Search clinical trials for: chemotherapy and targeted therapy

Total 475404 results

Hirva Mamdani
AstraZeneca; Barbara Ann Karmanos Cancer Institute

Recruiting

MOnaliZumab in Combination With durvAlumab (MEDI4736) Plus Platinum-based chemotheRapy for First-line Treatment of Extensive Stage Small Cell Lung Cancer (MOZART)

Small Cell Lung Cancer | SCLC | Extensive Stage Small Cell Lung Cancer

United States
GT Medical Technologies, Inc.

Not yet recruiting

Post-operative Adjuvant Therapy w/wo GammaTile + Systemic Therapy (PATHWAyS)

Glioblastoma
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Korea, Republic of, Spain, Canada, Brazil, China, Singapore, India, Turkey, Argentina, Australia, Belgium, Finland, Hong Kong, South Africa, Italy, United Kingdom, France, Poland, Taiwan, Colombia, Germany, Mexico
Dong Wang

Recruiting

CIETAI and Sequential Radiotherapy in Squamous Lung Cancer

Carcinoma, Non-Small-Cell Lung

China
Shanghai Pulmonary Hospital, Shanghai, China

Not yet recruiting

Neoadjuvant Therapy With Toripalimab and JS004 Combined With Platinum-based Doublet Chemotherapy for Resectable or Potentially Resectable Stage III Non-small Cell Lung Cancer: A Randomised Controlled, Open-label, Phase 2 Trial

Stage III Non-small Cell Lung Cancer
Cancer Institute and Hospital, Chinese Academy...
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

Induction Chemotherapy and Toripalimab Followed by Chemoradiotherapy for Large-volume Local Advanced NSCLC (InTRist)

Local Advanced Non-small Cell Lung Cancer

China
Novartis Pharmaceuticals

Recruiting

A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma (LEDA)

Follicular Lymphoma (FL)

Australia, Korea, Republic of, Spain, Singapore, Poland, Taiwan, Hungary, Czechia, Romania, Slovakia
Takeda

Recruiting

A Study of GDX012 in Adults With Relapsed or Refractory Acute Myeloid Leukemia

Leukemia

United States
SOLTI Breast Cancer Research Group
Merck Sharp & Dohme LLC; Pfizer; AstraZeneca; Astellas Pharma Inc; Advanced Accelerator... and other collaborators

Recruiting

Feasibility and Impact of Liquid Biopsy Genomic Profiling on Treatment Patients With Metastatic Prostate Cancer in Spain (SOLTI-2102) (HOPE-PROSTATE)

Metastatic Prostate Cancer

Spain
Second Affiliated Hospital, School of Medicine,...

Recruiting

Serplulimab Combined With Chemotherapy in Patients With Resectable Non-small-cell Lung Cancer

NSCLC | Neoadjuvant Therapy

China
University College, London
University College London Hospitals; Barts & The London NHS Trust; British Heart...

Recruiting

Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction (HER-SAFE)

Heart Failure | HER2-positive Breast Cancer | Cardiotoxicity | Cancer, Therapy-Related

United Kingdom
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25 (OFSET)

Breast Cancer

United States, Puerto Rico
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Nanfang Hospital of Southern... and other collaborators

Recruiting

Reduced-target Resection After Induction Chemotherapy in Resectable Recurrent Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma | De-escaltion Therapy

China
Suzhou Municipal Hospital

Recruiting

Optimization of Postoperative Adjuvant Therapy for Cervical Cancer Based on MRD(Minimal Residual Disease)

Cervical Cancer

China
Fred Hutchinson Cancer Center

Not yet recruiting

Online Nutrition Education to Decrease the Side Effects of Chemotherapy in Patients With Breast Cancer (ONE)

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8

United States
Biotheus Inc.

Recruiting

PM8002 in Combination With Chemotherapy as First Line Therapy in Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Peking Union Medical College Hospital
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

Dalpiciclib With Endocrine Therapy for Advanced Breast Cancer After CDK4/6 Inhibitor Failure (DAWNA-FES)

Advanced Breast Cancer

China
Amsterdam UMC, location VUmc

Recruiting

COLLISION RELAPSE Trial

Recurrence | Colorectal Cancer | Surgery | Chemotherapy Effect | Liver Metastases | Liver Metastasis Colon Cancer

Netherlands
Fudan University

Recruiting

PD-1 Combined With Adjuvant Chemotherapy and Antivascular Therapy Versus Chemotherapy Alone in Patients With Operable Triple-negative Breast Cancer

TNBC - Triple-Negative Breast Cancer

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

The Study of Trilaciclib Combined With Chemotherapy On The Neoadjuvant Therapy of TNBC

Breast Neoplasm
Chinese PLA General Hospital

Recruiting

Efficacy and Safety of Toripalimab Combined With AP-induced Chemotherapy Followed in Non-metastatic IVB Hypopharyngeal Cancer

Hypopharyngeal Cancer

China
Tata Memorial Centre

Recruiting

Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study (PARCERII)

Cervical Cancer | Endometrial Cancer

India
Institut Cancerologie de l'Ouest

Not yet recruiting

Music Therapy as a Tool for Anxiety Reduction in Localized Breast Cancer (CENSORIAL)

Breast Cancer | Anxiety | Chemotherapy

France
Charu Aggarwal
Loxo Oncology, Inc.

Recruiting

Liquid Biopsy Based NGS in Newly Diagnosed NSCLC (iNUDGE)

Non Small Cell Lung Cancer Metastatic | Non-Squamous Non-Small Cell Neoplasm of Lung | Newly Diagnosed NSCLC

United States
Dipenkumar Modi
Genmab

Recruiting

Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

Relapsed Cancer | Refractory Cancer | Large Cell Lymphoma, Diffuse

United States
Shanghai Zhongshan Hospital
Fudan University; Amoy Diagnostics Co., LTD

Not yet recruiting

Application of ctDNA in Evaluation of Neoadjuvant Chemotherapy Efficacy and Exploration of Chemoresistance Mechanisms in Pancreatic Cancer

Patients With Non-metastatic Pancreatic Cancer | Evaluation of Tumor Resectability Shall be Made in Consensus at Multidisciplinary Meetings, According to NCCN Guideline Version 1.2022 Pancreatic Adenocarcinoma

China
Moi University
Amsterdam UMC, location VUmc; Princess Maxima Center for Pediatric Oncology

Recruiting

CHildren Treated With Vincristine: A Trial Regarding Pharmacokinetics, DNA And Toxicity of Targeted Therapy In Pediatric Oncology Patients. (CHAPATI)

Pediatric Cancer

Kenya
Ludwig-Maximilians - University of Munich

Recruiting

Lower Urinary Tract Symptoms After Intravesical Therapy (LUTSI)

Overactive Bladder | Lower Urinary Tract Symptoms | Chemotherapy Effect | Chemotherapeutic Toxicity

Germany
Nationwide Children's Hospital

Not yet recruiting

Targeted Pediatric High-Grade Glioma Therapy

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma

United States, Australia, United Kingdom, Canada, Germany, Netherlands
The Fourth Affiliated Hospital of Zhejiang University...
Jiangsu Province Hospital of Traditional Chinese Medicine; Second Affiliated... and other collaborators

Recruiting

Effect of Short-term Compression Therapy After Thermal Ablation for Varicose Veins

Varicose Veins

China
Zhejiang University

Recruiting

A Phase II Trial to Evaluate the Efficiency and Safety of Serplulimab Plus Chemotherapy as Conversion Therapy in NSCLC

Unresectable Lung Non-Small Cell Carcinoma

China
Shanghai University of Traditional Chinese Medicine
Fudan University; Shanghai Zhongshan Hospital; Ruijin Hospital; Shanghai Chest... and other collaborators

Not yet recruiting

Clinical Study on the Prevention of Driver Gene Negative II-IIIa Lung Cancer Recurrence and Metastasis by Staged Chinese Herbal Medicine Combined With Chemotherapy and Immune Checkpoint Inhibitors

Lung Cancer

China
Guangzhou Institute of Respiratory Disease

Not yet recruiting

Cadonilimab in Combination With Chemotherapy for Locally Advaced Esophageal Squamous Cell Carcinoma

Neoadjuvant Therapy | Resectable Esophageal Squamous Cell Carcinoma
Lawson Health Research Institute

Recruiting

Implementation of Personalized Medicine for Optimal Drug Therapy in Cancer

Cancer Pain | Nausea With Vomiting Chemotherapy-Induced | Depression, Reactive

Canada
Nanfang Hospital of Southern Medical University
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Recruiting

Adjuvant Chemotherapy Combined With Camrelizumab for ⅡA -ⅢA NSCLC Patients (PANORAMA)

Chemotherapy | Immunotherapy

China
Fujian Cancer Hospital

Recruiting

HRQOL in Locally Advanced Thyroid Carcinoma (LATCQOL)

Thyroid Cancer | Health Related Quality of Life | Tyrosine Kinase Inhibitor

China
BAMF Health

Recruiting

Use of SPECT-CT for Comparison of Dosimetry Methods in PSMA-targeted Radioligand Therapy (SPECTacular Study) (SPECTacular)

Metastatic Castration-resistant Prostate Cancer

United States
Fujian Medical University Union Hospital

Not yet recruiting

Immunotherapy Plus Chemotherapy vs. Chemoradiotherapy for Thoracic Squamous Esophageal Carcinoma

Chemotherapy | Radiation Therapy

China
RenJi Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

Application Circulating Tumor DNA Dynamic Monitoring in Clinical Treatment of Metastatic Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma

China
Taizhou Hospital

Recruiting

Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy

Esophageal Cancer | Chemotherapy | Immunotherapy | Radiation Therapy

China
Debiopharm International SA

Recruiting

Debio 0123 in Combination With Carboplatin and Etoposide in Adult Participants With Small Cell Lung Cancer That Recurred or Progressed After Previous Standard Platinum-Based Therapy

Small Cell Lung Cancer Recurrent

United States, Spain
Zhejiang University

Recruiting

Study of Comparing of With and Without Sequential Therapy of S-1

Chemotherapy Effect | Locally Advanced Gastric Adenocarcinoma

China
WenBo Guo

Recruiting

Regorafenib Alone or in Combined With Transcatheter Arterial ChEmoembolization in Treatment of Advanced Hepatocellular Carcinoma After First Line Targeted Therapy (ROSE)

Hepatocellular Carcinoma | Regorafenib | Transcatheter Arterial ChEmoembolization

China
Vrije Universiteit Brussel
University of Applied Sciences and Arts of Southern Switzerland; Bern University...

Recruiting

Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT (BO2WL)

Chronic Low-back Pain | Overweight or Obesity

Belgium, Switzerland
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

Prostate Adenocarcinoma | Stage IIIB Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8

United States
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Recruiting

Rest to Overcome Loss and Reduce Risk (RESTore Plus)

Quality of Life | Inflammation | Sleep Disturbance | Bereavement | Spouses

United States
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA

Colorectal Cancer | Liver Metastases | Circulating Tumor Cell | Cancer, Therapy-Related

China
Trans Tasman Radiation Oncology Group
AstraZeneca

Recruiting

Chemotherapy and Immunotherapy in Extensive-Stage Small-Cell Lung Cancer With Thoracic Radiotherapy (CHEST RT)

Extensive-Stage Small-Cell Lung Cancer

Australia
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Teenage/Young Adult and Paediatric Patients With Cancers With HER2 Amplification or Activating Mutations (DETERMINE)

Colorectal Neoplasms | Ovarian Neoplasms | Solid Tumor | Gallbladder Neoplasms | Prostatic Neoplasm | Pancreatic Neoplasm | Lung Neoplasm | Haematological Malignancy | Urinary Bladder Neoplasm | Skin Neoplasm | Salivary Gland Neoplasm

United Kingdom
University of Michigan Rogel Cancer Center
Genentech, Inc.

Not yet recruiting

A Proof of Concept Pilot Study of the Addition of Venetoclax to Standard Remission Induction Chemotherapy Fludarabine or Cladrabine, Cytarabine, and Granulocyte Colony Stimulating Factor (G-CSF) (FLAG or CLAG) for Frontline Therapy of Secondary Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

United States

Search clinical trials for: chemotherapy and targeted therapy

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