Search clinical trials for: Cell Hypoxia

Total 50496 results

Shandong Qilu Stem Cells Engineering Co., Ltd.
Qilu Children's Hospital of Shandong University

Recruiting

Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases

Bronchopulmonary Dysplasia | Hypoxic-Ischemic Encephalopathy | Short Bowel Syndrome

China
Royal North Shore Hospital

Not yet recruiting

De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) (DE-RADIATE)

HPV Positive Oropharyngeal Squamous Cell Carcinoma

Australia
Mayo Clinic

Not yet recruiting

Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery

Skin Cancer | Skin Cancer Face | Malignant Cutaneous Adnexal Neoplasm

United States
Jian Chen

Recruiting

Randomized Study of Carbon Ion Boost in Hypoxic Lesions for Locally Advanced Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Rajiv Gandhi Cancer Institute & Research Center...
Varian, a Siemens Healthineers Company

Recruiting

Dose Escalation Using Hypoxia-adjusted Radiotherapy (DE-HyART)

Head and Neck Squamous Cell Carcinoma

India
Hospices Civils de Lyon

Recruiting

MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy) (ISRAR)

Kidney Cancer | Head and Neck Cancer | Glioblastoma | Prostate Cancer | Cervix Cancer

France
The Christie NHS Foundation Trust

Not yet recruiting

Assessing the Relationship Between Hypoxia and the Immune Environment in Myeloma Patients (CHIME) (CHIME)

Myeloma

United Kingdom
Vanderbilt-Ingram Cancer Center
National Institutes of Health (NIH)

Recruiting

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

Head and Neck Squamous Cell Carcinoma | Brain Metastases

United States
NiKang Therapeutics, Inc.
Pfizer

Recruiting

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Neoplasms | Kidney Cancer | Kidney Neoplasms | Carcinoma, Renal Cell | Urologic Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Kidney Diseases | Urologic Diseases | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Clear Cell Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Recurrent... and other conditions

United States
Shanghai East Hospital
Sir Run Run Shaw Hospital

Recruiting

UC-MSCs in the Treatment of Severe and Critical COVID-19 Patients With Refractory Hypoxia

COVID-19 Pneumonia | Mesenchymal Stem Cell

China
University of Sydney
The Brain Cancer Group

Not yet recruiting

MRI Hypoxia Study for Glioblastoma Multiforme (GBM) Radiation Therapy (MANGO)

Glioblastoma Multiforme

Australia
Federal State Budget Institution Research Center...

Not yet recruiting

The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants

Premature Birth | Neurodevelopmental Disorders | Extreme Prematurity | Preterm Intraventricular Hemorrhage | Hypoxia-Ischemia, Cerebral

Russian Federation
Merck Sharp & Dohme LLC

Recruiting

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Renal Cell Carcinoma

United States, Australia, Israel
Mirjana Grebenar Cerkez

Recruiting

The Role of the Device Operating Under the Continuous Positive Airway Pressure in the Recovery Process of Cochlea

Obstructive Sleep Apnea

Croatia
Fudan University
Merck Sharp & Dohme LLC

Recruiting

Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004) (HYPERION)

Esophageal Squamous Cell Carcinoma

China
Qianfoshan Hospital

Recruiting

Novel Biomarkers of Hypoxia and Metabolism in Clear Cell Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

China
NiKang Therapeutics, Inc.

Recruiting

A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Kidney Cancer | Kidney Neoplasms | Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma | Hypoxia | Metastatic Renal Cell Carcinoma | Recurrent Renal Cell Carcinoma | Renal Cancer | Advanced Renal Cell Carcinoma | Renal Neoplasms | ccRCC | Refractory Renal Cell Carcinoma | Hypoxia Inducible Factor (HIF) | HIF2α... and other conditions

United States
Stem Cell and Cancer Research Indonesia
Provincial Government of Central Java, Indonesia

Recruiting

Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia

Covid-19 | Cytokine Storm

Indonesia
Coventry University
University Hospitals Coventry and Warwickshire NHS Trust

Recruiting

pH, Hypoxia and Haemodialysis (pHHd)

End Stage Renal Disease on Dialysis

United Kingdom
University of Missouri-Columbia

Recruiting

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Healthy | Obesity | Vasodilation | Vasoconstriction

United States
Weill Medical College of Cornell University
William Rhodes Center for Glioblastoma

Recruiting

Tumor Hypoxia and Proliferation in Patients With High-Grade Glioma

Glioma

United States
The Royal Wolverhampton Hospitals NHS Trust
University of Wolverhampton

Recruiting

Zn-DDC to Target Hypoxia-NFkappaB-CSCs Pathway in Multiple Myeloma

Multiple Myeloma

United Kingdom
James Reynolds
National Heart, Lung, and Blood Institute (NHLBI); Case Western Reserve University

Recruiting

S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

Transfusion Related Complication

United States
Technische Universität Dresden

Not yet recruiting

Individualized Radiation Dose Prescription in HNSCC Based on F-MISO-PET Hypoxia-Imaging (INDIRA-MISO)

Head and Neck Squamous Cell Carcinoma

Germany
University Hospital of Ferrara
AUSL Romagna Rimini

Recruiting

Use of Melatonin for Neuroprotection in Asphyxiated Newborns (MELPRO)

Hypoxic-Ischemic Encephalopathy | Cell Damage | Asphyxia Perinatal

Italy, Holy See (Vatican City State)
Assistance Publique Hopitaux De Marseille

Recruiting

Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells (NEOSTEM)

Neonatal Hypoxic-ischaemic Encephalopathy

France
Danish Head and Neck Cancer Group

Recruiting

DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. (DAHANCA30)

Hypoxia | Head and Neck Squamous Cell Carcinoma | Radiotherapy | Hypoxic Modification | Gene Profile, Gene Signature

Denmark
Tanta University

Completed

Evaluating the Effect of Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
Michael Cotten

Completed

Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy

Neonatal Hypoxic Ischemic Encephalopathy

United States
Michael Cotten
The Robertson Foundation

Completed

A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy ((HIE))

Moderate or Severe Hypoxic-ischemic Encephalopathy in Newborns

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma

HPV-Associated Oropharyngeal Squamous Cell Carcinoma | Squamous Cell Carcinoma of the Neck

United States
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)

Carcinoma, Renal Cell

Poland, Australia, Japan, United States, Korea, Republic of, Taiwan, China, Brazil, Bulgaria, Canada, Chile, Colombia, Czechia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Malaysia, Mexico, Netherlands, New Zealand, Romani... and more
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

Carcinoma, Renal Cell

Hungary, United States, Brazil, Canada, Chile, Colombia, Czechia, Denmark, Finland, France, Germany, Hong Kong, Italy, Japan, Korea, Republic of, Norway, Russian Federation, Spain, Sweden, Taiwan, Turkey, Ukraine, United Kingdom
Joanne Kurtzberg, MD
Duke Clinical and Translational Science Institute (CTSI), part of the NIH...

Completed

Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE

Moderate to Severe Hypoxic-ischemic Encephalopathy

United States
Mount Sinai Hospital, Canada
Princess Margaret Hospital, Canada

Active, not recruiting

Low-Flow vs. High-Flow Nasal Cannula for Hypoxemic Immunocompromised Patients During Diagnostic Bronchoscopy

Hypoxia | Hematologic Malignancy | Immunocompromised | Post Hematopoietic Stem Cell Transplant | Pulmonary Infiltrates

Canada
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Carcinoma, Renal Cell

China
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Carcinoma, Renal Cell

United States, Colombia, Canada, Australia, Finland, Japan, United Kingdom, Brazil, Chile, China, Croatia, Czechia, Denmark, France, Germany, Guatemala, Hungary, Ireland, Italy, Korea, Republic of, Malaysia, Mexico, Norway, Philippines, Polan... and more
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Carcinoma, Renal Cell

United States, Australia, Belgium, Greece, Ireland, Israel, Netherlands, Russian Federation, United Kingdom
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Active, not recruiting

Prognostic Value of Tumor Hypoxia, as Measured by 18F-FMISO Breath Hold PET/CT, in Non-Small-Cell-Lung Cancer (NSCLC) Patients

Non-Small-Cell-Lung Cancer (NSCLC)

United States
Nagoya University
Life Science Institute, Inc.

Completed

The Clinical Trial of CL2020 Cells for Neonatal Hypoxic Ischemic Encephalopathy (SHIELD)

Hypoxia-Ischemia, Brain

Japan
Teclison Ltd.

Active, not recruiting

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Hepatocellular Carcinoma | Neuroendocrine Tumors | Gastrointestinal Cancer Metastatic

United States
University of California, San Francisco

Completed

Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy

Refractory Plasma Cell Myeloma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Recurrent Plasma Cell Myeloma | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | Recurrent High Grade B-Cell Lymphoma | Refractory High Grade B-Cell Lymphoma | Recurrent... and other conditions

United States
Hope Biosciences
The University of Texas Health Science Center, Houston

Active, not recruiting

A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy

Traumatic Brain Injury

United States
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Belzutifan (MK-6482) in Participants With Advanced Clear Cell Renal Cell Carcinoma (MK-6482-018)

Carcinoma, Renal Cell

United States
Peloton Therapeutics, Inc.

Active, not recruiting

A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)

Kidney Cancer | Renal Cell Carcinoma | Renal Cancer | Renal Cell Carcinoma (RCC) | Renal Cell Cancer Metastatic | Kidney | Clear Cell Renal Cell Carcinoma (ccRCC) | Renal Cell Carcinoma Recurrent | Renal Cell Cancer, Recurrent

United States
Universitaire Ziekenhuizen KU Leuven
Flemish League Against Cancer

Terminated

Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma

Head and Neck Cancer

Belgium
Tanta University

Completed

Evaluating the Effect of Digoxin and Ursodeoxycholic Acid in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)

Renal Cell Carcinoma

China
Rain Oncology Inc

Terminated

Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients (TH-4000)

NSCLC | Non-small Cell Lung Cancer | Non-squamous NSCLC

United States, Australia
Rain Oncology Inc

Terminated

Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin

Metastatic Head-and-neck Squamous-cell Carcinoma

United States, Australia

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