completed

Assessing Withdrawal of Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis (ARCTIC REWIND)

Rheumatoid Arthritis

Norway
Synthetic Biologics Inc.
Spaulding Clinical Research LLC

Completed

Multiple Ascending Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered SYN 020

Enteritis Caused by Radiation

United States
Myovant Sciences GmbH

Completed

LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Uterine Fibroid | Heavy Menstrual Bleeding

United States, Belgium, Czechia, South Africa, Chile, Brazil, Hungary, Poland
Myovant Sciences GmbH

Completed

LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Uterine Fibroid | Heavy Menstrual Bleeding

United States, Italy, Poland, Brazil, South Africa, United Kingdom
Botanix Pharmaceuticals

Completed

Evaluation of BTX 1503 in Patients With Moderate to Severe Acne Vulgaris

Acne Vulgaris

United States, Australia
Soligenix

Completed

FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides)

Cutaneous T-Cell Lymphoma

United States
Sebela Women's Health Inc.
Synteract, Inc.

Completed

Evaluation of the Efficacy and Safety of LevoCept

Contraception

United States
Emory University
Novartis

Terminated

Phase II Study of Everolimus Beyond Progression

Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-positive Breast Cancer | HER2-negative Breast Cancer

United States
Fudan University

Terminated

Metformin Plus Megestrol Acetate as a Fertility-sparing Treatment in Patients With Atypical Endometrial Hyperplasia

Atypical Endometrial Hyperplasia

China
HRA Pharma

Terminated

A Study of Oral Contraception Under Simulated OTC Conditions (OPTION)

Contraception

United States
Norton Healthcare

Completed

Use of Norethindrone Acetate for Management of Bleeding Associated With the Etonogestrel Contraceptive Implant

Etonogestrel Contraceptive Implant, Bothersome Bleeding

United States
University Hospital, Toulouse

Completed

Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester (MYFEFACY)

Pregnancy Loss, Early

France
Institut Cancerologie de l'Ouest

Completed

Feasibility of MRI Workflow Alone in External Radiotherapy for the Treatment of Brain and Prostate Tumors (PRIS)

Prostate Cancer | Brain Cancer

France
Washington University School of Medicine
Susan G. Komen Breast Cancer Foundation

Withdrawn

Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy

Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Triple-Negative Breast Cancer
University Hospital, Toulouse

Completed

Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients (STAR)

RheumatoId Arthritis

France
Medstar Health Research Institute

Completed

Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation (MMSAP)

Induced Abortion
Prof Mags Beksinska

Completed

Functional Performance and Acceptability Study of Synthetic Nitrile, and Latex Graphene, Compared to Standard Latex Male Condom

Functional Performance

South Africa
Far Eastern Memorial Hospital

Completed

The Impact of Hormone Therapy on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder

Menopausal Syndromes

Taiwan
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Completed

Role of Vitamin D3 Supplementation With Conventional Synthetic Disease Modifying Antirheumatic Drugs(csDMARD) in Rheumatoid Arthritis Patients

Rheumatoid Arthritis

Bangladesh
Organon and Co

Completed

Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)

Contraception
Novartis Pharmaceuticals

Completed

A Drug-Drug Interaction Study to Assess the Effect of Trametinib on the Pharmacokinetics of an Oral Contraceptive in Female Patients With Solid Tumors

Solid Tumors

Netherlands, Spain, United Kingdom, United States, Belgium
Corcept Therapeutics

Completed

A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers

Healthy

India
Organon and Co

Completed

Post-marketing, Observational Study to Confirm the Safety and Efficacy of MARVELON (Study P06083)

Contraception
Organon and Co

Completed

Efficacy of Tibolone Versus Transdermal E2/NETA on Sexual Function in Naturally Postmenopausal Women (P06089)

Sexual Dysfunction
Organon and Co

Completed

A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)

Contraception
Organon and Co

Completed

An Explorative Trial to Explore the Safety, Acceptability and Vaginal Bleeding Pattern of Three Etonogestrel-releasing Medicated Intrauterine Systems (Study P06060)

Contraception
Organon and Co

Completed

A Trial in Healthy Female Subjects to Compare the Pharmacokinetics of Ethinyl Estradiol of NuvaRing®, a Contraceptive Patch (EVRA(TM)) and an Oral Contraceptive (Microgynon® 30) (Study 34237 (P06650)) (COMPLETED)

Contraception
Organon and Co

Completed

Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696) (Xpect)

Infertility
Organon and Co

Completed

An Open-label, Single Center Trial to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Org 36286 (P07004)

Infertility
Hebei Yanda Ludaopei Hospital
China Immunotech (Beijing) Biotechnology Co., Ltd.

Completed

CD19-Synthetic T Cell Antigen Receptor(STAR)-T in B-cell Malignancies Patients

B Cell Malignancy

China
Viriom

Completed

Pharmacokinetics Study to Evaluate Drug-Drug Interactions and Safety of Elpida® in Co-Administration With Other Drugs

HIV-1-infection

Russian Federation
Teva Branded Pharmaceutical Products R&D, Inc.
FHI 360

Completed

A Study to Evaluate Injection Pain and Local Tolerability Following Subcutaneous (SC) Administration of TV-46046

Contraception

Dominican Republic
BioGend Therapeutics Co.Ltd

Completed

BiPhasic Cartilage Repair Implant (BiCRI) IDE Clinical Trial - Taiwan

Chondral or Osteochondral Lesion of Medial Femoral Condyle | Chondral or Osteochondral Lesion of Lateral Femoral Condyle | Chondral or Osteochondral Lesion of Trochlea

Taiwan

3

Subscribe