Search clinical trials for: Unresectable/metastatic cholangiocarcinoma

Total 830 results

Michael J Cavnar, MD

Terminated

Codman Catheter/Synchromed Pump Hepatic Artery Chemotherapy for Unresectable Colorectal Metastases/Intrahepatic Cholangiocarcinoma

Colorectal Neoplasms | Bile Duct Neoplasms

United States
Tempest Therapeutics

Completed

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Sarcoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Pancreatic Cancer | Squamous Cell Carcinoma of Head and Neck | Cholangiocarcinoma | Non-small Cell Lung Cancer | Urothelial Carcinoma | GastroEsophageal Cancer | Triple-Negative Breast Cancer | Metastatic Castration Resistant Prostate...

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)

Intrahepatic Cholangiocarcinoma | Cholangiocellular Carcinoma | Peripheral Cholangiocarcinoma | Cholangiolar Carcinoma

United States
QED Therapeutics, Inc.
Helsinn Healthcare SA

Terminated

A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

FGFR2 Gene Mutation | Advanced Cholangiocarcinoma

United States, Belgium, Germany, Italy, Korea, Republic of, Russian Federation, Singapore, Spain, Taiwan, Thailand, United Kingdom
Mayo Clinic
National Cancer Institute (NCI)

Completed

TAS-102 in Treating Advanced Biliary Tract Cancers

Cholangiocarcinoma | Stage III Gallbladder Cancer AJCC v7 | Stage IIIA Gallbladder Cancer AJCC v7 | Stage IIIB Gallbladder Cancer AJCC v7 | Stage IV Gallbladder Cancer AJCC v7 | Stage IVA Gallbladder Cancer AJCC v7 | Stage IVB Gallbladder Cancer AJCC v7

United States
Institut Paoli-Calmettes

Completed

Prospective Evaluation of the Ablation Therapy With Bipolar Radio Frequency for Nonresectable Bile Duct Cancer (RFA-BILIAIRE)

Nonresectable Bile Duct Cancer

France
Celldex Therapeutics

Completed

A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies

Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Cholangiocarcinoma | Non-small Cell Lung Cancer | Primary Peritoneal Carcinoma | Hepatic Cancer | Bladder Urothelial Carcinoma | Other Solid Tumors | MSI-H Colorectal Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Ramucirumab in Treating Patients With Advanced or Metastatic, Previously Treated Biliary Cancers That Cannot Be Removed by Surgery

Cholangiocarcinoma | Liver and Intrahepatic Bile Duct Carcinoma | Unresectable Gallbladder Carcinoma | Stage III Gallbladder Cancer AJCC v7 | Stage IIIA Gallbladder Cancer AJCC v7 | Stage IIIB Gallbladder Cancer AJCC v7 | Stage IV Gallbladder Cancer AJCC v7 | Stage IVA Gallbladder Cancer AJCC v7 | Stage... and other conditions

United States
Washington University School of Medicine

Terminated

Registry Study of Neoadjuvant Chemoradiation & Transplant for Cholangiocarcinoma Patients

Cholangiocarcinoma

United States
AIO-Studien-gGmbH
AstraZeneca

Completed

Durvalumab and Tremelimumab With Gemcitabine or Gemcitabine/Cisplatin Compared to Gemcitabine/Cisplatin in CCA Patients (IMMUCHEC)

Cholangiocarcinoma | Cholangiocarcinoma Non-resectable | Gall Bladder Carcinoma | Gallbladder Carcinoma Non-Resectable

Germany
Basilea Pharmaceutica
ArQule, Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary...

Completed

Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations

Solid Tumor

United States, Italy
InflaRx GmbH

Completed

Randomized, Controlled Study of IFX-1 in Patients With Severe COVID-19 Pneumonia (PANAMO)

Severe COVID-19 Pneumonia

Belgium, Brazil, France, Germany, Mexico, Netherlands, Peru, Russian Federation, South Africa
University of Chicago
National Cancer Institute (NCI)

Completed

Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer

Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Metastatic Pancreatic Adenocarcinoma | Malignant Gastrointestinal Neoplasm | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Gallbladder Carcinoma | Stage IV Gallbladder Cancer | Stage IV Gastric Cancer | Stage IIIA Gallbladder Cancer | Stage... and other conditions

United States
NuCana plc

Terminated

Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer

Biliary Tract Cancer

Canada, United States, Spain, Hungary, Korea, Republic of, United Kingdom, Czechia, Germany, Russian Federation, Australia, France, Taiwan, Ukraine, Italy, Turkey
The Christie NHS Foundation Trust

Completed

ABC-08: Phase Ib Trial of Acelarin in Combination With Cisplatin in Locally Advanced/ Metastatic Biliary Tract Cancers (ABC-08)

Cholangiocarcinoma | Biliary Tract Cancer | Gallbladder Cancer | Ampullary Cancer

United Kingdom
Basilea Pharmaceutica

Available

Expanded Access Use of Derazantinib for Advanced Intrahepatic Cholangiocarcinoma (iCCA) With FGFR Genomic Alterations

Intrahepatic Cholangiocarcinoma
Emory University
National Cancer Institute (NCI); National Institutes of Health (NIH); Celgene

Active, not recruiting

Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer

Resectable Cholangiocarcinoma | Stage IB Intrahepatic Cholangiocarcinoma AJCC v8 | Stage II Intrahepatic Cholangiocarcinoma AJCC v8 | Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8

United States
Tokyo Medical and Dental University

Withdrawn

Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

Hepatocellular Carcinoma | Cholangiocarcinoma | Gallbladder Neoplasms | Hepatoma

Japan
Sorrento Therapeutics, Inc.

Withdrawn

A Study of STI-3031 (an Anti-PD-L1 Antibody) in Patients With Selected Relapsed/Refractory Malignancies

Diffuse Large B Cell Lymphoma | Biliary Tract Cancer | Peripheral T Cell Lymphoma | Extranodal NK T Cell Lymphoma, Nasal
Centre Oscar Lambret
National Cancer Institute, France; Ligue contre le cancer, France; Région Nord-Pas...

Completed

Early Palliative Care in Patients With Metastatic Upper Gastrointestinal Cancers Treated With First-line Chemotherapy (EPIC-1511)

Gastric Cancer | Esophageal Cancer | Bile Duct Cancer | Pancreas Cancer | Gastroesophageal Cancer

France
Chinese University of Hong Kong

Completed

Treatment for Bile Duct Cancer in the Liver

Cholangio Carcinoma

Hong Kong
State Budget Public Health Institution Scientific...

Active, not recruiting

The Comparison of Miniinvasive and Open Pancreaticoduodenectomy for Cancer Pancreaticobiliary Zone

Pancreatic Cancer | Bile Duct Cancer | Ampulla of Vater Cancer

Russian Federation
Sirtex Medical

Completed

SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma (SIRCCA)

Intrahepatic Cholangiocarcinoma

France, United Kingdom, Belgium, Australia, Spain, United States, Italy, Netherlands
Georgetown University

Active, not recruiting

Study of Pembrolizumab and Olaparib in Bile Duct Cancer

Cholangiocarcinoma

United States
RedHill Biopharma Limited

Completed

A Study of ABC294640 (Yeliva ®) Alone and in Combination With Hydroxychloroquine Sulfate in Treatment of Patients With Advanced Cholangiocarcinoma

Cholangiocarcinoma | Cholangiocarcinoma Non-resectable | Cholangiocarcinoma, Perihilar | Cholangiocarcinoma, Extrahepatic | Cholangiocarcinoma, Intrahepatic

United States
Xencor, Inc.
ICON Clinical Research

Completed

A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors (DUET-4)

Melanoma | Renal Cell Carcinoma | Nasopharyngeal Carcinoma | Small Cell Lung Carcinoma | Hepatocellular Carcinoma | Fallopian Tube Cancer | Non-small Cell Lung Carcinoma | Squamous Cell Carcinoma of the Head and Neck | Triple Negative Breast Cancer | Epithelial Ovarian Cancer | Intrahepatic Cholangiocarcinoma and other conditions

United States
Peking Union Medical College Hospital

Completed

Lenvatinib Combined Pembrolizumab in Advanced Hepatobiliary Tumors

Cholangiocarcinoma | Biomarker | Combinational Immunotherapy | Liver Neoplasm Malignant Primary

China
National Cancer Institute (NCI)

Completed

A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)

Hepatocellular Carcinoma | Cholangiocarcinoma | Bile Duct Cancer | Biliary Tract Neoplasms | Liver Cancer

United States
National Cancer Institute (NCI)

Completed

Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers

Pancreatic Cancer | Cholangiocarcinoma | Colon Cancer | Liver Metastasis | Metastatic Colon Carcinoma

United States
Instituto Ecuatoriano de Enfermedades Digestivas

Active, not recruiting

AI Guidance for Biopsy in Suspected Cholangiocarcinoma

Neoplasms | Bile Duct Neoplasms | Bile Duct Lesions | Non-Neoplastic

Ecuador
Intensity Therapeutics, Inc.
Bristol-Myers Squibb; Merck Sharp & Dohme LLC

Completed

A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 (IT-01)

Sarcoma | Lymphoma | Breast Cancer | Head and Neck Cancer | Pancreatic Cancer | Lung Cancer | Bile Duct Cancer | Colon Cancer | Liver Cancer | Squamous Cell Carcinoma | Chordoma of Sacrum

United States, Canada
Incyte Corporation

Completed

Efficacy and Safety of Pemigatinib in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous Therapy - (FIGHT-202)

Cholangiocarcinoma

United States, France, Italy, United Kingdom, Germany, Taiwan, Spain, Belgium, Israel, Korea, Republic of, Japan, Thailand
First People's Hospital of Hangzhou
Xijing Hospital; Changhai Hospital; Cancer Institute and Hospital, Chinese Academy... and other collaborators

Completed

RFA Combined With Chemotherapy for Unresectable Cholangiocarcinoma

Cholangiocarcinoma

China
Stanford University

Terminated

Assessment of a Serious Illness Conversation Guide (SICG) in Advanced Gastro-Intestinal Cancers

Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Pancreatic Adenocarcinoma | Neuroendocrine Tumors | Cholangiocarcinoma | Gastrointestinal Cancer | GIST, Malignant

United States
Boston Scientific Corporation

Completed

Cholangioscopy in Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis (PSC)

United States, Canada, Netherlands, Norway
University Medicine Greifswald

Completed

Nutrition in Gastrointestinal Tumors (NutriGIT)

Gastric Cancer | Pancreatic Cancer | Small Intestine Cancer | Rectal Cancer | Neuroendocrine Tumors | Bile Duct Cancer | Colon Cancer | Liver Cancer | Oesophageal Cancer | GIST, Malignant

Germany
Quadriga Biosciences, Inc.
Novotech (Australia) Pty Limited

Completed

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

Melanoma | Sarcoma | Kidney Cancer | Cervical Cancer | Breast Cancer | Head and Neck Cancer | Astrocytoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Thymic Carcinoma | Lung Cancer | Prostate Cancer | Brain Cancer | Cholangiocarcinoma | Bladder Cancer | Liver Cancer | Brain Metastases | Tongue Cancer | Esophagus... and other conditions

Australia
Institut de Recherches Internationales Servier

Completed

Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy) (ClarIDHy)

Metastatic Cholangiocarcinoma | Advanced Cholangiocarcinoma

United States, Spain, Korea, Republic of, Italy, France, United Kingdom
Peking Union Medical College Hospital

Active, not recruiting

FAPI PET for Response Evaluation and Prognosis Prediction in Liver and Biliary Cancer Patients Treated With PD-1 Combination Therapy

Hepatocellular Carcinoma | Bile Duct Cancer

China
University Hospital, Ghent

Completed

Feasibility of Radiotherapy and Concomitant Gemcitabine and Oxaliplatin in Locally Advanced Pancreatic Cancer and Distal Cholangiocarcinoma

Locally Advanced and Unresectable, But Non-metastatic Pancreatic Adenocarcinoma or Cholangiocarcinoma

Belgium
Asan Medical Center
Seoul St. Mary's Hospital; Severance Hospital; Bundang CHA Hospital

Completed

Adjuvant Capecitabine vs Gemcitabine Plus Cisplatin in Resected Extrahepatic Cholangiocarcinoma

Cholangiocarcinoma | Biliary Tract Cancer | Adjuvant Chemotherapy | Capecitabine | Gemcitabine | Cisplatin

Korea, Republic of
Sunnybrook Health Sciences Centre
Taiho Oncology, Inc.

Terminated

Study of TRIFLURIDINE/TIPIRACIL in Previously Treated Cholangiocarcinoma (MOCHA)

Cholangiocarcinoma | Bile Duct Cancer

Canada
Xencor, Inc.
ICON plc

Completed

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors (DUET-2)

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Nasopharyngeal Carcinoma | Small Cell Lung Carcinoma | Hepatocellular Carcinoma | Thymic Carcinoma | Thymoma | Non-small Cell Lung Carcinoma | Mesothelioma | Squamous Cell Carcinoma of the Head and Neck | Cholangiocarcinoma | Breast Carcinoma | Fallopian Tube Carcinoma and other conditions

United States
Danielle Kim Turgeon

Terminated

Phase 1 In-vivo Biliary Study of KSP/QRH Heptapeptide Dimer

Cholangiocarcinoma

United States
Mayo Clinic

Enrolling by invitation

Prospective Evaluation of Biliary Tissue Sampling With ERCP

Biliary Tract Diseases | Cholangiocarcinoma | Biliary Stricture | Cholangiopancreatography, Endoscopic Retrograde

United States
University of Southern Denmark
Odense University Hospital

Completed

Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.

Breast Cancer | Gastric Cancer | Rectal Cancer | Bile Duct Cancer | Colon Cancer | Pancreas Cancer | Oesophageal Cancer | Adverse Drug Event

Denmark
Delcath Systems Inc.

Terminated

Melphalan for Use With the Hepatic Delivery System Treatment in Patients With Unresectable Hepatocellular Carcinoma or Intra Hepatic Cholangiocarcinoma

Hepatocellular Carcinoma | Intrahepatic Cholangiocarcinoma

Germany
Memorial Sloan Kettering Cancer Center

Completed

Trial of IRE in Cholangiocarcinoma

Cholangiocarcinoma

United States
Changhai Hospital
Xijing Hospital; First People's Hospital of Hangzhou; LanZhou University; Peking... and other collaborators

Withdrawn

Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures (ENBD)

Endoscopic Retrograde Cholangiopancreatography | Klatskin Tumor

China
Sun Yat-sen University

Completed

HAIC Plus Targeted Therapy and/or PD-1 Inhibitors for Unresectable Intrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

China

Search clinical trials for: Unresectable/metastatic cholangiocarcinoma

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