Search clinical trials for: CEP290 gene

Total 270136 results

Editas Medicine, Inc.

Completed

Natural History Study of CEP290-Related Retinal Degeneration

Eye Diseases | Retinal Degeneration | Eye Diseases, Hereditary | Vision Disorders | Blindness | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Netherlands, France, Germany
ProQR Therapeutics

Terminated

Extension Study to Study PQ-110-001 (NCT03140969) (INSIGHT)

Eye Diseases | Neurologic Manifestations | Eye Diseases, Hereditary | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Belgium
Editas Medicine, Inc.

Active, not recruiting

Single Ascending Dose Study in Participants With LCA10

Retinal Degeneration | Eye Diseases, Hereditary | Vision Disorders | Leber Congenital Amaurosis 10 | Inherited Retinal Dystrophies | Retinal Disease | Eye Disorders Congenital

United States
Ocugen

Recruiting

Study to Assess the Safety and Efficacy of OCU400 for Retinitis Pigmentosa and Leber Congenital Amaurosis (OCU400)

Retinitis Pigmentosa | Leber Congenital Amaurosis

United States
ProQR Therapeutics

Recruiting

An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. (BRIGHTEN)

Eye Diseases | Neurologic Manifestations | Retinal Degeneration | Retinal Dystrophies | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

Belgium, Brazil, Canada, Germany, Italy, Netherlands, United Kingdom
ProQR Therapeutics

Completed

Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Leber's Congenital Amaurosis

United States, Belgium
ProQR Therapeutics

Active, not recruiting

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE) (ILLUMINATE)

Eye Diseases | Neurologic Manifestations | Eye Diseases, Hereditary | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Belgium, Brazil, Canada, France, Germany, Italy, Netherlands, United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Assessment of the Prevalence of Genes AHI1, NPHP1 and CEP290 in Joubert Syndrome (JSCORS)

Joubert Syndrome | Cerebello-oculo-renal Syndromes

France
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Not yet recruiting

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

Generalized Myasthenia Gravis

United States, Germany
Danderyd Hospital
University of Trieste; Istituto Auxologico Italiano

Recruiting

Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea (AF-MiTriSto)

Hypertension | Atrial Fibrillation | Obstructive Sleep Apnea | Autonomic Dysfunction | Arterial Stiffness

Sweden, Italy
University of Kiel
University Hospital Schleswig-Holstein

Not yet recruiting

Impact of Diet on the Microbiome-Immune-Brain Axis in Parkinson's Disease

Parkinson Disease

Germany
Riphah International University

Not yet recruiting

tDCS and Lower Limb Performance in Stroke

Stroke

Pakistan
University of Washington

Not yet recruiting

Optimizing Infection Prophylaxis Prior to Shoulder Surgery

Periprosthetic Joint Infection | Arthroplasty Shoulder

United States
Nausicaa Medical
Clin-Experts

Not yet recruiting

Prevention of Pressure Ulcers in Patients at Medium to High Risk of Pressure Ulcers Using the R'GO SOINS Overlay Mattress (PRESERVE)

Pressure Ulcer

France
Hospital do Coracao
Brazilian Research in Intensive Care Network (BRICNet)

Not yet recruiting

Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis (NoVa)

Septic Shock

Brazil
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (ANTAMIN)

Limb Injury

France
Second Affiliated Hospital, School of Medicine,...

Recruiting

Randomized Phase II Trial: Chest Wall RT Omission After Prosthetic Reconstruction

Breast Neoplasms

China
Milton S. Hershey Medical Center
Aminex Therapeutics, Inc.

Not yet recruiting

Difluoromethylornithine (DFMO) and AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Ewing Sarcoma | Embryonal Tumor With Multilayered Rosettes | Osteosarcoma Recurrent | Atypical Teratoid/Rhabdoid Tumor | DIPG Brain Tumor | Neuroblastoma Recurrent
Chinese University of Hong Kong

Recruiting

Prospective Data on Bariatric Surgery Effect on IPSS and LUTS

Lower Urinary Tract Symptoms | Bariatric Surgery Candidate

Hong Kong
Yale University
Wallace Research Foundation

Not yet recruiting

Mechanistic Studies of Psilocybin in Headache Disorders

Migraine

United States
First Affiliated Hospital of Zhejiang University
First Affiliated Hospital of Wenzhou Medical University; The Affiliated Hospital... and other collaborators

Recruiting

Primary Multiple Myeloma Who Achieved MRD Negativity After Induction Therapy, ASCT or Not

Multiple Myeloma | Minimal Residual Disease

China
Hunter Holmes Mcguire Veteran Affairs Medical Center

Recruiting

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis (RESIST-PTSD)

PTSD | Cirrhosis

United States
AstraZeneca

Recruiting

STEP: Phase IIIb Study of Benralizumab to Step-down Maintenance Therapy in Patients With Severe Eosinophilic Asthma (STEP)

Severe Eosinophilic Asthma

China
French Cardiology Society
Lifetech Scientific (Shenzhen) Co., Ltd.

Recruiting

Post-marketing Clinical Study of the LAMBRE System for Left Auricle Closure (ESCALLE)

Atrial Fibrillation

France
Nanjing IASO Biotechnology Co., Ltd.

Recruiting

A Phase III Study of Eque-cel in Subjects With Len-refractory RRMM (FUMANBA-03) (FUMANBA-03)

Multiple Myeloma

China
Cosmetique Active International

Recruiting

Evaluation of Effaclar Duo+M on Acne Lesions in Subjects With Mild to Moderate Acne on Face and Trunk

Acne

Brazil
University of Sao Paulo
University of Campinas, Brazil; Faculdade de Medicina do ABC

Recruiting

Use of Botulinum Toxin A in Direct Eyebrow Lift Scar

Skin Scarring | Eyebrow Ptosis

Brazil
Emory University
The Marcus Foundation

Not yet recruiting

A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

Dilated Cardiomyopathy

United States
pablo Juan-Salvadores
Fundacin Biomedica Galicia Sur; Conselleria de Saúde Pública de Galicia; Conselleria...

Recruiting

Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease (AIRHEART)

Myocardial Infarction | Angina, Stable | Acute Coronary Syndrome | MINOCA | Coronary Artery Disease Premature

Spain
Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec and Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared With Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
Sohag University

Recruiting

Identification of Pattern and Factors Affecting Recurrence in Head and Neck Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma

Egypt
Wen-huo Chen

Recruiting

Endovascular Treatment for Mild Ischemic Stroke Due to Acute Large Vessel Occlusion in the Anterior Circulation (Mild-MT)

Mild Stroke | Endovascular Treatment

China
Minovia Therapeutics Ltd.

Recruiting

A Phase Ib Study to Evaluate the MNV-201 in Patients With Low Risk MDS

Myelodysplastic Syndromes

Israel
Asociación Colombiana de Hepatología

Recruiting

Screening for Hepatitis c in People Who Inject Drugs in Armenia-Colombia (HCV-PIWD)

Hepatitis C Virus Infection

Colombia
Alfonso Magliacano

Not yet recruiting

Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury (SEE-ABI)

Acquired Brain Injury | Disorders of Consciousness

Italy
VA Office of Research and Development

Not yet recruiting

Non-invasive Mapping-guided Ablation of VT (NoMo-VT)

Ventricular Tachycardia | Sudden Cardiac Death

United States
Aretaieion University Hospital

Recruiting

Opioid-based Versus Opioid-free Endotracheal Intubation

Anesthesia | Opioid Use | Fentanyl | Analgesic Non-narcotic | Anesthesia Intubation

Greece
ResoTher Pharma

Recruiting

An Exploratory, Randomised, Double-blind Study of RTP-026 to Assess Safety, Tolerability and Efficacy in Patients With ST-Elevation Myocardial Infarction (STEMI)

ST Elevation Myocardial Infarction

Denmark
Xuanwu Hospital, Beijing

Not yet recruiting

Forel's Field Electrical Stimulation for Lennox-Gastaut Syndrome (FESL)

Lennox Gastaut Syndrome

China
Istituto per la Ricerca e l'Innovazione Biomedica
Istituto di Gestalt HCC Italy - Centro Clinico e di Ricerca in Psicoterapia...

Not yet recruiting

Synchrony and Reciprocity of Body Movements and Prosody Between Psychotherapist and Patient (RECiPROsody)

Relationship, Professional Patient

Italy
Nanchong Central Hospital
Pengan County People's Hospital; Nanbu Hospital of County Chinese Medicine; Langzhong... and other collaborators

Recruiting

Stapler Reinforcement Patches Compared to Standard Staplers in Gastrojejunostomy

Postoperative Complications | Gastric Cancer | Gastrostomy | Anastomotic Leakage

China
Hackensack Meridian Health
Preprogen

Recruiting

Endometrial Cell Collection With the PadKit

Neoplasms

United States
Hospital Universitario La Paz
Hospital Universitario del Henares, Madrid, Spain

Not yet recruiting

CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea (CPAPLIP)

Dyslipidemias | Sleep Apnea | Hyperuricemia
Oslo University Hospital
University of Oslo; Lovisenberg Diakonale Hospital

Recruiting

Laryngomalacia, Examinations and Quality of Life in Children Before and After Treatment With Follow-up After 1 Year

Quality of Life | Sleep Apnea, Obstructive | Sleep Apnea | Surgery | Pediatric Disorder | Laryngomalacia | Ear, Nose and Throat Disorder

Norway
Egymedicalpedia

Recruiting

Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation

Valvular Cardiac Surgeries

Egypt
Merck Sharp & Dohme LLC

Not yet recruiting

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)

Non-alcoholic Fatty Liver Disease | NAFLD | Nonalcoholic Steatohepatitis | Metabolic Dysfunction-associated Steatotic Liver Disease | Metabolic Dysfunction-associated Steatohepatitis
Marmara University

Recruiting

Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients

Periodontitis | Periodontal Diseases

Turkey
Eli Lilly and Company
Loxo Oncology, Inc.

Not yet recruiting

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (NEXUS-01)

Cervical Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Triple Negative Breast Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Renal Pelvis Cancer | Urinary Bladder Neoplasm | Recurrent...

United States
University of Central Florida

Not yet recruiting

Collagen Protein Versus Placebo on Muscle Recovery

Anthropometrics: Height and Weight | Isometric Standing and Seated Plantarflexion | Calf Muscle Thickness | Achilles Tendon Length and Thickness | Myotonography of the Calf Musculature and Achilles Tendon | Pain Pressure Threshold of the Calf | Pain Scale | Endurance Calf Test | Dietary Analysis

United States
University of Maryland, Baltimore
The University of Texas Health Science Center, Houston

Not yet recruiting

Promoting Neuroplastic Changes of Patients With TBI

Traumatic Brain Injury

Search clinical trials for: CEP290 gene

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