Clinical Trials Sponsored by Wellcome Trust

Total 6226 results

Portsmouth Hospitals NHS Trust

Suspended

A Pilot Study to Characterise Saliva and Sputum FTIR Spectral Profiles in Patients With COPD During Exacerbations and When Stable (SPIT-D)

Chronic Obstructive Pulmonary Disease

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

The Value of Polyp Surface Pattern Recognition in the Identification of Neoplasia: a Prospective Study

Colonic Polyps

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Assessment of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device (Inflammacheck™) in Patients With Interstitial Lung Disease, Lung Cancer and Healthy Volunteers. (EXHALE 1B)

Lung Cancer | Interstitial Lung Disease

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Feasibility Study Using the CoronaCheck Device to Identify Incident Cases of SARS CoV-2 Covid-19

SARS-CoV Infection

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Cross Sectional, Diagnostic Accuracy Study to Validate the Use of a New Device(Inflammacheck™) in Diagnosing COPD (EXHALE 1V)

COPD Exacerbation

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

DRIVE - Perioperative Period (DRIVE-Periop)

Diabetes Mellitus | Surgical Procedure, Unspecified

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Eosinophilic Granulomatosis With Polyangiitis Cohort (EGPA Cohort)

Churg-Strauss Syndrome

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Epiretinal Membrane and Cystoid Macular Oedema Post-cataract Surgery (EPIC)

Epiretinal Membrane | Pseudophakic Cystoid Macular Oedema

United Kingdom
Royal Cornwall Hospitals Trust

Completed

CT Assessment of BMI in Endometrial Cancer Patients

Endometrial Cancer

United Kingdom
Devon Partnership NHS Trust

Completed

Sea Swimming for Treatment of Depression and Anxiety

Depression, Anxiety

United Kingdom
Vestre Viken Hospital Trust

Withdrawn

SlagSens (Effect of Tactile Stimulation After Stroke)

Stroke

Norway
Vestre Viken Hospital Trust

Terminated

Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture (thro-fract15)

Thromboembolism

Norway
Portsmouth Hospitals NHS Trust

Completed

Plenvu 1 - Questionnaire Study Exploring Patients Preference in Bowel Preparation Timings for Morning Colonoscopy

Bowel Disease

United Kingdom
Royal Cornwall Hospitals Trust

Completed

Urinary miRNA in Endometrial Cancer Study

Endometrial Cancer

United Kingdom
Royal Cornwall Hospitals Trust

Completed

A Retrospective Validations Microsatellite Instability (MSI) Testing v Mismatch Repair (MMR) in Gastric Adenocarcinoma

Gastric Cancer

United Kingdom
Royal Cornwall Hospitals Trust

Completed

Facial Hair, PPE and COVID-19 (FACIAL HAIR)

COVID | Safety Issues

United Kingdom
Medway Primary Care Trust

Completed

Surgical Consent During the COVID-19 Pandemic

Consent

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis (VIRTUOSO)

Ulcerative Colitis | Crohn's Colitis

United Kingdom
Somerset NHS Foundation Trust

Unknown

Prolonged Overnight Oximetry in Obstructive Sleep Apnoea (PROXIMO)

Obstructive Sleep Apnea
Portsmouth Hospitals NHS Trust

Completed

Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease (EXHALE 1A)

Asthma | COPD Exacerbation

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett's Oesophagus and Colorectal Polyps: The ELITE Study (ELITE)

Polyps | Barrett Esophagus

United Kingdom
Bedford Hospital NHS Trust

Unknown

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Xerostomia | Xerostomia Due to Radiotherapy | Xerostomia Due to Hyposecretion of Salivary Gland
Medway NHS Foundation Trust

Completed

A Long Term Follow up of Anterior Meshes for Recurrent Prolapse

Pelvic Organ Prolapse | Genital Diseases, Female

United Kingdom
St Stephens Aids Trust

Unknown

Targeted Clinical Strategies and Low Level Viraemia (LLV) in Boosted Protease Inhibitor Therapy

HIV

United Kingdom
St Stephens Aids Trust

Completed

A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS) Toxicity, to a Fixed Dose Combination of Tenofovir/Emtricitabine/Rilpivirine

HIV

United Kingdom
St Stephens Aids Trust

Completed

The Pharmacology/Aging Clinic (SSAT041)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.

HIV

United Kingdom
Vestre Viken Hospital Trust

Unknown

Maternal Metabolism and Pregnancy Outcomes in Obese Pregnant Women

Obesity | Pregnancy

Norway
Kingston Hospital NHS Trust

Unknown

The Effects of Serratus Plane Block Performed Under Direct Vision on Post-operative Pain in Breast Surgery

Breast Surgery | Post-operative Pain | Serratus Block
St Stephens Aids Trust

Completed

Atripla to Raltegravir Switch Study for CNS Toxicity (SSAT036)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Men Who Have Sex With Men (MSM) Neurocog 1&2 Study (MSM Neurocog)

HIV Related Neurocognitive Impairment

United Kingdom
St Stephens Aids Trust

Unknown

Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART) (SSAT039)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Pharmacokinetics of Tenofovir and Tenofovir-diphosphate, Emtricitabine and Emtricitabine-triphosphate, and Rilpivirine Once Daily Over 14 Days Following Drug Intake Cessation in Healthy Volunteers

HIV

United Kingdom
St Stephens Aids Trust

Completed

PK Switch Efavirenz to Maraviroc in Patients Initially Suppressed on an Efavirenz-containing Regimen (SSAT033)

HIV Infection

United Kingdom
St Stephens Aids Trust

Terminated

Impact of Maraviroc on the Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens

HIV Infections

United Kingdom
St Stephens Aids Trust

Completed

Raltegravir and Ezetimibe PK Study

HIV

United Kingdom
St Stephens Aids Trust

Completed

Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects

HIV

United Kingdom
Medway NHS Foundation Trust

Completed

Tension Free Vaginal Tape (TVT) Versus the Miniarc Sling

Urodynamic Stress Incontinence

United Kingdom
Medway NHS Foundation Trust

Unknown

Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding

Overactive Bladder Syndrome | Voiding Dysfunction

United Kingdom
African Malaria Network Trust

Unknown

Safety and Immunogenicity of 30 and 100 µg of GMZ2 in Gabonese Children Aged 1-5 Years

Malaria

Gabon
African Malaria Network Trust

Unknown

Safety and Immunogenicity of Apical Membrane Antigen 1 (PfAMA-1-FVO[25-545])

Malaria

Mali
London School of Hygiene and Tropical Medicine
University College, London; Wellcome Trust; National Institute for Health Research... and other collaborators

Not yet recruiting

SUNRISE CRT: Radio Intervention to Stimulate Early Child Development (SUNRISE)

Child Development

Burkina Faso
Imperial College London
London School of Hygiene and Tropical Medicine; Wellcome Trust; Medical Research... and other collaborators

Completed

Early Childhood Malaria Prevention With Maloprim in The Gambia

Malaria

Gambia
National Institute of Allergy and Infectious Diseases...
Glaxo Wellcome; Adams Laboratories

Withdrawn

Preventing Frequent Sinus Infections in HIV-Infected Patients

HIV Infections | Sinusitis

United States
The Leeds Teaching Hospitals NHS Trust
Cambridge University Hospitals NHS Foundation Trust; Nottingham University... and other collaborators

Completed

Hospital Onset Diarrhoea Investigation (HOODINI)

Diarrhea

United Kingdom
Vestre Viken Hospital Trust

Recruiting

Long vs Extended-short Nail When Treating Proximal Femur Fractures

Hip Fractures

Norway
Royal Cornwall Hospitals Trust

Recruiting

Virtual Reality Exercise Gaming in Patients Awaiting Bariatric Surgery

Bariatric Surgery | Prehabilitation

United Kingdom
Royal Cornwall Hospitals Trust

Enrolling by invitation

Simulation-based Stress Inoculation Training Study for UK Medical Professionals (SITS)

Stress | Stress, Psychological | Stress, Job

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Investigating Signal Change in Malignant and Non-malignant Pleural Effusions and asCitic Fluid Using fTiR Analysis (SPECTRA)

Ascites | Pleural Effusion

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Colonoscopy Outcome Database (COD)

Colonoscopy Procedures

United Kingdom

3

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