Clinical Trials Sponsored by Melinta Therapeutics, LLC

Total 454 results

Melinta Therapeutics, LLC

Recruiting

Open-Label, Dose-Finding, Pharmacokinetics, Safety and Tolerability Study of Oritavancin in Pediatric Patients With Suspected or Confirmed Bacterial Infections

Gram Positive Bacterial Infections

United States
Melinta Therapeutics, LLC

Recruiting

Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin

Acute Bacterial Skin and Skin Structure Infection

United States, Spain, Greece, Portugal, Bulgaria, Latvia, Romania, Lithuania, Poland
Hartford Hospital
Melinta Therapeutics, LLC

Not yet recruiting

Rezafungin PK in Patients on ECMO

Sepsis

United States
Melinta Therapeutics, Inc.

Completed

Open Label Study Evaluating the Effects of a Single Oritavancin Infusion on Cytochrome P450 in Healthy Volunteers (DDI)

Healthy

United States
Melinta Therapeutics, Inc.

Completed

Multiple Oritavancin Doses on Safety, Tolerability, and Pharmacokinetics in Healthy Subjects

Healthy

United States
Melinta Therapeutics, Inc.

Completed

Oritavancin Versus IV Vancomycin for the Treatment of Participants With Acute Bacterial Skin and Skin Structure Infection (SOLO I) (SOLO I)

Abscess | Cellulitis | Wound Infection | Systemic Inflammation

United States
Melinta Therapeutics, Inc.

Completed

Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection (SOLO II)

Abscess | Cellulitis | Wound Infection | Systemic Inflammation

United States
Melinta Therapeutics, Inc.

Completed

Delafloxacin Versus Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Skin and Subcutaneous Tissue Bacterial Infections

United States, Croatia, Israel, Latvia, Russian Federation, Spain, Ukraine
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy Study of Single-Dose Oral CEM-101 in Patients With Uncomplicated Urogenital Gonorrhea

Uncomplicated Urogenital Gonorrhea

United States
Melinta Therapeutics, Inc.

Completed

Study to Evaluate the Effect of Delafloxacin on the Pharmacokinetics of Midazolam in Healthy Subjects

VA Drug Interactions

United States
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy Study of Oxazolidinone to Treat Pneumonia

Community-Acquired Pneumonia (CAP)

Canada, United States, Russian Federation
Melinta Therapeutics, Inc.

Completed

A Study to Assess the Cardiac Safety of Oritavancin in Healthy Participants

Healthy

United States
Melinta Therapeutics, Inc.

Completed

Drug-Drug Interaction Potential of Orbactiv (Oritavancin) Co-Administered With Warfarin in Healthy Subjects

Healthy

United States
Melinta Therapeutics, Inc.

Completed

Relative Exposure and Safety Study of Kimyrsa in ABSSSI Patients

Acute Bacterial Skin and Skin Structure Infection

United States
Melinta Therapeutics, Inc.

Completed

Study to Compare Delafloxacin to Moxifloxacin for the Treatment of Adults With Community-acquired Bacterial Pneumonia (DEFINE-CABP)

Community Acquired Bacterial Pneumonia

United States, Argentina, Bulgaria, Colombia, Dominican Republic, Georgia, Germany, Hungary, Latvia, Peru, Poland, Romania, Russian Federation, Serbia, Slovenia, South Africa, Spain, Ukraine
Melinta Therapeutics, Inc.

Completed

A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections

Skin and Subcutaneous Tissue Bacterial Infections

United States
Melinta Therapeutics, Inc.

Completed

Evaluate Safety and Pharmacokinetic To Assess Bronchopulmonary Disposition of Intravenous Delafloxacin in Healthy Adults

Pneumonia

United States
Melinta Therapeutics, Inc.

Completed

A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Orbactiv® (Oritavancin) for Infections Caused by Gram Positive Bacteria in a Real World Setting

Gram-Positive Bacterial Infections

United States
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy of Solithromycin in the Treatment of Nonalcoholic Steatohepatitis Without Cirrhosis

Nonalcoholic Steatohepatitis

United States
Melinta Therapeutics, Inc.

Completed

Efficacy and Safety Study of Oral Solithromycin (CEM-101) Compared to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia (SOLITAIRE-ORAL)

Community-acquired Bacterial Pneumonia

Spain, United States, Hungary, Canada, Estonia, Russian Federation, Argentina, Bulgaria, Czech Republic, Dominican Republic, Ecuador, Germany, Latvia, Poland, Puerto Rico, Romania, South Africa
Melinta Therapeutics, Inc.

Completed

Efficacy and Safety Study of Intravenous to Oral Solithromycin (CEM-101) Compared to Intravenous to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia (SOLITAIRE-IV)

Community-acquired Bacterial Pneumonia

Spain, United States, Philippines, Taiwan, Canada, Germany, Poland, Russian Federation, Argentina, Bulgaria, South Africa, Slovenia, Serbia, Colombia, Hungary, Netherlands, Slovakia, Ukraine, Peru, Latvia, Guatemala, Romania, Chile, G... and more
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections

Staphylococcal Skin Infections | Bacterial Skin Diseases | Skin Structure Infections

United States, Puerto Rico
Melinta Therapeutics, Inc.

Withdrawn

A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (TANGOIII)

Hospital-Acquired Bacterial Pneumonia | Ventilator-Associated Bacterial Pneumonia | Hospital-Acquired Pneumonia | Ventilator-Associated Pneumonia
Melinta Therapeutics, Inc.

Terminated

Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea

Gonorrhea

United States
Melinta Therapeutics, Inc.

Completed

Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Skin and Subcutaneous Tissue Bacterial Infections | Skin Structures and Soft Tissue Infections

United States, Argentina, Brazil, Bulgaria, Chile, Estonia, Georgia, Hungary, Korea, Republic of, Latvia, Mexico, Moldova, Republic of, Peru, Romania, Slovakia, Taiwan
Melinta Therapeutics, Inc.

Completed

Efficacy and Safety Study of Oral CEM-101 Compared to Oral Levofloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia

Community-Acquired Bacterial Pneumonia

United States, Canada
Melinta Therapeutics, Inc.

Completed

Pharmacokinetics of Delafloxacin in Subjects With and Without Hepatic Impairment

Hepatic Impairment

United States
Melinta Therapeutics, Inc.

Completed

Safety and Efficacy Study of Oxazolidinones to Treat Uncomplicated Skin Infections

Streptococcal Infections | Abscess | Staphylococcal Skin Infections | Infectious Skin Diseases | Bacterial Skin Diseases

United States
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Department of Health and Human Services

Recruiting

Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections (TANGOKIDS)

Bacterial Infections

United States
Rempex (a wholly owned subsidiary of Melinta Therapeutics...

Completed

Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae

Bacteremia | Acute Pyelonephritis | Ventilator-associated Bacterial Pneumonia | Hospital Acquired Bacterial Pneumonia | Urinary Tract Infection, Complicated

Italy, United States, Greece, United Kingdom
Rempex (a wholly owned subsidiary of Melinta Therapeutics...

Completed

A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World Setting

Gram-Negative Bacterial Infections

United States
Imperial College London
Melinta Therapeutics, Inc.

Terminated

A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United Kingdom
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Innovative Medicines Initiative; Universitätsklinikum Köln

Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin (Minocycline) for Injection in Healthy Adults

Normal Healthy Volunteers

Netherlands
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Innovative Medicines Initiative; Universitätsklinikum Köln

Terminated

Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency

Renal Insufficiency, Chronic | Healthy Subjects | Renal Insufficiency, Acute

Germany
APRINOIA Therapeutics, LLC

Active, not recruiting

Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

Healthy Volunteers | Alzheimer's Disease | Mild Cognitive Impairment Due to Alzheimer's Disease

United States
APRINOIA Therapeutics, LLC

Active, not recruiting

A First-in-Human Study to Assess Single Doses of APNmAb005 in Healthy Participants

Alzheimer Disease | Tauopathies | Healthy Volunteers

United States
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Department of Health and Human Services

Completed

Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults

Bacteremia | Acute Pyelonephritis | Ventilator-associated Bacterial Pneumonia | Urinary Tract Infection Complicated | Hospital Acquired Bacterial Pneumonia | Abdominal Infection

Italy, United States, Colombia, Greece, Israel, Brazil, Argentina, United Kingdom
Rise Therapeutics LLC

Not yet recruiting

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

Melanoma | Basal Cell Carcinoma | Squamous Cell Carcinoma | Melanoma Recurrent | Squamous Cell Cancer | Basal Cell Cancer
Rise Therapeutics LLC

Not yet recruiting

R-2487 in Patients With Sjogren's Syndrome (SS) (R-2487-SS-01)

Sjogren's Syndrome | Sjögren | Sjögren Syndrome, Unspecified
Constant Therapeutics LLC

Recruiting

TXA127 in Non-Ambulant Patients With DMD Cardiomyopathy

DMD-Associated Dilated Cardiomyopathy

Israel
Rise Therapeutics LLC

Recruiting

R-2487 in Patients With Rheumatoid Arthritis (R-2487-RA01)

Arthritis, Rheumatoid

United States
Cerevel Therapeutics, LLC

Recruiting

A Study to Evaluate Efficacy, Safety, and Tolerability of Darigabat in Participants With Panic Disorder

Panic Disorder

United States
Olatec Therapeutics LLC

Recruiting

Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

Arthritis | Joint Pain | Gout | Gout Flare | Gouty Arthritis | Acute Gout Flare | Gout Attack

United States, Spain, France
Minneamrita Therapeutics LLC

Recruiting

Minnelide Along With Abraxane Plus Gemcitabine in Patients With Metastatic Adenocarcinoma of the Pancreas

Metastatic Adenocarcinoma of the Pancreas

Korea, Republic of
Cloudbreak Therapeutics, LLC

Recruiting

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

Pterygium

United States, China, India, Australia, New Zealand
Cerevel Therapeutics, LLC

Recruiting

A Study to Evaluate Safety and Tolerability of CVL-231 (Emraclidine) in Adult Participants With Schizophrenia

Schizophrenia

United States, Bulgaria, Hungary, Puerto Rico, Ukraine
Cerevel Therapeutics, LLC

Recruiting

A Trial of 15 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia

Schizophrenia

United States, Bulgaria, Hungary
Rapa Therapeutics LLC

Recruiting

RAPA-201 Therapy of Solid Tumors

Breast Cancer | Head and Neck Cancer | Gastric Cancer | Solid Tumor | Bladder Cancer | Triple Negative Breast Cancer | Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Malignant Melanoma | Carcinoma of Unknown Primary | Squamous Cell Carcinoma of Larynx | Squamous Cell Carcinoma of Oral Cavity | Squamous Cell Carcinoma of Nasopharynx and other conditions

United States
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
Expression Therapeutics, LLC

Not yet recruiting

Hematopoietic Stem Cell Transplantation Gene Therapy for Treatment of Severe Hemophilia A

Hemophilia A

Clinical Trials Sponsored by Melinta Therapeutics, LLC

Sponsors and Collaborators

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CROs in Lithuania

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