Search clinical trials for: drug/agent toxicity by tissue/organ

Total 115576 results

Royal Surrey County Hospital NHS Foundation Trust

Completed

Hemi-Ablative Prostate Brachytherapy (HAPpy)

Prostatic Neoplasms | Cancer of the Prostate

United Kingdom
Tanta University

Enrolling by invitation

Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients

Breast Cancer | Cognitive Impairment | Peripheral Neuropathy | Cardiac Toxicities | Hepatic Toxicity

Egypt
Tanta University

Enrolling by invitation

Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer

Mucositis | Colo-rectal Cancer | Neuropathy;Peripheral

Egypt
Michael Bau Mortensen

Completed

Treatment of Peritoneal Carcinomatosis With Pressurized IntraPeritoneal Aerosol Chemotherapy - (PIPAC-OPC2)

Quality of Life | Peritoneal Neoplasms | Chemotherapy Effect | Chemotherapeutic Toxicity | Peritoneal Metastases | Peritoneum; Carcinomatosis | Histologic Progression

Denmark
University of Miami

Completed

A Behavioral Health Intervention Using Digital Technology in Radiation Therapy for Prostate Cancer Patients (HIDRATEPRO)

Prostate Cancer | Prostate Adenocarcinoma | Radiation Toxicity

United States
Ontario Clinical Oncology Group (OCOG)
Canadian Cancer Society (CCS)

Completed

Stereotactic Body Radiotherapy Versus Conventional Radiotherapy in Medically-Inoperable Non-Small Lung Cancer Patients (LUSTRE)

Non-small Cell Lung Cancer

Canada
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery

Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer | Neurotoxicity | Radiation Toxicity | Cognitive/Functional Effects

United States
PETHEMA Foundation

Completed

Clinical Trial to Assess the Efficacy and Toxicity of Induction and Consolidation With CPX-351 for Patients Aged 60 to 75 Years With Secondary or High-risk Acute Myeloid Leukemia (LAMVYX)

Newly Diagnosed Secondary or High Risk AML

Spain
Oslo University Hospital
Swedish Orphan Biovitrum

Completed

Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum (TvsCH)

Chemotherapy-induced Nausea and Vomiting | Chemotherapy Effect | Chemotherapeutic Toxicity | Ovarian Neoplasm | Chemotherapy-induced Neutropenia
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
Centre Oscar Lambret

Active, not recruiting

Adjuvant Radiotherapy in Breast With Intensity Modulated by Tomotherapy: (TOMOBREAST)

Breast Cancer

France
University of Arkansas

Terminated

Phase I Clinical Trial of GRID Therapy in Pediatric Osteosarcoma of the Extremity

Radiation Toxicity | Osteosarcoma in Children

United States
Jean Edward

Completed

Coverage and Cost-of-Care (CC) Links- Financial Navigation Program (CC Links)

Financial Stress | Survivorship | Hematologic Cancer

United States
Azienda Ospedaliera Città della Salute e della...

Completed

Subclinical Cardio-toxicities Evaluation With Strain Rate Echocardiography After Chemotherapy and/or Mediastinal Radiotherapy in Patient With Lymphoma (Cardiocare)

Lymphoma, Non-Hodgkin | Hodgkin Lymphoma | Toxicity, Cardiac

Italy
Tyme, Inc

Completed

A Randomized Phase 2/3 Multi-Center Study of SM-88 in Patients With Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology; Cancer and Leukemia Group B; North...

Completed

High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

Lung Cancer | Radiation Toxicity

United States, Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer

Cervical Cancer | Endometrial Cancer | Radiation Toxicity | Perioperative/Postoperative Complications | Gastrointestinal Complications | Urinary Complications | Urinary Tract Toxicity

United States, Canada, Singapore, Hong Kong
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Radiation Therapy in Treating Patients With Prostate Cancer

Sexual Dysfunction | Prostate Cancer | Radiation Toxicity | Psychosocial Effects of Cancer and Its Treatment

United States, Canada
BTG International Inc.

Completed

Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Voraxaze (LVPK)

Lymphoma | Leukemia | Osteosarcoma

United States
Universitätsmedizin Mannheim

Completed

TARGeted Intraoperative radioTherapy With INTRABEAM as a Boost for Breast Cancer - A Quality Control Registry (TARGIT_BQR)

Breast Cancer

Germany
King Hussein Cancer Center

Withdrawn

Radiation Oncology Mobile Application (γ-App)

Head and Neck Cancer | Radiation Toxicity

Jordan
Attikon Hospital

Completed

Echocardiography and Spinal Induced Hypotension.

Spinal Anesthetic Toxicity

Greece
University of California, Los Angeles
Gilead Sciences

Completed

Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) (UCLACAREMITO)

HIV/AIDS | Mitochondrial Alteration | Antiviral Toxicity | Antiviral Drug Adverse Reaction

United States
Shanghai Henlius Biotech

Active, not recruiting

A Clinical Study to Evaluate Efficacy and Safety of HLX10 Combined With Albumin-Bound Paclitaxel in Patients With Advanced Cervical Cancer Who Have Progressive Disease or Intolerable Toxicity After First-Line Standard Chemotherapy

Cervical Cancer

China
Tata Memorial Hospital
Department of Atomic Energy

Active, not recruiting

To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer. (THYRO-RT)

Radiation Toxicity | Thyroid Cancer Stage IV

India
Kasr El Aini Hospital

Completed

Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma

Metastatic Colorectal Cancer

Egypt
National Cancer Institute (NCI)

Terminated

Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases

Neoplasms, Germ Cell and Embryonal | Lung Neoplasms | Esophageal Neoplasms | Thymus Neoplasms | Mesothelioma

United States
CR-CSSS Champlain-Charles-Le Moyne

Completed

HDR Brachytherapy as Monotherapy for Low and Intermediate Risk Prostate Cancer (BRP2)

Prostate Cancer

Canada
Peking University People's Hospital
Peking University Shougang Hospital

Completed

Apatinib + Ifosfamide and Etoposide for Relapsed or Refractory Osteosarcoma

Effect of Drug | Toxicity, Drug | Secondary Resistance

China
Emory University
National Multiple Sclerosis Society

Completed

Out of Pocket Cost Communication in Multiple Sclerosis Patients

Multiple Sclerosis

United States
CHU de Reims

Completed

Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed (IPPEM)

Patients With Non-small Cell Lung Cancer (NSCLC) and Pleural Mesothelioma and Treated With a Pemetrexed-based Chemotherapy

France
University Hospital, Bordeaux

Completed

Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain (CA2D)

Leukemia | Cardiac Toxicity

France
National Cancer Institute (NCI)

Completed

MR Image Guided Therapy in Prostate Cancer

Prostatic Neoplasms | Prostate Cancer

United States
China Medical University Hospital

Completed

Prophylactic TCM for Mitigation of EGFR-TKI Related Dermatological Adverse Effect

Advanced Lung Adenocarcinoma
Wake Forest University Health Sciences
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Preventing Anthracycline Cardiovascular Toxicity With Statins (PREVENT)

Lymphoma | Breast Cancer

United States
M.D. Anderson Cancer Center
Sanofi

Completed

Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Leukemia | Transplantation Infection | Disorder Related to Bone Marrow Transplantation

United States
Centre Hospitalier Universitaire de Besancon
Pfizer

Active, not recruiting

Study to Assess Various Sunitinib Schedules in Renal Cell Carcinoma (SURF)

Kidney Neoplasms | Metastatic Renal Cell Cancer

France
Anthony Sung, MD
Massachusetts General Hospital

Completed

Pasireotide in Prevention of GI Toxicity

Hematological Malignancies

United States
Joel Greenberger

Terminated

MnSOD (Esophageal Protectant) to Prevent Esophagitis During Radiation/Chemotherapy Treatment for Non-Small Cell Lung Cancer (NSCLC) (MnSOD)

Toxicity | Esophageal

United States
Center for Vascular Pathology, Moscow

Enrolling by invitation

The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma

Spinal Tumor | Spinal Hemangioma | Beta Blocker Toxicity

Russian Federation
Jessa Hospital

Withdrawn

A Novel Skin Barrier Protectant for Acute Radiodermatitis (CASP-ORL)

Skin Diseases | Head and Neck Cancer | Radiation Toxicity | Radiodermatitis | Radiation Dermatitis

Belgium
National Cancer Institute (NCI)

Completed

Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas

Subcutaneous Panniculitis-Like T-Cell Lymphoma | T-Cell Peripheral Lymphoma | Gamma Delta Hepatosplenic T-Cell Lymphoma | NK T-Cell Lymphoma

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors

Brain Tumors | Metastatic Disease

United States
National Cancer Institute (NCI)

Completed

NHS-IL12 for Solid Tumors

Epithelial Tumors, Malignant | Epithelial Neoplasms, Malignant | Malignant Mesenchymal Tumor

United States
Damanhour University

Completed

Alpha-Lipoic Acid in Breast Cancer Patients

Breast Cancer | Chemotherapeutic Toxicity

Egypt
University Health Network, Toronto
Cancer Care Ontario

Terminated

Self-Management and Activation to Reduce Treatment-Related Toxicities (SMARTCare)

Lymphoma | Lung Cancer | Colo-rectal Cancer

Canada
Gynecologic Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Stage I Ovarian Cancer AJCC v6 and v7 | Stage IA Fallopian Tube Cancer AJCC v6 and v7 | Stage IB Fallopian Tube Cancer AJCC v6 and v7 | Stage IC Fallopian Tube Cancer AJCC v6 and v7 | Stage II Ovarian Cancer AJCC v6 and v7 | Stage IIA Fallopian Tube Cancer AJCC v6 and v7 | Stage IIB Fallopian... and other conditions

United States
University of Copenhagen
Zealand University Hospital

Completed

The Relationship Between Fat Free Mass and Toxicity of Cytostatics in Cancer Patients

Colorectal Cancer | Pancreas Cancer

Denmark
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

L-Arginine Supplementation With or Without Enzyme Inhibitors Treating Erectile Function of Prostate Cancer Survivors

Prostate Cancer | Radiation Toxicity | Male Erectile Disorder

United States
National and Kapodistrian University of Athens

Completed

Oral Glutamine and Thoracic/Upper Aerodigestive Tumors Radiation Toxicity

Biopsy Confirmed Head and Neck Cancer and Tumors of the Chest

Search clinical trials for: drug/agent toxicity by tissue/organ

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