Clinical Trials Sponsored by NuCana plc

Total 11443 results

Luciana Almeida Moreira da Paz Oliveira

Completed

Evaluation of Swallowing in Patients With Obstructive Sleep Apnea

Sleep Apnea, Obstructive

Brazil
Overture Life
New Hope Fertility Center; Clinica Juana Crespo

Recruiting

Overture Metabolomics Non-Selection Study

Infertility

United States, Spain
USANA Health Sciences
Elegant And Olive Health Clinic, Canada

Completed

An Evaluation of Proglucamune in the Treatment of Protective Qi Insufficiency

Protective Qi Insufficiency

Canada
Nova Therapeutics LLC
Chinese PLA General Hospital

Recruiting

CART-PSMA Cells for Advanced Prostate Cancer

Prostate Cancer

China
MEDA Pharma GmbH & Co. KG
ClinResearch, GmbH; Trio Clinical Research, LLC, Raleigh, USA; NuCara Pharmacy... and other collaborators

Completed

Relative Potency of Formoterol Novolizer® 12 µg Compared to Formoterol Aerolizer® 12 µg

Asthma

United States
Pega-One S.A.S.
ICON plc

Withdrawn

Imgatuzumab in Patients With Advanced Cutaneous Squamous Cell Carcinoma (I-PACE)

Cutaneous Squamous Cell Carcinoma
MaxWell Clinic, PLC

Recruiting

Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19

Long COVID

United States
Oculis
ICON plc

Recruiting

Study of the Efficacy and Safety of OCS-01 Eye Drops in Subjects With Diabetic Macular Edema (DIAMOND-2)

Diabetic Macular Edema

United States
Gedeon Richter Plc.

Recruiting

Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome

Prader-Willi Syndrome

United States, Spain, Czechia, Italy, France
Adaptimmune
ICON plc

Recruiting

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Melanoma | Head and Neck Cancer | Esophageal Cancer | Ovarian Cancer | Endometrial Cancer | Urothelial Cancer | Gastric (Stomach) Cancer | Esophagogastric Junction (EGJ) | Non-small Cell Lung (NSCLC)

United States, Canada, Spain, Belgium
Silence Therapeutics plc

Completed

A Study Investigate the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Response of SLN124 in Adults With Alpha/Beta-thalassaemia and Very Low- and Low-risk Myelodysplastic Syndrome

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome | Very-Low Risk Myelodysplastic Syndrome

Thailand, Israel, Jordan, United Kingdom, Germany, Italy, Malaysia
Destiny Pharma Plc

Completed

Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection

Staphylococcal Infections | Surgical Site Infection

United States, Serbia, Georgia
Imperial Brands PLC

Completed

A Randomised, Cross-over, Relative Bioavailability Study of Nicotine Delivery and Nicotine Extraction From Oral Products

Healthy Volunteers

Sweden
Silence Therapeutics plc

Completed

A Phase 1 Study to Evaluate the Safety, Tolerability, PK and PD of SLN124 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Imperial Brands PLC

Completed

A Randomised, Cross-Over, Nicotine Pharmacokinetic and Pharmacodynamic Study of Heated Tobacco Products Compared to Combustible Cigarettes

Healthy Volunteers

United Kingdom
4D pharma plc

Completed

A Trial for New Treatment of Adult Participants With Irritable Bowel Syndrome

Irritable Bowel Syndrome

United States, United Kingdom, Ireland
Verona Pharma plc

Completed

Bronchodilator Effect of RPL554 Administered in Addition to Tiotropium/Olodaterol in Patients With COPD

COPD

United States, United Kingdom
GlaxoSmithKline
ICON plc

Completed

Study of Subjects With Diabetic Foot Ulcer (DFU)

Diabetic Foot

United States
e-Therapeutics PLC

Completed

A Phase 1 Study of Dexanabinol in Patients With Advanced Solid Tumours

Solid Tumour

United Kingdom
e-Therapeutics PLC

Completed

Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD) (ETS6103-003)

Major Depressive Disorder

United Kingdom
e-Therapeutics PLC

Completed

Assessment of Single Doses of Oral Dexanabinol in Healthy Subjects

Cancer | Pharmacokinetics | Tolerability | Safety

United Kingdom
e-Therapeutics PLC

Unknown

A Study of Dexanabinol in Combination With Chemotherapy in Patients With Advanced Tumours

Hepatocellular Carcinoma | Pancreatic Cancer

Germany, Poland, Spain, United Kingdom
Destiny Pharma Plc

Completed

Study to Assess Eradication of Nasal Carriage of Staphylococcus Aureus (SA) With Mupirocin (Bactroban 2% Nasal Ointment)

Staphylococcal Infection

United Kingdom
Verona Pharma plc

Completed

SAD/MAD Study of a New Formulation of Nebulised RPL554 in Healthy Subjects and COPD Subjects

Chronic Obstructive Pulmonary Disorder | Inflammatory Disorder of the Respiratory Tract

United Kingdom
Gedeon Richter Plc.

Completed

A Study Aimed at Assessing the Pharmacokinetic Properties of RGB-10 and Forsteo

Healthy

United Kingdom
Gedeon Richter Plc.

Completed

A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults

Healthy Volunteers; | Obese, Otherwise Healthy Volunteers

United Kingdom
AstraZeneca
ICON plc

Recruiting

Observational Study Protocol: LIVER-R (LIVER-R)

Hepatobiliary Cancers

United States, Germany, Italy
Imperial Brands PLC

Recruiting

Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products

Healthy Volunteers

United Kingdom
MaxWell Clinic, PLC

Recruiting

Impact of Therapeutic Plasma Exchange on RNA Biomarker Expression Levels in Alzheimer's Patients

Alzheimer Disease

United States
Silence Therapeutics plc

Recruiting

Study to Assess SLN124 in Patients With Polycythemia Vera (SLN)

Polycythemia Vera

United States, Australia, Malaysia, Bulgaria, Poland
Gedeon Richter Plc.

Recruiting

Efficacy and Safety of Cariprazine in the Treatment of Adolescent Participants (13 to 17 Years of Age) With Schizophrenia

Schizophrenia

Mexico, United States, Bulgaria, Colombia, Romania, Russian Federation, Serbia, Ukraine
Adaptimmune
ICON plc

Terminated

ADP-A2M4CD8 in HLA-A2+ Subjects With MAGE-A4 Positive Esophageal or Esophagogastric Junction Cancers (SURPASS-2)

Esophageal Cancer | Esophagogastric Junction Cancer

United States, Canada, United Kingdom, Spain, France
4D pharma plc

Terminated

A Study of MRx-4DP0004 in Asthma

Asthma

United States, United Kingdom
Silence Therapeutics plc

Active, not recruiting

Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Cardiovascular Diseases | Atherosclerosis | Lipoprotein(a)

Australia, Czechia, Denmark, Netherlands, Slovakia, South Africa, United Kingdom
Gedeon Richter Plc.

Completed

Comparative Efficacy and Safety Study of RGB-14-P and Prolia® in Women With Postmenopausal Osteoporosis

Postmenopausal Osteoporosis

Poland, United States, Spain, Hungary, Italy, Czechia, Bulgaria, Ukraine
Herantis Pharma Plc.

Active, not recruiting

Clinical Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema (AdeLE) (AdeLE)

Secondary Lymphedema

Finland, Sweden
4D pharma plc

Terminated

A Study of Live Biotherapeutic Product MRx0518 With Hypofractionated Radiation Therapy in Resectable Pancreatic Cancer

Pancreatic Cancer

United States
Imperial Brands PLC

Active, not recruiting

A Relative Bioavailability Study of Nicotine Delivery From Selected Oral Nicotine Products

Healthy Volunteers

Sweden
Herantis Pharma Plc.

Terminated

A Phase I Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema

Secondary Lymphedema

Finland
Poolbeg Pharma plc

Completed

Effects of p38 MAPK Inhibitor POLB 001 on in Vivo LPS Challenge Responses

Influenza, Human

Netherlands
Silence Therapeutics plc

Withdrawn

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Non-transfusion-dependent Thalassemia | Low Risk Myelodysplastic Syndrome

United Kingdom, Bulgaria
Verona Pharma plc

Completed

Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients

COPD

United Kingdom, Poland, Germany, Bulgaria, Czechia, Romania
Verona Pharma plc

Completed

The Effects of RPL554 in Addition to Tiotropium in COPD Patients

Chronic Obstructive Pulmonary Disease Moderate
Imperial Brands PLC

Completed

A Study to Evaluate the Safety Profile of an e-Vapour Product

Healthy Volunteers

United Kingdom
Destiny Pharma Plc

Completed

Study of the Nasal Decolonisation of Staphylococcus Aureus (SA) and the Safety and Tolerability of XF-73 Nasal Gel in Healthy Subjects

Staphylococcus Aureus Infection

United Kingdom
Verona Pharma plc

Completed

Comparison of RPL554 With Placebo and Salbutamol in Asthmatic Patients

Asthma

Sweden, United Kingdom
USANA Health Sciences
Roseman University of Health Sciences

Completed

The Effects of an Oral Probiotic Intervention With or Without a Novel ADP-1 Toothpaste

Oral Health

United States
Faculdade de Motricidade Humana
CIDEFES - Universidade Lusofona; Força Aerea Portuguesa

Recruiting

Fatigue in Air Search and Rescue Missions

Fatigue Syndrome, Chronic

Portugal
Faculdade de Motricidade Humana
Centro de Alto Rendimento do Jamor

Not yet recruiting

"Living Low - Training High" Methods and Physiological Responses in Well-trained Swimmers

Hypoventilation | Normoxia | Normobaric Hypoxia

Portugal
Redx Pharma Plc

Completed

A Study to Assess Efficacy of RXC004 +/- Nivolumab in Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer After Progression on Standard of Care (SOC)

Colorectal Cancer

Spain, Korea, Republic of, United Kingdom, United States

Clinical Trials Sponsored by NuCana plc

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