Search clinical trials for: Proof of Concept (POC)

Total 431606 results

Agency for Healthcare Research and Quality (AHRQ)
Centers for Disease Control and Prevention; Joint Commission on Accreditation... and other collaborators

Unknown

Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE)

Hysterectomy | Arthroplasty, Replacement | Cardiovascular Surgical Procedures

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Alternate-Day Buprenorphine Administration. Phase IV - 5

Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Alternate-Day Buprenorphine Administration. Phase VI - 7

Opioid-Related Disorders

United States
National Center for Research Resources (NCRR)

Completed

Body Water Content in Cyanotic Congenital Heart Disease

Heart Defects, Congenital

United States
National Institute of Allergy and Infectious Diseases...

Completed

A "Pre-Enrollment" Protocol for HIV-Infected Adolescents

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

The Effects of Illnesses on HIV Levels in the Body

HIV Infections

United States
Shaman Pharmaceuticals

Completed

Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS)

HIV Infections | Herpes Simplex

United States, Puerto Rico
Sandoz

Completed

A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia

HIV Infections | Cytopenias

United States
Immunobiology Research Institute

Completed

The Effects of Thymopentin on HIV Infectivity of Blood Cells and Semen in HIV-Infected Patients

HIV Infections

United States
Cytran

Completed

Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients

HIV Infections | Sarcoma, Kaposi

Canada, United States, Australia, Belgium
National Center for Research Resources (NCRR)
Baylor College of Medicine

Completed

Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary Hypertension

Hypertension, Pulmonary
National Center for Research Resources (NCRR)
University of Texas

Completed

Study of Nutritional Factors in Porphyria

Porphyria
National Center for Research Resources (NCRR)

Suspended

A Multi-Centered Study of the Long-Term Effect of Salmeterol and Albuterol in Cystic Fibrosis

Cystic Fibrosis

United States
University of Minnesota

Completed

Phase I/II Study of Total Body Irradiation, Cyclophosphamide, and Fludarabine Followed by Alternate Donor Hematopoietic Cell Transplantation in Patients With Fanconi's Anemia

Fanconi's Anemia

United States
National Center for Research Resources (NCRR)
University of Alabama at Birmingham

Completed

Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth

Herpes Simplex

United States, Canada
National Center for Research Resources (NCRR)
Duke University

Unknown

A Safety and Feasibility Study of Active Immunotherapy in Patients With Metastatic Prostate Carcinoma Using Autologous Dendritic Cells Pulsed With Antigen Encoded in Amplified Autologous Tumor RNA

Prostate Cancer

United States
National Center for Research Resources (NCRR)
Crohn's and Colitis Foundation

Completed

A Pharmacokinetic Study to Determine the Oral Bioavailability of Methotrexate in Patients With Inflammatory Bowel Disease

Inflammatory Bowel Disease

United States
National Institute of Allergy and Infectious Diseases...

Completed

Treatment of Acute HIV Infection to Preserve Immune Function

HIV Infections

United States
National Center for Research Resources (NCRR)
National Institute of Neurological Disorders and Stroke (NINDS); University...

Completed

Phase III Randomized, Double-Blind Study of Prednisone for Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy
Gilead Sciences

Unknown

Tenofovir Disoproxil Fumarate in HIV-Infected Patients Who Have Not Had Success With Other Anti-HIV Drug Combinations

HIV Infections

United States
National Center for Research Resources (NCRR)
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection

Herpes Simplex
National Center for Research Resources (NCRR)
Johns Hopkins University

Completed

Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders

Amino Acid Metabolism, Inborn Errors
Orphan Medical

Completed

Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patients

Narcolepsy

United States, Canada, Switzerland
National Eye Institute (NEI)

Unknown

Randomized Trials of Vitamin Supplements and Eye Disease

Macular Degeneration | Cataract
National Institute on Alcohol Abuse and Alcoholism...

Completed

Use of Naltrexone in a Clinical Setting

Alcoholism

United States
National Institute on Alcohol Abuse and Alcoholism...

Completed

Sertraline and Cognitive Therapy in Depressed Alcoholics

Depression | Alcoholism

United States
National Institute of Allergy and Infectious Diseases...
Janssen Pharmaceuticals

Completed

A Study of Letrazuril in the Treatment of AIDS-Related Diarrhea

HIV Infections | Cryptosporidiosis

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

A Third-Party Blinded, Placebo Controlled Comparative Study of AS-101 Administered Intravenously in HIV Positive Patients With Advanced Disease

HIV Infections

Brazil
Ionis Pharmaceuticals, Inc.

Completed

A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )

HIV Infections | Cytomegalovirus Retinitis

United States
Gilead Sciences

Completed

An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

HIV Infections | Cytomegalovirus Retinitis

United States
National Center for Research Resources (NCRR)
Yale University

Completed

Developmental Phenomenology of Obsessive Compulsive Disorder and Tourette Syndrome in Children and Adolescents

Obsessive Compulsive Disorder | Tourette Syndrome

United States
Hoechst Marion Roussel

Completed

A Study of MDL 28,574A in HIV-Infected Patients

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Rochester

Completed

Pilot Compassionate Use Study of Thioctic Acid Treatment in Mitochondrial Myopathy

Mitochondrial Myopathy
National Center for Research Resources (NCRR)
Icahn School of Medicine at Mount Sinai

Completed

Diagnostic and Screening Study of Genetic Disorders

Metabolism, Inborn Errors | Leukodystrophy, Globoid Cell | Tay-Sachs Disease | Porphyria, Erythropoietic

United States
National Center for Research Resources (NCRR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Ohio...

Completed

Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

IGA Glomerulonephritis

United States
Glaxo Wellcome

Completed

A Study of Amprenavir in HIV-Infected Patients

HIV Infections

United States
Light Sciences LLC

Completed

Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors

Sarcoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Rectal Cancer | Pelvic Cancer | Mouth Cancer | Liver Metastasis

United States
R W Johnson Pharmaceutical Research Institute

Completed

A Double-Blind Study to Evaluate the Safety and Pharmacokinetics of L-Ofloxacin (RWJ 25213) in Subjects With HIV Infection

HIV Infections

United States
Immune Enhancement Project

Completed

Acupuncture and Herbal Treatment of Chronic HIV Sinusitis

HIV Infections | Sinusitis

United States
Medstone International

Terminated

Lithotripsy for the Treatment of Gallstones

Cholelithiasis

United States
National Center for Research Resources (NCRR)
University of Vermont

Completed

Study of the Natural History and Genotype-Phenotype Correlations of Hereditary Hemorrhagic Telangiectasia Patients

Hereditary Hemorrhagic Telangiectasia
Columbia Research Laboratories

Completed

The Safety and Effectiveness of SPC3 in HIV-1 Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used With and Without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs

HIV Infections

United States
Fisons

Completed

The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts

HIV Infections | Pneumonia, Pneumocystis Carinii

United States, Puerto Rico
National Center for Research Resources (NCRR)

Completed

Disorders of Systemic Glucose Balance

Hypoglycemia

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Gradual Vs. Rapid Buprenorphine Detoxification - 2

Opioid-Related Disorders

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients

HIV Infections

United States
Pfizer

Completed

A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS

HIV Infections | Candidiasis, Oral

United States

Search clinical trials for: Proof of Concept (POC)

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