Drug Therapy for Alcohol Detoxification

June 23, 2005 updated by: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Carbamazepine and Lorazepam in Outpatient Detoxification

This project will provide relevant clinical information for primary care practitioners treating alcohol withdrawal syndrome in outpatient settings. This double-blind, placebo- controlled clinical trial will compare the effectiveness of lorazepam (Ativan) and carbamazepine (Tegretol) in alcoholics who meet the criteria for a diagnosis of uncomplicated alcohol withdrawal syndrome. Participants are randomized to five days of treatment with a 1-week posttreatment followup.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • South Carolina
      • Charleston, South Carolina, United States, 29425
        • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 70 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Meets criteria for alcohol dependence and uncomplicated alcohol withdrawal syndrome.
  • Ability to provide informed consent, complete self-rating questionnaires, and respond to structured clinician-rated instruments.
  • Must live within 50 miles or one hour of the study site and have reliable transportation to the site.
  • Must have a significant other who will provide a collateral report, attend outpatient visits, and be available by telephone.
  • Subjects must be medically stable.
  • Must have a clinical withdrawal assessment prior to study.

Exclusion Criteria:

  • Meets criteria for any other substance dependence syndrome other than alcohol dependence or marijuana abuse.
  • Use of other illicit psychoactive substances (except marijuana) in the last 7 days.
  • Use of pharmaceutical agents within the last 14 days that are known to lower the seizure threshold, augment or decrease the alcohol withdrawal syndrome.
  • History of status epilepticus or two or more seizures occurring within 24- hour period during a previous alcohol withdrawal or other forms of epilepsy.
  • Current major depressive illness, dementia, suicidal or homicidal ideation, or past or present schizophrenia.
  • Acute medical instability as characterized by hepatic encephalopathy, past or present severe liver failure.
  • Diabetes requiring insulin, or severe renal disease.
  • Pregnant females.
  • High blood pressure.
  • Individuals with vomiting who cannot take oral medications at beginning of study or whose vomiting can be controlled only with antiemetic medication.
  • High white blood count, or liver function test that is 3 times higher than normal.
  • Known hypersensitivity or previous adverse reaction to carbamazepine, lorazepam, or other benzodiazepines.
  • Any relevant ECG abnormality which might require hospitalization or greatly interfere with safety during outpatient withdrawal.
  • History of severe gastrointestinal (GI) disease which might render absorption of the medication difficult or produce medical instability of the patient during detoxification which would include active peptic ulcer disease, ulcerative colitis, regional ileitis, or evidence by history or physical examination of GI bleeding.
  • Familial tremor or other neurological condition, determined by history, known to produce tremor.
  • Unable to provide a written informed consent.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Masking: DOUBLE

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Completion

December 1, 2000

Study Registration Dates

First Submitted

November 2, 1999

First Submitted That Met QC Criteria

November 2, 1999

First Posted (ESTIMATE)

November 3, 1999

Study Record Updates

Last Update Posted (ESTIMATE)

June 24, 2005

Last Update Submitted That Met QC Criteria

June 23, 2005

Last Verified

August 1, 2002

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • NIAAAMAL10761

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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