Clinical Trials Sponsored by Dompé Farmaceutici S.p.A

Total 297 results

Dompé Farmaceutici S.p.A

Recruiting

Reparixin add-on Therapy to Std Care to Limit Progression in Pts With COVID19 & Other Community Acquired Pneumonia

Severe COVID-19 | Infectious Pneumonia

United States, Australia, Turkey, Argentina, Germany, Austria, Italy
Dompé Farmaceutici S.p.A

Terminated

Ascending Dose Tolerability Trial and PK Assessment in Healthy Volunteers After Single & Multiple Oral Intake of DF2755A

no Condition

France
Dompé Farmaceutici S.p.A

Completed

A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye

Dry Eye Syndrome

United States
Dompé Farmaceutici S.p.A

Completed

A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 Diabetes

Diabetes Mellitus, Insulin-Dependent

Germany, Belgium, Italy
Dompé Farmaceutici S.p.A

Completed

Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. (REPARO)

Keratitis | Neurotrophic Keratitis | Corneal Ulcer

Germany, Italy, France, Poland, Spain, United Kingdom
Dompé Farmaceutici S.p.A

Completed

A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) (Lumos)

Retinitis Pigmentosa

Italy
Dompé Farmaceutici S.p.A

Completed

A Single Dose Study About the Influence of Food on the Oral Bioavailability of Ladarixin Capsule in Healthy Volunteers

no Condition

Switzerland
Dompé Farmaceutici S.p.A

Completed

Multicenter Double Blind, Parallel-group Phase 2/3 Trial, to Study Raloxifene in Adult COVID-19 Patients.

SARS CoV 2 Infection

France, Spain, Italy
Dompé Farmaceutici S.p.A

Active, not recruiting

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (NGF0121 - PROTEGO-1 Study) (NGF0121)

Dry Eye

United States, Italy
Dompé Farmaceutici S.p.A

Completed

Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK

Neurotrophic Keratitis

United States
Dompé Farmaceutici S.p.A

Completed

A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Healthy Males

No Condition

United Kingdom
Dompé Farmaceutici S.p.A

Completed

Tolerability, Safety and Efficacy of Lubricin Eye Drops vs Sodium Hyaluronate Eye Drops in Subjects With Mod. Dry Eye

Dry Eye Syndrome | Tear Film Insufficiency

Italy
Dompé Farmaceutici S.p.A

Completed

Tolerability, Safety and Efficacy of Lubricin (150 µg/ml) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops in Patients With Moderate Dry Eye (DE)

Dry Eye Syndrome

Italy
Dompé Farmaceutici S.p.A

Recruiting

A Study to Evaluate Safety and Efficacy of a New Formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution in Patients With Dry Eye Disease (REDUCO)

Dry Eye Disease

United States, Italy
Dompé Farmaceutici S.p.A

Recruiting

Add-on Reparixin in Adult Patients With ARDS

Acute Respiratory Distress Syndrome, Adult

United States, Germany, Italy
Dompé Farmaceutici S.p.A

Withdrawn

To Assess Efficacy and Safety of Oral Reparixin in Patients With Fatigue and Locally Advanced / Metastatic Breast Cancer

Fatigue | Locally Advanced or Metastatic Breast Cancer

United States, Italy, Germany
Dompé Farmaceutici S.p.A

Active, not recruiting

A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function

New-onset type1 Diabetes

United States, Belgium, Georgia, Germany, Italy, Serbia, Israel, Slovenia
Dompé Farmaceutici S.p.A

Terminated

Reparixin in COVID-19 Pneumonia - Efficacy and Safety

Severe Pneumonia

Brazil, Italy
Dompé Farmaceutici S.p.A

Completed

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (NGF0221)

Dry Eye Syndrome

United States, Italy
Dompé Farmaceutici S.p.A

Terminated

Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes. (CONSERVA)

Type 1 Diabetes

Italy
Dompé Farmaceutici S.p.A

Withdrawn

Ladarixin as Adjunctive Therapy to Improve Insulin Sensitivity and Glucometabolic Outcomes in Type 1 Diabetes

Type I Diabetes

United States
Dompé Farmaceutici S.p.A

Completed

Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation

Pancreatectomy for Chronic Pancreatitis

United States, Canada
Dompé Farmaceutici S.p.A

Completed

Study on Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients With Severe COVID-19 Pneumonia.

Pneumonia, Viral

United States, Italy
Dompé Farmaceutici S.p.A

Terminated

Pilot Study to Evaluate Safety & Biological Effects of Orally Administered Reparixin in Early Breast Cancer

Breast Cancer

United States
Dompé Farmaceutici S.p.A

Completed

An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye

Dry Eye

United States
Dompé Farmaceutici S.p.A

Completed

Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation

Lung Transplantation | Ischemia-Reperfusion Injury

United States
Dompé Farmaceutici S.p.A

Recruiting

DEFENDO Long Term Follow-up Study in Stage 1 NK Patients (DEFENDO)

Neurotrophic Keratitis

United States
Dompé Farmaceutici S.p.A

Completed

A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo (KSL0117)

Acute Pain

Russian Federation
Dompé Farmaceutici S.p.A

Completed

A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery

Ocular Discomfort

Italy
Dompé Farmaceutici S.p.A

Completed

Clinical Trial of Efficacy and Safety of Levopront® 30 mg/5 ml in Patients With Dry Cough (LDP0114)

Cough

Russian Federation
Dompé Farmaceutici S.p.A

Completed

Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation

Kidney Diseases | Ischemia-Reperfusion Injury

United States, France, Italy, Spain
Dompé Farmaceutici S.p.A

Completed

Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation (REP0211)

Islet Transplantation in Diabetes Mellitus Type 1

United States, Czechia, Italy, Sweden, United Kingdom
Dompé Farmaceutici S.p.A

Terminated

A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.

New-onset Type 1 Diabetes

United States, Belgium, Georgia, Germany, Italy, Serbia
Dompé Farmaceutici S.p.A

Terminated

Pilot Efficacy and Safety Study of Oral DF2156A in Patients With Active Bullous Pemphigoid

Bullous Pemphigoid

Germany, Italy
Dompé Farmaceutici S.p.A

Completed

Reparixin in Pancreatic Islet Transplantation

Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus

Italy, Germany
Dompé Farmaceutici S.p.A

Completed

A 2 Weeks Study to Evaluate Tolerability, Safety, Permanence on the Ocular Surface and Efficacy of Two Concentrations of Lubricin Eye Drops Versus Sodium Hyaluronate 0.18% Eye Drops in Patients With Ocular Discomfort Following Refractive Surgery

Ocular Discomfort

Italy
Dompé Farmaceutici S.p.A

Completed

Pilot Study of Reparixin for Early Allograft Dysfunction Prevention in Liver Transplantation

Early Allograft Dysfunction | Ischemia-reperfusion Injury in Liver Transplant

Belarus, Russian Federation
Dompé Farmaceutici S.p.A
Dompé US

Completed

Study to Evaluate OXERVATE™ in Patients With Stage 1 Neurotrophic Keratitis (DEFENDO)

Neurotrophic Keratitis

United States
Dompé Farmaceutici S.p.A
Cromsource

Completed

Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers

Healthy Volunteers

United States
Dompé Farmaceutici S.p.A
Covance

Completed

Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers (NGF0112)

Healthy

Switzerland, United Kingdom
Dompé Farmaceutici S.p.A
Cromsource

Completed

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma (NGF-Glaucoma)

Glaucoma

United States
Dompé Farmaceutici S.p.A
Cross Research S.A.

Completed

Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye

Dry Eye Syndrome

Austria
Dompé Farmaceutici S.p.A
PRA Health Sciences

Completed

Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC)

Metastatic Breast Cancer

United States
Dompé Farmaceutici S.p.A
Cross Research S.A.

Completed

Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup

Bronchitis

Switzerland
Ospedale San Raffaele
Dompé Farmaceutici S.p.A

Completed

Nerve Growth Factor Eye Drops Treatment in Patients With Retinitis Pigmentosa and Cystoid Macular Edema (NEMO)

Retinitis Pigmentosa | Cystoid Macular Edema

Italy
Dompé Farmaceutici S.p.A
Cross Research S.A.

Completed

Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution

Pain Disorders

Switzerland
Tufts Medical Center
Dompé Farmaceutici S.p.A

Enrolling by invitation

QST for Corneal Nerve Function

Neurotrophic Keratitis | Neuropathy | Dry Eye Disease | Corneal Disease

United States
Tufts Medical Center
Dompé Farmaceutici S.p.A

Withdrawn

NGF Treatment for Patients With Neuropathic Corneal Pain

Neuropathy | Corneal Disease

United States
Dompé Farmaceutici S.p.A
PRA Health Sciences

Completed

A Double-blind Study of Paclitaxel in Combination With Reparixin or Placebo for Metastatic Triple-Negative Breast Cancer (FRIDA)

Metastatic Breast Cancer

United States, Spain, Belgium, Italy, France, Czechia, Poland
Icahn School of Medicine at Mount Sinai
Dompé Farmaceutici S.p.A

Recruiting

Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium (MPN-RC 120)

Myelofibrosis (PMF) | Post Essential Thrombocythemia Myelofibrosis (ET-MF) | Post Polycythemia Vera Related Myelofibrosis (PV-MF)

United States

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