Clinical Trials Sponsored by Cassava Sciences, Inc.

Total 1406 results

Cassava Sciences, Inc.

Not yet recruiting

A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function

Hepatic Insufficiency
Cassava Sciences, Inc.

Completed

Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Simufilam Following a Single Oral Dose in Healthy Male Subjects

Metabolism | Absorption | Excretion

United States
Cassava Sciences, Inc.

Enrolling by invitation

Open-label Extension for Phase 3 Clinical Trials of Simufilam

Alzheimer Disease

United States, Canada, Puerto Rico
Cassava Sciences, Inc.

Active, not recruiting

Open-Label Extension of the PTI-125-04 Study in Mild-to-Moderate Alzheimer's Disease

Alzheimer's Disease

United States, Canada
Cassava Sciences, Inc.
Worldwide Clinical Trials

Completed

Food Effect and Bioequivalence Study of Simufilam Tablets in Healthy Volunteers

Healthy Volunteers

United States
Cassava Sciences, Inc.
Premier Research Group plc

Active, not recruiting

Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease (REFOCUS-ALZ)

Alzheimer Disease

United States, Korea, Republic of, Canada, Puerto Rico
Cassava Sciences, Inc.
Premier Research Group plc

Active, not recruiting

Simufilam 100 mg for Mild-to-Moderate Alzheimer's Disease (RETHINK-ALZ)

Alzheimer Disease

United States, Australia, Canada
Cassava Sciences, Inc.
National Institute on Aging (NIA)

Completed

Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients (PTI-125)

Alzheimer Disease

United States, Canada
Cassava Sciences, Inc.
National Institute on Aging (NIA)

Completed

PTI-125 for Mild-to-moderate Alzheimer's Disease Patients

Alzheimer Disease

United States
Pain Therapeutics
National Institute on Aging (NIA)

Completed

A Safety Study of PTI-125 in Healthy Volunteers

Alzheimer Disease | Alzheimer Disease, Early Onset

United States
Pain Therapeutics
National Institute on Aging (NIA)

Completed

PTI-125 for Mild-to-moderate Alzheimer's Disease Patients

Alzheimer Disease

United States
Halucenex Life Sciences Inc.
KGK Science Inc.

Active, not recruiting

Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder

Post Traumatic Stress Disorder | Treatment Resistant Disorders

Canada
USANA Health Sciences
KGK Science Inc.

Completed

Effect of a MVM Dietary Supplement on Indices of Human Health

Metabolic Syndrome

Canada
SK Life Science, Inc.
PRA Health Sciences

Completed

Bioavailability and Food Effect Study of 3 Types of Carisbamate

Healthy Subjects

United States
IC-IT Sciences Inc.

Unknown

Comparison of the Natural Frequencies Technology Sleep Patches to Sham Patches During Sleep in the Home Environment

Sleep Disturbance

United States
Integrative Skin Science and Research
AgeLess Sciences Inc.

Active, not recruiting

The Effects of a Longevity Supplement on Aging and Photoaging

Photoaging

United States
Sight Sciences, Inc.

Not yet recruiting

A Clinical Trial Comparing the OMNI Surgical System to Standard Medical Treatment in Pseudophakic Eyes (EVOLVE)

Primary Open Angle Glaucoma

United States
Kodiak Sciences Inc

Completed

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) (DAYLIGHT)

Wet Age-related Macular Degeneration

United States, Puerto Rico
Kodiak Sciences Inc

Terminated

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 in Participants With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NPDR) (GLOW)

Non-proliferative Diabetic Retinopathy

United States, Latvia, Slovakia, Poland, Puerto Rico, Spain, Czechia
Kodiak Sciences Inc

Terminated

A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME) (GLIMMER)

Diabetic Macular Edema

United States, Israel, France, Italy, Hungary, Poland, Puerto Rico, Czechia
Dermavant Sciences, Inc.

Completed

A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis

Psoriasis

United States
Sight Sciences, Inc.

Active, not recruiting

Prospective, Randomized, Masked, Controlled Trial To Evaluate The Safety And Effectiveness Of The TearCare® System In The Treatment Of The Signs And Symptoms Of Dry Eye Disease (SAHARA)

Dry Eye | Meibomian Gland Dysfunction

United States
Sight Sciences, Inc.

Terminated

Study of OMNI Surgical System and iStent for Eyes With OAG (Trident)

Glaucoma, Open-Angle

Germany, Spain, United Kingdom
Sight Sciences, Inc.

Terminated

Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye Disease

Dry Eye Syndromes

United States
Rogers Sciences Inc.

Unknown

Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds

Burn Wound

United States
Sight Sciences, Inc.

Unknown

Use of the OMNI® Surgical System in Combination With Cataract Extraction in Open Angle Glaucoma

Open Angle Glaucoma

United States
Sight Sciences, Inc.

Terminated

Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study)

Open-Angle Glaucoma

United States
Hapten Sciences, Inc.

Completed

A Phase I, Single-Center Study of PDC-APB in Healthy Volunteers

Contact Dermatitis

United States
MELA Sciences, Inc.

Completed

Does the Aid of MelaFind Affect Clinical Management Decisions

Melanoma

United States
5i Sciences, Inc.

Completed

Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine Colonoscopy

Apnea | Airway Obstruction | Hypopnea

United States
Theraclone Sciences, Inc.

Unknown

Influenza Virus Challenge Study to Test Monoclonal Antibody TCN-032 as a Treatment for Influenza

Influenza

United Kingdom
Theraclone Sciences, Inc.

Completed

Safety Study of Anti-Influenza Virus Monoclonal Antibody to Treat Influenza

Influenza, Human

United States
MELA Sciences, Inc.

Completed

Survey Study - Sensitivity Comparison Between MelaFind and Physician Group

Melanoma
Larada Sciences, Inc.

Completed

Control of Head Lice Infestations in Children and Adults

Pediculosis

United States
Kodiak Sciences Inc

Recruiting

A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NPDR) (GLOW2)

Non-proliferative Diabetic Retinopathy

United States, Puerto Rico
Translational Sciences, Inc.

Recruiting

Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial (NAIL-IT)

Pulmonary Embolism

United States
Dermavant Sciences, Inc.

Completed

Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis

Atopic Dermatitis

United States, Canada
Kodiak Sciences Inc

Terminated

A Trial to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME) (GLEAM)

Diabetic Macular Edema

United States, Latvia, Spain, Germany, Italy, Slovakia, Hungary, Puerto Rico
Dermavant Sciences, Inc.

Completed

Maximal Use Study of Tapinarof Cream, 1% in Pediatric Subjects With Extensive Atopic Dermatitis

Atopic Dermatitis

United States, Canada
Kodiak Sciences Inc

Completed

A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO) (BEACON)

Macular Edema | Retinal Vein Occlusion

Spain, United States, Latvia, Israel, France, Italy, Hungary, Germany, Poland, Slovakia, Puerto Rico, Czechia
Autophagy Sciences, Inc.

Completed

A Study of A4368 in Healthy Subjects (A4368)

Health Subjects

Korea, Republic of
Sight Sciences, Inc.

Terminated

A Prospective, Multicenter Study of the OMNI® Surgical System in Pseudophakic Eyes With Open Angle Glaucoma (ORION)

Glaucoma, Open-Angle

United States
Sight Sciences, Inc.

Unknown

Pilot Study of TearCare System - Long-Term Extension

Dry Eye Syndromes

United States
Rogers Sciences Inc.

Unknown

An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne®) for the Treatment of Cutaneous Metastases of Breast Cancer

Metastatic Breast Cancer

United States
Translational Sciences, Inc.

Unknown

Study of Safety and Biomarker Efficacy of TS23 in Healthy Volunteer (TS23Phase1a)

Myocardial Infarction | Thrombosis | Venous Thrombosis | Pulmonary Embolism | Cerebral Ischemia
Theraclone Sciences, Inc.

Completed

Safety Study of Human Anti-Cytomegalovirus Monoclonal Antibody

Cytomegalovirus Infections

United States
MELA Sciences, Inc.

Completed

Evaluation of Pigmented Skin Lesions With MelaFind(R) System

Melanoma

United States
Dermavant Sciences, Inc.

Recruiting

Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

Plaque Psoriasis

United States, Canada
Kodiak Sciences Inc

Terminated

Exploratory Study to Investigate the Bioactivity, Ocular and Systemic Safety, Tolerability, and Pharmacokinetics Following Single and Multiple Intravitreal Administrations of KSI-301 in Subjects With wAMD, DME and RVO

Diabetic Macular Edema | Retinal Vein Occlusion | Wet Age-related Macular Degeneration

United States
Sight Sciences, Inc.

Completed

A Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System

Glaucoma, Open-Angle

United States

3

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