Search clinical trials for: open label

Total 9442 results

Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

A Study of PRS-344/S095012 (PD-L1x4-1BB Bispecific Antibody-Anticalin Fusion) in Patients With Solid Tumors

Solid Tumor

Spain, Australia, Belgium, United States
University of California, Irvine

Recruiting

Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department

Myofascial Trigger Point Pain | Myofacial Pain

United States
Lawson Health Research Institute
Seagen Inc.

Recruiting

Open Label Extension Study of Brentuximab Vedotin in Early dcSSc

Diffuse Cutaneous Systemic Sclerosis

Canada
Wits Health Consortium (Pty) Ltd
Fred Hutchinson Cancer Center; Janssen Vaccines & Prevention B.V.; Right to Care and other collaborators

Recruiting

Sisonke 2 - A COVID-19 Vaccine Boost Open Label Study. (Sisonke Boost)

SARS CoV 2 Infection

South Africa
Gangnam Severance Hospital

Recruiting

A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia (RELIEF)

Breast Cancer | Pain, Post Operative | Pain, Chronic | Mastectomy

Korea, Republic of
Pfizer

Recruiting

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors

Hemophilia A | Hemophilia B

Hong Kong, Spain, Serbia, Turkey, United States, China, Mexico, South Africa, India, Japan, Croatia, Korea, Republic of, Oman, Taiwan, Italy, Canada, France
Nanjing First Hospital, Nanjing Medical University

Recruiting

A Prospective Phase II Efficacy and Safety Study of Anlotinib in Metastatic or Locally Advanced Pheochromocytoma/ Paraganglioma : Open-label Single-arm, Exploratory Trial (EASOAIPPGL)

Advanced or Metastatic Paraganglioma/ Pheochromocytoma

China
University of Alabama at Birmingham

Recruiting

An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Deucravacitinib for the Treatment of Nail Psoriasis

Nail Psoriasis

United States
Tianjin Medical University General Hospital

Not yet recruiting

Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery

Postoperative Pain
APrevent Biotech GmbH

Recruiting

APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

Paralysis, Unilateral, Vocal Cord

Austria, United States, Germany
Addex Pharma S.A.

Recruiting

Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy

Parkinson Disease | Dyskinesias | Dyskinesia, Drug-Induced

United States
Holostem Terapie Avanzate s.r.l.
IRCCS San Raffaele; University of Modena and Reggio Emilia

Recruiting

Open-label, Pivotal Clinical Trial to Confirm Efficacy and Safety of Autologous Grafts Containing Stem Cells Genetically Modified for Epidermis Restoration in Patients With Junctional Epidermolysis Bullosa (HOLOGENE 5)

Junctional Epidermolysis Bullosa Non-Herlitz Type

France, Italy
Consorci Sanitari de l'Alt Penedès i Garraf
Institut Català de la Salut

Recruiting

Open Label Randomized Clinical Trial to Assess the Safety of Teleconsultation (ECASeT)

Various Clinical Conditions Commonly Followed up in a Secondary Hospital

Spain
Aretaieion University Hospital

Recruiting

Opioid-free Anesthesia in Laparoscopic Cholecystectomies

Pain, Postoperative | Analgesia | Pain, Acute | Ketamine | Dexmedetomidine | Pain, Chronic | Cholecystectomy | Lidocaine | Central Nervous System Depressants | Analgesics | Analgesic Non-narcotic

Greece
Sigknow Biomedical Co., Ltd.

Recruiting

An Open-label Study of EZYPRO® in Atrial Fibrillation Detection on ESUS Patients

Atrial Fibrillation | Embolic Stroke of Undetermined Source

Taiwan
Imperial College London
University College, London; Medical Research Council; National Institute for...

Recruiting

A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC) (REFINE-Lung)

Lung Cancer, Nonsmall Cell

United Kingdom
Institute of Cancer Research, United Kingdom
Merck Sharp & Dohme LLC; Cancer Research UK; Astex Pharmaceuticals, Inc.

Recruiting

ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab (ASTEROID)

Cervical Cancer | Triple Negative Breast Cancer | Advanced Cancer

United Kingdom
ADMA Biologics, Inc.

Recruiting

An Open Label, Multicenter Study to Evaluate the Pharmacokinetics, Efficacy and Safety of ASCENIV™ (IGIV) in Pediatric Subjects With Primary Immunodeficiency Diseases (PIDD)

Primary Immune Deficiency

United States
Far Eastern Memorial Hospital

Recruiting

The Minimum Effective Concentration of Lidocaine for Ultrasound-guided Axillary Block for Arterio-venous Fistula Creation Surgery

Anesthesia

Taiwan
Trethera

Recruiting

Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors

Oncology | Solid Tumor, Adult

United States
M.D. Anderson Cancer Center

Recruiting

A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma

Myeloma

United States
Beijing InnoCare Pharma Tech Co., Ltd.

Recruiting

A Randomized, Open-label, Multi-center, Phase III Study of Orelabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) vs. R-CHOP Alone in Patients With Treatment-naїve Mantle Cell Lymphoma

Treatment-naїve Mantle Cell Lymphoma

China
Centre Hospitalier Universitaire, Amiens

Recruiting

Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial (COMET)

Crohn Disease | Methotrexate | Azathioprine

France
Institut fuer Frauengesundheit
Samsung Bioepis Co., Ltd.

Recruiting

Neoadjuvant Ontruzant (SB3) in Patients With HER2-positive Early Breast Cancer: An Open-Label (NeoON) (NeoON)

Breast Cancer | Breast Neoplasms | HER2-positive Breast Cancer | Breast Cancer Female

Germany
The First Affiliated Hospital with Nanjing Medical...

Recruiting

CaRe-ECMO Program on ECMO Weaning (CaRe-ECMO)

Critical Illness

China
National Health Research Institutes, Taiwan
China Medical University Hospital; Kaohsiung Medical University Chung-Ho Memorial... and other collaborators

Recruiting

A Phase II Randomized Study of Gemcitabine and Nab-paclitaxel in Combination With S- 1/LV (GASL) or Oxaliplatin (GAP) as First-line Treatment for Metastatic Pancreatic Cancer

Phase II, Open-label, Parallel 2-arm, Multi-center

Taiwan
Neuren Pharmaceuticals Limited

Recruiting

An Open-Label Study of Oral NNZ-2591 in Pitt Hopkins Syndrome (PTHS-001) (PTHS-001)

Pitt Hopkins Syndrome

United States
Shandong University

Recruiting

A Multicenter Randomized Open-label Study of Diammonium Glycyrrhizinate Enteric-coated Capsule Plus DXM Versus DXM in Treatment of ITP

Immune Thrombocytopenia

China
Brown University
National Institute on Drug Abuse (NIDA); The Miriam Hospital; Rhode Island Hospital

Recruiting

Open Label Placebo to Reduce Prescription Opioid Use

Acute Pain

United States
University of Calgary

Recruiting

Hydroxychloroquine and Indapamide in SPMS

Multiple Sclerosis, Secondary Progressive

Canada
Neuren Pharmaceuticals Limited

Recruiting

An Open-Label Study of the Safety, Tolerability, and Pharmacokinetics of Oral NNZ-2591 in Angelman Syndrome (AS-001)

Angelman Syndrome

Australia
Viracta Therapeutics, Inc.

Recruiting

An Open-Label, Phase 2 Trial of Nanatinostat in Combination With Valganciclovir in Patients With Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas (NAVAL-1)

EBV Related Non-Hodgkin's Lymphoma | Epstein-Barr Virus Associated Lymphoproliferative Disorder | EBV-Related PTLD | EBV Associated Lymphoma | EBV-Positive DLBCL, NOS | EBV Related PTCL, NOS

United States, Spain, Italy, United Kingdom, Singapore, Taiwan, Korea, Republic of, Germany, Canada, Brazil, Australia, France, Malaysia, Hong Kong, Israel
Montefiore Medical Center

Recruiting

Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Subarachnoid Hemorrhage | Intracerebral Hemorrhage | Hydrocephalus | Ventriculitis, Cerebral

United States
Celgene

Recruiting

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (EXCALIBER-RRMM)

Multiple Myeloma

Austria, Italy, China, Australia, Spain, United States, Korea, Republic of, Taiwan, Germany, Ireland, Argentina, Brazil, Mexico, Netherlands, Belgium, Czechia, France, Greece, Japan, Poland, Israel, United Kingdom, Norway, Denmark, Finland and more
Johns Hopkins University
University of Maryland; American Academy of Otolaryngology-Head and Neck Surgery...

Recruiting

Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer

Postoperative Pain | Opioid Use

United States
Madrigal Pharmaceuticals, Inc.

Recruiting

A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)

Non-Alcoholic Fatty Liver Disease

United States, Puerto Rico
CymaBay Therapeutics, Inc.

Recruiting

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Hepatic Impairment | Compensated Cirrhosis | Primary Biliary Cholangitis

Korea, Republic of, United States, Spain, United Kingdom
Weill Medical College of Cornell University
Merck Sharp & Dohme LLC; United States Department of Defense

Recruiting

Phase I/II Trial of Pembrolizumab and Androgen-receptor Pathway Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

Prostate Cancer

United States
All India Institute of Medical Sciences, Bhubaneswar
Indian Council of Medical Research

Recruiting

Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression (APQ-TRD)

Treatment Resistant Depression

India
Marmara University

Recruiting

Lumbar Transforaminal Anterior Epidural Steroid Injections in Discogenic Low Back Pain

Low Back Pain | Degenerative Disc Disease

Turkey
Peking University People's Hospital
Wangjing Hospital, China Academy of Chinese Medical Sciences; First Affiliated...

Not yet recruiting

Effect of Perioperative Lidocaine on Gastrointestinal Function Recovery After Lumbar Spine Surgery in Adults

Pain | Gastrointestinal Dysfunction | Spinal Surgery | Opioid Consumption | Lidocaine

China
Yonsei University

Not yet recruiting

A Phase 2, Open-label Trial of Consolidation Nivolumab After Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma

Locally Advanced Nasopharyngeal Carcinoma

Korea, Republic of
Wuhan Union Hospital, China

Recruiting

The Efficacy and Safety of TACE, Lenvatinib and Camrelizumab in the Treatment of BCLC Stage B/C Hepatocellular Carcinoma: a Single-arm, Single-center, Open-label Study

Hepatocellular Carcinoma

China
GlaxoSmithKline

Recruiting

Open-label Study of Belimumab Plus Standard Therapy in Chinese Pediatric Participants With Active Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

China
NovoCure GmbH
Merck Sharp & Dohme LLC

Recruiting

EF-36/Keynote B36: A Pilot, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Pembrolizumab for First Line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer (KEYNOTE B36)

Non-small Cell Lung Cancer

United States
Sun Yat-sen University
Shanghai Junshi Bioscience Co., Ltd.

Not yet recruiting

An Open-label, Multicentre, Phase II/III RCT of PFLL Versus GP Combined With JS001 as the First-line Therapy for mNPC

Nasopharyngeal Carcinoma | Chemotherapy | Metastasis | Immunotherapy | Survival

China
Koya Medical, Inc.

Recruiting

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery (TIGRIS)

Lymphedema | Lymphedema, Breast Cancer | Lymphedema Arm

United States
Sun Yat-sen University

Recruiting

An Open-label, Single Arm, Phase II Trial of Niraparib in Combination With Anti-PD1（Programmed Cell Death Protein 1） Antibody in Recurrent/ Advanced Stage Endometrial Cancer Patients

Recurrent/ Advanced Stage Endometrial Cancer Patients

China
Mid-Atlantic Epilepsy and Sleep Center, LLC

Recruiting

Prospective Open-label Evaluation of Cenobamate Adjunctive Treatment of Adults With Refractory Focal Epilepsy

Focal Epilepsy

United States
IRCCS San Raffaele
Bristol-Myers Squibb

Recruiting

An Open Label, Single-arm, Phase 2 Study of Neoadjuvant Nivolumab and Nab-paclitaxel Before Radical Cystectomy for Patients With Muscle-invasive Bladder Cancer (NURE-Combo) (NURE-Combo)

Muscle-Invasive Bladder Carcinoma

Italy

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