Clinical Trials Sponsored by National Human Genome Research Institute (NHGRI)

Total 516 results

Duke University
National Human Genome Research Institute (NHGRI)

Not yet recruiting

Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase (GRACE)

Liver Diseases | Cardiovascular Diseases | Cancer | Hyperthermia

United States
Duke University
National Human Genome Research Institute (NHGRI)

Active, not recruiting

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Depression Trial) (ADOPT PGx)

Depression

United States
Indiana University
National Human Genome Research Institute (NHGRI)

Completed

A Prospective Trial to Assess Cost and Clinical Outcomes of a Clinical Pharmacogenomic Program (INGenious)

Adverse Drug Reaction

United States
Kaiser Permanente
National Human Genome Research Institute (NHGRI)

Completed

Clinical Implementation of Carrier Status Using Next Generation Sequencing (NextGen)

Genetic Disorders

United States
Stanford University
National Human Genome Research Institute (NHGRI)

Recruiting

Precision Diets for Diabetes Prevention

Diabetes Mellitus, Type 2 | Insulin Resistance | Pre Diabetes

United States
Duke University
National Human Genome Research Institute (NHGRI)

Active, not recruiting

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Chronic Pain Trial) (ADOPT PGx)

Chronic Pain

United States
Duke University
National Human Genome Research Institute (NHGRI)

Active, not recruiting

A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial) (ADOPT PGx)

Acute Pain

United States
Geisinger Clinic
National Human Genome Research Institute (NHGRI)

Active, not recruiting

Pediatric Reporting of Adult-Onset Genomic Results

Lynch Syndrome | Familial Hypercholesterolemia | Hereditary Breast and Ovarian Cancer Syndrome

United States
Boston University
National Human Genome Research Institute (NHGRI)

Completed

Communicating Risk Information for Obesity

Obesity

United States
Mayo Clinic
National Human Genome Research Institute (NHGRI)

Completed

Myocardial Infarction Genes (MI-GENES) Study (MI-GENES)

Myocardial Infarction | Coronary Artery Disease | Genomic Risk Communication

United States
National Human Genome Research Institute (NHGRI)
National Cancer Institute (NCI)

Completed

Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma

Melanoma (Skin)

United States
National Human Genome Research Institute (NHGRI)
National Cancer Institute (NCI)

Completed

Study of the Results of Education and Counseling for Persons Undergoing Genetic Testing for Hereditary Nonpolyposis Colon Cancer

Colorectal Cancer

United States
Boston Children's Hospital
National Human Genome Research Institute (NHGRI)

Active, not recruiting

Overcoming Barriers to Accessing Genetic Medicine

Genetic Disease | Genetic Predisposition

United States
University of Florida
National Human Genome Research Institute (NHGRI)

Completed

Implementing Genomics in Practice (IGNITE) Proof of Concept Study: Genotyping in Family Medicine Clinics (IGNITE)

Pain

United States
University of Florida
National Human Genome Research Institute (NHGRI)

Recruiting

CHOICES3: Sickle Cell Disease Parenting CHOICES (CHOICES3)

Sickle Cell Disease | Sickle Cell Trait

United States
Coral Genomics, Inc.
National Human Genome Research Institute (NHGRI)

Terminated

Predicting Medication Response for Autoimmune Disease (REEF)

Rheumatoid Arthritis | Psoriasis | Crohn's Disease | Ulcerative Colitis

United States
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Completed

Genetic Risk: Whether, When, and How to Tell Adolescents

Huntington Disease | Hereditary Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Non-polyposis Colon Cancer | Hereditary Non-Polyposis Colorectal Cancer Syndrome

United States
University of Florida
National Human Genome Research Institute (NHGRI)

Recruiting

Trial of Preemptive Pharmacogenetics in Underserved Patients (ToPP-UP)

Pharmacogenetic Testing | Use of Prescription Medications

United States
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Enrolling by invitation

Clinical Trial of the Sequence of Cardiovascular Genetic Counseling and Testing (RESEQUENCEGC)

Genetic Counseling | Inherited Cardiac Disease

United States
Selecta Biosciences, Inc.
National Human Genome Research Institute (NHGRI)

Suspended

A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 in Pediatric Subjects With MMA (reiMMAgine)

Methylmalonic Acidemia (MMA)

United States
National Institute on Aging (NIA)
National Human Genome Research Institute (NHGRI)

Completed

Risk Evaluation and Education for Alzheimer's Disease (REVEAL) II

Alzheimer Disease

United States
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)

Completed

Risk Evaluation and Education for Alzheimer's Disease (REVEAL I)

Alzheimer's Disease

United States
Brigham and Women's Hospital
National Human Genome Research Institute (NHGRI)

Completed

REVEAL III: Risk Evaluation and Education for Alzheimer's Disease (REVEAL)

Alzheimer Disease

United States
University of Maryland, Baltimore
National Human Genome Research Institute (NHGRI)

Terminated

KCNQ1 Cascade Screening

Long QT Syndrome

United States
Boston University
National Human Genome Research Institute (NHGRI); Northeastern University

Completed

Using Virtual Counselors to Overcome Genetic Literacy Barriers (VICKY)

Stroke | Diabetes | Cancer | Heart Disease
Georgetown University
National Cancer Institute (NCI); National Human Genome Research Institute (NHGRI)

Completed

Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2)

United States
National Human Genome Research Institute (NHGRI)

Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic Disease | Purine-Pyrimidine Metabolism | AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2 | UNG, OMIM *191525, Hyper-IgM Syndrome 5 | NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency | UMPS, OMIM *613891, Orotic Aciduria | DHODH, OMIM *126064,... and other conditions

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Study of Skeletal Disorders

Skeletal Disorders

United States
National Human Genome Research Institute (NHGRI)

Recruiting

MK-7075 (Miransertib) in Proteus Syndrome

Proteus Syndrome

United States
National Human Genome Research Institute (NHGRI)

Recruiting

New Technology and Child Health

Healthy Volunteers

United States
National Human Genome Research Institute (NHGRI)

Recruiting

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

Mitochondrial Disorders | Leigh Disease | Oxidative Phosphorylation Deficiencies | Electron Transport Chain Disorders, Mitochondrial

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Analysis of Specimens From Individuals With Pulmonary Fibrosis

Pulmonary Fibrosis | Healthy Volunteers | Hermansky-Pudlak Syndrome (HPS)

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Study of Chediak-Higashi Syndrome

Chediak-Higashi Syndrome

United States
National Human Genome Research Institute (NHGRI)

Active, not recruiting

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENE-FORECAST): Sodium Intervention Trial (SIT)

Cardiovascular Disease

United States
National Human Genome Research Institute (NHGRI)

Completed

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History Study

Heart Disease

United States
National Human Genome Research Institute (NHGRI)

Active, not recruiting

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Healthy Volunteers | Atherosclerotic Heart Disease

United States
National Human Genome Research Institute (NHGRI)

Completed

Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

Breast Cancer | Colon Cancer

United States
National Human Genome Research Institute (NHGRI)

Completed

Patient Provider Communication and Interaction in a Virtual Clinical Setting

Healthy Volunteer

United States
National Human Genome Research Institute (NHGRI)

Completed

New Approaches for Empowering Studies of Asthma in Populations of African Descent

Asthma

United States
National Human Genome Research Institute (NHGRI)

Enrolling by invitation

Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations

Cardiovascular Disease | Diabetes

United States
Mayo Clinic
National Institutes of Health (NIH); National Human Genome Research Institute...

Completed

Return of Actionable Variants Empirical Study (RAVE)

Familial Hypercholesterolemia
National Human Genome Research Institute (NHGRI)

Completed

A Study of the Genetic Analysis of Brain Disorders

Holoprosencephaly

United States
National Human Genome Research Institute (NHGRI)

Completed

Genetics of Type 2 Diabetes Among Han Chinese

Hypertension | Diabetes

China
National Human Genome Research Institute (NHGRI)

Completed

Personalized Genomic Research

Genetics | Birth Defects | Genetic Disease | Genetic Linkage | Genetic Variation

United States
National Human Genome Research Institute (NHGRI)

Completed

Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus

Diabetes | Genetic Variation

Norway, Finland
National Human Genome Research Institute (NHGRI)

Completed

Family Myopia Study

Myopia

United States
National Human Genome Research Institute (NHGRI)

Completed

The Genetic Basis of Acquired Heart Disease in Africa

Acquired Heart Disease | Rheumatic Heart Disease | Rheumatic Fever | Endomyocardial Fibrosis

Uganda, Nigeria
National Human Genome Research Institute (NHGRI)

Completed

Analysis of Data From the Women's Contraceptive and Reproductive Experiences (CARE) Study

Breast Cancer

United States
National Human Genome Research Institute (NHGRI)

Completed

The Experience of Caregivers of Children With Down Syndrome

Down Syndrome

United States
National Human Genome Research Institute (NHGRI)

Completed

Adaptation and Quality of Life Among Adults With Neurofibromatosis Type I

Neurofibromatosis Type 1 | NF1 | Von Recklinghausen Disease

United States

Clinical Trials Sponsored by National Human Genome Research Institute (NHGRI)

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