Search clinical trials for: Extended spectrum beta lactamase producing organisms

Total 17944 results

Brentwood Biomedical Research Institute

Completed

Nicotine Receptor Density & Response to Nicotine Patch: Pt 2 Extended Treatment

Smoking Cessation | Schizophrenia

United States
Hull University Teaching Hospitals NHS Trust
University of Hull

Completed

The Amputation Surgical Site Infection Trial (ASSIT) (ASSIT)

Wound Infection | Amputation Wound

United Kingdom
Xiangbei Welman Pharmaceutical Co., Ltd

Completed

Piperacillin Sodium and Sulbactam Sodium for Injection(2:1) for Treatment of Respiratory and Urinary System Infection (PIP-SBT)

Respiratory Tract Infections | Urinary Tract Infections

China
Xiangbei Welman Pharmaceutical Co., Ltd

Suspended

Study on Ceftazidime and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection (CAZ-SBT)

Respiratory Tract Infections | Urinary Tract Infections

China
Indiana University
Eli Lilly and Company

Terminated

The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia (Beta)

Schizophrenia

United States
Merck Sharp & Dohme LLC

Completed

Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)

Intra-abdominal Infections
University of Wisconsin, Madison
Thrasher Research Fund

Completed

Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children

Sinusitis

United States
Michael Cohen-Wolkowiez
The Emmes Company, LLC

Completed

Antibiotic Safety (SCAMP) (SCAMP)

Complicated Intra Abdominal Infections

United States, Canada
Emory University
Mallinckrodt

Completed

Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome

Nephrotic Syndrome

United States
Merck Sharp & Dohme LLC

Completed

Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)

Urinary Tract Infections | Pyelonephritis
Forest Laboratories
Mylan Laboratories

Terminated

Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension

Hypertension

United States
Pharmtechnology LLC
ClinPharmInvest, LLC

Completed

Bioequivalence Study of Clavamox, Film-coated Tablets, 875 mg + 125 mg Pharmtechnology LLC, Belarus), and Augmentin®, Film-coated Tablets, 875 mg + 125 mg (GlaxoSmithKline Trading CJSC, Russia), in Healthy Volunteers Under Fasting Conditions

Bioequivalence

Russian Federation
University of Malaya
Menzies School of Health Research

Completed

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Pneumonia

Malaysia
Brian J Lipworth

Completed

Differential Trough Effects of 'Triple Therapy' on Pulmonary Function in Chronic Obstructive Pulmonary Disease (COPD) (FARD12)

COPD

United Kingdom
Temple University
Allergan

Unknown

Study of Ceftazidime-Avibactam Blood Concentrations in Intensive Care Unit Patients With Renal Failure Requiring Continuous Dialysis

Critical Illness | Bacterial Infections | Renal Failure

United States
Respirent Pharmaceuticals Co Ltd.
Becro Ltd.

Completed

A Bioequivalence Study Between Fluticasone Propionate 250 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 250/50 Inhalation Powder/GSK in Healthy Volunteers

Bioequivalence

Greece
Nabriva Therapeutics AG
Medpace, Inc.

Completed

Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections (ZEUS)

Acute Pyelonephritis | Urinary Tract Infection Complicated | Urinary Tract Infection Symptomatic

Poland, Ukraine, Belarus, Bulgaria, Romania, Greece, United States, Russian Federation, Hungary, Lithuania, Slovakia, Czechia, Latvia, Croatia, Georgia, Estonia
Michigan State University

Completed

A Study of Avycaz (Ceftazidime/Avibactam) Pharmacokinetics/Pharmacodynamics (PK/PD) in Critically Ill Patients

Pharmacokinetics of Avycaz in ICU Patients
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Department of Health and Human Services

Completed

Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults

Bacteremia | Acute Pyelonephritis | Ventilator-associated Bacterial Pneumonia | Urinary Tract Infection Complicated | Hospital Acquired Bacterial Pneumonia | Abdominal Infection

Italy, United States, Colombia, Greece, Israel, Brazil, Argentina, United Kingdom
Allecra

Completed

Single Dose Mass Balance Study With C14 - Labeled AAI101 in Healthy Male Volunteers

Healthy

United States
Merck Sharp & Dohme LLC

Completed

Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)

Pyelonephritis | Complicated Urinary Tract Infection | Urinary Tract Infection (UTI) | Uncomplicated Pyelonephritis
All India Institute of Medical Sciences, New Delhi

Terminated

Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study (DALFEN)

Pediatric Cancer | Neutropenia, Febrile

India
Nathan Kline Institute for Psychiatric Research
Stanley Medical Research Institute

Completed

Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder | Autism Spectrum Disorder | Bipolar I Disorder | Psychotic Disorder Not Otherwise Specified | Bipolar II | Bipolar NOS(Not Otherwise Specified)

United States
Hartford Hospital
Merck Sharp & Dohme LLC

Completed

Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections

Diabetes | Healthy Volunteers | Wound Infection

United States
Melinta Therapeutics, Inc.

Withdrawn

A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (TANGOIII)

Hospital-Acquired Bacterial Pneumonia | Ventilator-Associated Bacterial Pneumonia | Hospital-Acquired Pneumonia | Ventilator-Associated Pneumonia
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Biomedical Advanced Research and Development Authority

Completed

Evaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy Volunteers

Healthy

United States
Melinta Therapeutics, Inc.
Biomedical Advanced Research and Development Authority

Terminated

Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia

Community-acquired Bacterial Pneumonia

Spain, United States, Philippines, Hungary, United Kingdom, Bulgaria
National Cancer Institute (NCI)

Completed

Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia

Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia

United States, Canada
Allergan

Completed

Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma

Melasma

United States
University of Southern California

Completed

Steady-state Pharmacokinetics of Ceftazidime/Avibactam in Cystic Fibrosis

Cystic Fibrosis

United States
Peter Minneci

Terminated

Non-operative Management of Pediatric Appendicitis With an Appendicoltih

Appendicitis

United States
Cubist Pharmaceuticals LLC

Terminated

Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia

Ventilator-Associated Pneumonia (VAP)

United States, Australia, New Zealand
Astellas Pharma Europe B.V.

Completed

This Was a Multinational Study Comparing the Efficacy and Safety of Two Medicines , Solifenacin Succinate and Mirabegron Taken Together, or Separately, or a Mock Treatment (Placebo) in Subjects With Symptoms of Overactive Bladder (SYNERGY)

Overactive Bladder | Urgency Incontinence | Urinary Bladder Overactive | Urinary Bladder Diseases\Urologic Diseases

United States, Argentina, Australia, Belgium, Bulgaria, Canada, China, Colombia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Italy, Korea, Republic of, Latvia, Lithuania, Malaysia, Mexico, Netherlands and more
Loma Linda University

Completed

PK/PD of High Dose Pip/Tazo in Obese Patients

Obesity

United States
Cubist Pharmaceuticals LLC

Completed

Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections

Complicated Intra-abdominal Infection

United States, Argentina, Serbia, Georgia, Russian Federation
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-7655A-013) (RESTORE-IMI 1)

Bacterial Infections
Pharmtechnology LLC
ClinPharmInvest, LLC

Completed

Bioequivalence Study of Clavamox, Powder for Oral Suspension, 400 mg + 57 mg / 5 ml (Pharmtechnology LLC, Belarus), and Augmentin®, Powder for Oral Suspension, 400 mg + 57 mg / 5 ml (GlaxoSmithKline Trading CJSC, Russia), in Healthy Volunteers Under Fasting Conditions

Bioequivalence

Russian Federation
Tribhuvan University, Nepal

Completed

Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children

Post Operative Wound Infection | Graft Uptake | Myringoplasty
Phillip Brian Smith

Completed

Pharmacokinetics and Safety of Piperacillin-tazobactam in Neonates

Sepsis

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study to Evaluate Whether BLI-489 Can be Safely Tolerated by Healthy Subjects Given Multiple Doses

Healthy

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Single Doses of BLI-489 in Healthy Japanese Male Subjects

Healthy

Japan
Allecra

Completed

Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers

Healthy
Allecra
Medpace, Inc.

Completed

Cefepime/AAI101 Phase 2 Study in Hospitalized Adults With cUTI

Urinary Tract Infections

Hungary, Czechia, Poland, Slovakia, Ukraine
Quanta Medical
Laboratoires Iprad-Vegebom

Terminated

A Multicentre, Randomized as a Double Blind Study, Triple Placebo, Comparative of the Efficacy and Safety of an Association Secnidazol-Ciprofloxacin Compared With Amoxicillin-Clavulanic Acid for the Treatment of Uncomplicated Episode of Diverticular Sigmoïditis Among Adults (DIVA)

Diverticular Sigmoïditis
TASK Applied Science
GlaxoSmithKline; Research Center Borstel; Eduardo Mondlane University; Barcelona...

Completed

Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
University Hospital, Brest

Completed

Optimization Management Study of Community Urinary Tract Infections Spectrum (OPTICUR-EBLSE)

Urinary Tract Infections | Community-Acquired Infections | Resistant Infection | Beta Lactam Resistant Bacterial Infection
Merck Sharp & Dohme LLC

Completed

Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)

Infection; Diabetic Foot
Providence Health & Services
Aduro Biotech, Inc.

Completed

Phase I Study of Safety and Immunogenicity of ADU-623

Brain Tumor | Glioblastoma Multiforme | Anaplastic Astrocytoma | Astrocytic Tumors

United States
Otsuka Pharmaceutical Development & Commercialization...

Completed

Open-label Study to Assess Usability of the Medical Information Device #1 (MIND1) System in Adults With Schizophrenia On Oral Aripiprazole

Nervous System Diseases | Schizophrenia | Mental Disorder

United States
Pfizer

Completed

Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs).

Complicated Intra-abdominal Infections

Spain, Taiwan, United States, Poland, Hungary, Czechia, Turkey, Greece, Romania, Russian Federation

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