Search clinical trials for: severe

Total 8585 results

Assistance Publique Hopitaux De Marseille

Recruiting

Impact of an Alternative to Incarceration by Housing and Support by Assertive Community Treatment Team for Homeless People With Severe Psychiatric Disorders Referred to Immediate Referral Procedure: AILSI Program (AILSI)

Severe Psychiatric Disorder

France
Third Wave Therapeutics

Recruiting

Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal Congestion

Nasal Congestion

United States
AbbVie

Recruiting

An Observational Study to Assess Change in Disease Activity and Adverse Events in Adolescent and Adult Participants With Moderate to Severe Active Crohn's Disease (CD) in Japan

Crohn's Disease

Japan
Nova Scotia Health Authority

Not yet recruiting

PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.

Cognitive Impairment | Frailty | Oncology Problem

Canada
AstraZeneca
Amgen

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma (HORIZON)

Asthma

United States, Poland, Korea, Republic of, Spain, France, China, United Kingdom, Canada, Netherlands, Argentina, Mexico, Brazil, Hungary, Japan, Philippines, South Africa, Colombia
Lady Reading Hospital, Pakistan
Pakistan Chest Society, Pakistan

Recruiting

Clopidogrel for the Prevention of Exacerbations in Severe COPD (CLOPEX)

COPD | COPD Exacerbation Acute

Pakistan
Third Wave Therapeutics

Recruiting

Sounds for Sleep Study in Patients Suffering From Moderate to Severe Insomnia

Insomnia

United States
Instituto Nacional de Psiquiatría Dr. Ramón de...
Columbia University; Research Foundation for Mental Hygiene, Inc.; Instituto...

Not yet recruiting

Individual Placement and Support Mexico (IPS)

Severe Mental Disorder

United States, Mexico
AstraZeneca

Recruiting

Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA (AJAX)

Asthma

United States, Denmark, South Africa, United Kingdom, Argentina, Vietnam, Brazil, Malaysia, Taiwan, France, Germany, Spain, Thailand, Bulgaria, Korea, Republic of, Philippines, Sweden
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia: a Multicenter Open-label Randomized Controlled Trial (DASSOH)

Hyponatremia
Sanofi

Recruiting

A Study to Evaluate the Quality of Life in Male and Female Adult Participants With Severe Asthma Treated With Dupilumab in a Real-world Setting (PROVERB)

Asthma

France
Postgraduate Institute of Dental Sciences Rohtak

Not yet recruiting

Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker

Gingivitis | Inflammatory Response | Periodontitis Chronic Generalized Severe

India
Institut National de la Santé Et de la Recherche...

Recruiting

Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects (NKAS)

Asthma Acute

France
Jordan Collaborating Cardiology Group

Not yet recruiting

Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR

Aortic Valve Stenosis | Severe Aortic Stenosis | ATTR Amyloidosis Wild Type | Middle East Studies
Taipei Medical University Hospital
Taipei Medical University; Panion & BF Biotech Inc.

Recruiting

Polymeric Microspheres vs Sculptra® in the Treatment of Moderate to Severe Nasolabial Folds

Nasolabial Fold Wrinkles

Taiwan
Mansoura University

Recruiting

Subperiosteal Implants Constructed With Digital Technology

Alveolar Bone Loss

Egypt
Tongji Hospital

Recruiting

A 6-month Follow-up Study of Patients With Severe Fever With Thrombocytopenia Syndrome

Severe Fever With Thrombocytopenia Syndrome

China
University of California, San Francisco
Centre de Recherche en Sante de Nouna, Burkina Faso

Not yet recruiting

Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition (AMOUR)

Malnutrition, Child | Severe Acute Malnutrition

Burkina Faso
AbbVie

Recruiting

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata (Up-AA)

Alopecia Areata

United States, Australia, Japan, Puerto Rico, New Zealand, China, Canada, Brazil, United Kingdom, Korea, Republic of, Chile
Peking Union Medical College Hospital

Not yet recruiting

Romiplostim in Combination With CsA vs. CsA in the Treatment of Newly Diagnosed NSAA

Non Severe Aplastic Anemia

China
Food and Health Bureau, Hong Kong
Hospital Authority, Hong Kong

Recruiting

A Decision Aid on End-of-life Care for Patients With Advanced COPD and Their Family

Chronic Obstructive Pulmonary Disease Severe

China
LEO Pharma

Recruiting

A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand Eczema

Chronic Hand Eczema

China
Novartis Pharmaceuticals

Recruiting

Study of Lutetium (177Lu) Vipivotide Tetraxetan in mCRPC Participants With Moderately and Severely Impaired and With Normal Renal Function

Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Spain, France
Mental Health Services in the Capital Region, Denmark
Innovation Fund Denmark

Recruiting

T-PEMF Headband Stimulation for Patients With Moderate to Servere Depression

Moderate Depression | Recurrent Depressive Disorder, Current Episode Moderate | Severe Depressive Episode Without Psychotic Symptoms | Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms

Denmark
Wen Jiang-3
Xijing Hospital; Xi'an Central Hospital; Tongji Hospital; Qilu Hospital of Shandong... and other collaborators

Recruiting

Optimizing Early Nutrition Support in Severe Stroke-2

Dysphagia | Acute Stroke | Severe Stroke

China
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Severe Aplastic Anemia | Single Lineage Cytopenias, T-LGL | Hypoplastic MDS

United States
Washington University School of Medicine
Thrasher Research Fund; Project Peanut Butter; Ministry of Health and Sanitation...

Recruiting

Eggs for Gut Health

Environmental Enteric Dysfunction | Moderate Acute Malnutrition | Stunting | Severe Acute Malnutrition

Sierra Leone
GlaxoSmithKline

Recruiting

A Dose Finding Study to Investigate the Safety and Effectiveness of GSK1070806 in Adult Participants With Moderate to Severe Atopic Dermatitis

Dermatitis, Atopic

Canada, Spain, China, United States, Argentina, Poland, Korea, Republic of, Panama, Japan, Bulgaria, Czechia, France, Germany, Greece, Italy, Mexico, Thailand
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
Jiangsu vcare pharmaceutical technology co., LTD

Recruiting

Efficacy and Safety Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis

Moderate to Severe Atopic Dermatitis

China
Pfizer

Recruiting

A Study To Learn About Two Study Medicines (PF-07275315 And PF-07264660) In People Who Have Moderate To Severe Atopic Dermatitis

Atopic Dermatitis

United States, Canada
Queen Mary University of London
University of Washington; University of Oxford; KEMRI-Wellcome Trust Collaborative... and other collaborators

Not yet recruiting

An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (Co-SAM)

HIV | Severe Acute Malnutrition | Comorbidities and Coexisting Conditions | Child Malnutrition
AbbVie

Recruiting

A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

Crohn's Disease

United States, Korea, Republic of, Taiwan, Israel, Switzerland, United Kingdom, Puerto Rico, Turkey
PENTA Foundation
Charite University, Berlin, Germany; University of Zurich; UMC Utrecht; Universiteit... and other collaborators

Not yet recruiting

Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in Neonatal Intensive Care. (NeoDeco)

Infection, Bacterial
Advagene Biopharma Co. Ltd.
Taipei Medical University Hospital

Recruiting

AD17002 Treating Poorly Controlled, Moderate to Severe Eosinophilic Asthma

Eosinophilic Asthma

Taiwan
Hoffmann-La Roche

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

Hemophilia A

Spain, Canada, United States, New Zealand, Italy, Poland
Societa Italiana di Dermatologia Medica, Chirurgica...

Recruiting

Real-world Experience on the Use of Upadacitinib in the Treatment of Moderate-severe Adult Atopic Dermatitis (ERUDA) (ERUDA)

Atopic Dermatitis

Italy
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease

China
Ceric Sàrl
European Cardiovascular Research Center; Biosensors International

Not yet recruiting

All Women Comparing Self-expanding ALLEGRA Valve to Any Other Balloon-expandable Valve

Aortic Stenosis, Severe
Almirall, S.A.

Recruiting

Effectiveness and Safety of Lebrikizumab Treatment in Adults and Adolescents With Moderate-to-Severe Atopic Dermatitis (ADhope)

Eczema | Atopic Dermatitis

Germany, Netherlands, United Kingdom
Tri-Service General Hospital

Recruiting

A Study on the Bone-health Effectiveness of Applying Recombinant Factor VIII Fc (rFVIIIFc) to Patients With Hemophilia A (Prototype A)

Severe Hemophilia A Without Inhibitor

Taiwan
Cara Therapeutics, Inc.

Recruiting

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica

Pruritus | Notalgia Paresthetica

United States, Poland, Spain, Canada, Germany
Ibrahim Talal Elshamy

Recruiting

Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyps

Chronic Rhinosinusitis With Nasal Polyps | Endoscopic Frontal Sinus Surgery | Draf III | Draf I or IIa

Egypt
Institute of Hematology & Blood Diseases Hospital

Recruiting

Cyclophosphamide Added to Standard Immunosuppressive Therapy With Eltrombopag as Front-line Therapy in Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

China
Children's Hospital of Philadelphia
Johns Hopkins University; University of Pennsylvania; Centers for Disease Control... and other collaborators

Recruiting

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP)

Sepsis | Septic Shock | Sepsis, Severe | Sepsis Bacteremia | Sepsis Mrsa | Antimicrobial - Induced Nephropathy | Septic Syndrome

United States
Kocaeli University

Not yet recruiting

The Effect of Motivational Interview Intervention for Caregivers of Individuals With Severe Mental Disorders

Mental Disorder | Caregiver | Motivational Interview

Turkey
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

China
Leonardo Calò, MD

Not yet recruiting

Evaluation of a Proactive Clinical Management and Early Diagnosis of Arrhythmias in Patients With Heart Failure and Non Severely Reduced Left Ventricular Function Through a Telemonitoring System (VASCO)

Heart Failure | Arrhythmias, Cardiac
Beijing Tiantan Hospital
Beijing Friendship Hospital; Beijing Chao Yang Hospital; Beijing Anzhen Hospital and other collaborators

Recruiting

China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）

Complications | Emergency Surgery | Severe Spontaneous Intracranial Hemorrhage | Long-term Antiplatelet Treatment

China
University of Miami

Recruiting

Pre vs Post Block in Total Knee Arthroplasty (TKA)

Postoperative Pain | Knee Osteoarthritis | Arthroplasty Complications

United States

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