Search clinical trials for: Drug Resistance

Total 261830 results

Laekna Limited

Recruiting

Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1

Cervical Cancer | Esophageal Cancer | NSCLC | Solid Tumor | Endometrial Cancer | Gastric and Gastroesophageal Junction Adenocarcinoma

China
Exerkine Corporation
University of Waterloo

Recruiting

Can we Achieve 'High-quality' Weight Loss Through Supplementation and Exercise? The TRIM MUSCLE Study

Obesity | Overweight

Canada
University Hospital, Toulouse

Recruiting

Adapted Physical Activity for Children Treated With Cancer and Insulin Sensitivity (APACIS)

Pediatric Cancer

France
Steno Diabetes Center Copenhagen

Recruiting

Low-Dose Glucagon and Advanced Hybrid Closed-Loop System for Prevention of Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes (The HYPO-AVOID)

Hypoglycemia | Type 1 Diabetes

Denmark
Zhejiang Doer Biologics Co., Ltd.

Recruiting

A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624

Healthy, Obesity, Metabolically

New Zealand
Institut Claudius Regaud
Artios Pharma Ltd

Recruiting

Study Evaluating DNA Double-strand Breaks (DSBs) REpair Factors (POLQ, Shieldin Complex and 53BP1) Expression as Biomarker of PARP Inhibitor Resistance in Patients With Deleterious Germline Mutation in BRCA 1/2 and HER2-negative, Metastatic or Locally Advanced Breast Cancer. (REPARP)

Breast Cancer

France
Hospital Arnau de Vilanova

Recruiting

Angina, Physiology, Biology (ANgina, FIsiologia BIOlogia) (ANFIBIO)

Angina Pectoris

Spain
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa (RESOLVE)

HIV Infections | AIDS | Virologic Failure

South Africa, Uganda
Baylor Research Institute
Translational Genomics Research Institute

Recruiting

The TIOB - Collection of Patients' Biospecimens for Analysis of Immunological and Molecular Biomarkers. (TIOB)

Cancer

United States
Third Military Medical University

Recruiting

Effect of Bariatric Surgery Versus Medical Therapy on Metabolic Syndrome (EBSMTMS)

Metabolic Syndrome

China
University of Nevada, Las Vegas
University of Oklahoma

Recruiting

Strawberries and Risk of Diabetes in Adults

Metabolic Syndrome | PreDiabetes

United States
Virginia Polytechnic Institute and State University
Duke University

Recruiting

Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis

Insulin Sensitivity | 24-hour Glucose Control

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Glioma | Melanoma | Thyroid Cancer | Non-Small-Cell Lung Cancer

United States, Canada, Israel
Leiden University Medical Center
Maastricht University Medical Center; FrieslandCampina; ZonMw: The Netherlands... and other collaborators

Recruiting

The VOILA Intervention Study (VOILA)

Aging

Netherlands
Lo.Li.Pharma s.r.l

Recruiting

Efficacy and Safety of D-chiro-inositol in Obese Patients

Insulin Resistance

Italy
Yasemin Çırak
Istinye University

Not yet recruiting

Personalised Exercise Training in Adolescents With Type 2 Diabetes for the Early Prevention of Beta Cell Dysfunction (PT4DEEP)

Type 2 Diabetes
Vrije Universiteit Brussel
Universitair Ziekenhuis Brussel

Not yet recruiting

Walking With the EksoNR in Stroke Patients and Healthy Controls: Biomechanical Changes and User Experience.

Stroke | Healthy
Beijing Anzhen Hospital

Recruiting

The Efficacy of SGLT-2 Inhibitor in Patients With CAD and DM Undergoing PCI.

Coronary Artery Disease | Diabete Mellitus

China
Dana-Farber Cancer Institute
Pfizer; Prostate Cancer Foundation

Recruiting

Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

Prostate Cancer | Prostate Cancer Metastatic | Androgen Deprivation Therapy

United States
University of Milano Bicocca

Recruiting

Vacuolar ATPase and Drug Resistance of High Grade Gliomas (GLIODRUG-V)

Glioblastoma Multiforme

Italy
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Mechanisms of Diuretic Resistance in Heart Failure, Aim 1 (MsDR)

Heart Failure

United States
Instituto Nacional de Ciencias Medicas y Nutricion...

Recruiting

Effect of Dietary Protein on the Regulation of Exosome microRNA Expression in Patients With Insulin Resistance.

Insulin Resistance

Mexico
Xiaojun Chen

Recruiting

GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients

Atypical Endometrial Hyperplasia | Endometrial Neoplasms | Progesterone Resistance

China
ANRS, Emerging Infectious Diseases
CIRBA, Abidjan, Ivory Coast; SEREFO, Bamako, Mali; BIOLIM/FSS/UL, Lomé, Togo

Not yet recruiting

Large Scale Transition to a Dolutegravir-based First-line ART in the South: Virological Response and Impact on HIV Drug Resistance in a Real Life Context (DoReaL Study)

HIV Infections

Côte D'Ivoire, Mali, Togo
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

Brain Clock and Insulin Resistance

Insulin Resistance | Type 2 Diabetes

Netherlands
Roswell Park Cancer Institute

Recruiting

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Plasma Cell Myeloma | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Smoldering Plasma Cell Myeloma

United States
Lei Li

Recruiting

HRD and Resistance to PAPPi in EOC Patients

Epithelial Ovarian Cancer | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation | Drug Resistance | Overall Survival | Progression-free Survival | Poly(ADP-ribose) Polymerase Inhibitor

China
Centre Hospitalier Universitaire de Nice

Recruiting

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma (MEL-META)

Melanoma (Skin)

France
Marco J. Bruno
Boston Scientific Corporation

Recruiting

Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing an ERCP in Four Different Countries (PREVENT)

Cholangiopancreatography, Endoscopic Retrograde | Drug Resistance, Multiple, Bacterial

United States, India, Netherlands, Italy
Dr. Ronnie Shapira

Not yet recruiting

Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma (MK3475-C01)

Metastatic Melanoma | Malignant Melanoma | Immunotherapy | Malignant Melanoma Stage IV | BRAF V600E
Centro de Investigação em Saúde de Manhiça
University of California, San Francisco; Barcelona Institute for Global Health and other collaborators

Recruiting

Plasmodium Falciparum Genomic Intelligence in Mozambique (GenMoz)

Malaria | Malaria in Pregnancy | Malaria,Falciparum

Mozambique
Dror MarChaim, MD
Hadassah Medical Organization

Recruiting

A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"

Sepsis

Israel
McGill University Health Centre/Research Institute...

Recruiting

Empagliflozin in Acute Heart Failure (DRIP-AHF-1)

Chronic Kidney Diseases | Acute Heart Failure

Canada
Texas Tech University
University of Houston; Texas Tech University Health Sciences Center

Not yet recruiting

Pilot: Combining HIIT and n-3 PUFA Supplementation to Reduce Inflammation and Improve Metabolic Health (HIIT&PUFA)

Inflammation | Obesity | Insulin Resistance | Dyslipidemias | Gut Microbiome
Texas Tech University
University of Houston; Texas Tech University Health Sciences Center

Not yet recruiting

Combining HIIT and n-3 PUFA to Reduce Inflammation and Improve Metabolic Health (HIIT&PUFA)

Inflammation | Obesity | Insulin Resistance | Dyslipidemias | Human Microbiome
University of California, San Francisco

Recruiting

Ocular Rosacea Biome Study (ORBS)

Antimicrobial Resistance | Ocular Rosacea

United States
University of California, San Francisco
Bill and Melinda Gates Foundation; Ministry of Health, Niger

Recruiting

Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR) (AVENIR)

Child Health | Morality | Implementation | Resistance Bacterial

United States
University of Washington

Recruiting

SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection

Neisseria Gonorrhoeae Infection

United States
Institut de Recherche en Sciences de la Sante,...

Recruiting

Algorithm Using a Rapid Diagnostic Test for the Management of Childhood Febrile Diseases. (e-MANIC)

Antimicrobial Resistance

Burkina Faso
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
University of Palermo

Recruiting

Impact of Extra Virgin Olive Oil (EVOO) With Health Properties in Metabolic Syndrome

Metabolic Syndrome

Italy
Fudan University
Merck Sharp & Dohme LLC

Recruiting

Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004) (HYPERION)

Esophageal Squamous Cell Carcinoma

China
PT. Prodia Stem Cell Indonesia

Recruiting

Stem Cells and Secretomes for Infertility Therapy in Polycystic Ovary Syndrome (PCOS) Patients With Insulin Resistance.

Polycystic Ovary Syndrome

Indonesia
Azienda Ospedaliero Universitaria Maggiore della...
Laboratoire THERASCIENCE

Recruiting

Effects of VLCKD in Metabolic Syndrome (KETO-MI)

Obesity | Diabetes Mellitus, Type 2 | Metabolic Syndrome | Non-alcoholic Fatty Liver Disease

Italy
Second Affiliated Hospital, School of Medicine,...

Recruiting

Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis

Keratitis, Ulcerative | Antibiotic Resistance, Microbial | Photothermal Therapy

China
VA Office of Research and Development
University of Colorado, Denver

Recruiting

Mode of Exercise and Bone Biomarkers in Older Veterans (MOVE)

Musculoskeletal Diseases | Aging | Osteoporosis

United States
Royal College of Surgeons, Ireland
University of Oxford; University of Birmingham

Recruiting

Dissecting the IMpact of 11-OXygenated and Classic Androgens on Skeletal Muscle Insulin Sensitivity (DIMOXIS) (DIMOXIS)

Endocrine System Diseases | Polycystic Ovary Syndrome | Insulin Resistance | Androgen; Hypersecretion

Ireland
University of Cadiz
Ministerio de Ciencia e Innovación, Spain

Recruiting

Efficacy of a Nutritional Education Strategy and Physical Exercise on the Gut Microbiota in Type 2 Diabetics (EDUGUTION)

Cardiovascular Diseases | Diabetes Mellitus, Type 2 | Fat Burn | Metabolism Disorder

Spain
Black Diamond Therapeutics, Inc.

Recruiting

Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer | NSCLC | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | EGF-R Positive Non-Small Cell Lung Cancer | Advanced Lung Carcinoma | EGFR-TKI Resistant Mutation | Advanced Non-Small Cell Squamous Lung Cancer | Epidermal Growth Factor Receptor C797S | Epidermal...

Korea, Republic of, United States
Vanderbilt University Medical Center
Nashville VA Medical Center

Recruiting

Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease (GLIMP)

Chronic Kidney Diseases

United States

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