Clinical Trials Sponsored by Legend Biotech

Total 2025 results

Hookipa Biotech GmbH

Recruiting

HB-302/HB-301 Therapy in Participants With Metastatic Castration-Resistant Prostate Cancer

Prostate Cancer Metastatic

United States
Shanghai Henlius Biotech

Recruiting

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Extensive Stage Small Cell Lung Cancer

United States
Shanghai Henlius Biotech

Not yet recruiting

HLX07(Anti-EGFR mAb) in Patients With Advanced or Metastatic Solid Tumors

Solid Tumor

China
Shanghai Henlius Biotech

Not yet recruiting

HLX07 Combination Therapy or Motherapy in Patient With Advanced Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma
Shanghai Henlius Biotech

Recruiting

HLX07+HLX10+Chemotherapy or HLX07 Monotherapy in Patients With Advanced Metastatic Gastric Cancer

Gastric Cancer (GC) Gastroesophageal Junction Cancer (GEJ)

China
Shanghai Henlius Biotech

Recruiting

HLX301 (TIGIT×PDL1 Bispecific) in Patients With Locally Advanced or Metastatic Solid Tumors

Non-small Cell Lung Cancer | Locally Advanced or Metastatic Solid Tumors

Australia
Krystal Biotech, Inc.

Recruiting

A Phase I Study of KB301, a Replication-Incompetent, Non-Integrating Vector Expressing Human Type III Collagen (COL3) for the Treatment of Superficial Skin Depressions

Wrinkle | Skin Roughness | Fine Lines | Skin Thickness

United States
Acepodia Biotech, Inc.

Recruiting

ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors

Solid Tumor | Metastatic Cancer | HER2-positive Gastric Cancer | HER2-positive Metastatic Breast Cancer | Locally Advanced Solid Tumor

United States, Taiwan
Shanghai Henlius Biotech

Not yet recruiting

to Evaluate Efficacy and Safety of HLX10 in Combination With Chemotherapy Versus Placebo in Combination With Chemotherapy as Neoadjuvant Therapy and HLX10 Versus Placebo as Adjuvant Therapy in Patients With Triple Negative Breast Cancer (TNBC)

Triple Negative Breast Cancer
Shanghai Henlius Biotech

Recruiting

A Clinical Study of HLX10 Combined With Chemotherapy Versus Placebo Combined With Chemotherapy for Neoadjuvant/Adjuvant Treatment of Gastric Cancer

Gastric Cancer

China
Cook Biotech Incorporated

Recruiting

Oasis Donor Site Wounds Post-Market Study

Wounds and Injuries | Surgical Wound | Wound Heal | Wound

United Kingdom
Janssen Biotech, Inc.

Active, not recruiting

IMAAGEN: Impact of Abiraterone Acetate in Prostate-Specific Antigen

Prostate Cancer | Prostatic Neoplasm

United States
Janssen Biotech, Inc.

Active, not recruiting

An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis (OPAL)

Ulcerative Colitis

United States, France, Germany, Spain, Canada, Greece, Korea, Republic of, Austria, Czechia
Shanghai Henlius Biotech

Completed

Compare Efficacy, Safety and Immunogenicity of HLX02 and Herceptin in Previously Untreated HER2 +Overexpressing Metastatic Breast Cancer

Breast Cancer

China, Ukraine, Philippines
Shanghai Henlius Biotech

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of HLX11 vs. EU-Perjeta® in the Neoadjuvant Therapy of HER2-Positive and HR-Negative Early-stage or Locally Advanced Breast Cancer

Breast Cancer | Breast Neoplasms | HER2-positive Breast Cancer

China
Shanghai Henlius Biotech

Active, not recruiting

A Study to Investigate the Safety, Tolerability and Efficacy of HLX60 Combination With HLX10 in Subjects With Advanced or Metastatic Solid Tumors

Advanced or Metastatic Solid Tumors

Australia
Shanghai Henlius Biotech

Active, not recruiting

A Phase I Clinical Study of HLX53 in Advanced/Metastatic Solid Tumors

Advanced/Metastatic Solid Tumors

China
Hookipa Biotech GmbH

Terminated

A Study HB-201 in Patients With Newly Diagnosed HPV16+ Oropharynx or Locally Advanced Cervical Cancer

HPV 16+ Confirmed Oropharynx Cancer and Cervical Cancer

United States
Shanghai Henlius Biotech

Completed

A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of HLX26 Monoclonal Antibody Injection in Patients With Solid Tumor or Lymphoma

Lymphoma | Solid Tumor, Adult

China
Bionos Biotech S.L.

Active, not recruiting

Clinical Evaluation of the Magnesium Absorption Kinetics in Human Plasma Upon Oral Intake of Magnesium-based Products

Healthy Volunteers

Spain
Steba Biotech S.A.

Completed

Safety and Tolerability Study Using WST11 In Patients With Localized Prostate Cancer

Prostate Cancer

United States
Shanghai Henlius Biotech

Completed

Mass Balance Study of [14C]HLX208 in China Healthy Subjects

Mass Balance Study in Healthy Subjects

China
SciVision Biotech Inc.

Completed

The Evaluation of the Safety and Effectiveness of a Novel Gel-type Sodium Hyaluronate for the Correction of Aging Mid-face

Lidocaine | Hyaluronic Acid | Dermal Filler | Aging Mid-Face

Taiwan
Araclon Biotech S.L.

Completed

Safety and Immunogenicity of Repeated Doses of ABvac40 in Patients With a-MCI or Vm-AD

Alzheimer Disease | Mild Cognitive Impairment

Spain, France, Sweden, Italy
SciVision Biotech Inc.

Completed

Evaluate the Safety and Effectiveness of Mannitol-combined Hyaluronan Supplement in the Treatment of Knee OA

Knee Osteoarthritis | Hyaluronic Acid

Taiwan
PCI Biotech AS

Terminated

PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer (RELEASE)

Cholangiocarcinoma

United States, Spain, Belgium, Germany, Italy, Denmark, Finland, France, Korea, Republic of, Norway, Poland, Sweden, Taiwan, Ukraine
Shanghai Henlius Biotech

Active, not recruiting

The Efficacy of HLX208 (BRAF V600E Inhibitor) With Cetuximab for Metastatic Colorectal Cancer (mCRC) With BRAF V600E Mutation After First-line Treatment

CRC

China
Shanghai Henlius Biotech

Suspended

Evaluate the Efficacy, Safety and Tolerability of HLX26 and Serplulimab in Patients With mCRC

Colorectal Cancer Metastatic

China
Shanghai Henlius Biotech

Active, not recruiting

The Efficacy and Safety of HLX208 in Adult Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) With BRAF V600E Mutation

Langerhans Cell Histiocytosis | Erdheim-Chester Disease | LCH | ECD

China
Shanghai Henlius Biotech

Active, not recruiting

A Study of HLX10 in Combination With Carboplatin Plus (+) Pemetrexed With or Without HLX04 Compared With Carboplatin+Pemetrexed in 1L Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Carcinoma | Non-Small-Cell Lung

China
Shanghai Henlius Biotech

Active, not recruiting

The Efficacy and Safety of HLX208 in Metastatic Colorectal Cancer (mCRC) With BRAF V600E Mutation

Metastatic Colorectal Cancer | mCRC

China
Steba Biotech S.A.

Active, not recruiting

Study of the Efficacy, Safety and Quality of Life After TOOKAD® Soluble (VTP) for Intermediate Risk Prostate Cancer.

Localized Prostate Cancer

United States
NKGen Biotech, Inc.

Active, not recruiting

Safety of SNK01 in Subjects With Pathologically Confirmed Metastatic and/or Unresectable Cancer Refractory to Conventional Therapy

Metastatic Cancer | Advanced Solid Tumor | Advanced Cancer | Solid Tumor, Adult | Refractory Cancer | Recurrent Cancer | Unresectable Carcinoma

United States
Maxigen Biotech Inc.

Completed

Clinical Trial of Cross-linked Hyaluronic Acid Dermal Filler

Hyaluronic Acid | Dermal Fillers

China
SciVision Biotech Inc.

Terminated

Evaluate the Effectiveness of Crosslinked HA on the Adhesion Preventing After Trigger Finger Release Surgery

Trigger Finger | Hyaluronic Acid

Taiwan
Maxigen Biotech Inc.

Completed

Formaderm (Hyaluronic Acid) for Facial Soft Tissue Augmentation

Dermal Filler
CEN Biotech
PiLeJe

Completed

Incidence of Cystitis in Women Consuming a Mixture of Cranberry, Cinnamon, Probiotics

Cystitis | Urinary Tract Infections

France
Aptarion Biotech AG

Completed

Ascending Multiple Intravenous Doses of AON-D21 in Healthy Male Subjects.

Healthy

Germany
Shanghai Henlius Biotech

Completed

A Phase 1 Study of HLX20, a Human Monoclonal Antibody Targeting PD-L1Protein in Patients With Advanced Solid Tumors (HLX20)

Advanced Solid Tumors

Australia
Shanghai Henlius Biotech

Completed

Compare Pharmacokinetics, Safety, and Immunogenicity of HLX11 vs. Perjeta in Healthy Chinese Male Subjects

Healthy Male Volunteers

China
Shanghai Henlius Biotech

Terminated

Compare Pharmacokinetic, Safety, Tolerability and Immunogenicity of HLX12 and Ramucirumab in Healthy Male Adult Subjects

Healthy Male Volunteers

China
Shanghai Henlius Biotech

Completed

Study of Efficacy and Safety of HLX03 in Subjects With Moderate to Severe Plaque Psoriasis

Plaque Psoriasis

China
Shanghai Henlius Biotech

Withdrawn

A Clinical Study to Compare the Efficacy and Safety of HLX10 in Combination With HLX04 Versus Sorafenib as the First-line Treatment in Patients With Locally Advanced or Metastatic HCC

Hepatocellular Carcinoma (HCC)

China
Shanghai Henlius Biotech

Completed

Evaluate Safety, Tolerability and Pharmacokinetics of HLX22 in Patients With Advanced Solid Tumors Overexpressing HER2

Solid Tumor

China
Shanghai Henlius Biotech

Withdrawn

A Phase III Study to Evaluate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy in Patients With Advanced Cervical Cancer

Cervical Cancer

China
Shanghai Henlius Biotech

Active, not recruiting

A Clinical Study Evaluating the Use of HLX10 in Combination With HLX04 for the Treatment of Advanced Hepatocellular Carcinoma (HCC) Patients

Hepatocellular Carcinoma

China
Krystal Biotech, Inc.

Active, not recruiting

Topical Beremagene Geperpavec (KB103) Gene Therapy to Restore Functional Collagen VII for the Treatment of Dystrophic Epidermolysis Bullosa (GEM-1)

Dystrophic Epidermolysis Bullosa

United States
Cook Biotech Incorporated

Completed

Treatment of Wounds Using Oasis® ECM

Non-healing Wound

United Kingdom
NKGen Biotech, Inc.

Withdrawn

Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers

Sarcoma | Cervical Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Metastatic Cancer | Bladder Cancer | Triple Negative Breast Cancer | Advanced Solid Tumor | HER2-positive Breast Cancer | Head and Neck Squamous Cell Carcinoma | EGF-R Positive Non-Small... and other conditions
Metagone Biotech Inc.

Completed

Assess the Safety and Activity of Combined MG005 and Sorafenib (NEXAVAR®) Treatment With Solid Tumor

Solid Tumor

Taiwan

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