Search clinical trials for: Challenge

Total 1370 results

University Hospital, Lille

Completed

Tidal Volume Challenge and Lung Recruitment Maneuver (TIDALREC): the Reliability of Pulse Pression Variation or Stroke Volume Variation on Fluid Responsiveness. (TIDALEC)

Hemodynamic Monitoring | Fluid Challenge

France
ENA Respiratory Pty Ltd

Completed

INNA-051 Influenza Challenge Study

Influenza Prophylaxis

United Kingdom
Aldeyra Therapeutics, Inc.

Completed

A Double Masked, Placebo Controlled, Single Center, Randomized Clinical Trial to Assess the Safety and Efficacy of Subjects With Mild Asthma Induced by the Bronchial Allergen Challenge (BAC)

Atopic Asthma

Canada
Radboud University Medical Center

Completed

High-fat Challenge Induced Trained Innate Immunity (SHAKE Study)

Cardiovascular Diseases

Netherlands
Nutrition Institute, Slovenia
National Institute of Public Health, Slovenia; Slovenian Research Agency; Higher...

Enrolling by invitation

Challenges in Achieving Adequate Vitamin D Status in the Adult Population - Part 3 (VITAD/3)

Vitamin D Serum Levels

Slovenia
Janssen Research & Development, LLC

Completed

A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 4

Healthy

Belgium
AstraZeneca

Completed

To Determine the Effect of Food on the Pharmacokinetics of Olaparib and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours

Solid Tumours

Denmark, Belgium, United Kingdom, Netherlands
Lumen Bioscience, Inc.
University of Maryland; Naval Medical Research Center; Pharmaron

Completed

LMN-101 in a Campylobacter Human Challenge Model

Campylobacter Infections

United States
Spaulding Rehabilitation Hospital

Completed

FES-Rowing: Preventing the Secondary Conditions of Paralysis Through Vigorous Exercise

Paralysis, Legs

United States
AnewPharma
Shanghai East Hospital

Active, not recruiting

Study of Challenge Meditech 082 (CM082) Tablets in Patients With Advanced Malignant Solid Tumors

Advanced Malignant Solid Tumors

China
University of York
Medical Research Council

Completed

A Clinical Study to Develop an Uninfected Sand Fly Biting Protocol (FLYBITE)

Leishmaniasis, Cutaneous | Insect Bites

United Kingdom
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Screening Inhaled Allergen Challenge for Dermatophagoides Farinae (MiteScreen)

Asthma

United States
Janssen Research & Development, LLC

Completed

A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 3

Healthy

Belgium
University of Pennsylvania

Terminated

Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury

TBI

United States
Vaxart
Biomedical Advanced Research and Development Authority

Completed

A Phase 2 Influenza A Challenge Study Following Oral Administration of an H1N1 HA Ad-Vector Seasonal Flu Vaccine

Influenza

United States
Istanbul Saglik Bilimleri University

Completed

Short Time Low PEEP Challenge and Mini Fluid Challenge

Fluid Responsiveness | Intraoperative Care

Turkey
Postgraduate Institute of Medical Education and...

Completed

A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion

Malignant Pleural Effusion

India
MemorialCare Health System

Completed

Does Venous pCO2 Increase by 20 mmHg or More During Apnea Challenge Test?

Brain Death

United States
University of Florida
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of Miami and other collaborators

Active, not recruiting

30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes

Liver Diseases | HIV Infections | Alcohol Drinking | Chronic Inflammation | Neurocognitive Dysfunction

United States
Erasme University Hospital

Terminated

Fluid Challenges and Microcirculation (FC)

Surgery

France
Merck Sharp & Dohme LLC

Completed

Phase 2a Respiratory Syncytial Virus (RSV) Human Challenge Study of Clesrovimab (MK-1654) in Healthy Participants (MK-1654-005)

Respiratory Syncytial Viruses

United Kingdom
Merck Sharp & Dohme LLC

Completed

Hepatitis B Challenge Dose in Adults (V232-059-10)

Hepatitis B
PATH

Completed

Inactivated Poliovirus Vaccine (IPV) With or Without E.Coli Double Mutant Heat-Labile Toxin (dmLT) Challenge Study in Healthy Adults

Polio

Belgium
University of Southampton
University of Edinburgh; University Hospital Southampton NHS Foundation Trust

Completed

Lactamica 9: Neisseria Lactamica Inoculation in Late Pregnancy

Microbial Colonization

United Kingdom
Manal F Abdelmalek

Terminated

Impact of Fructose on Metabolism, Energy Homeostasis and Magnetic Resonance Biomarkers in Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease (NAFLD)

United States
Marinomed Biotech AG

Completed

Therapeutic Effect of Tacrosolv in Patients With Allergic Rhinoconjunctivitis

Allergic Rhinitis | Allergic Conjunctivitis

Austria
Alexandria University

Completed

Role of Echocardiography in Guiding Fluid Therapy in Shocked Patients With Impaired Cardiac Contractility in Emergency Department

Shock

Egypt
Prescott Woodruff
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics (ACE)

Asthma

United States
University of Massachusetts, Worcester
National Cancer Institute (NCI)

Completed

Take a Break (TAB): mHealth-assisted Skills Building Challenge for Unmotivated Smokers

Smoking Cessation

United States
Meissa Vaccines, Inc.
Hvivo

Completed

Human Challenge Study to Evaluate the Efficacy of MV-012-968 Vaccine

RSV Infection

United Kingdom
State University of New York at Buffalo

Completed

The Get Outside Study (GO)

Covid19 | Stress | Sleep | Risk Reduction

United States
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Impact of Carrier Solutions for House Dust Mite Allergen on Allergic Reactions (SIMBA)

Allergic Rhinitis

Germany
Imperial College London
Royal Free Hospital NHS Foundation Trust; Hvivo

Completed

SARS-CoV-2 Human Challenge Characterisation Study

COVID-19 | Covid19 | Corona Virus Infection | SARS-CoV Infection | Coronavirus

United Kingdom
Imperial College London
ANRS, Emerging Infectious Diseases; Minka Therapeutics

Completed

3Sm Challenge Model Protocol

Healthy

United Kingdom
Merck Sharp & Dohme LLC

Completed

A Hepatitis B Vaccine Challenge Study After Previous Vaxelis® Vaccination (V419-013)

Hepatitis B

Finland
Centre for Infectious Disease Research in Zambia
Institut National de la Santé Et de la Recherche Médicale, France; Imperial... and other collaborators

Active, not recruiting

Human Challenge With Live-attenuated Rotavirus to Assess Next-generation Rotavirus Vaccines in Africa

Diarrhea | Diarrhea Rotavirus

Zambia
Cairo University
Hala Mostafa Gomaa; Ahmed Mohamed Ahmed Mostafa; Mohamed Abdel Ghany Ali Elshazly

Completed

T.V Challenge to Predict Early Post- Operative Acute Kidney Injury and Intra-operative Hypotension in Laparoscopic Abdominal Surgeries

Tidel Volume Challenge Test

Egypt
Sanaria Inc.
Fred Hutchinson Cancer Center

Completed

Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults

Malaria

United States
National Institute of Allergy and Infectious Diseases...

Completed

Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

Malaria

Mali
Charite University, Berlin, Germany

Completed

Pizza Meal Challenge and Immunometabolism (PIMETA) (PIMETA)

Healthy

Germany
Wageningen University and Research

Completed

Digital Twin - Modelling Postprandial Triglyceride and Glucose Responses

Glucose Metabolism | Lipid Metabolism

Netherlands
ALK-Abelló A/S

Terminated

A Research Study in Chinese People With Allergy to House Dust Mites, Using an Environmental Exposure Chamber (QUEST)

Allergic Rhinoconjunctivitis

Austria, China
University of Leipzig

Completed

VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility (VOLTA)

Shock | Septic Shock | Hemodynamic Instability

Germany
Imperial College London
Medical Research Council; Wellcome Trust; National Institute for Health Research...

Terminated

A Study of Protective Immunity Against RSV and Influenza in Experimental Human Challenge of Volunteers

Influenza, Human | Respiratory Syncytial Virus Infections

United Kingdom
Shanghai Chest Hospital
Bristol-Myers Squibb

Completed

Nivolumab Combined With Anlotinib as Re-challenge Treatment in Advanced NSCLC

NSCLC Stage IV | Checkpoint Inhibitor

China
University Medical Centre Ljubljana
University Medical Centre Maribor

Completed

Effect of Yoga in Pregnancy on Cardio-respiratory Adaptation to Challenge (YOGADAPT)

Pregnancy | Yoga | Autonomic Nervous System

Slovenia
VistaGen Therapeutics, Inc.

Completed

PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge (Palisade-1)

Social Anxiety Disorder

United States
Rush University Medical Center
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Alcohol, Gut Leakiness, & Liver Disease

Alcoholic Liver Disease

United States
MedSIR

Completed

Molecular Mechanisms of Resistance and Sensitivity to Palbociclib Re-challenge in ER+ mBC (BioPER)

Metastatic Breast Cancer

Spain, Italy
University of Oxford
Brigham and Women's Hospital; University of Liverpool

Completed

Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study

Typhoid Fever | Paratyphoid Fever

United Kingdom

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