Clinical Trials Sponsored by Orphan Europe

Total 3055 results

Swedish Orphan Biovitrum
Amgen

Completed

Study to Evaluate Palifermin in the Reduction of Dysphagia in Patients With Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer | Lung Cancer | Dysphagia
Swedish Orphan Biovitrum
Amgen

Completed

Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer

Head and Neck Cancer | Mucositis | Stomatitis | Solid Tumors | Squamous Cell Carcinoma
Swedish Orphan Biovitrum
Amgen

Completed

Pharmacokinetic Study of Palifermin in Subjects Receiving Radiation Therapy and Chemotherapy Followed by Blood Stem Cell Support

Lymphoma | Leukemia | Myeloma
AOP Orphan Pharmaceuticals AG

Completed

A Pharmacokinetic, Pharmacodynamic, Safety Study With AOP LDLA202, ONO LDL50 and Esmolol in Healthy Volunteers

Healthy

Czech Republic
Amgen

Completed

Evaluating Kineret® (Anakinra) in Rheumatoid Arthritis (RA) Subjects Using aSelf-Reported Questionnaire

Rheumatoid Arthritis
Amgen

Completed

Evaluation of the Efficacy of Combination Treatment With Anakinra and Pegsunercept in Improving Rheumatoid Arthritis

Rheumatoid Arthritis
AOP Orphan Pharmaceuticals AG

Completed

Lancovutide (Moli1901) Inhalation Solution Study in Adolescents and Adults With Cystic Fibrosis

Cystic Fibrosis

Austria
Biosensors Europe SA
European Cardiovascular Research Center

Active, not recruiting

BioFreedom French Registry

Coronary Artery Disease

France
Biosensors Europe SA
European Cardiovascular Research Center

Completed

e-BioMatrix 6 Month DAPT France

Ischemia | Stable Angina | STEMI | NSTEMI - Non-ST Segment Elevation MI | Coronary Artery Stenoses
Biosensors Europe SA
European Cardiovascular Research Center

Unknown

A Randomized Clinical Evaluation of the BioFreedom™ Stent (Leaders Free)

Bleeding | Stable Angina | In-stent Coronary Artery Restenosis | Ischemic Heart Disease Silent | ST Elevation (STEMI) and Non-ST Elevation (NSTEMI) Myocardial Infarction

Switzerland
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Orphan...

Completed

Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria

Hyperoxaluria

United States
OrphAI Therapeutics

Recruiting

A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension

Pulmonary Hypertension

United States
OrphAI Therapeutics

Completed

A Study of LAM-003 in Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia | Oncology

United States
AOP Orphan Pharmaceuticals AG

Completed

Safety Study of Pegylated Interferon Alpha 2b to Treat Polycythemia Vera (PEGINVERA)

Polycythemia Vera

Austria
Swedish Orphan Biovitrum
Amgen

Completed

A Study of Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer Receiving Postoperative Radiotherapy and Concurrent Chemotherapy

Head and Neck Cancer | Mucositis
AOP Orphan Pharmaceuticals AG

Completed

Anagrelide Retard vs. Placebo: Efficacy and Safety in "At-risk" Patients With Essential Thrombocythaemia (ARETA)

Essential Thrombocythaemia

Poland, Slovakia, Bulgaria, Russian Federation, Romania, Croatia, Lithuania, Austria, Ukraine
AOP Orphan Pharmaceuticals AG

Completed

Anagrelide Retard in Essential Thrombocythemia (TEAM-ET)

Essential Thrombocythemia

Austria, Bulgaria, Lithuania, Poland, Russian Federation
AOP Orphan Pharmaceuticals AG

Completed

Long-term PK and Safety/Tolerability Testing LDLL600 Against Esmolol in Healthy Volunteers

Healthy

Czech Republic
Swedish Orphan Biovitrum
Amgen

Completed

Palifermin for the Reduction of Oral Mucositis in Single-dose Evaluation (PROMISE)

Lymphoma | Leukemia | Cancer
Swedish Orphan Biovitrum
Amgen

Completed

Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation

Hematologic Malignancies | Graft Versus Host Disease
AOP Orphan Pharmaceuticals AG

Completed

Anagrelide vs. Hydroxyurea - Efficacy and Tolerability Study in Patients With Essential Thrombocythaemia (ANAHYDRET)

Essential Thrombocythaemia

Austria, Czech Republic, France, Germany, Hungary, Italy, Lithuania, Poland, Singapore, Slovenia
Swedish Orphan Biovitrum
Amgen

Withdrawn

A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Locally Advanced Head and Neck Cancer Receiving Postoperative Radiotherapy

Head and Neck Cancer
Orpha Labs

Unknown

Study of ORL-1M (D-mannose) in Patients With CDG-Ib

CDG Ib

Turkey
Orpha Labs

Unknown

Study of ORL-1G (D-galactose) in Patients With Glycogen Storage Disease Type 14

Glycogen Storage Disease, Type 14

Turkey
Orpha Labs

Completed

Study of ORL-1B in Patients With Biotinidase Deficiency

Biotinidase Deficiency
Swedish Orphan Biovitrum
Cerner Enviza

Completed

Impact on French Physician's Haemophilia Treatment Management Decision Based on Systematic Joint Examination (A-MOVE)

Hemophilia A

France
Swedish Orphan Biovitrum
Cerner Enviza

Completed

rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia A

Hemophilia A With Inhibitor

France, Ireland, Italy, Norway, Germany, Kuwait, Saudi Arabia, Switzerland
Vicore Pharma AB
Orphan Reach

Completed

Safety and Efficacy of C21 in Subjects With COVID-19

COVID-19

India, United Kingdom
Orpha Labs

Completed

Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II

Leukocyte Adhesion Deficiency, Type II
Swedish Orphan Biovitrum
Syneos Health

Recruiting

A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa (FREEDOM)

Hemophilia A, Severe

Italy, Ireland, Croatia, Greece, Spain, Sweden, Slovenia, United Kingdom, France, Germany, Norway, Austria, Czechia, Netherlands, Belgium
Northwell Health
Swedish Orphan Biovitrum

Recruiting

Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease

Meniere's Disease | Autoimmune Inner Ear Disease

United States
Orphan Medical
Johns Hopkins University

Completed

Physiological, Behavioral and Subjective Effects of Drugs (GHB)

Sedative Abuse

United States
Vicore Pharma AB
Orphan Reach

Completed

Safety, Efficacy and Pharmacokinetics of C21 in Subjects With IPF

Idiopathic Pulmonary Fibrosis

United Kingdom, India, Ukraine, Russian Federation
Swedish Orphan Biovitrum
Cerner Enviza

Active, not recruiting

An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B (B-MORE)

Hemophilia B

Czechia, Greece, Ireland, Italy, Norway, Saudi Arabia, Spain, Sweden, United Kingdom
Swedish Orphan Biovitrum
Cerner Enviza

Completed

A Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B in France (B-SURE)

Haemophilia B

France
Swedish Orphan Biovitrum
ICON plc

Completed

Prospective, Non-interventional Study to Evaluate the Effectiveness of Elocta Compared to Conventional Factor Products

Hemophilia A

France, Italy, Norway, Sweden, United Kingdom, Austria, Belgium, Finland, Spain
Swedish Orphan Biovitrum
Apellis Pharmaceuticals, Inc.

Recruiting

Evaluate the PK Efficacy Safety and Tolerability of Pegcetacoplan in Patients With Thrombotic Microangiopathy

Transplant-Associated Thrombotic Microangiopathy

United States, France, Greece, Italy, Spain
University Hospital, Bonn
Swedish Orphan Biovitrum

Recruiting

Sonography and Haemophilia

Haemophilia | Sonography

Germany
Swedish Orphan Biovitrum
Bioverativ Therapeutics Inc.

Completed

Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies (ReITIrate)

Hemophilia A

Ireland, United Kingdom, Germany, United States, Canada, Slovenia, Sweden
FDA Office of Orphan Products Development

Completed

An Implant for Hearing Loss Due to Removal of Neurofibromatosis 2 Tumors

Neurofibromatosis 2

United States
FDA Office of Orphan Products Development

Completed

Risk-adapted Therapy for Primary Systemic (AL) Amyloidosis

Amyloidosis
FDA Office of Orphan Products Development

Completed

Keratinocyte Growth Factor to Prevent Acute GVHD

Graft-vs-Host Disease

United States
Orphalan

Recruiting

Real World Evidence Study in Subjects With Wilson's Disease (REASON)

Wilson Disease

United States
Swedish Orphan Biovitrum
IQVIA Pvt. Ltd

Terminated

An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog Alfa (JOIN-us)

Hemophilia A | Hemophilia B

Bulgaria, Croatia, Czechia, France, Hungary, Ireland, Italy, Romania, Slovenia, Spain, United Kingdom
Oslo University Hospital
Swedish Orphan Biovitrum

Completed

Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum (TvsCH)

Chemotherapy-induced Nausea and Vomiting | Chemotherapy Effect | Chemotherapeutic Toxicity | Ovarian Neoplasm | Chemotherapy-induced Neutropenia
Swedish Orphan Biovitrum
Richmond Pharmacology Limited

Terminated

Safety and Tolerability of SOBI002 in Healthy Volunteers Following Single and Repeated Administration

Healthy

United Kingdom
FDA Office of Orphan Products Development

Completed

Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine

Guillain-Barre Syndrome

United States
FDA Office of Orphan Products Development

Completed

Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation

Pneumonia | Bronchiolitis Obliterans | Respiratory Distress Syndrome, Adult

United States
Lynkcell Europe

Enrolling by invitation

Phase I Clinical Trials Investigating the Potential Efficacy of Axitinib in Patients With a BRCA 1/2 Mutations

Breast Cancer | Breast Neoplasms | Ovarian Neoplasms | Ovarian Cancer | HER2-positive Breast Cancer | HER2-negative Breast Cancer | HER-2 Protein Overexpression | BRCA Mutation

Ukraine
Metagenics Europe

Terminated

Evaluation of a Nutraceutical for Endometriosis Pain Relief

Endometriosis

Belgium

Clinical Trials Sponsored by Orphan Europe

Sponsors and Collaborators

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