Search clinical trials for: C5aR antagonist

Total 33542 results

ChemoCentryx

Completed

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis (ADVOCATE)

ANCA-Associated Vasculitis

United States, Australia, Belgium, Canada, France, Italy, Japan, Netherlands, Spain, United Kingdom, Austria, Czechia, Denmark, Germany, Hungary, Ireland, New Zealand, Norway, Sweden, Switzerland
Amgen

Completed

A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications

Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

United States
ChemoCentryx

Completed

Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis

ANCA-associated Vasculitis

United States, Canada
Mario Negri Institute for Pharmacological Research
ChemoCentryx

Terminated

Complement Inhibition in aHUS Dialysis Patients (ACCESS)

Atypical Hemolytic Uremic Syndrome

Italy
Ain Shams University

Recruiting

The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

Intraoperative Bleeding

Egypt
Merck Sharp & Dohme LLC

Not yet recruiting

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Metastatic Breast Cancer
Tufts University

Not yet recruiting

Systemic Absorption of Dexamethasone Oral Rinse in Patients With Oral Lichen Planus

Oral Lichen Planus | Oral Lichenoid Reaction

United States
Zhuhai Beihai Biotech Co., Ltd

Not yet recruiting

An Relative Bioavailability Study of BH006 for Injection in Healthy Subjects

Bioavailability
Milky Kohno
Portland VA Medical Center

Recruiting

Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder (ABSTAIN)

Alcohol Use Disorder

United States
Fundación Santiago Dexeus Font
Regen Lab SA

Not yet recruiting

Efficacy of the Use of Cellular Matrix/ A-CP-HA Kit (CellularMatrix)

Genitourinary Syndrome of Menopause

Spain
Etlik Zubeyde Hanım Women's Health Care, Training...

Not yet recruiting

Effect of Antimullerian Hormone Levels on the Inflammatory Index, Phytochemical Index and NRF Nutrient Density (AMH)

Polycystic Ovary Syndrome | Diet Habit | AMH | Ovarian Failure
University of Copenhagen
Rigshospitalet, Denmark

Recruiting

The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes (GA-17b)

Blood Flow

Denmark
West China Hospital

Recruiting

Fruquintinib Plus S-1 and Raltitrexed (RSF) for mCRC

Fruquintinib | S-1 | Raltitrexed

China
Celgene

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma (GOLSEEK-2)

Lymphoma, Follicular

United States, Australia, Brazil, Canada, Chile, France, Germany, Italy, Korea, Republic of, Poland, Spain, Taiwan, United Kingdom
Ewha Womans University Seoul Hospital

Not yet recruiting

Comparison of the Improvement and Safety of the Ankle Brachial Arterial Pressure Index of Sarpogrelate and Clopidogrel in Stroke Patients With Decreased Ankle Brachial Arterial Pressure Index and Intermittent Claudication of Lower Limb Vascular Atherosclerosis.

Stroke | Atherosclerosis
Mayo Clinic

Not yet recruiting

Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

PreDiabetes

United States
Tanta University

Recruiting

Preoperative Ondansetron Lozenge for Prevention of Postoperative Nausea and Vomiting in Pediatrics Undergoing Squint Surgeries

Postoperative Nausea and Vomiting | Pediatrics | Squint | Ondansetron Lozenge

Egypt
Tanta University

Recruiting

Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section

Cesarean Section | Ondansetron Lozenge | Post-Spinal Shivering

Egypt
AstraZeneca
Premier HealthCare Solutions Inc.

Recruiting

Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care (ANCHOR)

Asthma

United States
Radboud University Medical Center

Not yet recruiting

The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II (RAID-II)

Inflammation | Diabetes Mellitus, Type 1
Odense University Hospital
University of Ulm; University of Birmingham; Hospital of South West Jutland

Not yet recruiting

Identifying Individuals at Risk of Glucocorticoid-Induced Impairment of Bone Disease (RIGID)

Osteoporosis Secondary

Denmark
Yanyan Liu

Recruiting

Linperlisib Combined With Chidamide in Patients With PTCL

Peripheral T-cell Lymphoma

China
British University In Egypt

Not yet recruiting

Efficacy of Thyme Honey in The Management of Oral Aphthous Ulcers

Treatment Compliance | Aphthous Stomatitis (Major) (Minor)

Egypt
Ain Shams University

Recruiting

Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females

Polycystic Ovary Syndrome | Infertility, Female

Egypt
University of Southern California

Not yet recruiting

Ketamine HCl Prolonged Release Oral Tablets for CRPS

Complex Regional Pain Syndromes

United States
VA Office of Research and Development

Not yet recruiting

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Depression | Chronic Low Back Pain

United States
Howard University
National Institute on Drug Abuse (NIDA); University of Miami; University of Illinois... and other collaborators

Not yet recruiting

Integrating MOUD in African American Community Settings (Better Together)

Opioid Use Disorder

United States
University of Udine

Recruiting

Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy (ENDOmiRNA)

Endometriosis

Italy
Cairo University

Not yet recruiting

Effect of Adding Dexamethasone to Bupivacaine 0.25% in SCPB on Surgical Field Visibility During Tympanomastoid Surgery

Postoperative Pain | Surgical Field

Egypt
University of Missouri-Columbia

Not yet recruiting

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia (2100208)

Hypoxia | Menopause | Aging | Vasodilation
Jacobio Pharmaceuticals Co., Ltd.

Not yet recruiting

JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

Advanced Non-squamous Non-small-cell Lung Cancer | Metastatic Non-squamous Non Small Cell Lung Cancer
University of Oxford

Recruiting

Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants (Baby-CINO)

Caffeine | Infant,Premature

United Kingdom
Margaux M. Salas, PhD

Not yet recruiting

The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

PTSD | Neuropathic Pain
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

Obesity

United States
AstraZeneca
Daiichi Sankyo

Not yet recruiting

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung15)

Metastatic Non-small Cell Lung Cancer
University of Colorado, Denver

Not yet recruiting

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome

Obesity | Infertility

United States
Kite, A Gilead Company
Arcellx, Inc.

Not yet recruiting

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3)

Multiple Myeloma
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Phase II Study of SSGJ-707 Combination Therapy in Advanced NSCLC Patients

First-line Advanced NSCLC Patients

China
Peking Union Medical College Hospital

Recruiting

68Ga-NOTA-RM26 PET/CT in Glioma Patients

Glioma

China
Ondokuz Mayıs University

Recruiting

Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case

Sedation | Ketamine | Gynecologic Disease

Turkey
University Hospital Tuebingen
German Center for Mental Health

Not yet recruiting

Pharmacologic Treatment Augmentation in Chronic Depression (Ket+CBASP)

Major Depressive Disorder

Germany
General Hospital of Shenyang Military Region

Not yet recruiting

Efficacy and Safety of Local Glucocorticoids for the Treatment of Radiation-Induced Intestinal Injury

Radiation-Induced Intestinal Injury

China
Peking University People's Hospital

Not yet recruiting

The Efficacy and Safety of Insulin Degludec/Liraglutide Combination (IDegLira) in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2
Assiut University

Not yet recruiting

Comparison Between Ketamine Intrathecal and iv Dexamethasone for Post Cesarean Analgesia

Post Cesarean Analgesia
The First Affiliated Hospital of Soochow University

Not yet recruiting

Treatment of High-risk Newly Diagnosed Multiple Myeloma With Minimal Residual Disease Detection

Multiple Myeloma | Newly Diagnosed | MRD | High Risk
M.D. Anderson Cancer Center

Not yet recruiting

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Hormone Receptor-positive Human Epidermal Growth Factor 2-negative | Metastatic Invasive LObular Carcinoma

United States
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

Pilot Study of Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer

Metastatic Breast Cancer

United States
University of New Mexico

Not yet recruiting

Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose

Opioid Overdose | Opiate Overdose

United States
Teeradon Waewworawit

Not yet recruiting

Efficacy of Intra-Articular Corticosteroid Injections on Clinical Outcomes in Patients With Operative Distal Radius Fractures

Wrist Fractures | Intraarticular Injection
AstraZeneca
Parexel

Recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States

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