- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04486820
Immunohistochemical Study of Chordomas to Improve Their Diagnosis and Prognosis Care (CHORDOMES)
July 22, 2020 updated by: Centre Hospitalier Universitaire de Saint Etienne
Chordomas are very rare malignant tumors, chemo-resistant with high propensity for recurrence.
The role of immunotherapy in these patients remains largely unexplored while PD-L1 and CD8 status in the micro-environment of chordomas is basically not known.
Similarly, this tumor often poses diagnostic difficulties due to its resemblance with metastasis or chondrosarcoma, thus, it would be useful to know the expression status of factors used during the work-up of metastatic or mesenchymal tumors, like CDX2, INSM1 and FOXA1, which remains unknown for chordomas.
Thus, the aim of the study is to explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression in a series of chordomas and compare it with clinico-pathological and prognostic features.
Study Overview
Detailed Description
Retrospective, non-interventional study.
A series of chordomas will be analyzed for detailed histologic features and for various immunohistochemical factors and results will be compared with clinical factors, like overall and disease-free survival.
Study Type
Observational
Enrollment (Actual)
40
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Saint-Étienne, France
- CHU de Saint-Etienne
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients diagnosed with chordoma
Description
Inclusion Criteria:
- Patients diagnosed with chordoma
- Sufficient histological material available
- Tumor expression of brachyury
Exclusion Criteria:
- Insufficient histological material
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Chordoma
Patients diagnosed with chordoma
|
Analysis of histological material for immunohistochemical study.
To explore PD-L1, CD8, CDX2, INSM1 and FOXA1 expression
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Expression of PD-L1
Time Frame: Baseline
|
measured by immunohistochemical method
|
Baseline
|
Expression of CD8
Time Frame: Baseline
|
measured by immunohistochemical method
|
Baseline
|
Expression of CDX2
Time Frame: Baseline
|
measured by immunohistochemical method
|
Baseline
|
Expression of INSM1
Time Frame: Baseline
|
measured by immunohistochemical method
|
Baseline
|
Expression of FOXA1
Time Frame: Baseline
|
measured by immunohistochemical method
|
Baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Histological type of tumor
Time Frame: Baseline
|
data collected in personal health records.
|
Baseline
|
Tumor location
Time Frame: Baseline
|
data collected in personal health records.
|
Baseline
|
survival of patients after diagnosis with or without progression
Time Frame: Baseline
|
data collected in personal health records.
|
Baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Georgia KARPATHIOU, MD, CHU Saint-Etienne
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 1, 2020
Primary Completion (Actual)
July 1, 2020
Study Completion (Actual)
July 1, 2020
Study Registration Dates
First Submitted
July 22, 2020
First Submitted That Met QC Criteria
July 22, 2020
First Posted (Actual)
July 27, 2020
Study Record Updates
Last Update Posted (Actual)
July 27, 2020
Last Update Submitted That Met QC Criteria
July 22, 2020
Last Verified
July 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 20CH028
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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