Search clinical trials for: CD8 Depleted

Total 340 results

Ohio State University

Terminated

Trial Comparing Three Single Dose Injections for Knee Osteoarthritis

Osteoarthritis, Knee

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Drug Levels of BMS-986165 When Taken as Various Solid Tablet Prototypes by Healthy Participants

Healthy Volunteers

United Kingdom
Haukeland University Hospital
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Unknown

Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) (SuResponsSUR)

Permanent Neonatal Diabetes Mellitus

Norway
China Medical University Hospital

Completed

Functional Plasticity of Human IL-17-producing CD8+ T Cells

IL-17+ CD8 T Cells in Cancer Patients

Taiwan
AgonOx, Inc.
Providence St Joseph Health; Phio Pharmaceuticals Corp.

Recruiting

Adoptive Cell Therapy Using Cancer Specific CD8+ Tumor Infiltrating Lymphocytes in Adult Patients With Solid Tumors (ACT)

Melanoma | Gynecologic Cancer | Colorectal Cancer | Lung Cancer | HNSCC | Urogenital Cancer

United States
Novartis Pharmaceuticals

Terminated

This Study Will Evaluate the Effect of Canakinumab or Pembrolizumab Given as Monotherapy or in Combination as Neo-adjuvant Treatment for Subjects With Early Stages NSCLC. (CANOPY-N)

Non-small Cell Lung Cancer

Canada, Netherlands, Spain, France, Japan, Russian Federation, Germany, Belgium, Greece, Turkey, Taiwan, United States
Centre Hospitalier Universitaire de Saint Etienne

Completed

Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery. (POIR)

Lung Cancer | Surgery

France
Institut National de la Santé Et de la Recherche...
Assistance Publique - Hôpitaux de Paris; Institut Pasteur

Completed

Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage (FluBAL)

Influenza | Acute Respiratory Distress Syndrome | Acute Lung Injury

France
M.D. Anderson Cancer Center
Eligix

Terminated

CD8 DLI for Patients With Relapse or Residual Disease Following Allogeneic Stem Cell Transplantation

Multiple Myeloma | Chronic Lymphocytic Leukemia | Chronic Myelogenous Leukemia | Non Hodgkin's Lymphoma | Hodgkin's Disease

United States
Cytovation AS
Merck Sharp & Dohme LLC

Active, not recruiting

A Study to Evaluate the Safety and Efficacy of CyPep-1 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic Cancers (Catalyst)

Advanced Breast Cancer | Advanced Melanoma | Advanced Head and Neck Squamous Cell Carcinoma

United States, France, Italy, Spain, Netherlands
Nektar Therapeutics
ImaginAb, Inc.

Withdrawn

A CD8 Positron Emission Tomography With Computed Tomography (PET/CT) Study Using ⁸⁹Zr Df-IAB22M2C in Patients With Metastatic Melanoma Receiving Bempegaldesleukin (NKTR-214) and Nivolumab

Metastatic Melanoma

United States
Hellenic Cooperative Oncology Group

Completed

Prognostic Biomarkers in Patients With Urothelial Carcinoma

Bladder Cancer
Centre Hospitalier Universitaire de Saint Etienne

Completed

Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care (CHORDOMES)

Chordoma

France
Cytovation AS
Merck Sharp & Dohme LLC

Active, not recruiting

CyPep-1 Injections in Cancer Inducing Lymphocyte Infiltrate Accumulations (CICILIA)

Advanced Solid Tumor Malignancy

Netherlands, France, Spain
AstraZeneca
ImaginAb, Inc.

Terminated

A First-in-human Study to Evaluate the Safety and Tolerability of AZD8853 in Participants With Selected Advanced/Metastatic Solid Tumours

Carcinoma, Non-Small-Cell Lung | Urinary Bladder Neoplasms | Colorectal Cancer

United States, Canada
ImaginAb, Inc.

Completed

⁸⁹Zr-Df-IAB22M2C (CD8 PET Tracer) for PET/CT in Patients With Metastatic Solid Tumors (iCorrelate)

Metastatic Solid Tumors | Positron-Emission Tomography

United States
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France

Active, not recruiting

The Immunoscore as a Prognostic Marker for Patients With a Colorectal Cancer (IMMUCOL)

Colorectal Cancer | Surgical Resection of the Colorectal Tumor

France
George Washington University

Withdrawn

Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP)

Pneumocystis Carinii Pneumonia

United States
National University Hospital, Singapore
Singapore General Hospital

Unknown

T-cell Depleted Donor Lymphocyte Infusion (DLI)for Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)

Acute Myeloid Leukemia | Myelodysplastic Syndromes

Singapore
Shanghai Public Health Clinical Center

Active, not recruiting

Clinical Safty and Efficacy Study of Infusion of iNKT Cells and CD8+T Cells in Patients With Advanced Solid Tumor

Renal Cell Carcinoma | Small Cell Lung Cancer | Hepatocellular Carcinoma | Gastric Cancer | Non-small Cell Lung Cancer | Pancreas Cancer

China
Imperial College London

Withdrawn

Autologous Cytomegalovirus (CMV) Specific CD8+ T Cells as Treatment for CMV Reactivation

Allogeneic Stem Cell Transplantation | CMV Reactivation | Autologous CMV Specific CD8+ T Cells

United Kingdom
Assiut University

Not yet recruiting

Immune Markers in Pediatric ITP on Second Line Therapy

ITP - Immune Thrombocytopenia
T-knife GmbH

Terminated

A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors (IMAG1NE)

Advanced Solid Tumors

Germany, Belgium, Spain, Netherlands, United Kingdom
Centre Georges Francois Leclerc

Active, not recruiting

Relevance of T Lymphocytes Tumor Infiltrates CD8 and Foxp3 as Immune Prognostic Biomarker in Breast Cancer Treated by Neo Adjuvant Chemotherapy (PRIMUNEO)

Breast Cancer

France
Assistance Publique - Hôpitaux de Paris

Completed

Injection of CD4 and CD8 + T Cells Anti-Cytomegalovirus (CMV) or Anti-adenovirus (CTLantiCMV)

Cytomegalovirus Infections | Adenovirus Infections

France
Wuhan Union Hospital, China

Recruiting

Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study

Sepsis | Inflammatory Response

China
Diwakar Davar
Merck Sharp & Dohme LLC; Gateway for Cancer Research

Not yet recruiting

Pembrolizumab/Lenvatinib With and Without Responder-derived FMT in Relapsed/Refractory Melanoma

PD-1 Refractory Advanced Melanoma

United States
Centre Hospitalier Universitaire Dijon

Completed

Study of the T CD8 Immune Response in Horton's Disease (Horton CD8)

Horton's Disease

France
Guangzhou 8th People's Hospital
Sun Yat-sen University

Completed

Reconstitution of HIV-specific Immunity Against HIV

HIV

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

T-Cell Infusion, Aldesleukin, and Utomilumab in Treating Patients With Recurrent Ovarian Cancer

Recurrent Ovarian Carcinoma | HLA-A*0201 Positive Cells Present | COL6A3 Positive | PRAME Positive

United States
University Medical Center Groningen

Active, not recruiting

ImmunoPET With an Anti-CD8 Imaging Agent

Metastatic Cancer | Unresectable Malignant Neoplasm

Netherlands
Nantes University Hospital

Completed

Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis (Prévall-DP)

Allergic Rhinitis | Atopic Dermatitis | Allergic Asthma

France
University of Erlangen-Nürnberg Medical School

Completed

Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC

Locally Advanced Head and Neck Squamous Cell Carcinoma

Germany
Jean-Pierre Routy
St. Joseph's Health Care London

Not yet recruiting

Fecal Microbiota Translantation (FMT) to Reduce Inflammation in PLWH: The Gutsy Pilot Study (Gutsy)

HIV-1-infection
ImaginAb, Inc.
University of Hull

Recruiting

CD8 Minibody Repeatability Study (PRETZCEL)

Melanoma | Renal Cell Carcinoma

United Kingdom
Institut National de la Santé Et de la Recherche...

Completed

Identification of Hepatitis C Virus (HCV) Specific T Cells (TETRA)

Hepatitis C

France
Centre Hospitalier Universitaire de Nice

Recruiting

Comparison of Inflammatory Markers and Incidence of Comorbidities in Patients on Antiretroviral Therapy With Second-generation Anti-integrase Drugs on Triple Versus Dual Therapy (COLLATERAL 2)

Hiv

France
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

NY-ESO-1-Specific T-cells in Treating Patients With Advanced NY-ESO-1-Expressing Sarcomas Receiving Palliative Radiation Therapy

Sarcoma

United States
Fujian Medical University

Not yet recruiting

Study Evaluating Neoadjuvant Immunotherapy Increasing CD8+ Cell Infiltration in Advance Gastric Adenocarcinoma

Advanced Gastric Carcinoma | Neoadjuvant Immunotherapy | CD8+ Tumor Infiltrating Lymphocytes
Nantes University Hospital
UMR892

Completed

Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study (MelSort)

Metastatic Melanoma

France
Fundacion para la Investigacion Biomedica del Hospital...

Completed

Effects of Maraviroc vs. Efavirenz on CD4/CD8 Ratio (MeritRate)

HIV/AIDS
H. Lee Moffitt Cancer Center and Research Institute

Active, not recruiting

CD8 Depleted, Non-engrafting, HLA Mismatched Unrelated Infusion With MDS and Secondary AML

Myelodysplastic Syndromes | Secondary Acute Myeloid Leukemia

United States
ImaginAb, Inc.

Recruiting

Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies (iPREDICT)

Melanoma | Renal Cell Carcinoma | Non Small Cell Lung Cancer | Merkel Cell Carcinoma, Unspecified

United States, Australia, Belgium, Netherlands, Switzerland, United Kingdom
Shanghai General Hospital, Shanghai Jiao Tong University...
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China

Unknown

Immunotherapy of CD8+NKG2D+ AKT Cell With Chemotherapy to Pancreatic Cancer (AKT)

Pancreatic Ductal Adenocarcinoma

China
National Institute of Allergy and Infectious Diseases...

Terminated

CD8 Reactivity to Microorganisms in Blood and Breast Milk

Pertussis | Tuberculosis | Lyme Disease | Leprosy | Immune Modulation

United States
University of Liege

Completed

Nonmyeloablative Stem Cell Transplantation With CD8-depleted or Unmanipulated Peripheral Blood Stem Cells (PBSC)

Hematologic Malignancies

Belgium
Fred Hutchinson Cancer Center
HighPass Bio, Inc.

Suspended

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Acute Myeloid Leukemia | Leukemia | Chronic Myelomonocytic Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Chronic Myelomonocytic Leukemia | Recurrent Myelodysplastic Syndrome | Refractory... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Juno Therapeutics, Inc.

Completed

Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States
Dren Bio
Novotech

Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Aggressive NK Cell Leukemia | Hepatosplenic T-cell Lymphoma | Enteropathy-Associated T-Cell Lymphoma | Subcutaneous Panniculitis-Like T-Cell Lymphoma | Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma | LGLL - Large Granular Lymphocytic Leukemia | Primary Cutaneous T-Cell Lymphoma - Category and other conditions

United States, Australia, France, Spain
University of North Carolina, Chapel Hill
National Institute on Drug Abuse (NIDA); National Institute on Alcohol Abuse... and other collaborators

Completed

Evaluation of Genetic Markers as Explanations for the Observed Differences in Disease Progression in HIV+ Youth

HIV Infection

United States

Search clinical trials for: CD8 Depleted

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Brazil

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations