Clinical Trials Sponsored by Constant Therapeutics LLC

Total 409 results

Vitrac Therapeutics, LLC
Westat

Terminated

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States
PrECOG, LLC.
Celldex Therapeutics

Terminated

Study of Glembatumumab Vedotin in gpNMB-Expressing, Advanced or Metastatic SCC of the Lung (PrE0504)

Squamous Cell Carcinoma of the Lung

United States
Calm Water Therapeutics LLC

Completed

Tear Film Break-up Time After Instillation of Artificial Tears

Keratoconjunctivitis Sicca

United States
Elios Therapeutics, LLC
LumaBridge

Recruiting

Autologous TLPO Vaccine Basket

Cancer | Tumor | Tumor, Solid | Tumor Metastasis

United States
Elios Therapeutics, LLC
LumaBridge

Completed

Multi-center Phase I/IIa Trial of an Autologous Tumor Lysate (TL) + Yeast Cell Wall Particles (YCWP) + Dendritic Cells (DC) Vaccine in Addition to Standard of Care Checkpoint Inhibitor of Choice in Metastatic Melanoma Patients With Measurable Disease.

Metastatic Melanoma

United States
Trius Therapeutics LLC
Bayer

Completed

A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study

Cellulitis | Erysipelas | Major Cutaneous Abscess

United States
Celsus Therapeutics PLC

Terminated

Double-Blind, Trial to Evaluate the Safety and Efficacy of MRX-6 Cream 2% (C012013)

Atopic Dermatitis

Israel
Hartford Hospital
Melinta Therapeutics, LLC

Not yet recruiting

Rezafungin PK in Patients on ECMO

Sepsis

United States
Hartford Hospital
Oui Therapeutics, LLC

Not yet recruiting

A Feasibility Open Trial of App-Enhanced Brief CBT for Suicidal Inpatients

Suicidal and Self-injurious Behavior

United States
Akcea Therapeutics
United BioSource, LLC

Recruiting

A Non-interventional Cohort Safety Study of Patients With hATTR-PN

Hereditary Transthyretin Amyloidosis With Polyneuropthy

United States, France, Greece, Italy, Spain, Canada, Germany, Portugal
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Further LDL-C Reduction (LIBerate-HR)

Cardiovascular Diseases | Hypercholesterolemia | Cardiovascular Risk Factor | Cardiovascular Stroke

United States, Israel, India
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reduction (LIBerate-CVD)

Cardiovascular Diseases | Hyper-LDL-cholesterolemia

United States
LIB Therapeutics LLC
Medpace, Inc.

Enrolling by invitation

Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction (LIBerate-OLE)

Familial Hypercholesterolemia | Elevated Cholesterol | Cardiovascular Disease With Mention of Arteriosclerosis

United States, Israel, Norway, South Africa, Turkey, India
LIB Therapeutics LLC
Medpace, Inc.

Completed

Cross-Over Study to Compare the Pharmacokinetics and Pharmacodynamics of LIB003 Process 1 and Process 2 Drug Product

Hypercholesterolemia

United States
Insight Therapeutics, LLC
Brown University

Completed

High Dose Influenza Vaccine in Nursing Home - Pilot Study

Influenza

United States
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Assess the Efficacy and Safety of LIB003 in HeFH Patients on Oral Lipid Therapy Needing Further LDL-C Reduction (LIBerate-FH)

Heterozygous Familial Hypercholesterolemia

United States, Israel, Norway, South Africa, Turkey
Anelixis Therapeutics, LLC

Completed

Multiple Doses of AT-1501-A201 in Adults With ALS

Amyotrophic Lateral Sclerosis

United States, Canada
Anelixis Therapeutics, LLC

Withdrawn

Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation

Type 1 Diabetes Mellitus

Canada
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Evaluate the Safety, PK, and Pharmacodynamics of LIB003 (LIB003SAD)

Hypercholesterolemia

United States
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patients (LIBerate-VI)

Hypercholesterolemia | Atherosclerotic Ischemic Disease

Spain, Germany, France, Norway, United Kingdom
Oncternal Therapeutics, Inc
Pharmacyclics LLC.

Withdrawn

A Study of Zilovertamab and Ibrutinib in Patients With Relapsed or Refractory Mantle Cell Lymphoma

Immune System Diseases | Lymphoma | Lymphoma, B-Cell | Lymphoproliferative Disorders | Lymphatic Diseases | Immunoproliferative Disorders | Lymphoma, Non-Hodgkin | Lymphoma, Mantle-Cell
Mindful Diagnostics and Therapeutics, LLC

Completed

BCG and Plasma Amyloid in Non-Demented Adults

Alzheimer Disease, Late Onset

United States
PTC Therapeutics
Axio Research. LLC

Completed

Safety and Efficacy Study of EPI-743 in Children With Leigh Syndrome

Leigh Syndrome

United States
Columbia University
Grifols Therapeutics LLC

Completed

Intravenous Immunoglobulin (IVIG) in Lung Transplantation

Lung Transplantation | Hypogammaglobulinemia

United States
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Evaluate Efficacy and Safety of LIB003 in Patients on Lipid-Lowering Therapy Needing Additional LDL-C Reduction

LDL Cholesterol

United States
Silence Therapeutics plc

Recruiting

Study to Assess SLN124 in Patients With Polycythemia Vera (SLN)

Polycythemia Vera

United States, Australia, Malaysia, Bulgaria, Poland
Silence Therapeutics plc

Active, not recruiting

Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Cardiovascular Diseases | Atherosclerosis | Lipoprotein(a)

Australia, Czechia, Denmark, Netherlands, Slovakia, South Africa, United Kingdom
Silence Therapeutics plc

Withdrawn

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome

United Kingdom, Bulgaria
Silence Therapeutics plc

Completed

A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome | Very-Low Risk Myelodysplastic Syndrome

Thailand, Israel, Jordan, United Kingdom, Germany, Italy, Malaysia
Silence Therapeutics plc

Completed

A Phase 1 Study to Evaluate the Safety, Tolerability, PK and PD of SLN124 in Healthy Volunteers

Healthy Volunteers

United Kingdom
e-Therapeutics PLC

Completed

A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours

Solid Tumour

United Kingdom
e-Therapeutics PLC

Completed

Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD) (ETS6103-003)

Major Depressive Disorder

United Kingdom
e-Therapeutics PLC

Completed

Assessment of Single Doses of Oral Dexanabinol in Healthy Subjects

Cancer | Pharmacokinetics | Tolerability | Safety

United Kingdom
e-Therapeutics PLC

Unknown

A Study of Dexanabinol in Combination With Chemotherapy in Patients With Advanced Tumours

Hepatocellular Carcinoma | Pancreatic Cancer

Germany, Poland, Spain, United Kingdom
Phanes Therapeutics
Merck Sharp & Dohme LLC

Recruiting

PT886 For Treatment of Patients With Metastatic/Advanced Gastric, Gastroesophageal Junction and Pancreatic Adenocarcinoma (the TWINPEAK Study)

Pancreatic Ductal Adenocarcinoma | Gastric or Gastroesophageal Junction Adenocarcinoma

United States
Bicara Therapeutics
Merck Sharp & Dohme LLC

Recruiting

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Head and Neck Neoplasms | Carcinoma, Squamous Cell | Colorectal Cancer | Squamous Cell Carcinoma of Head and Neck | Epithelial Ovarian Cancer | Head and Neck Squamous Cell Carcinoma | Pancreas Cancer | Squamous Cell Carcinoma of the Lung | Cutaneous Squamous Cell Carcinoma | Squamous Cell Carcinoma of... and other conditions

United States, Canada
Jason Ahee, M.D.

Not yet recruiting

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Endophthalmitis

United States
Minneamrita Therapeutics LLC
Translational Drug Development

Recruiting

A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors (Minnelide 101)

Breast Cancer | Gastric Cancer | Pancreatic Cancer | Solid Tumor | Advanced Cancer | Colo-rectal Cancer | Prostate Cancer Metastatic | Solid Carcinoma | Solid Carcinoma of Stomach | Cancer of Stomach

United States
Grifols Therapeutics LLC
Instituto Grifols, S.A.

Recruiting

Efficacy and Safety of Fanhdi®, a High-purity Von Willebrand Containing FVIII Concentrate, in Pediatric Patients With Von Willebrand Disease

Von Willebrand Disease

Spain
Eikon Therapeutics
Merck Sharp & Dohme LLC

Active, not recruiting

BDB001-101: Clinical Study of BDB001 as a Mono-therapy or in Combination With Pembrolizumab

Tumor, Solid

United States
Celldex Therapeutics
Merck Sharp & Dohme LLC

Completed

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Melanoma | Follicular Lymphoma | Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Pancreatic Adenocarcinoma | Ovarian Cancer | Fallopian Tube Cancer | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Lymphoplasmacytic Lymphoma | Non-Hodgkin Lymphoma | ... and other conditions

United States
Eikon Therapeutics
Merck Sharp & Dohme LLC

Active, not recruiting

Clinical Study of BDB018: Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Tumor, Solid

United States
Instituto Grifols, S.A.

Terminated

Study of the Efficacy and Safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in Patients With Post-polio Syndrome (FORCE)

Post-polio Syndrome

United States, Denmark, Spain, Germany, Poland, Canada, Czechia, Italy, Netherlands
Insight Therapeutics, LLC
Brown University; Seqirus

Completed

Adjuvanted Influenza Vaccination Year 2 Follow-On Survey

Influenza | Influenza, Human | Influenza-like Illness

United States
Cerebral Therapeutics LLC
Neuroscience Trials Australia

Completed

A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures

Epilepsy

Australia
Chemlmmune Therapeutics LLC
EURRUS Biotech GmbH

Completed

XC8 in the Treatment of Patients With the Eosinophilic Phenotype of Bronchial Asthma

Eosinophilic Asthma | Bronchial Asthma

Russian Federation
Instituto Grifols, S.A.

Completed

Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"

Liver Failure | Liver Cirrhosis

Spain
SPR Therapeutics, Inc.
NDI Medical, LLC

Completed

Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain

Shoulder Pain

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients

Hypercholesterolemia | Coronary Heart Disease

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of Mipomersen in Japanese Healthy Volunteers

Healthy Volunteer

Germany

Clinical Trials Sponsored by Constant Therapeutics LLC

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Chile

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Drug Interventions

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