Search clinical trials for: human leukocyte antigen (HLA)

Total 27167 results

National Cancer Institute (NCI)

Completed

Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies

Lymphoma | Hodgkin Lymphoma | AML | Myelodysplastic Syndrome | Non Hodgkin's Lymphoma | CML | ALL | Lymphocytic Leukemia | Mixed Cell Leukemia

United States
David Rizzieri, MD

Completed

Safety Trial of NK DLI From 6/6 HLA Matched Family Member Following Nonmyeloablative ASCT

Lymphoma

United States
Hillel Yaffe Medical Center
Technion, Israel Institute of Technology

Unknown

Proteomic Analysis of HLA Complex in Solid Cancers: Breast, Ovary, Colon, Rectum, Stomach, and Pancreas

Stomach Neoplasms | Breast Neoplasms | Colorectal Neoplasms | Pancreatic Neoplasms | Ovarian Cancer

Israel
Seoul National University Hospital
Roche Pharma AG

Unknown

Desensitization Protocol for Highly Sensitized Patients on the Waiting List for Kidney Transplant

End Stage Renal Disease

Korea, Republic of
University of California, Los Angeles

Recruiting

Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants

Chronic Kidney Diseases | End Stage Kidney Disease | Kidney Transplant Failure and Rejection | Immunological Tolerance

United States
University of Liege
KU Leuven; Maastricht University Medical Center

Completed

Allogeneic HCT With HLA-matched Donors : a Phase II Randomized Study Comparing 2 Nonmyeloablative Conditionings

Hematological Malignancies

Belgium, Netherlands
Massachusetts General Hospital
Dana-Farber Cancer Institute

Terminated

Non-Myeloablative HLA-Mismatched Ex-Vivo T-cell Depleted Stem Cell Transplantation for Hematologic Malignancies

Lymphoma | Leukemia | Multiple Myeloma | Myelodysplastic Syndrome

United States
Shandong Provincial Institute of Dermatology and...
Shandong Provincial Hospital; Jinan Military General Hospital; Jinan Central... and other collaborators

Unknown

Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome

Psoriasis | Urticaria | Acne | Leprosy | Pneumocystis Pneumonia | Allergic Cutaneous Vasculitis | Bullous Skin Diseases | Sterile Pustulosis

China
National Institute of Allergy and Infectious Diseases...

Recruiting

Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

Primary Immunodeficiency

United States, Turkey, Italy
Cliniques universitaires Saint-Luc- Université...
Institut Pasteur

Unknown

Safety and Toxicity Study of Vaccination for Advanced Metastatic Melanoma Patients (THERAVAC)

Melanoma

Belgium
Gilead Sciences

Terminated

Study to Evaluate the Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers

Human Papillomavirus (HPV) 16+ Relapsed/Refractory Cancer

United States
Institut Bergonié

Completed

Intraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid Treatment (PROTOX)

Chronic Pain

France
Altor BioScience
James and Esther King Biomedical Research Program

Unknown

A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer

Non-muscle Invasive Bladder Cancer

United States
M.D. Anderson Cancer Center

Completed

Busulfan and Fludarabine Followed by Post-transplant Cyclophosphamide

Lymphoma | Hematologic Diseases | Leukemia | Myeloma

United States
Memorial Sloan Kettering Cancer Center

Completed

Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best Donor

Hematologic Malignancy

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors

HIV

United States
Altor BioScience
National Cancer Institute (NCI)

Terminated

QUILT-3.020: A Study of ALT-801 in Patients With Relapsed or Refractory Multiple Myeloma

Relapsed or Refractory Multiple Myeloma

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

A Prospective Study of the Relevance of the HLA-G Immune Checkpoint in Cancer Immunotherapy (GEIA)

Solid Tumor
Medeor Therapeutics, Inc.

Withdrawn

Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney Transplants

Kidney Transplant Rejection
Chong Kun Dang Pharmaceutical

Completed

Impact of Lymphocyte Anti-metabolite Immunosuppressions on Donor-Specific Anti-HLA Antibody and Kidney Graft Outcome

Kidney Transplant

Korea, Republic of
Samsung Medical Center

Completed

Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

Immunity

Korea, Republic of
Grupo Espanol de trasplantes hematopoyeticos y...

Completed

Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT (BUFLU)

Acute Myeloid Leukemia | Myeloproliferative Disorders | Chronic Myeloid Leukemia | Myelodysplastic Syndrome
Beth Israel Deaconess Medical Center
Bayer

Completed

Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | AML | Myelodysplastic Syndrome | Aplastic Anemia | Myeloproliferative Disorder | CLL | ALL

United States
Juan Francisco Delgado Jimenez
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Active, not recruiting

MuLtimodality EvaluatiOn of aNtibody mEdiated Damage in Heart Transplantation (LEONE-HT) (LEONE-HT)

Antibody-mediated Rejection | Heart Transplant Rejection | Transplant Failure

Spain
Second Affiliated Hospital, School of Medicine,...
The First Affiliated Hospital of Anhui Medical University; Peking Union Medical... and other collaborators

Recruiting

A Study of Efficacy and Safety of Idebenone vs. Placebo in Prodromal Parkinson Disease (SEASEiPPD)

Parkinson Disease | REM Sleep Behavior Disorder

China
Fundación FLS de Lucha Contra el Sida, las Enfermedades...
National Department of Health, Papua New Guinea; School of Medicine and Health...

Active, not recruiting

Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) (Trep-AByaws)

Yaws | Cutaneous Ulcer

Papua New Guinea
Wuhan Union Hospital, China

Not yet recruiting

CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
University Hospital, Grenoble
Bristol-Myers Squibb

Recruiting

The Safety/Efficacy Of Daratumumab With Belatacept In Highly HLA-Sensitized Patients Awaiting Kidney Transplantation (COMBAT)

Sensitisation | Highly Sensitised Dialysis Patients

France
Western University, Canada

Not yet recruiting

Preemptive HLA Genotyping for the Safe Use of Infliximab-combination Therapy in Inflammatory Bowel Disease (INHERIT)

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis

Canada
Institute for Clinical and Experimental Medicine

Completed

rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation (INHIBIT) (INHIBIT)

Kidney Transplantation

Czechia
Bicetre Hospital

Unknown

Pediatric Intensive Care and COVID-19 (CLOVIS)

Critical Illness | Covid19 | Pediatric ALL | SARS-CoV Infection | Infection

France
Ossium Health, Inc.
Center for International Blood and Marrow Transplant Research

Recruiting

A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Acute Leukemia | Acute Undifferentiated Leukemia | Acute Biphenotypic Leukemia

United States
Centre Hospitalier Universitaire Dijon

Completed

Monocyte Chemotactic Protein-1 (MCP-1) Expressing Monocytes to Predict Preterm Delivery: PhenoMAP Study (PHENOMAP)

Preterm Labour

France
Cedars-Sinai Medical Center
Veloxis Pharmaceuticals

Active, not recruiting

Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in HLA Sensitized Kidney Transplant Recipients

Kidney Transplant Rejection

United States
Nelson Chao

Terminated

Trial of CMV Specific DLIs From 3-6/6 HLA Matched Family Member Following Nonmyeloablative Allo SCT

Cytomegalovirus Infections

United States
Nanfang Hospital of Southern Medical University

Unknown

Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia Major

Thalassemia Major

China
National Cancer Institute (NCI)

Completed

T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 Positive

Melanoma | Cervical Cancer | Breast Cancer | Renal Cancer | Urothelial Cancer

United States
Groupe Hospitalier Paris Saint Joseph
Assistance Publique - Hôpitaux de Paris; Institut Pasteur; BioMérieux

Completed

SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU (Captain)

Sepsis | Septic Shock | Severe Sepsis | SIRS

France
National Cancer Institute (NCI)

Completed

Immunization of HLA-A201 Patients With Metastatic Melanoma Using a Combination of Immunodominant Peptides From Three Melanoma Antigens, MART-1, GP100 and Tyrosinase

Melanoma | Neoplasm Metastasis

United States
Adaptimmune
ICON plc

Terminated

ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)

Esophageal Cancer | Esophagogastric Junction Cancer

United States, Canada, Spain
Hanyang University Seoul Hospital
Corestem, Inc.

Completed

Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Neuromuscular Disease | Central Nervous System Disease | Neurodegenerative Disease

Korea, Republic of
Colorado Blood Cancer Institute

Unknown

Tacrolimus and MMF as Post Grafting Immunosuppression After Conditioning With Flu TBI for HLA Matched Family Donor

Lymphoma | Multiple Myeloma | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia

United States
Assistance Publique - Hôpitaux de Paris
Fondation Centaure

Completed

Bortezomib in Rejection of Kidney Transplants (TRIBUTE)

Chronic Antibody-mediated Transplant Rejection

France
Hospital do Rim e Hipertensão

Not yet recruiting

Evaluation of the Prophylactic Use of Letermovir in Kidney Transplant Recipients at Risk of Cytomegalovirus Infection

CMV Infection
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co....

Withdrawn

A Study of Mitoxantrone Hydrochloride Liposome Injection for Relapsing Multiple Sclerosis

Relapsing Multiple Sclerosis

China
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

Acute Myeloid Leukemia | Hodgkin Lymphoma | Myelofibrosis | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Hematopoietic and Lymphoid System Neoplasm | Myeloproliferative Neoplasm | Chronic Myeloid Leukemia, BCR-ABL1 Positive

United States
Insel Gruppe AG, University Hospital Bern

Recruiting

Virtual Reality Games in Pediatric Surgery

Analgesia | Surgical Procedure, Unspecified | Immersion

Switzerland
Nantes University Hospital
INSERM U01232 CRCINA

Recruiting

Phase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation (CTL-DP 01)

Haematologic Disease

France
Washington University School of Medicine

Completed

Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) in Combination With Azacitidine for the Treatment of Myelodysplastic Syndrome (MDS) (MDS)

Myelodysplastic Syndromes

United States
Maria Sklodowska-Curie National Research Institute...

Unknown

Melanoma Vaccine in Treating Patients With Stage III Melanoma After Surgery to Remove Lymph Nodes

Melanoma (Skin)

Poland

Search clinical trials for: human leukocyte antigen (HLA)

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