Search clinical trials for: AL-335

Total 54132 results

Alios Biopharma Inc.

Completed

First in Human Study of AL-335; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1

Chronic Hepatitis C

France, Moldova, Republic of, Georgia
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335

Renal Insufficiency

United States
Janssen Research & Development, LLC

Completed

Efficacy and Safety of Combinations of AL-335, Odalasvir (ODV) and Simeprevir (SMV) in the Treatment of Chronic Hepatitis C Infection

Hepatitis C, Chronic

Poland, Belgium, Germany, Spain, Canada, Singapore
Janssen Research & Development, LLC

Completed

Study to Investigate the Pharmacokinetics, Safety and Tolerability of Odalasvir and AL-335 in Healthy Japanese Participants

Healthy

United Kingdom
Janssen Research & Development, LLC

Withdrawn

A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Odalasvir and AL-335 Alone and in Combination With Simeprevir in Participants With Moderately Impaired Hepatic Function

Hepatic Impairment
Janssen Pharmaceutical K.K.

Completed

A Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Combination Treatment of AL-335, Odalasvir, and Simeprevir in Japanese Participants With Chronic Hepatitis C Genotype 1 or 2 Virus Infection, With or Without Compensated Cirrhosis Who Are Direct Acting Antiviral Treatment-naive

Hepatitis C, Chronic

Japan
Assistance Publique Hopitaux De Marseille

Unknown

Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination

Surgical Abortion

France
Ohio State University Comprehensive Cancer Center

Active, not recruiting

Ramucirumab and Pembrolizumab for the Treatment of EGFR Mutant Recurrent or Metastatic Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Recurrent Lung Non-Small Cell Carcinoma

United States
Alios Biopharma Inc.
Alexion

Completed

A Study to Evaluate the Effect of ACH-3102 and Simeprevir on AL-335 Pharmacokinetics in Healthy Volunteers

Chronic Hepatitis C

France
Janssen Research & Development, LLC

Completed

To Evaluate the Effects of Odalasvir and AL-335 With Simeprevir on the Single-Dose Pharmacokinetics of Ethinylestradiol and Drospirenone in Healthy Female Participants

Healthy

United States
Alios Biopharma Inc.

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335, Odalasvir, and Simeprevir

Chronic Hepatitis C

New Zealand, Moldova, Republic of, Mauritius, United Kingdom
Janssen Research & Development, LLC

Completed

Study to Investigate the Pharmacokinetic Interaction Between 2 Direct Acting Antiviral Agents Odalasvir and AL-335 and Between 3 Direct Acting Antiviral Agents Simeprevir, Odalasvir and AL-335 at Steady State in Healthy Japanese Participants

Healthy

United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Cardiac Safety of a Single Dose of AL-335 Administered on a Background of Simeprevir and Odalasvir and of Repeated Doses of Odalasvir Administered Alone in Healthy Participants

Healthy

United States
Baxalta now part of Shire

Active, not recruiting

Open-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With Hemophilia B

Hemophilia B

United States
Karyopharm Therapeutics Inc

Terminated

Trial of Safety and Tolerability of Oral Verdinexor (KPT-335) in Healthy Adults

Healthy

Australia
Alcon Research

Withdrawn

Safety and Efficacy of AL-15469A 0.5% / AL-6515 0.3% Ophthalmic Suspension for Treatment of Bacterial Conjunctivitis

Bacterial Conjunctivitis
Alios Biopharma Inc.

Completed

A Study to Assess the PK of AL-794 Formulations in Healthy Subjects

Influenza

United Kingdom
Western Galilee Hospital-Nahariya

Completed

Pivotal Study of the Al-Sense Study Protocol

Amniotic Fluid Leakage

United States, Israel
Alcon Research

Completed

Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa

Acute Otitis Externa
Alcon Research

Completed

Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa

Acute Otitis Externa
Janssen Research & Development, LLC

Terminated

Study to Assess the Relative Bioavailability of Fixed-Dose Combination (FDC) Tablet (Simeprevir, Odalasvir and AL-335) Compared With Single Agents Administered Together, and to Assess the Effect of Multiple-Dose Lansoprazole or Omeprazole on Single-Dose Pharmacokinetics of SMV, ODV, and AL-335 (FDC)

Healthy

United States
University of Copenhagen
VentriJect ApS; University of Southern Denmark

Completed

Changes in Peak Fat Oxidation and Aerobic Fitness During Pre-season in Sub-elite Football Players

Sub-elite Football Players

Denmark
University of California, San Francisco

Completed

Davunetide (AL-108) in Predicted Tauopathies - Pilot Study

Progressive Supranuclear Palsy | Corticobasal Degeneration Syndrome | Progressive Nonfluent Aphasia | Predicted Tauopathies, Including | Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17

United States
University of Alabama at Birmingham
Mobile County Health Deparment; Alabama Department of Public Health

Recruiting

Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama (COAST-AL)

HIV | HIV Testing | HIV Linkage to Care | HIV Treatment

United States
Alcon Research

Completed

A Phase II Study of AL-37807 to Treat Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Hospital General Universitario Elche

Unknown

RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm

Weight Loss
University of California, Los Angeles
Massachusetts General Hospital; Washington University School of Medicine; University... and other collaborators

Completed

A Multicenter Study of NAP (AL-108) in Schizophrenia (AL-108)

Schizophrenia

United States
Allon Therapeutics

Completed

Safety, Tolerability and Efficacy Study to Evaluate Subjects With Mild Cognitive Impairment

Mild Cognitive Impairment, So Stated

United States
IRCCS Policlinico S. Matteo

Recruiting

Daratumumab and Pomalidomide in Previously Treated Patients With AL Amyloidosis (DarPAL)

AL Amyloidosis

Italy
Semmelweis University

Completed

Study of the Choroidal and Retinal Thickness in Relation to Axial Length. (CHORAL)

Healthy

Hungary
Masonic Cancer Center, University of Minnesota

Completed

Gut Microbiota in Intestinal Barrier Damage in Acute Leukemia Patients Undergoing Inpatient Induction

Acute Leukemia | Chemotherapy-Induced Gut Barrier Damage

United States
University College, London

Completed

A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis (CATALYST)

Amyloidosis

United Kingdom
IRCCS Policlinico S. Matteo

Terminated

Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosis (EpiCardiAL)

Primary Amyloidosis of Light Chain Type

Italy
Heidelberg University
Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH

Completed

A Trial of Treatment With Lenalidomide-Melphalan-Dexamethasone in Patients With Primary (AL) Amyloidosis (LEOMEX)

Primary Amyloidosis

Germany
Nexcella Inc.

Not yet recruiting

Study of NXC-201 CAR-T in Patients With Light Chain (AL) Amyloidosis (NEXICART-2)

Light Chain (AL) Amyloidosis

United States
Alcon Research

Completed

24 Hour IOP Lowering Efficacy of AL-3789

Open-angle Glaucoma

United States
Alios Biopharma Inc.

Terminated

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Repeated Dosing Regimens of AL-794 in Healthy Volunteers

Healthy

United Kingdom
Allon Therapeutics

Completed

Study to Evaluate Safety, Tolerability, and Effect of AL208 on Mild Cognitive Impairment Following Coronary Artery Bypass Graft Surgery

Mild Cognitive Impairment

United States, Canada
Texas Christian University

Completed

Family Assessment Motivation, and Linkage Intervention (FAMLI) (FAMLI)

Mapping Enhanced Counseling (MEC) | Active Linkage (AL)

United States
AJ Vaccines A/S

Completed

Evaluation of Persistence of Immunity in 4-year-old Children Previously Immunised With IPV-Al AJV (Picovax®)

Poliomyelitis

Panama
Tufts Medical Center
National Institute on Aging (NIA)

Completed

Screening to Improve Survival in AL Amyloidosis

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
University of Tennessee Graduate School of Medicine

Completed

124I-p5+14 Injection Safety in Subjects With Systemic Amyloidosis

Systemic Amyloidosis

United States
University of Chicago

Completed

TMP-Visitas al Hogar (TMP-HV RCT)

Language Development

United States
Common Sense

Unknown

AL-SENSE 1-Step - Determination of Product Specificity (ROM)

PREMATURE RUPTURE OF MEMBRANES

Israel
Universidad Complutense de Madrid
Osteology Foundation

Recruiting

Partial-thickness/Non-advanced vs. Full-thickness/MCAT Tunnelling for the Treatment of Multiple Gingival Recessions (Tun_RCT)

Gingival Recession

Italy
Riphah International University

Completed

Effects of Al-Lisaan Urdu Digital Software for Self-Assessment and Treatment of Adult Stutters (Al-Lisaan)

Stuttering, Adult

Pakistan
Common Sense

Completed

Pivotal Study of the Rx Al-Sense Liner for Amniotic Fluid Leakage Screening (PRALS)

Amniotic Problems

United States
Northwestern University

Not yet recruiting

Anxiety Lowering and Deprescribing Through Emotion Regulation (ALDER)

Anxiety Disorders | Sleep Disturbance | Benzodiazepine Dependence
Tufts Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Smoldering Multiple Myeloma

United States
Alcon Research

Terminated

A Multicenter, Proof-Of-Concept Study Of Intravitreal AL-78898A In Patients With Geographic Atrophy (GA) Associated With Age-Related Macular Degeneration (AMD)

Geographic Atrophy

3

Subscribe