Search clinical trials for: Phase II detoxification enzymes

Total 47423 results

Boehringer Ingelheim

Completed

An Open-Label Study in HIV+ Patients to Determine the Effects of Nevirapine (Viramune) on the Pharmacokinetics of Clarithromycin and Activity of Cytochrome 3A4.

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...
Children's National Research Institute

Terminated

Phase I Pilot Study of Liver-Directed Gene Therapy for Partial Ornithine Transcarbamylase Deficiency

Ornithine Transcarbamylase Deficiency Disease
Merck Sharp & Dohme LLC

Unknown

Safety and Effectiveness of Giving Indinavir, Ritonavir, Stavudine, and Lamivudine to HIV-Infected Patients Who Have Never Received Anti-HIV Drugs

HIV Infections

United States
Schering-Plough

Completed

Safety and Effectiveness of Fluconazole Versus SCH 56592 to Treat Thrush in HIV-Positive Patients

HIV Infections | Candidiasis, Oral

United States, Barbados
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Safety and Immunogenicity Trial of UBI SynVac (HIV-1 MN Octameric V3 Peptide Vaccine)

HIV Infections

United States
Jacobus Pharmaceutical

Completed

A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Sequus Pharmaceuticals

Completed

A Study of DOX-SL in the Treatment of AIDS-Related Kaposi's Sarcoma

HIV Infections | Sarcoma, Kaposi

United States
Dupont Merck

Completed

A Study of Efavirenz in Combination With Stavudine and Didanosine

HIV Infections

United States
Hoffmann-La Roche

Completed

The Safety and Effectiveness of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs

HIV Infections

United States
Genentech, Inc.

Completed

A Phase I Study of the Safety and Immunogenicity of Rgp 120/HIV-1IIIB Vaccine in HIV-1 Seropositive Adult Volunteers

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Texas

Completed

Phase I Study of Tin Mesoporphyrin in Patients on Long Term Heme Therapy for Prevention of Acute Attacks of Porphyria

Porphyria
National Center for Research Resources (NCRR)
Children's Hospital Colorado

Unknown

Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis

Liver Cirrhosis | Cirrhosis
Glaxo Wellcome

Completed

A Study of the Safety and Effectiveness of Combination Anti-HIV Therapy in HIV-Infected Adults

HIV Infections

United States
The Avicena Group

Unknown

Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS)

United States
GlaxoSmithKline

Unknown

Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine

HIV Infections

United States, Puerto Rico, Canada
Gilead Sciences

Completed

Phase I Study of the Safety, Tolerance, and Pharmacokinetics of 9-[2-(Bispivaloyloxymethyl)Phosphonylmethoxyethyl]Adenine (Bis-POM PMEA; Adefovir Dipivoxil) in HIV-Infected Patients

HIV Infections

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Alternate-Day Buprenorphine Administration. Phase IV - 5

Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Alternate-Day Buprenorphine Administration. Phase VI - 7

Opioid-Related Disorders

United States
Sandoz

Completed

A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia

HIV Infections | Cytopenias

United States
National Center for Research Resources (NCRR)
Baylor College of Medicine

Completed

Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary Hypertension

Hypertension, Pulmonary
Schering-Plough

Completed

A Comparison of SCH 56592 and Fluconazole in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive Patients

HIV Infections | Candidiasis, Oral

United States, Canada, Chile, Germany, France, Argentina, Belgium, Dominican Republic, Ethiopia, Guatemala, Honduras, Israel, Mexico, Panama, South Africa, Spain, Thailand, Venezuela
National Institute on Drug Abuse (NIDA)
University of Vermont

Completed

Gradual Vs. Rapid Buprenorphine Detoxification - 2

Opioid-Related Disorders

United States
Hoffmann-La Roche

Completed

A Study of Saquinavir Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients

HIV Infections

United States
Pfizer

Completed

A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS

HIV Infections | Candidiasis, Oral

United States
ViRx

Completed

ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

HIV Infections

United States
Agouron Pharmaceuticals

Terminated

Safety and Effectiveness of 3 Anti-HIV Treatments in Patients Who Have Failed Previous Treatments Containing Nelfinavir

HIV Infections

United States
Chiron Corporation

Completed

A Phase I, Observer-Blind, Placebo-Controlled Study of the Chiron Vaccine HIV p24/MF59 Administered to Healthy HIV-Seronegative Adults

HIV Infections | HIV Seronegativity

United States
Hoffmann-La Roche

Completed

A Study of ddC in Patients With AIDS or Advanced AIDS-Related Complex (ARC) Who Have Not Had Success With Zidovudine (AZT)

HIV Infections

United States
National Center for Research Resources (NCRR)
University of North Carolina

Completed

Phase I Pilot Study of Ad5-CB-CFTR, an Adenovirus Vector Containing the Cystic Fibrosis Transmembrane Conductance Regulator Gene, in Patients With Cystic Fibrosis

Cystic Fibrosis
Pfizer

Completed

Phase I Study of the Clinical Pharmacology of Azithromycin in Buffy Coat of HIV-Infected Subjects.

HIV Infections | Bacterial Infections

United States
Tularik

Terminated

T138067 Versus Doxorubicin in Chemotherapy-Naive, Unresectable, Hepatocellular Carcinoma Patients

Hepatocellular Carcinoma

United States, Russian Federation, United Kingdom, Singapore, Thailand, Ukraine, Brazil, China, Poland, Puerto Rico, South Africa
Pfizer

Completed

A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B

HIV Infections | Meningitis, Cryptococcal

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Randomized Dose/Formulation Comparison Study of SC-52151

HIV Infections

United States
Pfizer

Completed

Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome

HIV Infections | Meningitis, Cryptococcal

United States, Canada
Pfizer

Completed

A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients

HIV Infections | Mycoses | Mycobacterium Avium-Intracellulare Infection

United States
Anderson Clinical Research
Hoechst Marion Roussel

Completed

Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia.

HIV Infections | Mycobacterium Avium-Intracellulare Infection

United States
National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 (rCD4) in Infants and Children Infected With or at Risk for HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

The Efficacy and Safety of Retrovir in Patients Infected With HIV Who Are Asymptomatic (CDC Group II) or Have Persistent Generalized Lymphadenopathy (CDC Group III)

HIV Infections | Lymphatic Disease

United States
Merck Sharp & Dohme LLC

Completed

Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

HIV Infections

United States
PPD

Unknown

Differences Between Women and Men Taking a Combination of Indinavir, Ritonavir, Enteric-Coated Didanosine, and Stavudine Who Previously Took Anti-HIV Drugs

HIV Infections

United States, Puerto Rico
Daiichi Pharmaceuticals

Completed

A Phase I Trial of Tecogalan Sodium ( DS-4152 ) Administered as an Infusion Weekly x 4

HIV Infections | Sarcoma, Kaposi

United States
National Institute on Alcohol Abuse and Alcoholism...

Completed

Drug Therapy for Alcohol Detoxification

Alcoholism

United States
Fairview University Medical Center

Unknown

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders

Hemophagocytic Lymphohistiocytosis | Graft Versus Host Disease | Chediak-Higashi Syndrome | Virus-Associated Hemophagocytic Syndrome | X-Linked Lymphoproliferative Syndrome | Familial Erythrophagocytic Lymphohistiocytosis

United States
Pfizer

Completed

Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States
Aronex Pharmaceuticals

Unknown

A Safety and Effectiveness Study of Aroplatin in Patients With Advanced Solid Malignancies

Neoplasms | Colorectal Neoplasms | Hepatocellular Carcinoma | Pancreatic Neoplasms | Esophageal Neoplasms | Ovarian Neoplasms

United States
National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns

HIV Infections | Pregnancy

United States
Janssen Pharmaceuticals

Completed

Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.

HIV Infections | Candidiasis, Esophageal

United States
Janssen, LP

Completed

A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole

HIV Infections | Candidiasis, Oral

United States
Pfizer

Completed

Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States

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