Search clinical trials for: ARID1A mutation; solid tumors; tazemetostat

Total 8744 results

Prisma Health-Upstate
Ipsen

Recruiting

Phase II Study of Tazemetostat in Solid Tumors Harboring an ARID1A Mutation

Solid Tumor | ARID1A Gene Mutation

United States
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

Solid Tumors | ER+ Breast Cancer | ARID1A Gene Mutation | Triple Negative Breast Cancer, TNBC | Small Cell Lung Cancer, SCLC

United States, China
Nuvectis Pharma, Inc.
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Recruiting

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

Ovarian Cancer | Ovarian Endometrioid Adenocarcinoma | Advanced Solid Tumor | Ovarian Clear Cell Carcinoma | Ovarian Clear Cell Adenocarcinoma | Ovarian Clear Cell Tumor | Ovarian Endometrioid Tumor | ARID1A Gene Mutation

United States, United Kingdom
M.D. Anderson Cancer Center

Recruiting

Nivolumab for the Treatment of Metastatic or Unresectable Solid Tumors With ARID1A Mutation and CXCL13 Expression

Metastatic Malignant Solid Neoplasm | Unresectable Solid Neoplasm

United States
Institut Bergonié
Epizyme, Inc.; AstraZeneca

Recruiting

Combining Epigenetic And Immune Therapy to Beat Cancer. (CAIRE)

Adult Solid Tumor | Advanced Solid Tumor | Advanced Pancreatic Adenocarcinoma | Advanced Colorectal Carcinoma | Advanced Soft-tissue Sarcoma

France
Epizyme, Inc.
Sponsor GmbH

Recruiting

A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Hepatic Impairment | Advanced Malignant Solid Tumor

France, Belgium, United States, Poland, Slovakia
National Cancer Institute (NCI)

Recruiting

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Malignant Glioma | Rhabdoid Tumor | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Ependymoma | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Solid Neoplasm | Recurrent... and other conditions

United States, Puerto Rico, Australia, Canada
Epizyme, Inc.

Enrolling by invitation

A Study to Assess the Long-term Safety of Tazemetostat (TRuST)

Advanced Solid Tumors | Mesothelioma | Synovial Sarcoma | Renal Medullary Carcinoma | Diffuse Large B-cell Lymphoma (DLBCL) | Follicular Lymphoma (FL) | Non-Hodgkin Lymphoma (NHL) | Epitheliod Sarcoma (ES)

United States, France, United Kingdom, Poland, Australia, Belgium, Ukraine
Epizyme, Inc.

Completed

A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

Synovial Sarcoma | Epithelioid Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumors (MRT) | Rhabdoid Tumors of the Kidney (RTK) | Atypical Teratoid Rhabdoid Tumors (ATRT) | Selected Tumors With Rhabdoid Features | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Poorly Differentiated... and other conditions

France, United States, Australia, Taiwan, Belgium, United Kingdom, Canada, Germany, Italy
Epizyme, Inc.

Completed

Study of Tazemetostat as Single Agent in Solid Tumors or B-cell Lymphomas and in Combination With Prednisolone in DLBCL

B-cell Lymphomas (Phase 1) | Advanced Solid Tumors (Phase 1) | Diffuse Large B-cell Lymphoma (Phase 2) | Follicular Lymphoma (Phase 2) | Transformed Follicular Lymphoma | Primary Mediastinal Large B-Cell Lymphoma

Australia, Canada, France, Germany, Italy, Poland, Taiwan, Ukraine, United Kingdom, United States
National Cancer Institute (NCI)
Children's Oncology Group

Active, not recruiting

Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)

Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Rhabdoid Tumor | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Ann Arbor Stage III Hodgkin Lymphoma | Ann Arbor Stage IV Hodgkin Lymphoma | Recurrent Ependymoma | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent... and other conditions

United States, Puerto Rico
Epizyme, Inc.

No longer available

Tazemetostat Expanded Access Program for Adults With Solid Tumors

Renal Cell Carcinoma | Malignant Mesothelioma | Chondrosarcoma | Synovial Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumor | Poorly Differentiated Chordoma | Malignant Rhabdoid Tumor of Ovary | Epithelioid Malignant Peripheral Nerve Sheath Tumor | Sinonasal Carcinoma | Spindle Cell Sarcoma | Epithelioid... and other conditions
Epizyme, Inc.

Completed

Open-Label, Multi-Center, Two-Part, Ph1 Study to Characterize the PKs of an Intravenous Micro-Dose of [14C]-Tazemetostat (EPZ 6438) and the ADME of an Oral [14C]-Labeled Dose of Tazemetostat in Subjects With B-Cell Lymphomas or Adv Solid Tumors

Follicular Lymphoma | Marginal Zone Lymphoma | Advanced Solid Tumors | Mantle-Cell Lymphoma | Diffuse Large B Cell Lymphoma | Primary Mediastinal Lymphoma

United Kingdom
Epizyme, Inc.

Completed

Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients

Mantle Cell Lymphoma | Marginal Zone Lymphoma | Advanced Solid Tumor | Diffuse Large B Cell Lymphoma | Primary Mediastinal Lymphoma

United States
Epizyme, Inc.

Completed

Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer

Solid Tumor | Mesothelioma | Rhabdoid Tumor | Hematologic Malignancy | Advanced Malignancies | Synovial Sarcoma | Renal Medullary Carcinoma | Diffuse Large B-Cell Lymphoma (DLBCL) | Follicular Lymphoma (FL) | Non-Hodgkin Lymphoma (NHL) | All Malignancies | Epithelioid Sarcoma (ES)

Spain, United States
Opna-IO LLC

Completed

A Study of PLX2853 in Advanced Malignancies.

Follicular Lymphoma | Small Cell Lung Cancer | Solid Tumor | Non-Hodgkin Lymphoma | Diffuse Large B Cell Lymphoma | Ovarian Clear Cell Carcinoma | Uveal Melanoma | Advanced Malignancies

United States
National Cancer Institute (NCI)

Withdrawn

Tazemetostat in Treating Patients With Metastatic or Unresectable Solid Tumors or B-Cell Lymphomas With Liver Dysfunction

Metastatic Malignant Solid Neoplasm | Unresectable Solid Neoplasm | Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma | Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma | Stage IV Hepatocellular Carcinoma AJCC... and other conditions

United States
Mayo Clinic

Recruiting

Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Sound Biopharmaceuticals Ltd.

Not yet recruiting

Study in Patients With Advanced Solid Tumors to Evaluate the Safety of FTL008.16

Solid Tumors

China
University Hospital, Basel, Switzerland

Not yet recruiting

Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors (ISCA-CHECK)

Advanced Solid Tumor

Switzerland
Sound Biopharmaceuticals Ltd.

Recruiting

Study in Patients With Advanced Solid Malignancies to Evaluate the Safety of FTL001

Solid Tumor

China
Fondazione IRCCS Istituto Nazionale dei Tumori,...
EHE Rare Cancer Charity UK

Recruiting

The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN) (EHE)

Sarcoma,Soft Tissue | Epithelioid Hemangioendothelioma

United Kingdom, Italy, Denmark, Spain, Sweden, Austria, Germany, France, Norway, Poland
Asan Medical Center

Not yet recruiting

Gut Microbiome Analysis in Organ Transplant Recipient

Microbial Colonization
Qilu Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors

Colorectal Cancer | Pancreatic Cancer | Solid Tumor | Non-small Cell Lung Cancer

China
Wuxi People's Hospital

Recruiting

Low-dose Chemotherapy Under Hypoglycaemia for the Treatment of Relapsed Refractory Advanced Solid Tumours

Solid Tumors, Adult

China
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Clinical Trial of BT02 in Patients With Advanced Solid Tumors (BT02)

Advanced Solid Tumor

China
Changzhou No.2 People's Hospital

Not yet recruiting

γδ T-PD-1 Ab Cells in the Treatment of Advanced Solid Tumors

Advanced Solid Tumor
CDR-Life AG

Not yet recruiting

First in Human Study of CDR404 in HLA-A*02:01 Participants With MAGE-A4 Expressing Solid Tumors

Select Advanced Solid Tumors
TOLREMO therapeutics AG

Recruiting

A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors (TT-CSP-001)

Cancer | Adult Solid Tumor | Advanced Solid Tumor | Adult Disease

Spain, Switzerland
University of Connecticut
Department of Health and Human Services (DHHS) Administration for Community... and other collaborators

Not yet recruiting

Evaluating an Enhanced Home-delivered Meal Program on Older Adults' Health and Well-being

Quality of Life | Food Insecurity | Loneliness | Diet, Healthy
Eli Lilly and Company
Loxo Oncology, Inc.

Not yet recruiting

A Study of LY4170156 in Participants With Selected Advanced Solid Tumors

Uterine Cervical Neoplasms | Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Ovarian Neoplasms | Endometrial Neoplasms | Triple Negative Breast Neoplasms | Pancreatic Neoplasm

United States
Constellation Pharmaceuticals

Not yet recruiting

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

Solid Tumor | Hematologic Malignancy | Advanced Malignancies
Multitude Therapeutics Inc.

Not yet recruiting

AMT-676 in Patients With Advanced Solid Tumors

Advanced Solid Tumors

Australia
Twinpig Biolab, Inc.

Not yet recruiting

Clinical Trial of TB511 in Advanced Solid Tumors

Hepatocellular Carcinoma | Colorectal Cancer | NSCLC | Prostate Cancer
Apollo Therapeutics Ltd

Not yet recruiting

A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

Colorectal Cancer | Pancreatic Adenocarcinoma | Ovarian Cancer | Prostate Cancer | Gastric Adenocarcinoma | Cholangiocarcinoma | Triple Negative Breast Cancer | Endometrial Adenocarcinoma | Appendiceal Adenocarcinoma
Grit Biotechnology

Recruiting

Autologous Tumor-Infiltrating Lymphocyte (GT307 Injection ) for Treatment of Patients With Solid Tumours

Solid Tumor, Adult

China
Rise Therapeutics LLC

Not yet recruiting

R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors

Melanoma | Basal Cell Carcinoma | Squamous Cell Carcinoma | Melanoma Recurrent | Squamous Cell Cancer | Basal Cell Cancer
Policlinico Hospital

Recruiting

Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation (REDOX-TX)

Transplantation | Ascorbic Acid Deficiency

Italy
858 Therapeutics, Inc.

Recruiting

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies (ERADIC8)

Breast Cancer | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Prostate Cancer | Endometrial Cancer | Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Advanced or Metastatic Solid Tumors | ER+ Breast Cancer | Castrate Resistant Prostate Cancer | BRCA Mutation

United States
Mayo Clinic

Not yet recruiting

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
MediLink Therapeutics (Suzhou) Co., Ltd.

Not yet recruiting

A Phase 1 Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Advanced Solid Tumors

Advanced Solid Tumors

China
Merck Sharp & Dohme LLC

Not yet recruiting

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Burkitt Lymphoma | Ewing Sarcoma | Neuroblastoma | Diffuse Large B-cell Lymphoma | B-cell Acute Lymphoblastic Leukemia
Merck Sharp & Dohme LLC

Not yet recruiting

A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01)

Neoplasm Metastasis
Fudan University

Recruiting

A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors

Solid Tumor

China
GenVivo, Inc.

Recruiting

Phase 1 Study of GEN2 in Patients With Advanced Solid Tumors

Solid Tumor, Adult

United States
Boston University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Not yet recruiting

Online Intervention for Transgender/Nonbinary Young Adults' Experiences With Alcohol and Romantic Relationships

Depression, Anxiety | Alcohol Use, Unspecified | Relationship, Social | Transgenderism

United States
Takeda

Not yet recruiting

A Study of TAK-853 in Adult Participants With Folate Receptor Alpha-Positive Advanced Ovarian Cancer And Other Solid Tumors

Ovarian Cancer | Solid Tumors
Genmab
BioNTech SE

Recruiting

Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy

Malignant Solid Tumor

Spain
Gazi University

Not yet recruiting

Return to School Adaptation Programme for Children With Cancer (web-based)

Lymphoma | Childhood Cancer | AML, Childhood | Solid Tumor, Childhood | ALL, Childhood

Turkey
Coherus Biosciences, Inc.

Not yet recruiting

A Study of CHS-1000 in Participants With Advanced or Metastatic Solid Tumors

Advanced or Metastatic Solid Tumors

Search clinical trials for: ARID1A mutation; solid tumors; tazemetostat

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