Clinical Trials Sponsored by Optos, PLC

Total 11336 results

HepQuant, LLC

Terminated

The HepQuant SHUNT Test for Monitoring Liver Disease and Treatment Effects by Measuring Liver Function and Physiology

NASH - Nonalcoholic Steatohepatitis

United States
Squarex, LLC

Terminated

A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis

Herpes Labialis | HSV

United States
Ethicon, LLC

Completed

The SURGICEL® Powder Mild or Moderate Parenchymal or Soft Tissue Intraoperative Bleeding (China Study)

Hemorrhage

China
MedImmune LLC

Completed

A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Type 2 Diabetes Mellitus

Netherlands, Sweden
Somahlution LLC

Active, not recruiting

EU Multicenter Registry to Assess Outcomes in CABG Patients: Treatment of Vascular Conduits With DuraGraft [VASC] (VASC)

Cardiovascular Diseases | Coronary Artery Disease

Spain, Austria, Ireland, Switzerland, Germany, Italy, Turkey, United Kingdom
Stimgenics LLC

Completed

Stimgenics Open-Label, Post Market Study (SGX-SCS-RCT)

Chronic Low Back Pain

United States
Bioventus LLC

Enrolling by invitation

Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk (BONES)

Mitigation of Fracture Non-union in Patients at Risk

United States
Epico, LLC

Completed

Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts

Cataract

United States
MedImmune LLC

Completed

Study to Evaluate the Safety and Pharmacokinetics of MEDI9090 in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

United States, Japan
MedImmune LLC

Terminated

A Study of Carboplatin and Paclitaxel With or Without MEDI-575 in Untreated, Advanced Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States, Canada, Japan, Poland, Germany, Hungary, France
PTC Therapeutics

Completed

Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS) (EPI-589)

Amyotrophic Lateral Sclerosis

United States
MedImmune LLC

Completed

Safety and Tolerability of MEDI3506 in Healthy Participants, in Participants With COPD and Healthy Japanese Participants

Part I (SAD) - Healthy Participants | Part II (MAD) - Chronic Obstructive Pulmonary Disease | Part III (J-SD) - Healthy Japanese Participants

United Kingdom
Pharmacyclics LLC.

Completed

A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Chronic Lymphocytic Leukemia | Small-Cell Lymphoma

United States, Australia, Austria, Belgium, Canada, Czechia, France, Israel, Italy, New Zealand, Poland, Russian Federation, Spain, Sweden, Turkey, United Kingdom
Austarpharma, LLC

Unknown

Bioequivalence Study of Oseltamivir Phosphate and TAMIFLU Under Fed Condition in Healthy Volunteers

Bioequivalence

United States
HemoSonics LLC

Completed

QStat in Trauma and Obstetric Hemorrhage

Trauma | Post Partum Hemorrhage | Blood Loss Massive

United States
MedImmune LLC

Terminated

A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses

Healthy Volunteers

United Kingdom
PTC Therapeutics

Completed

Study of Ataluren in ≥2 to <5 Year-Old Male Participants With Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United States
PTC Therapeutics

Terminated

An Extension Study of Ataluren (PTC124) in Participants With Nonsense Mutation Dystrophinopathy

Nervous System Diseases | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Musculoskeletal Diseases | Muscular Diseases | Neuromuscular Diseases | Muscular Dystrophies | Muscular Disorders, Atrophic | Muscular Dystrophy, Duchenne

United States, Spain, Korea, Republic of, Belgium, France, Canada, Australia, United Kingdom, Israel, Italy, Germany, Brazil, Bulgaria, Chile, Czechia, Poland, Sweden, Switzerland, Turkey
Umbulizer LLC

Completed

Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation

Respiratory Failure | Respiratory Insufficiency | Respiratory Arrest

Pakistan
HemoSonics LLC

Completed

Reference Range Study for the Quantra QStat System

Coagulation Disorder

United States
MedImmune LLC

Completed

MEDI5083 Alone and in Combination With Durvalumab, Tremelimumab, and/or Docetaxel.

Advanced Solid Tumors

United States, Australia
HemoSonics LLC

Completed

Pre-surgical Evaluation for the Quantra System in Adult Patients Undergoing Cardiac Surgery

Blood Loss, Surgical

United States
HemoSonics LLC

Completed

HemoSonics - UTMB Cardiac Surgery Study

Blood Loss, Surgical

United States
PHARMENTERPRISES LLC

Completed

Study to Assess Safety, Tolerability and Pharmacokinetics of Treamid in Healthy Volunteers

Metabolic Syndrome
MedImmune LLC

Completed

Study of MEDI-573 Plus Standard Endocrine Therapy for Women With Hormone-sensitive Metastatic Breast Cancer

Hormone-sensitive, HER-2 Negative Metastatic Breast Cancer

Spain, United States, Belgium, France, United Kingdom, Canada, Israel, Germany, Hungary, Poland, Bahamas
PTC Therapeutics

Completed

Phase 2B Study of PTC124 (Ataluren) in Duchenne/Becker Muscular Dystrophy (DMD/BMD)

Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

United States, Germany, Spain, Sweden, Canada, Italy, Australia, Belgium, France, Israel, United Kingdom
MedImmune LLC

Completed

A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

United States, Germany, Spain, Canada, France, Korea, Republic of, Israel, Netherlands, United Kingdom
MedImmune LLC

Withdrawn

Evaluation of the Safety and Efficacy of a Monoclonal Antibody to Treat Influenza

Influenza
MedImmune LLC

Completed

Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes

Type 2 Diabetes Mellitus

Hungary, Germany, United Kingdom
OmegaD LLC

Completed

Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease

Dry Eye

United States
PharmPak, LLC

Unknown

Multicenter Study to Evaluate Efficacy, Tolerability, Safety of Derinat

Respiratory Infections in Children

Russian Federation
HemoSonics LLC

Completed

Evaluation of the Clinical Performance of the Quantra System With the QStat Cartridge

Trauma | Hemorrhage, Postpartum | Blood Loss Massive

United States
MedImmune LLC

Completed

A Study to Evaluate MEDI0562 in Combination With Immune Therapeutic Agents in Adult Subjects With Advanced Solid Tumors

Select Advanced Solid Tumors

United States, France, Netherlands
ivWatch, LLC

Completed

ivWatch SmartTouch Sensor: Device Validation for Non-Infiltrated Tissues

Infiltration of Peripheral IV Therapy

United States
Lumendi, LLC

Completed

A Double Balloon Endoscopic Platform for ESD

Colon Adenoma | Colon Polyp

United States
Berg, LLC

Completed

Safety Study of Sterile Compound C31510 for Injection to Subjects With Solid Tumors

Solid Tumors

United States
Biointegrator LLC

Terminated

Safety, Tolerability, PK and PD of Biosimilar Drug Ritumax® Compared to Original Drug MabThera®

Rheumatoid Arthritis

Russian Federation
Biointegrator LLC

Terminated

Open-label Study of Safety, Tolerability and Pharmacokinetics of Multiple Doses of BI-CON-02 in Patients With HER2-positive Metastatic Breast Cancer, Previously Treated With Trastuzumab

Metastatic Breast Cancer

Russian Federation
MedImmune LLC

Completed

A Phase 1/2 Study of MEDI4276 in Adults Subjects With Select HER2-expressing Advanced Solid Tumors. (MEDI4276)

HER2 Expressing Breast or Gastric/Stomach Cancers

United States
MDbackline, LLC

Completed

Satisfaction & Spectacle Independence With ReSTOR 2.5 & ReSTOR 3.0 IOLs

Cataract

United States
MedImmune LLC

Completed

Phase 1 Study to Evaluate MEDI4736 in Subjects With Myelodysplastic Syndrome

Myelodysplastic Syndrome

United States, United Kingdom, France, Germany
Synecor, LLC

Unknown

The Conveyor Study

Heart Failure | Mitral Valve Insufficiency | Mitral Valve Regurgitation | Mitral Valve Disease
MedImmune LLC

Completed

A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Germany
Regenexx, LLC

Withdrawn

Case Series on Using Bone Marrow Concentrate for Alar Ligament Injuries

Craniocervical Injuries

United States
Orsenix LLC

Completed

A Phase I, Two-part Study to Determine the Recommended Dose and Evaluate the Safety and Tolerability of a Novel Oral Arsenic Trioxide Formulation (ORH-2014) in Subjects With Advanced Hematological Disorders

Advanced Hematological Disorders

United States
MedImmune LLC

Completed

A Phase 1 Study to Evaluate MEDI6383 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors

Recurrent or Metastatic Solid Tumors

United States, Australia
Berg, LLC

Completed

Dose-Ranging Clinical Trial of Topical Creams Containing API 31510 for the Treatment of Superficial Basal Cell Carcinoma

Superficial Basal Cell Carcinoma

United States
MedImmune LLC

Completed

A Dose-escalation Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-573 in Subjects With Advanced Solid Tumors

Cancer

United States
MedImmune LLC

Completed

MEDI-573 in Combination With SOC in Unresectable or Metastatic HCC. (MEDI-573-1028)

Unresectable or Metastatic Hepatocellular Carcinoma (HCC)

United States
Asepticys LLC

Completed

A Safety and Effectiveness Study of a New Multi-Purpose Contact Lens Care Solution

Contact Lens Wear

United States

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