Search clinical trials for: single dose bioavailability

Total 27552 results

Cytokinetics

Recruiting

A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants

Healthy Participants

United States
The Affiliated Hospital of Qingdao University

Recruiting

XKDCT080 in GCC-positive Recurrent or Refractory Solid Tumors With Single Center, Single Arm, and Dose Escalation

Colon Cancer

China
Immunocore Ltd

Recruiting

Study of IMC-I109V in Non-cirrhotic HBeAg-negative Chronic HBV Infection

Hepatitis B, Chronic

Hong Kong, Korea, Republic of, Taiwan, Denmark, United States, Australia, Romania, United Kingdom, Spain
HealthPartners Institute

Recruiting

Measurement of Insulin Levels in Cerebral Spinal Fluid (CSF) of Healthy Adults After a Single Intranasal Dose (INI-CSF)

Healthy

United States
TRB Chemedica International SA

Not yet recruiting

Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease (BUSTON-01)

Dry Eye Disease
TRB Chemedica International SA

Not yet recruiting

Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease (BUSTON-02)

Dry Eye Disease
Aer Therapeutics

Recruiting

Single and Multiple Ascending Dose Study of AER-01

COPD

Australia
Medical College of Wisconsin
University of Oklahoma

Recruiting

Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage (TheoPHyLNNe)

Acute Kidney Injury | HIE

United States
Abdul El-Rabbany

Recruiting

Antibiotics for Prevention of Infection Following Orthognathic Surgery

Orthognathic Surgical Site Infection

Canada
Sirnaomics

Recruiting

Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects

FXI

United States, Canada
Aligos Therapeutics

Recruiting

A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558

COVID-19

United Kingdom
Federal University of Health Science of Porto Alegre

Not yet recruiting

Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS (L-AmB_phase3)

Fungal Infection | Immunosuppression | AIDS and Infections | Disseminated Histoplasma Capsulatum Infection

Brazil
David D'Andrea

Not yet recruiting

Single-Dose Intravesical Chemotherapy After Diagnostic URS (MINERVA)

Bladder Cancer | Upper Urinary Tract Urothelial Carcinoma

Austria
Peking University Third Hospital

Not yet recruiting

Single Ultra-high Dose Stereotactic Body Radiation Therapy for Early Lung Cancer (USBRT-1)

Stereotactic Body Radiotherapy | Early Lung Cancer

China
Brigham and Women's Hospital
Bill and Melinda Gates Foundation

Not yet recruiting

A Single-Dose, Three-Way, Three-Sequence, Crossover BA Study of Azithromycin Oleogel

Infectious Disease | Drug Effect | Clinical Infection
Neuramedy Co. Ltd.
Quotient Sciences

Not yet recruiting

Single and Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of NM-101

Parkinson Disease

United Kingdom
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Study of HS-10517 in Chinese Adult Participants

COVID-19

China
Ciusss de L'Est de l'Île de Montréal

Recruiting

Dexmedetomidine Added to Ropivacaine Single Shot vs Continuous Interscalene Nerve Block (DEXBIB)

Shoulder Pain | Anesthesia | Post Operative Pain

Canada
National Institute of Allergy and Infectious Diseases...

Recruiting

A Study to Evaluate the Safety and Immunogenicity of a Single Dose of H1ssF-3928 mRNA-LNP in Healthy Adults

Influenza

United States
Biocad

Recruiting

Study of the Safety and Efficacy of an Adeno-Associated Viral Vector Carrying the SMN Gene After a Single Intravenous Administration of Escalating Doses in Children With Spinal Muscular Atrophy (BLUEBELL) (BLUEBELL)

Spinal Muscular Atrophy (SMA)

Belarus, Russian Federation
McMaster University
Center for Medicinal Cannabis Research

Recruiting

The Pharmacokinetics of Single Dose Oral Tetrahydrocannabinol and Cannabidiol (POT-GFR-PK)

Chronic Kidney Diseases | Cannabis | Dialysis

Canada
Zuyderland Medisch Centrum
AtriCure, Inc.

Recruiting

Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (ICE)

Funnel Chest | Pectus Excavatum

Netherlands
Nirsum Labs
National Institute on Drug Abuse (NIDA)

Recruiting

Single Ascending Dose Study of NRS 033 in Healthy Volunteers

Healthy Volunteers

United States
First Affiliated Hospital, Sun Yat-Sen University
Baxter Healthcare Corporation

Recruiting

Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis

Peritoneal Dialysis

China
University of Reading
Wild Blueberry Association of North America (WBANA)

Recruiting

Effects of a Single Dose of Wild Blueberries on Mood and Executive Function in Healthy Emerging Adults

Executive Function | Mood | Affect

United Kingdom
Jiangsu Simcere Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Escalating Doses of SIM0348 as a Single Agent in Advanced Solid Tumors

Advanced Solid Tumors
Onconic Therapeutics Inc.

Not yet recruiting

Clinical Trial to Evaluate Food-Effects on Pharmacokinetics and Pharmacodynamics of Oral Single Dose of JP-1366 Tablet in Healthy Volunteers

Healthy

Korea, Republic of
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Recruiting

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy (HYPOGRYPHE)

Melanoma | Renal Cell Carcinoma | NSCLC | SCLC | Breast Carcinoma | Non-small Cell Lung Cancer | Small-cell Lung Cancer | Brain Metastases, Adult

United States
Mercy Health Ohio
Northeast Ohio Medical University

Recruiting

Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

Urinary Tract Infections

United States
Centre for Chronic Disease Control, India
All India Institute of Medical Sciences, New Delhi; Imperial College London

Recruiting

Treatment Optimisation for Blood Pressure With Single-Pill Combinations in India (TOPSPIN)

Primary Hypertension

India
Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences; Infectious Diseases Clinical...

Recruiting

Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct (TrEAT_TD2)

Diarrhoea;Acute | Diarrhea Travelers

Djibouti, Honduras, Kenya
Beckley Psytech Limited

Recruiting

An Open-Label, Single Dose Study in Patients With Alcohol Use Disorder

Alcohol Use Disorder

United Kingdom
argenx

Recruiting

A Clinical Trial to Investigate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Single and Multiple Ascending Doses of ARGX-119 in Healthy Participants

Healthy Volunteers

Netherlands
Juventas Cell Therapy Ltd.

Recruiting

A Study of CNCT19 Treatment in Children and Adolescent r/r ALL Patients(Pediatric)

B-cell Acute Lymphoblastic Leukemia

China
Cytokinetics

Recruiting

A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants

Healthy Participants

United States
Beckley Psytech Limited

Recruiting

An Open-Label, Single Dose Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression

Treatment Resistant Depression

United Kingdom
ModernaTX, Inc.

Recruiting

A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure

Chronic Heart Failure

United States, United Kingdom, Poland
Suzhou Ribo Life Science Co. Ltd.

Recruiting

A Single Ascending Doses Phase I Study to Evaluate the Safety and Pharmacokinetics of RBD4059 in Healthy Subjects

Healthy Volunteers

Australia
ViiV Healthcare

Recruiting

A Study to Investigate Safety, Tolerability, and Pharmacokinetics (PK) of VH4524184 and the Potential for Changes in Cytochrome P450 3A (CYP3A) Activity

HIV Infections

United States
SRI International

Recruiting

Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics

Toxicity;Chemical

United States
Bayer

Recruiting

A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States, United Kingdom, Korea, Republic of, Japan, Spain, Belgium, China
IlDong Pharmaceutical Co Ltd
Parexel; YUNOVIA CO.,LTD.

Recruiting

Safety, Tolerability, and Pharmacokinetics of ID119031166M With the Exploration of Pharmacodynamic Effects

Healthy Participants

United States
National Institute of Allergy and Infectious Diseases...
NeoImmune Tech

Not yet recruiting

A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia

Idiopathic CD4 Lymphopenia

United States
Melinta Therapeutics, LLC

Recruiting

Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin

Acute Bacterial Skin and Skin Structure Infection

United States, Spain, Greece, Portugal, Bulgaria, Latvia, Romania, Lithuania, Poland
Second Affiliated Hospital, School of Medicine,...

Recruiting

Preoperative Stereotactic Body Radiotherapy (SBRT) Followed by Hepatectomy for Centrally Located Hepatocellular Carcinoma: a Prospective, Single-center, Phase I Study

Hepatectomy | Stereotactic Body Radiotherapy | Centrally Located Hepatocellular Carcinoma

China
University of Zurich

Recruiting

Dose Escalation for SBRT of Recurrent VT Ventricular Tachyarrhythmia - a Single Center, Phase II Clinical Trial (DEFT STAR)

Ventricular Tachycardia

Switzerland
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis

Tuberculosis | Rifampicin Resistant Tuberculosis

Brazil, India, South Africa, Tanzania, Thailand
University of Texas Southwestern Medical Center
National Cancer Institute (NCI)

Recruiting

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

Head and Neck Cancer | Head and Neck Squamous Cell Carcinoma | Unknown Primary Cancer

United States
Fujian Akeylink Biotechnology Co., Ltd.
The First Hospital of Jilin University

Recruiting

Safety, Tolerability and Pharmacokinetic Characteristics Evaluation on GST-HG121 Tablets

Pharmacokinetics | Food Affect | Single Ascending Dose | Maximum Applicable Dose

China
Lipum AB
QPS Netherlands B.V.

Recruiting

First in Human Study of a Monoclonal Antibody (SOL-116) Targeting BSSL (Bile Salt-Stimulated Lipase), Single and Multiple Dose Parts

Rheumatoid Arthritis

Netherlands

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