Mycoprotein and Muscle Protein Synthetic Response (PIMP)

Comparing the Muscle Protein Synthetic Response to Ingestion of Mycoprotein vs Protein Isolated From Mycoprotein

Dietary protein is vital for the preservation of health and optimal adaptation to training. However, traditional animal proteins come with a number of economic, environmental, and ethical issues. Accordingly, there is a need to develop an understanding of the utility of more sustainable non-animal derived dietary proteins to support our nutrition. Mycoprotein, produced by Quorn Foods™, has recently been shown to stimulate a greater anabolic response within skeletal muscle compared with milk protein, suggesting its utility within sports nutrition. However, it is unclear what accounted for the greater anabolic response of mycoprotein. One explanation could be the non-protein nutrients contained within mycoprotein (e.g. fibre, carbohydrate, fat or micronutrients).

Therefore, the present study will compare the muscle anabolic response between mycoprotein (MYC) as a whole food and the protein isolated from mycoprotein (PIM).

Study Overview

• Status: Completed
• Conditions: Anabolic Response to Mycoprotein and Micronutrient Ingeston
• Intervention / Treatment: Dietary supplement: Mycoprotein ingestion

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Exeter, United Kingdom
    • University of Exeter

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• BMI between 18 and 30.
• Resistance trained

Exclusion Criteria:

• Any metabolic impairments.
• Cardio/pulmonary diseases.
• Chronic use of over the counter pharmaceuticals
• A personal or family history of epilepsy, seizures or schizophrenia.
• Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Mycoprotein; Mycoprotein in its full food matrix	Dietary supplement: Mycoprotein ingestion; The ingestion of mycoprotein
Experimental: Protein Isolated from Mycoprotein; Protein from mycoprotein isolated from the food matrix	Dietary supplement: Mycoprotein ingestion; The ingestion of mycoprotein

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle protein synthesis	The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)	7.5 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Plasma Amino Acid Kinetics	The rate of appearance of amino acids ingested in the drink	7.5 hours
Blood Glucose	The levels of glucose in the blood	7.5 hours
Serum Insulin	The levels of insulin in blood serum	7.5 hours

Collaborators and Investigators

• Sponsor: University of Exeter
• Collaborators: Quorn

Study record dates

Study Major Dates

• Study Start (Actual): April 15, 2019
• Primary Completion (Actual): December 11, 2019
• Study Completion (Actual): December 11, 2019

Study Registration Dates

• First Submitted: September 6, 2019
• First Submitted That Met QC Criteria: September 9, 2019
• First Posted (Actual): September 10, 2019

Study Record Updates

• Last Update Posted (Actual): May 27, 2022
• Last Update Submitted That Met QC Criteria: May 26, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: 190206/B/07UOE

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No