Search clinical trials for: Calcineurin

Total 1926 results

Indiana University

Terminated

Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function

Kidney Failure

United States
Rennes University Hospital

Completed

Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)

Hepatic Transplantation

France
Indiana University

Terminated

Everolimus Monotherapy as Immunosuppression After Liver Transplant

Kidney Failure

United States
Temple University
Veloxis Pharmaceuticals

Completed

Dosing Strategies for de Novo Once-daily Extended Release Tacrolimus (LCPT) in Kidney Transplant Recipients

Kidney Transplant

United States
University College, London

Withdrawn

NOMINATE/ Minimisation of Immunosuppression in Kidney Transplantation

Renal Transplant Rejection | Renal Transplant Infection
Stanford University

Completed

Ph II of Non-myeloablative Allogeneic Transplantation Using TLI & ATG In Patients w/ Cutaneous T Cell Lymphoma

Lymphoma, Non-Hodgkin | Mycoses | Lymphoma, T-Cell, Cutaneous | Sezary Syndrome | Cutaneous T-cell Lymphoma | Bone Marrow Transplant Failure

United States
University Medical Center Groningen
Radboud University Medical Center; Universitaire Ziekenhuizen KU Leuven; UMC... and other collaborators

Active, not recruiting

RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients (OPTIMIZE)

Elderly Patients | Immunosuppression | Renal Transplant Recipients

Netherlands, Belgium
University of Alabama at Birmingham

Completed

Efficacy of Cyclosporine Ophthalmic Emulsion in the Treatment of Dry Eye Syndrome in Contact Lens Wearers

Contact Lens Wearers With Dry Eye Syndrome

United States
University of Maryland, Baltimore

Withdrawn

Standard Therapy Using Tacrolimus, Mycophenolate Mofetil and Prednisone For Chronic Lung Transplant Rejection (BOS)

Chronic Rejection of Lung Transplant | Disorder Related to Lung Transplantation | Decreased Immunologic Activity
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Genentech, Inc.; Biologics, Inc.

Completed

Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Lymphoma | Leukemia

United States
Ohio State University
Food and Drug Administration (FDA)

Completed

Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic Thrombocytopenic Purpura

United States
University of California, Los Angeles
Food and Drug Administration (FDA)

Completed

Prospective Study Comparing Brand and Generic Immunosuppression on Transplant Outcomes, Adherence, & Immune Response in Kidney Transplant Recipients

Renal Transplant Rejection

United States
Vastra Gotaland Region
Oslo University Hospital; Helsinki University Central Hospital; Skane University... and other collaborators

Active, not recruiting

Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD. (ScanCLAD)

Lung Transplantation | Allografts

Norway, Sweden, Finland, Denmark
Boston Sight

Withdrawn

Novel Use of Restasis and PROSE Devices

Ocular Surface Disease

United States
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

PROACTIVE: Preventing Acute/Chronic GVHD With TocIlizumab Combined With GVHD Prophylaxis Post allogEneic Transplant

Hematologic Malignancy

United States
Boston Sight
Allergan

Completed

Novel Use of Cyclosporine Ophthalmic Emulsion 0.05% on Application of PROSE Devices for Management of Patients With Ocular Surface Disease

Ocular Surface Disease

United States
University of Utah
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Myocarditis Treatment Trial

Heart Diseases | Cardiovascular Diseases | Myocarditis
Lorenzo Gallon

Completed

Extended Release Tacrolimus vs. Twice-Daily Tacrolimus

End Stage Renal Disease | Rejection of Renal Transplant

United States
Indiana University
Food and Drug Administration (FDA)

Completed

Effects of Altered Formulation on the Bioequivalence of Tacrolimus in Healthy Female and Male Volunteeers (ASDBioequiv)

Bioequivalence

United States
Alexion

Completed

Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants

Healthy

United States
National Cancer Institute (NCI)

Completed

Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

United States
University of Pittsburgh

Terminated

Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity (Sirolimus)

Hypertension
Aurinia Pharmaceuticals Inc.

Completed

Aurinia Renal Response in Active Lupus With Voclosporin (AURORA)

Lupus Nephritis

United States, Argentina, Belarus, Brazil, Bulgaria, Canada, Chile, Colombia, Costa Rica, Croatia, Dominican Republic, Guatemala, Japan, Korea, Republic of, Malaysia, Mexico, Netherlands, North Macedonia, Peru, Philippines, Poland, Puerto Rico and more
CareDx

Withdrawn

KidneyCare Immuno-optimization in Renal Allografts (KIRA)

Immunosuppression | Kidney Transplant | Allograft
AstraZeneca
Parexel

Completed

Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers

Chronic Kidney Disease

Germany
National Institute of Allergy and Infectious Diseases...
Bristol-Myers Squibb; PPD

Withdrawn

Selective CD28 Blockade in Renal Transplant Recipients

Kidney Transplantation | Renal Transplant Recipients

United States
Shanghai General Hospital, Shanghai Jiao Tong University...
Ruijin Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine and other collaborators

Completed

The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Severe Aplastic Anemia

China
Farwaniya Hospital

Completed

Topical Cyclosporin A 0.05% Eye Drops for Management of Symptomatic Acquired Punctal Stenosis. A Prospective, Controlled Clinical Study.

Management of Punctal Stenosis

Kuwait
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

Bone Marrow Failure Syndromes | Severe Aplastic Anemia

United States
William R. Drobyski, MD

Completed

A Study of Tacrolimus/Methotrexate and Tocilizumab to Prevent Acute Graft-Versus-Host Disease (AGVD) After Allogeneic Hematopoietic Stem Cell Transplant

Hematopoietic Stem Cell Transplantation

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Cancer Institute (NCI); Blood and Marrow Transplant Clinical Trials...

Completed

Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

Acute Leukemia | Myelodysplasia

United States
Bing Han

Completed

Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA (PRCA)

Pure Red Cell Aplasia, Acquired

China
M.D. Anderson Cancer Center

Withdrawn

Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies

Sickle Cell Disease | Sickle Beta Thalassemia | Beta Thalassemia Major | Sickle Cell-SS Disease | Sickle Beta 0 Thalassemia | Sickle Beta Plus Thalassemia

United States
Fred Hutchinson Cancer Center

Completed

Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant

Myelodysplastic Syndrome (MDS) | Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Acute Biphenotypic Leukemia | Acute Myeloid Leukemia in Remission | Acute Lymphoblastic Leukemia in Remission | Blasts Under 5 Percent of Bone Marrow...

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Acute Myeloid Leukemia | Recurrent Hodgkin Lymphoma | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Aplastic Anemia | Recurrent Non-Hodgkin... and other conditions

United States
Surface Pharmaceuticals, Inc.

Completed

A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease

Dry Eye Disease

United States
Eli Lilly and Company

Completed

A Drug Interaction Study of Cyclosporine and LY3502970 in Healthy Participants

Healthy

Singapore
Campus Bio-Medico University

Completed

Cyclosporine 0.1% Eye Drops as Prophylactic Treatment In Cataract Surgery (CSA2020)

Ocular Inflammation | Ocular Surface Disease

Italy
Chang Gung Memorial Hospital
Ministry of Science and Technology, Taiwan

Completed

Comparison of Lindioil (Indigo Naturalis Oil Extract) Ointment to Protopic® Ointment 0.1% in Treating Atopic Dermatitis

Atopic Dermatitis

Taiwan
University of California, Los Angeles
Veloxis Pharmaceuticals

Active, not recruiting

Envarsus XR® in Adolescent Renal Transplant Recipients (EnvarsusXR)

Kidney Transplantation | Renal Transplantation | Grafting, Kidney

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Syndrome

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Previously Treated Myelodysplastic Syndrome | Adult Acute Myeloid Leukemia in Remission | Adult Acute Lymphoblastic Leukemia in Remission | Refractory Anemia With Excess Blasts | Refractory... and other conditions

United States
Lorenzo Gallon
Bristol-Myers Squibb

Completed

Belatacept 3 Month Post Transplant Conversion Study

EBV | Transplant; Failure, Kidney

United States
OncoImmune, Inc.

Terminated

Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) (CATHY)

Acute Graft Versus Host Disease | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Hematopoietic Stem Cell Transplantation

United States
Baylor Research Institute

Active, not recruiting

Phase II Study Evaluating the Efficacy of Tacrolimus Extended Release Tablets to Twice Daily Tacrolimus Dosing Regimen (Veloxis)

Compliance, Patient | Graft Failure | Heart Transplant Rejection

United States
Fred Hutchinson Cancer Center

Terminated

Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Recurrent Hodgkin Lymphoma | Recurrent Mantle Cell Lymphoma | Recurrent Marginal Zone Lymphoma | Burkitt Lymphoma | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Acute Leukemia in Remission | Acute Undifferentiated Leukemia | Acute Biphenotypic Leukemia and other conditions

United States
Indonesia University

Completed

Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery

Myocardial Injury | Cardiac Surgery

Indonesia
Peking Union Medical College Hospital

Completed

Efficacy and Safety of Eltrombopag + Tacrolimus in Chinese Refractory or Relapsed Aplastic Anemia Patients

Drug Effect | Aplastic Anemia

China
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Cancer Institute (NCI)

Completed

Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

Follicular Lymphoma | Myeloid Leukemia | Polycythemia Vera | Hodgkin Lymphoma | Myelofibrosis | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Refractory... and other conditions

United States
Mayo Clinic

Withdrawn

Bortezomib Before Donor Stem Cell Transplant in Treating Patients With Multiple Myeloma

Multiple Myeloma | Refractory Multiple Myeloma
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Terminated

Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202)

Follicular Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma

United States

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