Search clinical trials for: CYP2B6 polymorphism

Total 1892 results

Tufts University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Withdrawn

Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism

Depression | Alcohol Drinking | Smoking Cessation | Attention Deficit Disorder

United States
TC Erciyes University

Completed

Identification of Polymorphisms Involved in the Metabolism of Propofol

UGT1A1*28 Polymorphism

Turkey
Mahidol University

Unknown

Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients

HIV | Cytochrome P-450 CYP2B6 | Efavirenz

Thailand
Indiana University

Completed

Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics

HIV

United States
Washington University School of Medicine

Completed

CYP2B6 Polymorphisms in Methadone Disposition

Healthy Volunteers

United States
Indiana University
National Institutes of Health (NIH); National Institute of General Medical...

Completed

Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers

Efavirenz, Metabolism and Pharmacokinetics Changes

United States
Vanderbilt University

Completed

Genetic Determinants of the Metabolism of Non-nucleoside Reverse Transcriptase Inhibitors

HIV Infections
Washington University School of Medicine

Completed

CYP2B6 Polymorphisms in Ketamine

Healthy Volunteers

United States
Indiana University
National Institute of General Medical Sciences (NIGMS)

Completed

CYP2B6 Genetics and Drug Interactions in Healthy Volunteers

Healthy

United States
University of Washington

Unknown

Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone

Substance-Related Disorders

United States
Indiana University
National Institute of General Medical Sciences (NIGMS)

Recruiting

Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK

Drug-Drug Interaction

United States
Alexion

Completed

Study of ALXN1840 on the Metabolism of a CYP2B6 Substrate in Healthy Participants

Wilson Disease

United States
Janssen Research & Development, LLC

Completed

A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates

Healthy

Netherlands
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Ibrutinib on the Pharmacokinetics of Oral Contraceptives, CYP2B6, and CYP3A4 Substrates in Female Participants With B Cell Malignancy

Leukemia, Lymphocytic, Chronic, B-Cell

Spain, Poland
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects

Healthy

Belgium
Boehringer Ingelheim

Completed

Evaluation of the Effect of Multiple Dosing With BI 201335 on CYP2B6 Metabolism and Effect of Multiple Dosing With Efavirenz on the Steady-state Pharmacokinetics of BI 201335 and on CYP3A4/5 Metabolism in Healthy Volunteers

Healthy

Switzerland
Daiichi Sankyo, Inc.

Completed

A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS

Healthy

United Kingdom
Universidade Estadual Paulista Júlio de Mesquita...
University of Sao Paulo

Completed

Influence of Diabetes on Tramadol Pharmacokinetics

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus | Neuropathic Pain

Brazil
Yonsei University

Completed

Effect of CYP2C9/CYP2C19 Polymorphism on Pharmacokinetics of Phenobarbital in Korean Neonatal Seizure Patients.

Neonatal Seizure
Annemieke Geluk
The Leprosy Mission Bangladesh

Recruiting

Novel Interventions and Diagnostic Tests for Leprosy (INDIGO#2)

Leprosy

Bangladesh
Takeda

Completed

A Study of Soticlestat and Rifampin in Healthy Adults

Healthy Volunteers

United Kingdom
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

A Drug-drug Interaction Study of SHR2150 on Healthy Chinese Volunteers

Human Immunodeficiency Virus Infection

China
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Drug-Drug Interaction of Pyrotinib With a Moderate CYP3A Inducer

Healthy Subjects, Drug-drug Interaction, Pyrotinib

China
Johns Hopkins University

Withdrawn

Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis

Cystic Fibrosis | MRSA

United States
Peking Union Medical College Hospital
National Key Technologies R&D Program for the 13th Five-year Plan; National... and other collaborators

Completed

Efavirenz 400mg in Treatment-naïve Chinese HIV-infected Patients

HIV-1-infection

China
Bristol-Myers Squibb

Completed

An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants

Healthy Participants

United States
University of Oulu
Oulu University Hospital

Completed

The Effects of PXR Activation on Hepatic Fat Content

Non-alcoholic Fatty Liver Disease

Finland
Hoffmann-La Roche

Completed

A Study of the Effect of Multiple Doses of Rifampin on the Single Dose Pharmacokinetics of RO5424802

Healthy Volunteer

United States
Nivalis Therapeutics, Inc.
Davita Clinical Research

Completed

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Drug Interaction Potentiation

United States
Bristol-Myers Squibb
Truven health

Completed

Risk of CV Events With EFV vs. EFV-free Regimens

HIV/AIDS
Kirby Institute
Imperial College London

Completed

The Efavirenz (EFV) Central Nervous System Exposure Sub-study of Encore1 (ENCORE1-CNS)

HIV Infection

Thailand, Germany, United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Rifampin on the Pharmacokinetics of PCI-32765 in Healthy Participants

Healthy Participants

United States
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Terminated

Safety and Pharmacokinetics of Single and Multiple Dose Rifampin in Infants

Infection

United States
Bamrasnaradura Infectious Diseases Institute
Thai Red Cross AIDS Research Centre; Clinical Research Collaborative Network

Completed

Effectiveness of Efavirenz-based Regimen in HIV-1-infected Patients With Nevirapine Hypersensitivity

Treatment Failure, HIV or AIDS | CD4 Cell Counts

Thailand
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study to Determine the Impact of Multiple Doses of Rifampin on Single-dose Pharmacokinetics of HCV-796

Healthy
Reata, a wholly owned subsidiary of Biogen
Celerion; Q2 Solutions; Altasciences Company Inc.

Completed

An Open-label DDI Study of Omaveloxolone in Healthy Subjects

Healthy Adult Subjects

United States
Boehringer Ingelheim

Completed

A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 894416 in the Blood

Healthy

Germany
Case Western Reserve University
Massachusetts General Hospital; University Hospitals Cleveland Medical Center

Completed

Efavirenz for Patients With Alzheimer's Disease (EPAD)

Alzheimer Disease, Early Onset

United States
Daiichi Sankyo Co., Ltd.

Completed

A Study of the Effect of a Moderate CYP3A Inducer Efavirenz on Quizartinib Pharmacokinetics in Healthy Participants

Healthy Subjects | Pharmacokinetics | Drug-drug Interaction | Quizartinib

United States
Institut Bergonié

Completed

Efavirenz in Treating Patients With Metastatic Prostate Cancer (FAVE)

Prostate Cancer

France
Jiangsu HengRui Medicine Co., Ltd.

Completed

Drug-Drug Interaction of SHR1459 With a Strong CYP3A Index Inducer (Rifampicin)

Healthy Subjects, Drug-drug Interaction, Pharmacokinetics, SHR1459

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Rifampin Effect Study of SHR2554 on Healthy Chinese Adult Subjects

Healthy

China
AstraZeneca

Completed

A Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin

Solid Tumors

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Drug-drug Interaction Trial of Rifampicin Pharmacokinetics Effect on Fluzoparib

Healthy Male Subjects

China
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Rifampin Capsules

Anesthesia | Sedation

China
Bristol-Myers Squibb

Completed

An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants

Healthy Participants

United States
PTC Therapeutics

Completed

Effects of Rifampin on the Pharmacokinetics of Ataluren

Healthy

Canada
Enanta Pharmaceuticals, Inc

Completed

Drug-drug Interaction Study Between EDP-305, Intraconazole and Rifampin in Healthy Volunteers

NASH - Nonalcoholic Steatohepatitis

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

Atherothrombotic Diseases
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics of BMS-986177 in Healthy Subjects

Thrombosis

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