Clinical Trials Sponsored by National Institutes of Health (NIH)

Total 35513 results

National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of Oral Alpha-Cyclodextrin for Decreasing Serum Cholesterol

Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignancies

Hematologic Malignancies | Bone Marrow Transplant Rejection

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Rilonacept to Improve Artery Function in Patients With Atherosclerosis

Coronary Artery Disease | Inflammation | Atherosclerosis | Endothelial Dysfunction

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Screening for Inherited Heart Disease

Heart Disease | Hypertrophic Cardiomyopathy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Long Term Effects of Enalapril and Losartan on Genetic Heart Disease

Myocardial Ischemia | Hypertrophic Cardiomyopathy | Left Ventricular Hypertrophy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia

Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease

Coronary Arteriosclerosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Muscle Abnormalities in Patients With Specific Genetic Mutations

Cardiomyopathy, Hypertrophic | Muscular Dystrophy, Oculopharyngeal

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Magnetic Resonance Imaging to Detect Blood Vessel Inflammation in Patients Undergoing Peripheral Balloon Angioplasty

Atherosclerosis | Peripheral Vascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Medical Treatment for Diamond Blackfan Anemia

Hematologic Disease | Fanconi's Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women

Hypercholesterolemia | Postmenopause

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Lipoprotein Metabolism in Normal Volunteers and Patients With Abnormal Levels of Lipoproteins

Healthy | Hyperlipoproteinemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Hormone Replacement Therapy on Inflammation and Stiffening of Artery Walls

Healthy | Atherosclerosis | Vascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol

Hypertension | Hypercholesterolemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential Hypertension

Hypertension

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle

Hypertrophic Cardiomyopathy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM)

Leiomyomatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of Echocardiographic Techniques in Diagnosis of Coronary Artery Disease

Coronary Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Vitamin Replacement in Abetalipoproteinemia

Abetalipoproteinemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Miconazole on Blood Flow

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery

Renal Artery Obstruction | Kidney Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure

Hypertension | Hyperaldosteronism

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Investigation Into the Use of Ultrasound Technique in the Evaluation of Heart Disease

Healthy | Hypertrophic Cardiomyopathy | Left Ventricular Hypertrophy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia

Heart Diseases | Metabolism, Inborn Errors

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety and Dosing Evaluation of REG1 Anticoagulation System

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Magnetic Resonance Imaging of Narrowed Arteries

Arteriosclerosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Effect of Exercise on Stem Cell Mobilization and Heart Function in Patients Undergoing Cardiac Rehabilitation

Coronary Arteriosclerosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

MRI Evaluation of Chest Pain

Myocardial Infarction | Coronary Disease | Chest Pain

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Collection of Liver Tissue for Virologic Studies

Virus Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

Hemoglobinuria, Paroxysmal

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation

Hyperinsulinemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease

Congenital Heart Defect

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers

Purpura, Thrombocytopenic, Idiopathic | Immune Thrombocytopenic Purpura

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Treatment of T-Large Granular Lymphocyte (T-LGL) Lymphoproliferative Disorders With Cyclosporine

Anemia | Thrombocytopenia | Neutropenia | Leukemia, T-Cell | Lymphocytosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

United States
Oregon Social Learning Center
National Institute on Drug Abuse (NIDA); National Institute of Mental Health...

Completed

Prevention Program for Problem Behaviors in Girls in Foster Care

Drug Abuse | Juvenile Justice Involvement

United States
University of California, San Francisco
National Institute of Mental Health (NIMH); Kenya Medical Research Institute

Active, not recruiting

Enhanced Virologic Monitoring for Pregnant and Postpartum Women With HIV

HIV Infections | Pregnancy Related | Viremia

Kenya
Friends Research Institute, Inc.
National Institute of Mental Health (NIMH); University of California, Los Angeles

Completed

Depression Intervention Among Gay and Bisexual Men Receiving Treatment for Methamphetamine Use

Depression | HIV/AIDS | Methamphetamine Abuse

United States
National Cancer Institute (NCI)

Not yet recruiting

A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and Toxicity

Carcinoma, Neuroendocrine | Tumor, Neuroendocrine | Tumors, Neuroendocrine | Neuroendocrine; Carcinoma | Small Cell; Receptors

United States
National Cancer Institute (NCI)

Recruiting

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Gastrointestinal Cancer | Genitourinary Cancer | Metastatic Solid Cancers

United States
National Cancer Institute (NCI)

Recruiting

Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer

Endometrial Cancer | Endometrial Carcinoma | Cancer of Endometrium | Carcinoma of Endometrium

United States
National Cancer Institute (NCI)

Not yet recruiting

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

Squamous Cell Carcinoma of the Head and Neck | Drug Therapy | Oropharynx | Human Papillomavirus Viruses | Cancer Vaccine

United States
National Cancer Institute (NCI)

Not yet recruiting

Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART) Such as Small Cell, Adenocarcinoma, and Squamous Cell Bladder/Urinary Tract Cancer, Renal Medullary Carcinoma and Penile Cancer

Squamous Cell Carcinoma of the Penis | Renal Medullary Carcinoma | Squamous Cell Carcinoma of the Bladder | Small Cell Carcinoma of the Bladder | Small Cell Carcinoma of the Urinary Tract | Squamous Cell Carcinoma of the Urinary Tract | Primary Adenocarcinoma of the Bladder | Primary Adenocarcinoma...

United States
National Cancer Institute (NCI)

Recruiting

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

Metastatic Colorectal Cancer

United States
National Cancer Institute (NCI)

Not yet recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Metastatic Melanoma | Locally Advanced Melanoma | Metastatic Alveolar Soft Part Sarcoma | Metastatic Non Small Cell Lung Cancer | Metastatic Hepatocellular Carcinoma | Locally Advanced Hepatocellular Carcinoma | Metastatic Small Cell Lung Cancer | Locally Advanced Non Small Cell Lung Cancer | Locally... and other conditions

United States
National Cancer Institute (NCI)

Not yet recruiting

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

Adenocarcinoma of the Bladder | Squamous Cell Carcinoma of the Bladder | Testicular Germ Cell Tumors

United States
National Cancer Institute (NCI)

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation With JSP191-Based Conditioning in Participants With GATA2 Deficiency

Immunodeficiency | GATA2

United States

Clinical Trials Sponsored by National Institutes of Health (NIH)

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CROs in United Arab Emirates

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