Search clinical trials for: Brain metabolism

Total 61785 results

Leiden University Medical Center
The Dutch Brain Foundation (funding)

Not yet recruiting

Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy (Clear-Brain)

Cerebral Amyloid Angiopathy
Zhujiang Hospital

Recruiting

The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy (CAIS-MT)

Vascular Diseases | Stroke | Cerebrovascular Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Ischemic Stroke | Stroke, Acute | Intracranial Arterial Calcification

China
Universitätsklinikum Hamburg-Eppendorf

Not yet recruiting

Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study, 2nd Wave (CLIMATE-II)

Depressive Disorder | Myocardial Infarction | Heart Failure | Stroke | Coronary Disease | Diabetes Mellitus, Type 2 | Renal Insufficiency | Diabetes Mellitus, Type 1 | Schizophrenia | Pulmonary Disease, Chronic Obstructive | Peripheral Nervous System Diseases | Anxiety Disorders | Ischemic Attack, Transient | Arrhythmias... and other conditions
Tisento Therapeutics

Not yet recruiting

A Phase 2b Study of Zagociguat in Patients With MELAS (PRIZM)

Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)

United States, Australia, Italy, Germany, Canada, United Kingdom
Petra Zimmermann
ETH Zurich; University of Luzern

Not yet recruiting

NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood (NapBiome)

Neurobehavioral Manifestations | Sleep Problem

Switzerland
Maastricht University Medical Center

Not yet recruiting

Effects of Ketone Monoesters on Brain Function

Cerebral Blood Flow | Cognitive Performance | Appetite Control | Brain Vascular Function | Brain Insulin Sensitivity

Netherlands
Alnylam Pharmaceuticals

Recruiting

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy (cAPPricorn-1)

Cerebral Amyloid Angiopathy

Canada
Erasme University Hospital

Not yet recruiting

Investigating Brain Insulin Resistance In Alzheimer Disease With IntraNasal Insulin : A Multimodal Neuroimaging Study (Memori³)

Alzheimer Disease | Mild Cognitive Impairment
GeneCradle Inc

Recruiting

Evaluation of the Safety and Efficacy of Late-onset Pompe Disease Gene Therapy Drug

Pompe Disease (Late-onset)

China
Johns Hopkins University
American Heart Association

Not yet recruiting

Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet

Epilepsy | Dyslipidemia
Lawson Health Research Institute
Greenstone Biosciences, Inc.

Not yet recruiting

iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease (INFERENCE)

Cardiovascular Diseases | Heart Failure | Cardiomyopathies | Congenital Heart Disease | Cerebrovascular Accident | Arrythmia | Cardiometabolic Syndrome
Jirair Krikor Bedoyan
Ultragenyx Pharmaceutical Inc

Recruiting

Triheptanoin for Children With Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency

Pyruvate Dehydrogenase Complex Deficiency

United States
Rigshospitalet, Denmark

Not yet recruiting

Evaluating the Efficacy and Safety of Large Neutral Amino Acids in the Treatment of Classical Phenylketonuria

Brain Diseases | Genetic Diseases, Inborn | Metabolism, Inborn Errors | Brain Diseases, Metabolic | Phenylketonurias | Brain Diseases, Metabolic, Inborn | Amino Acid Metabolism, Inborn Errors | Metabolic Disease

Denmark
Helga Ellingsgaard

Not yet recruiting

Exercise-regulated Organ Crosstalk, Influence of IL-6 (EVEX)

Healthy Volunteers Only | Energy Metabolism

Denmark
University of Michigan

Recruiting

Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones (BIPO)

Bipolar Disorder

United States
NGGT (Suzhou) Biotechnology Co., Ltd.

Not yet recruiting

AAV Gene Therapy Clinical Study in Adult Classic PKU

Phenylketonurias
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Recruiting

Effects of Olfactory Training on the Brain Function in T2DM Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus | Mild Cognitive Impairment

China
Chiesi Farmaceutici S.p.A.
ICON plc

Not yet recruiting

A Study to Learn About the Safety and Effects of the Study Drug PRX-102 in Children and Adolescents With Fabry Disease (FLY)

Fabry Disease
Caroline Michaela Kistorp
Sanofi

Not yet recruiting

Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease (FORTIFY)

Chronic Kidney Diseases | Fabry Disease

Denmark
University of California, Los Angeles

Not yet recruiting

Type 2 Diabetes and Blood Brain Barrier Improvement

Type2diabetes

United States
National Taiwan University Hospital

Recruiting

The Natural History of Sialidosis Type I

Observational Study

Taiwan
Forge Biologics, Inc

Not yet recruiting

Long-term Follow-up Study to Evaluate Safety and Efficacy of FBX-101 in Krabbe Patients

Krabbe Disease

United States
BioMarin Pharmaceutical

Recruiting

A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

Phenylketonuria (PKU)

United States
University of Pennsylvania

Recruiting

Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

Tauopathies

United States
PTC Therapeutics

Recruiting

A Study of Sepiapterin in Participants With Phenylketonuria (PKU) (EPIPHENY)

Phenylketonuria

United States
metaX Institut fuer Diatetik GmbH
Great Ormond Street Hospital for Children NHS Foundation Trust; Birmingham...

Not yet recruiting

Acceptability/Tolerance of Protein Substitutes in Tablet Form for the Dietary Management of Rare Aminoacidopathies (ZeroMinisMR)

Alkaptonuria | Homocystine; Metabolic Disorder | Tyrosinemia, Type I | Tyrosinemia, Type II | Tyrosinemia, Type III | MSUD (Maple Syrup Urine Disease)
Nilgün Erdoğan

Recruiting

The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort

Diabetes Mellitus, Type 2 | Pulmonary Disease, Chronic Obstructive | Respiratory Insufficiency | Stroke, Ischemic | High Blood Pressure

Turkey
University of Ulm

Recruiting

Relative Contribution of Brain Insulin Action for Postprandial Metabolism (BrainInsPPM)

Glucose Metabolism Disorders

Germany
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Announcement of Rare Metabolic Diseases in Systematic Newborn Screening: the Phenylketonuria Experience. (ANNPHE)

Phenylketonuria

France
Hospital Universitario Dr. Jose E. Gonzalez
Ever Neuro Pharma GmbH

Recruiting

Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke

Diabetes Mellitus, Type 2 | Ischemic Stroke, Acute | Blood Brain Barrier

Mexico
Xinhua Hospital, Shanghai Jiao Tong University...
Shanghai Vitalgen BioPharma Co., Ltd.

Recruiting

An Exploratory Clinical Trial of VGN-R08b in Patients With Type II Gaucher Disease

Type II Gaucher Disease

China
UniQure Biopharma B.V.

Recruiting

Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease

Fabry Disease

United States
Brunel University
Royal Free Hospital NHS Foundation Trust

Recruiting

A Co-designed Physical Activity Intervention in Fabry Disease

Fabry Disease

United Kingdom
Chung-Hsing Wang
Sanofi

Not yet recruiting

Screening for Gaucher Disease and Acid Sphingomyelinase Deficiency

Gaucher Disease

Taiwan
iECURE, Inc.

Recruiting

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency (OTC-HOPE)

Urea Cycle Disorders, Inborn | Ornithine Transcarbamylase Deficiency | Ornithine Transcarbamylase Deficiency Disease | Ornithine Carbamoyltransferase Deficiency (Disorder)

United Kingdom
Insel Gruppe AG, University Hospital Bern
Psychiatric University Hospital, Zurich

Recruiting

Molecular Imaging Study of Harmine/DMT: a Basic Research Approach (HaD-PET)

Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine

Switzerland
Centre for Addiction and Mental Health

Recruiting

Effects of Antipsychotics on Brain Insulin Action in Females

Insulin Resistance | Type 2 Diabetes | Menstrual Cycle | Antipsychotics

Canada
Travere Therapeutics, Inc.

Recruiting

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment (HARMONY)

Homocystinuria

United States
Steno Diabetes Center Copenhagen
Glostrup University Hospital, Copenhagen; University Hospital Bispebjerg and...

Recruiting

Determining Circadian Metabolic and Behavioural Rhythms in Patients With and Without Type 2 Diabetes (Cir-D-Brain)

Type 2 Diabetes | Circadian Rhythm

Denmark
Rupert Lanzenberger
University of Konstanz

Not yet recruiting

Impact of Stress on Brain Energy Metabolism

Stress
Swedish Orphan Biovitrum

Recruiting

A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 Patients

Hereditary Tyrosinemia, Type I

China
University of Cambridge
Sanofi

Recruiting

Molecular Imaging in Fabry Disease of the Heart

Fabry Disease, Cardiac Variant

United Kingdom
bluebird bio
Center for International Blood and Marrow Transplant Research

Recruiting

A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel (Stargazer)

Cerebral Adrenoleukodystrophy (CALD)

United States
Mclean Hospital
Baszucki Family Foundation

Recruiting

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Schizoaffective Disorder | Psychosis | Bipolar I Disorder

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Recruiting

Efficacy Comparison of Polyethylene Glycol Loxenatide and Gliclazide on the Brain Function in T2DM Patients

Type 2 Diabetes Mellitus | Cognitive Function Abnormal

China
Shanghai Vitalgen BioPharma Co., Ltd.

Recruiting

A Study to Evaluate the Tolerability, Safety and Efficacy of VGM-R02b

Glutaric Acidemia Type I | Glutaric Aciduria Type I

China
Children's Hospital of Fudan University

Not yet recruiting

Evaluation of the Safety, Tolerability and Efficacy of a Gene Therapy Drug for the Treatment of Pediatric Fabry Disease

Fabry Disease

China
New York Stem Cell Foundation Research Institute

Recruiting

NYSCF Scientific Discovery Biobank

PTSD | Multiple Sclerosis | Cervical Cancer | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Macular Degeneration | Diabetes Mellitus, Type 1 | Parkinson Disease | Amyotrophic Lateral Sclerosis | Dementia | Ovarian Cancer | Alzheimer Disease | ALS | Vulvar Cancer | Post Traumatic Stress Disorder | Lewy Body Disease and other conditions

United States
University College Cork

Not yet recruiting

Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography (DiFuSE)

Gestational Diabetes | Neonatal Encephalopathy | Diastolic Dysfunction | Trisomy 21 | Transient Tachypnea of the Newborn | Small for Gestational Age at Delivery

Ireland
Hospital Affiliated to the Institute of Neurology...

Not yet recruiting

Clinical Value of DWI-ADC Matching in the Short-term Prognosis of Wilson's Disease

Hepatolenticular Degeneration; Wilson

China

Search clinical trials for: Brain metabolism

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