- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05384431
Can we Achieve 'High-quality' Weight Loss Through Supplementation and Exercise? The TRIM MUSCLE Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The purpose of the proposed study is to determine if the addition of two supplements (TRIM 7 and MUSCLE 5) to an exercise regime can induce more favorable effects on body weight, BMI, body composition (lean mass, fat mass, % body fat, ASM, and lean mass/fat mass), upper & lower body strength, aerobic fitness (VO2max), insulin sensitivity (OGTT), blood lipids (cholesterol and triglycerides), antioxidant capacity (total reducing capacity of plasma), inflammation (TNFα, IL6, CRP, IL- 10) and overall health in overweight men and women.
Primary objective/research question*:
-Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater 'high-quality' weight loss?
Co-primary objectives/research questions*:
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater loss of bodyweight?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvement in body mass index (BMI)?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvement in waist-to-hip ratio?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater loss of fat mass?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program maintain or improve lean mass?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program maintain or improve lean mass/fat mass ratio (e.g., body composition index)?
Secondary objectives/research questions:
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvements in muscle strength and aerobic capacity?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvements in insulin sensitivity?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater reductions in inflammation and greater increases in antioxidant status?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvements in sleep quality, perceived stress, health-related quality of life and the overall health index?
- Can the addition of TRIM 7 and MUSCLE 5 to an exercise program induce greater improvements in hair & nail growth?
Hypotheses:
- The addition of TRIM 7 and MUSCLE 5 will induce greater 'high-quality' weight loss than exercise alone as evidenced by A) greater loss of fat mass, B) greater gain (or maintenance) of lean mass, C) greater improvement in lean mass/fat mass ratio (e.g., body composition index) D) greater loss of bodyweight E) greater reduction in waist-to-hip ratio and/or F) greater improvement in BMI.
- The addition of TRIM 7 and MUSCLE 5 will induce greater improvements in muscle strength and aerobic fitness than exercise alone as evidenced by a greater improvement in 1RM and VO2peak than exercise alone.
- The addition of TRIM 7 and MUSCLE 5 will induce greater improvements in insulin sensitivity (HOMA-IR, glycemic control during an OGTT, Matsuda Index) than exercise alone.
- The addition of TRIM 7 and MUSCLE 5 will induce a greater reduction in inflammation (TNFα, IL6, CRP, IL- 10) and induce a greater improvement in antioxidant status (GSH:GSSG, CuZn SOD, MnSOD, catalase, total reducing capacity of plasma) than exercise alone.
- The addition of TRIM 7 and MUSCLE 5 will induce greater improvements in sleep quality, perceived stress, health-related quality of life, and an overall health index than exercise alone.
- The addition of TRIM 7 and MUSCLE 5 will induce greater improvements in hair & nail growth than exercise alone.
Study Type
Enrollment (Estimated)
Phase
- Phase 3
Contacts and Locations
Study Contact
- Name: Michaela Devries-Aboud, PhD
- Phone Number: 9054147897
- Email: m4devrie@uwaterloo.ca
Study Contact Backup
- Name: Jennifer Wilkinson
- Phone Number: 9054147897
- Email: j7wilkin@uwaterloo.ca
Study Locations
-
-
Ontario
-
Waterloo, Ontario, Canada, N2L3G1
- Recruiting
- Michaela Devries-Aboud
-
Contact:
- Michaela Devries-Aboud
- Phone Number: 9054147897
- Email: m4devrie@uwaterloo.ca
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- age 18 - 45 years
- BMI > 25 kg/m2
- low physical activity level < 150 min/week (< ACSM and CSEP recommendations)
- have had two doses of the COVID-19 vaccine
Exclusion Criteria:
- renal disease (creatinine > 140)
- liver disease (i.e. diagnosed NAFLD, NASH, cirrhosis, previous liver transplant)
- GI disorders (i.e. Colitis, Crohns)
- cardiovascular disease (recent myocardial infarction (< 6 months), hypertension requiring more than 2 medications, congestive heart failure requiring more than one medication for control, unstable arrhythmia, angina previous stroke with residual hemiparesis)
- severe osteoarthritis
- significant weight loss in the 3-month period prior to the study (10% of total body weight)
- muscular dystrophy
- severe peripheral neuropathy
- severe osteoporosis
- uncontrolled hypertension (>140/90 mmHg)
- orthopedic problems
- type I or II diabetes
- respiratory conditions (i.e. chronic pulmonary obstructive disorder), chronic obstructive pulmonary disease (FVC or FEV1 < 70% of age predicted mean value), and asthma requiring more than two medications
- individuals with prior bariatric surgery
- women who have ammenorrhea, dysregulated menstrual cycle, are peri-menopausal, menopausal, pregnant, looking to become pregnant, or nursing
- medications, including anti-inflammatory medications, more than one glucose lowering medication, insulin, platelet inhibitors, anti-coagulant medications, or Simvastatin (zocor), beta-blockers, or weight loss medications (Orlistat, Saxenda Contrave) or any other medications known to affect protein metabolism (i.e.corticosteroids).
- inability to take part in the exercise program
- vegan
- smoking
- history of glaucoma or
- overactive bladder syndrome
- consumption of more than 10 drinks/week or 2 drinks/d for women and 15 drinks/week or 3 drinks/d for men.
- history of allergy, sensitivity or strong dislike towards any component of the study products (supplements)
- have undergone a barium swallow or an infusion of a contrast agent in the past 3 weeks
- have an implantable electronic device
- inability to perform exercise as determined by the Get Active Questionnaire (GAQ)
- inability to consent
- participants on volitional dietary supplements will be considered on a case-by-case basis, but they will be asked to refrain from intake for at least 2 weeks prior to partaking in this study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Muscle5 and TRIM7
MUSCLE5 and TRIM7 natural health product supplementation Name of natural health product (brand name, generic) - MUSCLE 5, chocolate Is this a market-approved natural health product (per Health Canada)? - Yes Dose - 1 scoop Ingredients (per dose) - Whey protein isolate (24g), milk protein isolate (16g), Creatine (3g), Calcium (450mg), Vitamin D (1000 IU) Frequency of administration - Once/day Duration (e.g., six weeks) - 12 weeks Route of administration - Oral Name of natural health product (brand name, generic) - TRIM7 Is this a market-approved natural health product (as per Health Canada)? Yes Dose - 3 capsules Ingredients (per dose) - Alpha lipoic acid (200mg), CoEnzyme Q10 (100mg), beet root extract (250mg), green coffee bean extract (250mg), green tea extract (250mg), forskolin (25mg), Vitamin E (22 mg AT) Frequency of administration - Twice/day Duration (e.g., six weeks) - 12 weeks Route of administration - Oral |
Intake of MUSCLE 5 and TRIM 7 supplements on a daily basis for 12 weeks
Mixed exercise (aerobic and resistance) three days per week for 12 weeks
|
Placebo Comparator: Placebo
Placebo collagen and microcrystalline cellulose intake Placebo Control 1 (Counter to MUSCLE5) Dose - 1 scoop Ingredients (per dose) - Collagen (40g) Frequency of administration - once/day Duration - 12 weeks Route of administration - Oral Placebo Control 2 (Counter to TRIM7) Dose - 3 capsules Ingredients (per dose) - Microcrystalline cellulose (400 mg) Frequency of administration - twice/day Duration - 12 weeks Route of administration - Oral |
Mixed exercise (aerobic and resistance) three days per week for 12 weeks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Bodyweight change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
scale
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
BMI change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Body mass index (weight/height squared)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Fat mass change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
body composition by DEXA
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Lean mass change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
body composition by DEXA
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Lean mass/fat mass (body composition index) change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
body composition by DEXA
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Percent body fat change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
body composition by DEXA
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Waist-to-hip ratio change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
measure tape
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
VO2max change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Maximal aerobic capacity test (gas exchange and indirect calorimetry measured using a metabolic cart and incremental cycle ergometry)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Lower body strength change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
1-repetition and 5-repetition maximal strength
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Upper body strength change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
1-repitition maximal strength and 5-repeitition maximal strength
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Appendicular lean mass change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
body composition by DEXA
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Insulin sensitivity change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Oral glucose tolerance test (OGTT)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Blood lipids change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
cholesterol (LDL, HDL, and total cholesterol) and triglycerides
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Inflammation CRP change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
pro-inflammatory circulatory factor (ng/mL) by Luminex Performance Assay
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Inflammation TNF-alpha change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
pro inflammatory circulatory factor (pg/ml) by Luminex Performance Assay
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Inflammation IL-1 change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
pro inflammatory circulatory factor (pg/ml) by Luminex Performance Assay
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Inflammation IL-10 change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
anti-inflammatory circulatory factors (pg/mL) by Luminex Performance Assay
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Inflammation IL-6 change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
pro-inflammatory circulatory factor (pg/mL) by Luminex Performance Assay
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Antioxidant capacity change
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
TEAC (trolox equivalent antioxidant assay)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Perceived stress change (Perceived Stress Scale)
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Perceived Stress Scale (PSS-10; 0 = lowest stress, 40 = highest stress)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Sleep quality change (Bergen Insomnia Scale)
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Bergen Insomnia Scale (0 = lowest insomnia, 42 = highest insomnia)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Health-related quality of life (SF 36)
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
36 Item Short Form Survey (SF 36; 0 = maximal disability, 100 = no disability)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Male hair growth & quality (Merk & Co, 1996)
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
5 item survey (Merk & Co; 38 = maximal score (highest quality), 5 = lowest score (lowest quality))
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Female hair growth & quality (WHGQ)
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
4 item survey (WHGQ; 28 = maximal score (highest quality), 4 = lowest score (lowest quality))
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Nail health
Time Frame: baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
5 item survey (25 = maximal score, 5 = lowest score)
|
baseline 0 weeks ("pre study") to 12 weeks ("post study")
|
Nail growth change
Time Frame: baseline 0 weeks ("pre study"), 6 weeks ("midway"), and 12 weeks ("post study")
|
Ten-day nail growth will be measured by a digital caliper (Mitotoyu 500) three times during the course of the study (baseline, midway, and post).
|
baseline 0 weeks ("pre study"), 6 weeks ("midway"), and 12 weeks ("post study")
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Michaela Devries-Aboud, PhD, Kinesiology and Health Sciences, University of Waterloo
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 43396
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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